LOCUS       NM_001077429            1531 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus lunapark, ER junction formation factor (Lnpk),
            mRNA.
ACCESSION   NM_001077429 XM_001061085 XM_342450
VERSION     NM_001077429.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1531)
  AUTHORS   Breuss,M.W., Nguyen,A., Song,Q., Nguyen,T., Stanley,V., James,K.N.,
            Musaev,D., Chai,G., Wirth,S.A., Anzenberg,P., George,R.D.,
            Johansen,A., Ali,S., Zia-Ur-Rehman,M., Sultan,T., Zaki,M.S. and
            Gleeson,J.G.
  TITLE     Mutations in LNPK, Encoding the Endoplasmic Reticulum Junction
            Stabilizer Lunapark, Cause a Recessive Neurodevelopmental Syndrome
  JOURNAL   Am J Hum Genet 103 (2), 296-304 (2018)
   PUBMED   30032983
REFERENCE   2  (bases 1 to 1531)
  AUTHORS   Wang,S., Tukachinsky,H., Romano,F.B. and Rapoport,T.A.
  TITLE     Cooperation of the ER-shaping proteins atlastin, lunapark, and
            reticulons to generate a tubular membrane network
  JOURNAL   Elife 5, e18605 (2016)
   PUBMED   27619977
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1531)
  AUTHORS   Chen,S., Desai,T., McNew,J.A., Gerard,P., Novick,P.J. and
            Ferro-Novick,S.
  TITLE     Lunapark stabilizes nascent three-way junctions in the endoplasmic
            reticulum
  JOURNAL   Proc Natl Acad Sci U S A 112 (2), 418-423 (2015)
   PUBMED   25548161
REFERENCE   4  (bases 1 to 1531)
  AUTHORS   Shemesh,T., Klemm,R.W., Romano,F.B., Wang,S., Vaughan,J.,
            Zhuang,X., Tukachinsky,H., Kozlov,M.M. and Rapoport,T.A.
  TITLE     A model for the generation and interconversion of ER morphologies
  JOURNAL   Proc Natl Acad Sci U S A 111 (49), E5243-E5251 (2014)
   PUBMED   25404289
REFERENCE   5  (bases 1 to 1531)
  AUTHORS   Moriya,K., Nagatoshi,K., Noriyasu,Y., Okamura,T., Takamitsu,E.,
            Suzuki,T. and Utsumi,T.
  TITLE     Protein N-myristoylation plays a critical role in the endoplasmic
            reticulum morphological change induced by overexpression of protein
            Lunapark, an integral membrane protein of the endoplasmic reticulum
  JOURNAL   PLoS One 8 (11), e78235 (2013)
   PUBMED   24223779
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1531)
  AUTHORS   Gross,S., Krause,Y., Wuelling,M. and Vortkamp,A.
  TITLE     Hoxa11 and Hoxd11 regulate chondrocyte differentiation upstream of
            Runx2 and Shox2 in mice
  JOURNAL   PLoS One 7 (8), e43553 (2012)
   PUBMED   22916278
REFERENCE   7  (bases 1 to 1531)
  AUTHORS   Herault,Y., Fraudeau,N., Zakany,J. and Duboule,D.
  TITLE     Ulnaless (Ul), a regulatory mutation inducing both loss-of-function
            and gain-of-function of posterior Hoxd genes
  JOURNAL   Development 124 (18), 3493-3500 (1997)
   PUBMED   9342042
REFERENCE   8  (bases 1 to 1531)
  AUTHORS   Rusiniak,M.E., O'Brien,E.P., Novak,E.K., Barone,S.M., McGarry,M.P.,
            Reddington,M. and Swank,R.T.
  TITLE     Molecular markers near the mouse brachymorphic (bm) gene, which
            affects connective tissues and bleeding time
  JOURNAL   Mamm Genome 7 (2), 98-102 (1996)
   PUBMED   8835524
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC126100.1.
            
            [WARNING] On Oct 24, 2024 this sequence was replaced by
            NM_001077429.2.
