LOCUS       NM_053709               2103 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus LIM homeobox transcription factor 1 beta (Lmx1b),
            mRNA.
ACCESSION   NM_053709 XM_006224366 XM_006234024
VERSION     NM_053709.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2103)
  AUTHORS   Laguna,A., Schintu,N., Nobre,A., Alvarsson,A., Volakakis,N.,
            Jacobsen,J.K., Gomez-Galan,M., Sopova,E., Joodmardi,E.,
            Yoshitake,T., Deng,Q., Kehr,J., Ericson,J., Svenningsson,P.,
            Shupliakov,O. and Perlmann,T.
  TITLE     Dopaminergic control of autophagic-lysosomal function implicates
            Lmx1b in Parkinson's disease
  JOURNAL   Nat Neurosci 18 (6), 826-835 (2015)
   PUBMED   25915474
REFERENCE   2  (bases 1 to 2103)
  AUTHORS   Zhou,T.B., Ou,C., Qin,Y.H., Lei,F.Y., Huang,W.F. and Drummen,G.P.
  TITLE     LIM homeobox transcription factor 1B expression affects renal
            interstitial fibrosis and apoptosis in unilateral ureteral
            obstructed rats
  JOURNAL   Am J Physiol Renal Physiol 306 (12), F1477-F1488 (2014)
   PUBMED   24785190
  REMARK    GeneRIF: LMX1B may be considered to be a negative regulator of the
            renal fibrosis index.
REFERENCE   3  (bases 1 to 2103)
  AUTHORS   Narytnyk,A., Verdon,B., Loughney,A., Sweeney,M., Clewes,O.,
            Taggart,M.J. and Sieber-Blum,M.
  TITLE     Differentiation of human epidermal neural crest stem cells
            (hEPI-NCSC) into virtually homogenous populations of dopaminergic
            neurons
  JOURNAL   Stem Cell Rev Rep 10 (2), 316-326 (2014)
   PUBMED   24399192
REFERENCE   4  (bases 1 to 2103)
  AUTHORS   Deng,Q., Andersson,E., Hedlund,E., Alekseenko,Z., Coppola,E.,
            Panman,L., Millonig,J.H., Brunet,J.F., Ericson,J. and Perlmann,T.
  TITLE     Specific and integrated roles of Lmx1a, Lmx1b and Phox2a in ventral
            midbrain development
  JOURNAL   Development 138 (16), 3399-3408 (2011)
   PUBMED   21752929
REFERENCE   5  (bases 1 to 2103)
  AUTHORS   Gu,W.X. and Kania,A.
  TITLE     Identification of genes controlled by LMX1B in E13.5 mouse limbs
  JOURNAL   Dev Dyn 239 (8), 2246-2255 (2010)
   PUBMED   20589901
REFERENCE   6  (bases 1 to 2103)
  AUTHORS   Ding,Y.Q., Marklund,U., Yuan,W., Yin,J., Wegman,L., Ericson,J.,
            Deneris,E., Johnson,R.L. and Chen,Z.F.
  TITLE     Lmx1b is essential for the development of serotonergic neurons
  JOURNAL   Nat Neurosci 6 (9), 933-938 (2003)
   PUBMED   12897786
REFERENCE   7  (bases 1 to 2103)
  AUTHORS   Dreyer,S.D., Morello,R., German,M.S., Zabel,B., Winterpacht,A.,
            Lunstrum,G.P., Horton,W.A., Oberg,K.C. and Lee,B.
  TITLE     LMX1B transactivation and expression in nail-patella syndrome
  JOURNAL   Hum Mol Genet 9 (7), 1067-1074 (2000)
   PUBMED   10767331
REFERENCE   8  (bases 1 to 2103)
  AUTHORS   Smidt,M.P., Asbreuk,C.H., Cox,J.J., Chen,H., Johnson,R.L. and
            Burbach,J.P.
