LOCUS       NM_001113403           11250 bp    mRNA    linear   ROD 08-APR-2024
DEFINITION  Rattus norvegicus leucyl and cystinyl aminopeptidase (Lnpep), mRNA.
ACCESSION   NM_001113403
VERSION     NM_001113403.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 11250)
  AUTHORS   Albiston,A.L., Cacador,M., Sinnayah,P., Burns,P. and Chai,S.Y.
  TITLE     Insulin-regulated aminopeptidase inhibitors do not alter glucose
            handling in normal and diabetic rats
  JOURNAL   J Mol Endocrinol 58 (4), 193-198 (2017)
   PUBMED   28356324
  REMARK    GeneRIF: Acute inhibition of IRAP aminopeptidase activity does not
            affect glucose homeostasis.
REFERENCE   2  (bases 1 to 11250)
  AUTHORS   Pearson-Leary,J. and McNay,E.C.
  TITLE     Novel Roles for the Insulin-Regulated Glucose Transporter-4 in
            Hippocampally Dependent Memory
  JOURNAL   J Neurosci 36 (47), 11851-11864 (2016)
   PUBMED   27881773
REFERENCE   3  (bases 1 to 11250)
  AUTHORS   Park,B.M., Cha,S.A., Lee,S.H. and Kim,S.H.
  TITLE     Angiotensin IV protects cardiac reperfusion injury by inhibiting
            apoptosis and inflammation via AT4R in rats
  JOURNAL   Peptides 79, 66-74 (2016)
   PUBMED   27038740
  REMARK    GeneRIF: Ang IV protects myocardial injury against reperfusion by
            inhibiting inflammation and apoptosis via AT4R and PI3K-Akt-mTOR
            signaling pathway in anesthetized rats.
REFERENCE   4  (bases 1 to 11250)
  AUTHORS   De Bundel,D., Fafouri,A., Csaba,Z., Loyens,E., Lebon,S., El
            Ghouzzi,V., Peineau,S., Vodjdani,G., Kiagiadaki,F., Aourz,N.,
            Coppens,J., Walrave,L., Portelli,J., Vanderheyden,P., Chai,S.Y.,
            Thermos,K., Bernard,V., Collingridge,G., Auvin,S., Gressens,P.,
            Smolders,I. and Dournaud,P.
  TITLE     Trans-Modulation of the Somatostatin Type 2A Receptor Trafficking
            by Insulin-Regulated Aminopeptidase Decreases Limbic Seizures
  JOURNAL   J Neurosci 35 (34), 11960-11975 (2015)
   PUBMED   26311777
  REMARK    GeneRIF: IRAP is involved in vesicular trafficking and shares
            common regional distribution with the sst2A receptor in the
            hippocampus.
REFERENCE   5  (bases 1 to 11250)
  AUTHORS   Prieto,I., Villarejo,A.B., Segarra,A.B., Wangensteen,R.,
            Banegas,I., de Gasparo,M., Vanderheyden,P., Zorad,S., Vives,F. and
            Ramirez-Sanchez,M.
  TITLE     Tissue distribution of CysAP activity and its relationship to blood
            pressure and water balance
  JOURNAL   Life Sci 134, 73-78 (2015)
   PUBMED   26006037
  REMARK    GeneRIF: Sol and MB CysAP activities, acting separately or in
            concert and mainly in renal medulla, regulate the function of their
            susceptible endogenous substrates, and may participate meaningfully
            in the control of blood pressure and fluid balance.
REFERENCE   6  (bases 1 to 11250)
  AUTHORS   Aledo,J.C., Lavoie,L., Volchuk,A., Keller,S.R., Klip,A. and
            Hundal,H.S.
  TITLE     Identification and characterization of two distinct intracellular
            GLUT4 pools in rat skeletal muscle: evidence for an endosomal and
            an insulin-sensitive GLUT4 compartment
  JOURNAL   Biochem J 325 (Pt 3) (Pt 3), 727-732 (1997)
   PUBMED   9271094
REFERENCE   7  (bases 1 to 11250)
  AUTHORS   Malide,D., St-Denis,J.F., Keller,S.R. and Cushman,S.W.
  TITLE     Vp165 and GLUT4 share similar vesicle pools along their trafficking
            pathways in rat adipose cells
  JOURNAL   FEBS Lett 409 (3), 461-468 (1997)
   PUBMED   9224710
REFERENCE   8  (bases 1 to 11250)
  AUTHORS   Keller,S.R., Scott,H.M., Mastick,C.C., Aebersold,R. and
            Lienhard,G.E.