            
            On or before Oct 29, 2006 this sequence version replaced
            XM_342450.3, XM_001061085.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC126100.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1531
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q23"
     gene            1..1531
                     /gene="Lnpk"
                     /gene_synonym="Lnp"
                     /note="lunapark, ER junction formation factor"
                     /db_xref="GeneID:362151"
                     /db_xref="RGD:1312042"
     exon            1..55
                     /gene="Lnpk"
                     /gene_synonym="Lnp"
                     /inference="alignment:Splign:2.1.0"
     exon            56..144
                     /gene="Lnpk"
                     /gene_synonym="Lnp"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..1248
                     /gene="Lnpk"
                     /gene_synonym="Lnp"
                     /note="protein lunapark; limb and neural patterns"
                     /codon_start=1
                     /product="endoplasmic reticulum junction formation protein
                     lunapark"
                     /protein_id="NP_001070897.1"
                     /db_xref="GeneID:362151"
                     /db_xref="RGD:1312042"
                     /translation="MGGLFSRWRAKPSTVEVLENIDKEIQALEEFREKNQRLQKLWVG
                     RLIIYSSILYLFTCLIVYLWYLPDEFIARLVMTLPFFAFPLIIWTLRTVLIFFFSKRT
                     ERNNEALDDLKSQKKKILEEVMEKETYKTAKLILERFDPDSKKAKEFEPPSAGAAATA
                     KPGQEIRQRTAAQRNLSPAPANSNQGPPPQVPVSPGPSKDASAPGGPPERTVAPALPR
                     RLGSPATSVPGMGLHPPGPPLARPVLPRERGALDRIVEYLVGDGPQNRYALICQQCFS
                     HNGMALKEEFEYIAFRCAYCFFLNPARKTRPQAPRLPEFSFEKRQAVEGSSSTGPMLL
                     ESVPSPENQLTEGGTIPQMSHFLSEISGMKSNWLKVNPSKTL"
     exon            145..186
                     /gene="Lnpk"
                     /gene_synonym="Lnp"
                     /inference="alignment:Splign:2.1.0"
     exon            187..374
                     /gene="Lnpk"
                     /gene_synonym="Lnp"
                     /inference="alignment:Splign:2.1.0"
     exon            375..433
                     /gene="Lnpk"
                     /gene_synonym="Lnp"
                     /inference="alignment:Splign:2.1.0"
     exon            434..474
                     /gene="Lnpk"
                     /gene_synonym="Lnp"
                     /inference="alignment:Splign:2.1.0"
     exon            475..558
                     /gene="Lnpk"
                     /gene_synonym="Lnp"
                     /inference="alignment:Splign:2.1.0"
     exon            559..610
                     /gene="Lnpk"
                     /gene_synonym="Lnp"
                     /inference="alignment:Splign:2.1.0"
     exon            611..808
                     /gene="Lnpk"
                     /gene_synonym="Lnp"
                     /inference="alignment:Splign:2.1.0"
     exon            809..914
                     /gene="Lnpk"
                     /gene_synonym="Lnp"
                     /inference="alignment:Splign:2.1.0"
     exon            915..985
                     /gene="Lnpk"
                     /gene_synonym="Lnp"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1156
                     /gene="Lnpk"
                     /gene_synonym="Lnp"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1239
                     /gene="Lnpk"
                     /gene_synonym="Lnp"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1506
                     /gene="Lnpk"
                     /gene_synonym="Lnp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgcaatgtaa accttttttg ctgccttctg catgacagct gttctgggat ctcagctgtg
       61 acttcttttg gacaactcat gatatttatt attgtgccaa gtttctacag ataaaagatg
      121 ggtggattat tttctcgatg gagggcaaaa ccttcaacag tagaagttct agaaaatata
      181 gataaggaaa ttcaagcatt ggaagaattt agagaaaaaa atcagagatt gcaaaaatta
      241 tgggttggaa gattaattat ctattcttca attctttatc tgtttacatg tttaattgtg
      301 tacttgtggt atcttcctga tgaatttata gcaagacttg tcatgacact cccattcttt
      361 gcttttcctt tgatcatctg gacattaaga actgtgctta ttttcttctt ttccaagaga
      421 acagagagaa ataatgaagc attggatgat ttaaaatccc agaagaaaaa gatacttgaa
      481 gaagtcatgg aaaaagaaac ttataagaca gcaaaattaa ttcttgaaag gtttgatcca
      541 gactcaaaga aagcaaagga gtttgagccg ccatctgctg gagcagctgc aactgcaaag
      601 ccaggacaag agattcgtca gcgaactgca gctcaaagaa acctttcccc agcaccagca
      661 aactctaatc agggtcctcc tccacaagtt ccagtatctc ctgggccatc aaaggacgct
      721 tcagctcctg ggggaccgcc agaaaggact gttgctccag ccttacccag gcgccttgga
      781 tcccctgcta cttcagttcc tggaatgggc cttcatcctc caggcccacc tttagcaaga
      841 cccgttctcc cccgagaacg aggtgctctg gatagaattg ttgaatattt agttggtgat
      901 ggcccacaga acaggtacgc cctcatatgt cagcagtgtt tttctcacaa tggtatggct
      961 ttgaaggaag aatttgaata tattgctttt cgatgtgcct actgtttttt cttgaatcct
     1021 gcaagaaaaa cgagacctca agccccacgg cttccagagt ttagttttga gaagaggcag
     1081 gcagtagaag gctcaagttc aactggtccc atgttactag aaagtgtgcc ctcaccagaa
     1141 aaccagctca ctgaaggagg aacaatacct cagatgtctc attttctatc tgaaatctcc
     1201 ggaatgaagt ctaactggct caaagtgaac cccagtaaga ctctttagaa gaacaagatg
     1261 atcttgataa tagtactgag cagaaagatg acaaaatacc agttacagag cagacaaacc
     1321 aagtgattga agaaacatct ggtccagagg ggtcagaaga gaaccaagaa gagactgaga
     1381 acgaggaaac atcgacaaat gaagccaagt cacctgttct cagatctgat tctgtttcta
     1441 atcttgaact gagtgaagac tctgtggtga caaagtagta aatacttccc tgtgccttca
     1501 actggaaaaa aaaaaaaaaa aaaaaaaaaa a
//