  TITLE     A second independent pathway for development of mesencephalic
            dopaminergic neurons requires Lmx1b
  JOURNAL   Nat Neurosci 3 (4), 337-341 (2000)
   PUBMED   10725922
REFERENCE   9  (bases 1 to 2103)
  AUTHORS   Pressman,C.L., Chen,H. and Johnson,R.L.
  TITLE     LMX1B, a LIM homeodomain class transcription factor, is necessary
            for normal development of multiple tissues in the anterior segment
            of the murine eye
  JOURNAL   Genesis 26 (1), 15-25 (2000)
   PUBMED   10660670
REFERENCE   10 (bases 1 to 2103)
  AUTHORS   Dreyer,S.D., Zhou,G., Baldini,A., Winterpacht,A., Zabel,B.,
            Cole,W., Johnson,R.L. and Lee,B.
  TITLE     Mutations in LMX1B cause abnormal skeletal patterning and renal
            dysplasia in nail patella syndrome
  JOURNAL   Nat Genet 19 (1), 47-50 (1998)
   PUBMED   9590287
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On or before Jan 16, 2015 this sequence version replaced
            XM_006234024.2, XM_006224366.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN11044071
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-207               JAXUCZ010000003.1  37338351-37338557   c
            208-394             JAXUCZ010000003.1  37337399-37337585   c
            395-627             JAXUCZ010000003.1  37265444-37265676   c
            628-809             JAXUCZ010000003.1  37263317-37263498   c
            810-887             JAXUCZ010000003.1  37263039-37263116   c
            888-954             JAXUCZ010000003.1  37262829-37262895   c
            955-1119            JAXUCZ010000003.1  37261115-37261279   c
            1120-2103           JAXUCZ010000003.1  37259855-37260838   c
FEATURES             Location/Qualifiers
     source          1..2103
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p11"
     gene            1..2103
                     /gene="Lmx1b"
                     /note="LIM homeobox transcription factor 1 beta"
                     /db_xref="GeneID:114501"
                     /db_xref="RGD:620843"
     exon            1..207
                     /gene="Lmx1b"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..1277
                     /gene="Lmx1b"
                     /codon_start=1
                     /product="LIM homeobox transcription factor 1-beta"
                     /protein_id="NP_446161.1"
                     /db_xref="GeneID:114501"
                     /db_xref="RGD:620843"
                     /translation="MDIATGPESLERCFPRGQTDCAKMLDGIKMEEHALRPGPATLGV
                     LLGSDCPHPAVCEGCQRPISDRFLMRVNESSWHEECLQCAACQQALTTSCYFRDRKLY
                     CKQDYQQLFAAKCSGCMEKIAPTEFVMRALECVYHLGCFCCCVCERQLRKGDEFVLKE
                     GQLLCKGDYEKEKDLLSSVSPDESDSVKSEDEDGDMKPAKGQGSQNKGSGDDGKDPRR
                     PKRPRTILTTQQRRAFKASFEVSSKPCRKVRETLAAETGLSVRVVQVWFQNQRAKMKK
                     LARRHQQQQEQQNSQRLGQEVLSSRMEGMMASYTPLAPPQQQIVAMEQSPYGSSDPFQ
                     QGLTPPQMPGDHMNPYGNDSIFHDIDSDTSLTSLSDCFLGSSDVGSLQARVGNPIDRL
                     YSMQSSYFAS"
     exon            208..394
                     /gene="Lmx1b"
                     /inference="alignment:Splign:2.1.0"
     exon            395..627
                     /gene="Lmx1b"