  TITLE     Cloning and characterization of a novel insulin-regulated membrane
            aminopeptidase from Glut4 vesicles
  JOURNAL   J Biol Chem 270 (40), 23612-23618 (1995)
   PUBMED   7559527
  REMARK    Erratum:[J Biol Chem 1995 Dec 15;270(50):30236]
REFERENCE   9  (bases 1 to 11250)
  AUTHORS   Mastick,C.C., Aebersold,R. and Lienhard,G.E.
  TITLE     Characterization of a major protein in GLUT4 vesicles.
            Concentration in the vesicles and insulin-stimulated translocation
            to the plasma membrane
  JOURNAL   J Biol Chem 269 (8), 6089-6092 (1994)
   PUBMED   8119954
REFERENCE   10 (bases 1 to 11250)
  AUTHORS   Kalinkov,D. and Buchholz,R.
  TITLE     Early primary diagnosis of ovarian cancer and detection of
            recurrence by serum cystine aminopeptidase assay
  JOURNAL   Am J Obstet Gynecol 138 (8), 1148-1150 (1980)
   PUBMED   7446622
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Feb 10, 2021 this sequence version replaced NM_001113403.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U76997.1, SRR26643287.555.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-90                JAXUCZ010000001.1  67027521-67027610   c
            91-931              JAXUCZ010000001.1  66990273-66991113   c
            932-1070            JAXUCZ010000001.1  66983042-66983180   c
            1071-1202           JAXUCZ010000001.1  66981738-66981869   c
            1203-1323           JAXUCZ010000001.1  66977415-66977535   c
            1324-1478           JAXUCZ010000001.1  66976707-66976861   c
            1479-1592           JAXUCZ010000001.1  66974251-66974364   c
            1593-1724           JAXUCZ010000001.1  66972590-66972721   c
            1725-1856           JAXUCZ010000001.1  66968251-66968382   c
            1857-2017           JAXUCZ010000001.1  66966058-66966218   c
            2018-2106           JAXUCZ010000001.1  66965765-66965853   c
            2107-2290           JAXUCZ010000001.1  66957805-66957988   c
            2291-2447           JAXUCZ010000001.1  66956499-66956655   c
            2448-2632           JAXUCZ010000001.1  66950220-66950404   c
            2633-2794           JAXUCZ010000001.1  66948573-66948734   c
            2795-2935           JAXUCZ010000001.1  66941216-66941356   c
            2936-3017           JAXUCZ010000001.1  66940550-66940631   c
            3018-11250          JAXUCZ010000001.1  66931712-66939944   c
FEATURES             Location/Qualifiers
     source          1..11250
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q12"
     gene            1..11250
                     /gene="Lnpep"
                     /gene_synonym="GP160; IRAP; OTase; P-LAP; Vp165"
                     /note="leucyl and cystinyl aminopeptidase"
                     /db_xref="GeneID:171105"
                     /db_xref="RGD:621752"
     exon            1..90
                     /gene="Lnpep"
                     /gene_synonym="GP160; IRAP; OTase; P-LAP; Vp165"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..3149
                     /gene="Lnpep"
                     /gene_synonym="GP160; IRAP; OTase; P-LAP; Vp165"
                     /EC_number="3.4.11.3"
                     /note="insulin-regulated membrane aminopeptidase IRAP;
                     placental leucine aminopeptidase; oxytocinase; cystinyl
                     aminopeptidase; vesicle protein of 165 kDa;
                     leucyl/cystinyl aminopeptidase; insulin-responsive
                     aminopeptidase; aminopeptidase Vp165; angiotensin IV
                     receptor; leucyl-cystinyl aminopeptidase-like"
                     /codon_start=1
                     /product="leucyl-cystinyl aminopeptidase"
                     /protein_id="NP_001106874.1"
                     /db_xref="GeneID:171105"
                     /db_xref="RGD:621752"
                     /translation="METFTNDRLQLPRNMIENSMFEEEPDVVDLAKEPCLHPLEPDEV
                     EYEPRGSRLLVRGLGEHEMDEDEEDYESSAKLLGMSFMNRSSGLRNSATGYRQSPDGT
                     CSVPSARTLVICVFVIVVAVSVIMVIYLLPRCTFTKEGCHKTNQSAELIQPIATNGKV
                     FPWAQIRLPTAIIPQRYELSLHPNLTSMTFRGSVTISLQALQDTRDIILHSTGHNISS
                     VTFMSAVSSQEKQVEILEYPYHEQIAVVAPESLLTGHNYTLKIEYSANISNSYYGFYG
                     ITYTDKSNEKKNFAATQFEPLAARSAFPCFDEPAFKATFIIKITRDEHHTALSNMPKK
                     SSVPTEEGLIQDEFSESVKMSTYLVAFIVGEMRNLSQDVNGTLVSVYAVPEKIDQVYH
                     ALDTTVKLLEFYQNYFEIQYPLKKLDLVAIPDFEAGAMENWGLLTFREETLLYDNATS
                     SVADRKLVTKIIAHELAHQWFGNLVTMQWWNDLWLNEGFATFMEYFSVEKIFKELNSY
                     EDFLDARFKTMRKDSLNSSHPISSSVQSSEQIEEMFDSLSYFKGASLLLMLKSYLSED
                     VFQHAIILYLHNHSYAAIQSDDLWDSFNEVTGKTLDVKKMMKTWTLQKGFPLVTVQRK
                     GTELLLQQERFFPSMQPEIQDSDTSHLWHIPISYVTDGRNYSEYRSVSLLDKKSDVIN
                     LTEQVQWVKVNTNMTGYYIVHYAHDGWAALINQLKRNPYVLSDKDRANLINNIFELAG
                     LGKVPLQMAFDLIDYLRNETHTAPITEALFQTDLIYNLLEKLGHMDLSSRLVTRVHKL
                     LQNQIQQQTWTDEGTPSMRELRSALLEFACAHSLENCTTMATKLFDGWMASNGTQSLP
                     TDVMTTVFKVGARTEKGWLFLFSMYSSMGSEAEKDKILEALASSADAHKLYWLMKSSL
                     DGDIIRTQKLSLIIRTVGRQFPGHLLAWDFVKENWNKLVHKFHLGSYTIQSIVAGSTH
                     LFSTKTHLSEVQEFFENQSEATLQLRCVQEAFEVIELNIQWMARNLKTLTLWL"
     exon            91..931
                     /gene="Lnpep"
                     /gene_synonym="GP160; IRAP; OTase; P-LAP; Vp165"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1070
                     /gene="Lnpep"
                     /gene_synonym="GP160; IRAP; OTase; P-LAP; Vp165"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1202
                     /gene="Lnpep"
                     /gene_synonym="GP160; IRAP; OTase; P-LAP; Vp165"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1323
                     /gene="Lnpep"
                     /gene_synonym="GP160; IRAP; OTase; P-LAP; Vp165"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1478
                     /gene="Lnpep"
                     /gene_synonym="GP160; IRAP; OTase; P-LAP; Vp165"
                     /inference="alignment:Splign:2.1.0"
     exon            1479..1592
                     /gene="Lnpep"
                     /gene_synonym="GP160; IRAP; OTase; P-LAP; Vp165"
                     /inference="alignment:Splign:2.1.0"
     exon            1593..1724
                     /gene="Lnpep"
                     /gene_synonym="GP160; IRAP; OTase; P-LAP; Vp165"