                     /inference="alignment:Splign:2.1.0"
     exon            628..809
                     /gene="Lmx1b"
                     /inference="alignment:Splign:2.1.0"
     exon            810..887
                     /gene="Lmx1b"
                     /inference="alignment:Splign:2.1.0"
     exon            888..954
                     /gene="Lmx1b"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1119
                     /gene="Lmx1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..2103
                     /gene="Lmx1b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggagcgggc ggacggaccg gagggcgagc ggcccagccg gcggggtccg cagcgcgccc
       61 ggcgtcccat ggatatagca acaggtcccg agtcgctgga gaggtgcttc cctcgcgggc
      121 agacggactg cgccaagatg ttggacggca tcaagatgga ggagcacgcc ctacgccccg
      181 ggcccgccac cctgggtgtg ctgctgggct ccgactgccc gcatcccgcc gtctgcgagg
      241 gctgccagcg gcccatctcc gaccgcttcc tgatgcgagt caacgagtcg tcctggcacg
      301 aggagtgttt gcagtgcgcg gcatgtcagc aagccctcac caccagctgc tacttccggg
      361 atcggaaact gtactgcaaa caagactacc aacagctctt cgcggcaaag tgcagcggct
      421 gcatggagaa gatcgcaccc actgagttcg tcatgcgggc gctcgagtgt gtgtaccacc
      481 tgggctgttt ctgctgctgt gtgtgcgaga ggcagctgcg gaagggtgat gagttcgtgc
      541 tcaaggaggg ccagctgctg tgcaagggtg actacgagaa ggagaaagac ctcctcagct
      601 ccgtgagccc ggatgagtct gactctgtga agagtgagga tgaagatgga gacatgaagc
      661 cagccaaggg gcagggcagc cagaataagg gcagtgggga tgacgggaag gacccgagaa
      721 ggcccaaacg gccccggacc atcctcacca cacagcagcg aagagctttc aaggcttcgt
      781 ttgaggtctc ctccaagccc tgtcggaagg tccgagagac actagccgca gagacaggcc
      841 tcagtgtgcg tgtggtccag gtctggtttc agaaccaaag agcaaagatg aagaagctgg
      901 cccggaggca ccagcaacag caagagcagc agaactccca gcggctgggc caagaggttc
      961 tgtcaagccg catggagggc atgatggcct cctacacgcc gctggcccct ccgcagcagc
     1021 agatcgtggc catggagcag agcccctacg gaagcagcga ccccttccag cagggcctca
     1081 cgccgcccca aatgccaggt gaccacatga acccctatgg aaatgactcc attttccacg
     1141 atatcgatag tgatacctcc ctcaccagcc tcagcgactg cttcctcggc tcttccgacg
     1201 tgggctccct gcaggcccgt gtggggaacc ccatcgaccg gctctactcc atgcagagct
     1261 cctactttgc ctcctgagag ccggctgggc cgcatggacg cttgggcctg ggcctagggt
     1321 gggaccacag gcctctgcag ccagccggcc ccccagcccg ccacccgctc agactctaca
     1381 gacagccata cggtgccctc ccctcggcca gccagacctg gctcaagtgc ccgccgggca
     1441 cagccagaca aggcagatgg gtgcagcctg ggcagggact gtgtcctgcc cacagagacc
     1501 ttgtgacccc tggggaccca gagctcttgg acagccactc gcctcccagc cctgtgactt
     1561 cgtcactacc ttccccgtcc ccaactcttt tttggggaag cttaaatttg ttcttctttc
     1621 gttgtttttt taaacattct gttttcagcc aacctccatt gtccctgcaa ggccagccct
     1681 gggacagtgc ctggtacctg agaaacagtt atacgggtgt cctgcgctgg agaccacttc
     1741 cccttctggt cagcgcaggg gatggtttct gggtcctagg aggcccaggg tcactgtttc
     1801 cagctctaag ctggagcaca ggagaggagg gcccatgcag gtgtggcagg ctctttggcc
     1861 ctgcctgaac cctagtctcc acaagaggag ggatgtggac agagcccaga gagacccaga
     1921 gggacagaga tgcacacata aagccacaca cacctgaagg cacacctgtg caagcatgca
     1981 tgtgcacctg ggtgcacagg cacacgcagt ggaagaggtt gccattcctt ccaggaagca
     2041 gagcgagatc agtgggtagg gcctacctct gagagcaatt ggagagggag ggggggaggc
     2101 ctg
//