                     /inference="alignment:Splign:2.1.0"
     exon            1725..1856
                     /gene="Lnpep"
                     /gene_synonym="GP160; IRAP; OTase; P-LAP; Vp165"
                     /inference="alignment:Splign:2.1.0"
     exon            1857..2017
                     /gene="Lnpep"
                     /gene_synonym="GP160; IRAP; OTase; P-LAP; Vp165"
                     /inference="alignment:Splign:2.1.0"
     exon            2018..2106
                     /gene="Lnpep"
                     /gene_synonym="GP160; IRAP; OTase; P-LAP; Vp165"
                     /inference="alignment:Splign:2.1.0"
     exon            2107..2290
                     /gene="Lnpep"
                     /gene_synonym="GP160; IRAP; OTase; P-LAP; Vp165"
                     /inference="alignment:Splign:2.1.0"
     exon            2291..2447
                     /gene="Lnpep"
                     /gene_synonym="GP160; IRAP; OTase; P-LAP; Vp165"
                     /inference="alignment:Splign:2.1.0"
     exon            2448..2632
                     /gene="Lnpep"
                     /gene_synonym="GP160; IRAP; OTase; P-LAP; Vp165"
                     /inference="alignment:Splign:2.1.0"
     exon            2633..2794
                     /gene="Lnpep"
                     /gene_synonym="GP160; IRAP; OTase; P-LAP; Vp165"
                     /inference="alignment:Splign:2.1.0"
     exon            2795..2935
                     /gene="Lnpep"
                     /gene_synonym="GP160; IRAP; OTase; P-LAP; Vp165"
                     /inference="alignment:Splign:2.1.0"
     exon            2936..3017
                     /gene="Lnpep"
                     /gene_synonym="GP160; IRAP; OTase; P-LAP; Vp165"
                     /inference="alignment:Splign:2.1.0"
     exon            3018..11250
                     /gene="Lnpep"
                     /gene_synonym="GP160; IRAP; OTase; P-LAP; Vp165"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcggggccgc ttcagctctc ggagtagaaa gcttggggcg ctgggctggt gaggacccgc
       61 agcgggcgaa gatggagacc tttaccaatg atcgacttca gcttccaagg aatatgattg
      121 aaaacagcat gtttgaagaa gaaccagatg tggtagattt agccaaagaa ccttgtttac
      181 atcctctgga acctgatgaa gttgaatatg agccccgagg ttcgaggctt ctggtgagag
      241 gtcttggtga gcatgagatg gatgaggatg aagaggatta tgagtcatct gccaagctgc
      301 tgggcatgtc cttcatgaac agaagctcag gccttcggaa cagtgcaaca ggctacaggc
      361 agagtccaga tgggacttgt tcagtaccct ctgccaggac cttagtaatc tgtgtttttg
      421 tcattgtggt tgctgtctct gtaatcatgg tgatttatct actgcctaga tgtaccttta
      481 ccaaagaagg ctgccacaaa acaaaccagt cagcagaact cattcagccg attgctacaa
      541 acgggaaagt gtttccatgg gcacaaatta ggcttcccac tgccattatt cctcaacgct
      601 atgaacttag cctacatcca aacctaacct caatgacatt caggggttct gtgacaattt
      661 cacttcaggc tcttcaagat acacgggaca tcattctcca tagcacagga cataatattt
      721 caagtgtgac atttatgtcg gcggtttcca gtcaagaaaa acaagttgaa attctggaat
      781 atccatatca tgaacaaatc gccgttgttg cccctgaaag ccttctaaca ggacacaatt
      841 ataccttgaa gatagaatat tcagcaaata tatctaactc ttactatggg ttttatggca
      901 tcacctacac agataaaagt aatgagaaaa agaactttgc agcaactcag tttgaacctt
      961 tggcagcaag atctgctttt ccttgttttg atgaaccagc atttaaggcc acatttatca
     1021 tcaagatcac aagggatgag caccatactg cattatcaaa tatgcctaag aagtcatcag
     1081 tccctacaga agaaggactt attcaagatg agttttctga aagtgtgaaa atgagcacat
     1141 acctggttgc tttcattgta ggggagatga ggaacctgag tcaggatgta aacgggactc
     1201 tggtttctgt atatgctgta ccagaaaaaa ttgatcaagt ttaccatgcc ttggacacaa
     1261 ctgtaaagct ccttgagttt tatcaaaatt actttgaaat tcaataccca ctaaagaaat
     1321 tggatctggt ggccattcct gactttgaag caggagcaat ggaaaattgg ggcctgctta
     1381 cgttccgaga agagactctt ctgtatgaca atgccacttc ttcagtagca gatagaaaac
     1441 tggtcactaa aatcatcgct cacgagctgg cacatcagtg gtttggtaat ctggttacaa
     1501 tgcagtggtg gaatgacctg tggctaaacg aaggctttgc cactttcatg gagtatttct
     1561 ctgtggaaaa aatattcaaa gagctcaaca gttatgaaga cttcttagat gctcgattta
     1621 aaaccatgag gaaagattcc ttgaattcgt ctcatccaat atcatcatct gttcagtcat
     1681 cagaacaaat agaagaaatg tttgattctc tttcgtattt taagggagcg tctctcttgt
     1741 tgatgttgaa aagttacctt agtgaagacg tgtttcagca tgccatcatt ctttacctgc
     1801 acaatcacag ctatgcagca attcaaagcg atgacctctg ggacagcttc aatgaggtca
     1861 caggcaaaac tctagatgta aagaaaatga tgaaaacctg gaccctacag aaaggattcc
     1921 cattagtgac cgtccagaga aaggggactg agcttcttct acaacaagaa agattttttc
     1981 caagcatgca accagaaatt caggattcag atacaagcca cctttggcat attccaatat
     2041 cctatgtcac tgatggaaga aactattcag aatatcgatc agtttcacta ctggacaaga
     2101 aatcagatgt catcaatctt acagaacaag tacaatgggt caaagtcaat acaaacatga
     2161 cgggctacta cattgttcac tatgctcatg atggctgggc agctctaatc aaccagttaa
     2221 aaagaaatcc ctatgttctg agtgacaaag accgagccaa cctgatcaat aacatctttg
     2281 aacttgcagg ccttggcaaa gtgcctcttc agatggcatt cgatttgatt gactacctta
     2341 gaaatgagac ccacactgca cctatcactg aagccctgtt ccagactgac ctcatctata
     2401 atctcctgga aaaactggga cacatggacc tgtcctcaag attagtgacc agagtacata
     2461 aattgctcca gaaccaaatc cagcagcaga catggacaga tgaaggcaca ccatccatgc
     2521 gagagcttcg gtcagccttg ctggaatttg cctgcgccca cagcctagag aactgtacca
     2581 ctatggccac aaagctgttt gatggttgga tggcatcaaa tggaactcag agcctgccga
     2641 ctgacgtcat gaccactgtg ttcaaagttg gagcaagaac cgagaaaggc tggttgttcc
     2701 tctttagcat gtactcctcc atgggctctg aagcagagaa ggataaaata cttgaagccc
     2761 tggccagctc agcggatgca cataaacttt actggttaat gaaaagtagc cttgatggtg
     2821 atatcattcg gacacagaag ttgtcactta tcattagaac agtgggcaga cagtttcctg
     2881 gacatttgct ggcatgggat tttgttaagg aaaactggaa taagcttgta cataagttcc
     2941 atctgggctc ctataccatt caaagcattg ttgctggatc tactcactta ttttcaacga
     3001 agacacattt atctgaggtc caggaattct tcgaaaatca gtcagaggca accttgcagc
     3061 ttcggtgtgt tcaggaggcc ttcgaagtga ttgagctgaa tatccagtgg atggccagga
     3121 atctgaaaac tctgacactg tggctgtagc cctcacagct gatcttccgg tgcccatggc
     3181 tctgctgctt ttgcaaaggt tgagtgaagg ccggcctgct actgagttgt ttgcactgtt
     3241 aggatctagt tagctcaggg cccaattgta tttttcatat cttttctgaa atgtccttag
     3301 gcggtagtta tttattacaa aattatattc acctgtacgt caaccatcta caataacagt
     3361 gaagaatttt tctttgacac acaaatggag aaaagtcaga aattttgttt gatttcttag
     3421 tgtccagagt gtttctgtta cagtgcaacc gaggaaggtc cgtaagaacc actgcctttg
     3481 gaggttgctg attgtcagct gtttgttgct tctcgttaaa cagtacacct gcattctggg
     3541 agttaccctg aagagtgaca aagacattga aggtgcagct ctagacagat gacctcaggt
     3601 gttctttaaa cctgattggg ggttctttaa aaaggtttat gtcaacgtta taatttttcc
     3661 tgcagaatag ccaggttcta aagaattttt catttttcca ttaaattgaa cagctgaaca
     3721 atcaggccca aaatttcaat tttccaaata tttcacactt tccgcttcat ctttatggca
     3781 ctatgtagga agtattctga actaagttaa cattaattac tttactcatg aattccagta
     3841 ccctcaactt tgtatgctgg taaggccttc catcagcttt ctcctgtaga gggaggagaa
     3901 cccatgcttg ggaggcagct ttctcctgta cagtatggga ggctttctgt gtgcactggt
     3961 ggctttctcc ttactttcac ccaagaatgt aatttgttta agttgccttt tgaacctgac
     4021 aaatggtacc ctcttctctg tgaatcgtac ccatgtgtgg tttgttactt tttgttacag
     4081 tgtatattag aagcatttct taaatagggt catctggaat taaagctttt tattttgaag
     4141 ttcaccatag taccttaaag gaacaatgaa aatgtggaac aggaggaagt tgaaaatatg
     4201 gtgggctttg aattcttttt tcactgttaa agacagtgct ttgctttagt tgaaaaaaaa
     4261 ttatagttgt ttgtttgttt gtttgtttgt ttgtttgttt atcatggcca aactatgtta
     4321 aacagcgagg ccaaggatca agcagaggac aagcaaggga ggggccccga gcaaaatgtg
     4381 ggcgcttcac tccttctgaa ggagaggtat cgtacttgaa ttttttgagc tatgcagact
     4441 tattcctaga ttgttgtgtt tctttgattc ttaggagaga agctttcttc ttaataactc
     4501 atgagaattc tatattttgt ttgaaaacag tgtccatgta cataaaaagg gaattactca
     4561 tttgtgaaca ctgaaaacac tccacagagt cagaccatag aaaggccact ttttttttta
     4621 ttcagctgtt gtaaagctag aatatgtgga gttatataca aagttatagt ttattttatg
     4681 agaatatttt tatataacaa ttttaatggc tgacaagctg aaaaatagcc tgctttaatc
     4741 ctagagtttg ttcccaattt aatcttttct aaacattttt tgattttttt ttttttggtt
     4801 tttttttttt aaagtggaaa atgttattcc tgagagtcat agaattatct tgatatttta
     4861 gtgaaatagg taattgtaga tctctagtcc ccttgtgctt ttggtaaatg aatgacagtt
     4921 cagttgatac tgaaggttaa tggggttttc tatttttaaa gtgaaggaaa gatgctcttg
     4981 tgggttttgg ttgccccttt tcatttttta ccatgttgta ttactaaatt atactttaat
     5041 aacagagttt aacttttgct acttctcagg atcagtccaa tcctgagatt tacctgccca
     5101 tcttggtgtt gactgtaaag tctttctgca tatggcaaat cttgtcttaa ataacacttt
     5161 tttccatgta tgagtgtaaa tgtggtgtgc cctgttttaa ataaagcctt atgaagatat
     5221 gggcttaaaa agagctaatt cttgatccag tgctattagt agctgcttgt tcccaggata
     5281 ctggagccat actttaagta ttatctagaa ccttcacctg gctttttaaa catttcccca
     5341 cagaactctg tctgtttcat gttttgttag ctcatctctg tgcagcttct tagctaactc
     5401 aaagtcagtg ctctaaggct gaggtagcat ttgtagtctg agaagtatat tgatagcatt
     5461 cagattttct tcctcaaatt taattcttct ctctgtactt ttaggaagga agattgaagc
     5521 acaggggtca gcttgtgctt tgggcatcag cacaaatacc tgacatcatt gggtagcagt
     5581 taaatgagca ttctgctcac cgcagagaaa gggtgttctt gaatgtaata tgaaaggtct
     5641 tgattactag gaaagataga attagaaatc tagacttgag gacaagagat gattcggaga
     5701 tttgagagtt tattaaagtt agacgttgga gtaaacaagt ttactttgct aataataaga
     5761 cgtaaagtag tggcagtgcc cccatccccc gaagcgtatg ccctcctctg tctcattgca
     5821 tctgtctgtg aaaatgaaat tgtatttgtc attgcttcag agtgttcaca gacgttcttc
     5881 tatcacaggt tctacttaat tttctttgtc atatgtgttt ttattttcat gagattttag
     5941 ccaccattag agcaaaagct gccagaagag tcctgggcat caaaacaaat cgagctgctt
     6001 gaggtttacg gggtacacaa caatcctttc tgattattgg gaagcaagaa attacaatta
     6061 agtcttgtgt tgttgcaaga ttgtctgttg ttaaattgga ttttaaagat ggttccttaa
     6121 tctaaagcac ctgagctgag ggtcttcagc ccgactgctg agcacttata taaggccatg
     6181 tgctctgtgg gtttccagga cggcacggca cggcgggtct caggtgcttt gctgccaagg
     6241 agtgagatga gtttgccgat aggaatgggt cgtttcccat aggccgctaa tgcctgggac
     6301 catgggcaca ctgtaggttt cctcaccttt gccttacttg tgtttatgtg ggattaattc
     6361 tcttgtttgg gaaatgttct gtctccttac atttgtattt ctggaaactc aggtatatat
     6421 ttttgctggg ttttttattc ttttattttg ttcttaaatc tctaaaatat caaaaagtac
     6481 caaatgaaaa ttgaagtccc aaagtatgac agatgaccct ttgcccagcc cttatggcct
     6541 agttagtcag taactactag aattagtgat tgacctttag agaacttgta ctagggtttt
     6601 tttggggggt agggtgggag gtgatgcata ttttgaaaca tatacatgta tttttagatt
     6661 ttttatattt tataagtttt gtcctgttaa tgaaagagcg aaataactac tctctgataa
     6721 tctctcctct tcccatattg cctactgtag gcaagagtta cagaataatt ttattttaat
     6781 atttttaaca acgtgggttt caagagggca gcttctttta agagtgtgta taaatagttt
     6841 tgctgctatt tggtacttat ttaatgctgc cctctataca tttttcttgt ggacatgtac
     6901 ataaaccgtg caaggtcaca tagatgtctg atggcagcag aatagtggta gtccctatta
     6961 ttctgttcca gtcttaggaa cttaggctgt ctctcatcct tcaaacatgt tatagatgca
     7021 atgccacttg tatttcactt agacttgtct ctttgcatag acactcagtt tccattgtgg
     7081 ttgagtgtgt cagattcttc cctgtcgctt gttgcctctc agggcagtag cagtgtggaa
     7141 gacagcagag tagtgcttgc tatggccttt tattactaat tcatttggtc ctatgccctt
     7201 caaacacatg tgaaaatacc tgatgaaatg tggcagacta catgtgaaca gtcctctctt
     7261 cttctcacct cttagagcct gttggcaaca gctaataaaa tggctgtctg tgtggaagat
     7321 ggagggaaat gtacttaatg tctgtgtata tgtttttact actgtatcat agtaattcac
     7381 tgcgtggtca gagtggagat gcccaatgta ccgtggagtt cagatgcata acagtgccct
     7441 ctttcccttt attgtctggc ttcaatactt cttaaagtat tttgagtgtt tgaaagttgt
     7501 ttggggttcg gatggttgtt atctagttgg ttggtttttg ctaggctcag aaagtagcta
     7561 gggggcggaa tatatccttt tcgagttgac aaacatgttg ttgctgtgtt tttacttcct
     7621 tgctctccct gaccttttta tggctttatg cgtaaagtta gggatctctc taagcggttc
     7681 cttccttccc atgtgggccg tgcagtggct atctgtagca tggacggtga tttggggctg
     7741 ctcctgtgca tttccctagg tgctcttgct tcctcgtcac tgcttcattg ggtgcctgtc
     7801 ctgatggact gtggactctg aatgtagtgt cctctggttc ctgttccatc tctgtgagga
     7861 ggtgtttctt ctcagttttt tctcttagct ttagtgggga ctaagggcga aaaatagatt
     7921 ctttacaaat atatataatt ttgttactat actgtgctat ttcatttggt actgagtcct
     7981 ttacatggac ataaagtacc taatgagacg tggaggtccg gatgtatgaa aacttcctct
     8041 ttcccctttt cctctttgcc tctgtgggca atagttgtag agtagcatag attttctaat
     8101 tctcttccac ccggaggggt gggatatgta tatactttaa aatgtaaata taaatttttt
     8161 aatctttttg ttgttacttc atttgtacct aaatctattt gtggacactt aggtacatga
     8221 ggaatattga ggttcattct atgaaaaatc tcccctttcc cttccctcac tgcctgtttg
     8281 ggcagtggct tgtagagtag ttgtgtagct ttggcatggg ggtgcagggt gagaacagtt
     8341 ctgggtttct attttagatg tatttaaaag tctgtcagtt atttcagttc ttcactctca
     8401 gtctgccttt gtgttaatga agcaaagcaa cggtctgtat cagtacccag aagtgtagaa
     8461 catctgcccc tcactctgcc cctgtgccat accgcagtag tgtacacgta ctgtaaggct
     8521 tgagttcttg ttttgtctgt tgcttataat acagcttgtt agagaaaagg gtaaccatat
     8581 gttatatatg tatataggat tgtaaatgcc ttgtggtatt aacttcattt tgaacgtggt
     8641 ccatggtgcg actattttta ctatgtactt aatgaacact gagattgatt ctatgaaaac
     8701 tctccacact ccctatccct cattgcctgg tgggcagtgg tagactagat gttttatttg
     8761 cttatctttt gtttgctttg ggggggggtc tgggtgttta tatattttta atgtatatac
     8821 aatattgcta tattctatat attattccat gtagcaccag ttttttgctg gaatttgtac
     8881 atagataata aaacattgag gtccagaggt atgataactc tcccgtgctc cctttccctc
     8941 attgcctaca gaggcaataa ttttataact tgtttttgtt ttgttttctt ttcttttctt
     9001 ttttttaggg ggtgggaatg ggattgctta ggtgggtagt ggttagggga aagggatgag
     9061 tgcatgattt taaaatatat tttttcatgg tactgattag gccccttttc atttgcatgg
     9121 atagatgggt acctaatcaa aattgaggat cagtgtatga catatctccc attctaccct
     9181 ttcccttatg cctgcacagg caacagtgag taaagcagct ctgtgttatt tacttgtttg
     9241 gatttatttt gatagtagac tattcttaat ataaagtttt catttcttta tttcattttg
     9301 tgttcagccc tttgcctagc tataaagaac ataatgaaat tagtttcata agatgacagg
     9361 gcacatcttt tgttgtatat ttcctcactt agtagtagct agtacaggtg gtttgtgttt
     9421 ttccaggtta ttctgtagga tagatatctt taaagataca aatatgtata catttttaat
     9481 tttctccctt gctctcattg tttcccttta gtatacttat tctcttgaag gtttttacat
     9541 gtatctagag ggaaaagaaa aaaccaaagg ctcattacat gttaagtatc tgaaagtaca
     9601 accctgggac tccatgtata gcagtggcaa tgggcttgaa gcaaatacaa tgggaaagga
     9661 cactcagata tggctacatt gtggaaacta accagatcca gcattgctgg tgtcgattta
     9721 aactgagatg gtgaaaggca agctttagtt ttataaatac cggaacaaca gagggcaggg
     9781 cattgctgag taaacgtgag tttaagtagc ttcagtggtg gaggcaagcc aatatcagtg
     9841 tttcctataa ctaattcaaa gagcccttaa gagagtagtg ttctgtgagg cctaaagctc
     9901 agatttatct ccagagttct gttgactgtt cttatgtacc caggagaagt cattgattct
     9961 tagaatggac catttgattg caacttctct ggtggctcac agacaacatg gtcccaaaag
    10021 aatgtcaggg gcaagccctt tctgtcttag gacatccaca tgtggcaggg cacagtggcc
    10081 ctttcttacc cagaactctt ttgtgtggct gcatctcttt ctccggttgt ctcttaactg
    10141 ggccgttcct gttccttttc cttttgctgt cagtaccttc atcgttagat gccatctgag
    10201 gttacactca cacgctgcct tctcgttcgc tttgtgattc tgtgtgcatt tcatgcacta
    10261 gagcctgtgt gtttgctcgc agcattctta catttcttct tgtctcttct tccaccacat
    10321 ggtaaatgtt gactacacat ttgtctgcat caaagaaaat gcatgtgaaa acctccctgt
    10381 ccttcttgca tgttagcatt gttttgttct cacatttttt ctgatattcc atgaggaaga
    10441 tttgccatat ccacttaaag aaacattgag tgctagatag ggctcctaga aattctcaaa
    10501 gacatgttat ttaccatatc aaactctcag gaatgggttg gaaaattatc ctcgtaacat
    10561 tgctgttact tatacctgct gctggaggaa aaagtttatt catgacacat ttacctttga
    10621 tcataaataa aagagaaagg gccacctttt tgcagttagt catggtagtc attagtgata
    10681 tttttgaact gcttttaatt tgaaatactt caaaggaagt aaaggtcatg gctttactca
    10741 aagaaatgct ccagaagttg ggctgtataa atcatcagta caataataca ctgtgtgcgt
    10801 gtgcgtgtgc gtgtgcgtgt gtgtgtatga aatgagaatt gccacataat tggagcattt
    10861 gcattcatca gcaaataata ttgagacaaa ctatagtcaa ctctcttgat taaagccaag
    10921 tgttccctgt ggctgtgagg aagagttttt cttgcaaata ctttggaaag tgattacttg
    10981 gaaacttaca aagctattgc cttttttttt ttttaacacc agtagagacc tttggttcct
    11041 tcagtctgag tttaaggcta gaattctaat ttgtattata atctgtcttt tgtggaaaat
    11101 tttgaaaata gtacgtatat gtaatattgt atatgcaaat tgtgttgttt tacttgtttt
    11161 gcatatgacc agcactgact gaaaggcatg tttaactata aacactgttg ctttctttgt
    11221 gaaatgaaaa taaaagtatt taaatacaaa
//
