LOCUS       NM_001100964            2237 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus leiomodin 2 (Lmod2), mRNA.
ACCESSION   NM_001100964 XM_001060472 XM_238342
VERSION     NM_001100964.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2237)
  AUTHORS   Li,S., Mo,K., Tian,H., Chu,C., Sun,S., Tian,L., Ding,S., Li,T.R.,
            Wu,X., Liu,F., Zhang,Z., Xu,T. and Sun,L.V.
  TITLE     Lmod2 piggyBac mutant mice exhibit dilated cardiomyopathy
  JOURNAL   Cell Biosci 6, 38 (2016)
   PUBMED   27274810
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2237)
  AUTHORS   Pappas,C.T., Mayfield,R.M., Henderson,C., Jamilpour,N., Cover,C.,
            Hernandez,Z., Hutchinson,K.R., Chu,M., Nam,K.H., Valdez,J.M.,
            Wong,P.K., Granzier,H.L. and Gregorio,C.C.
  TITLE     Knockout of Lmod2 results in shorter thin filaments followed by
            dilated cardiomyopathy and juvenile lethality
  JOURNAL   Proc Natl Acad Sci U S A 112 (44), 13573-13578 (2015)
   PUBMED   26487682
REFERENCE   3  (bases 1 to 2237)
  AUTHORS   Boczkowska,M., Rebowski,G., Kremneva,E., Lappalainen,P. and
            Dominguez,R.
  TITLE     How Leiomodin and Tropomodulin use a common fold for different
            actin assembly functions
  JOURNAL   Nat Commun 6, 8314 (2015)
   PUBMED   26370058
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2237)
  AUTHORS   Yuen,M., Sandaradura,S.A., Dowling,J.J., Kostyukova,A.S., Moroz,N.,
            Quinlan,K.G., Lehtokari,V.L., Ravenscroft,G., Todd,E.J.,
            Ceyhan-Birsoy,O., Gokhin,D.S., Maluenda,J., Lek,M., Nolent,F.,
            Pappas,C.T., Novak,S.M., D'Amico,A., Malfatti,E., Thomas,B.P.,
            Gabriel,S.B., Gupta,N., Daly,M.J., Ilkovski,B., Houweling,P.J.,
            Davidson,A.E., Swanson,L.C., Brownstein,C.A., Gupta,V.A., Medne,L.,
            Shannon,P., Martin,N., Bick,D.P., Flisberg,A., Holmberg,E., Van den
            Bergh,P., Lapunzina,P., Waddell,L.B., Sloboda,D.D., Bertini,E.,
            Chitayat,D., Telfer,W.R., Laquerriere,A., Gregorio,C.C.,
            Ottenheijm,C.A., Bonnemann,C.G., Pelin,K., Beggs,A.H.,
            Hayashi,Y.K., Romero,N.B., Laing,N.G., Nishino,I.,
            Wallgren-Pettersson,C., Melki,J., Fowler,V.M., MacArthur,D.G.,
            North,K.N. and Clarke,N.F.
  TITLE     Leiomodin-3 dysfunction results in thin filament disorganization
            and nemaline myopathy
  JOURNAL   J Clin Invest 124 (11), 4693-4708 (2014)
   PUBMED   25250574
  REMARK    Erratum:[J Clin Invest. 2015 Jan;125(1):456-7. doi:
            10.1172/JCI80057.. PMID: 25654555]
REFERENCE   5  (bases 1 to 2237)
  AUTHORS   Skwarek-Maruszewska,A., Boczkowska,M., Zajac,A.L., Kremneva,E.,
            Svitkina,T., Dominguez,R. and Lappalainen,P.
  TITLE     Different localizations and cellular behaviors of leiomodin and
            tropomodulin in mature cardiomyocyte sarcomeres
  JOURNAL   Mol Biol Cell 21 (19), 3352-3361 (2010)
   PUBMED   20685966
  REMARK    GeneRIF: Lmod contributes to the final organization and maintenance
            of sarcomere architecture by promoting tropomyosin-dependent actin
            filament nucleation.
REFERENCE   6  (bases 1 to 2237)
  AUTHORS   Takebayashi,H., Yamamoto,N., Umino,A. and Nishikawa,T.
  TITLE     Developmentally regulated and thalamus-selective induction of
            leiomodin2 gene by a schizophrenomimetic, phencyclidine, in the rat
  JOURNAL   Int J Neuropsychopharmacol 12 (8), 1111-1126 (2009)
   PUBMED   19254430
REFERENCE   7  (bases 1 to 2237)
  AUTHORS   Chereau,D., Boczkowska,M., Skwarek-Maruszewska,A., Fujiwara,I.,
            Hayes,D.B., Rebowski,G., Lappalainen,P., Pollard,T.D. and
            Dominguez,R.
  TITLE     Leiomodin is an actin filament nucleator in muscle cells
  JOURNAL   Science 320 (5873), 239-243 (2008)
   PUBMED   18403713
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC128755.1.
            
            On or before Aug 12, 2007 this sequence version replaced
            XM_238342.4, XM_001060472.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC128755.1, AB331240.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2237
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q22"
     gene            1..2237
                     /gene="Lmod2"
                     /note="leiomodin 2"
                     /db_xref="GeneID:296935"
                     /db_xref="RGD:1592092"
     exon            1..415
                     /gene="Lmod2"
                     /inference="alignment:Splign:2.1.0"
     CDS             143..1792
                     /gene="Lmod2"
                     /note="C-LMOD; cardiac leiomodin; leiomodin 2 (cardiac);
                     leiomodin-2-like"
                     /codon_start=1
                     /product="leiomodin-2"
                     /protein_id="NP_001094434.1"
                     /db_xref="GeneID:296935"
                     /db_xref="RGD:1592092"
                     /translation="MSTFGYRRGLSKYESIDEDELLASLTAEELKELERELEDIEPDR
                     NLPVGLRQKSLTEKTPTGNFSREALMAYWEKESQKLLEKERLGECGKLAEEDKEESEE
                     ELIFTESNSEVSEEVCTEEEEESTEEEEEEEEEDSEEEEVTTEVTKHINGTVSHNGVN
                     PDNSKPKTFKSQIENINLTNGNSGGTQRNTESPAAIHPCGNPTVIEDALEKIKNNDPD
                     TTEVNLNNIENITTQTLSRFAEALKENTVVKTFSLANTHADDAAAIAIAEMLKVNEHI
                     TSVNVESNFITGKGILAIMRALQHNTVLTELRFHNQRHIMGSQVEMEIVKLLKENTTL
                     LRLGYHFELPGPRMSMTSILTRNMDKQRQKRMQEQKQQEGHDGGATLRTKVWQRGTPG
                     SSPYASPRQSPWSSPKVSKKVHTGRSRPPSPVAPPPPPPPPPLPPHMLPPPPPPPAPP
                     LPGKKLITRNIAEVIKQQESAQRALQNGQRKKKGKKVKKQPNNILKEIKNSLRSVQEK
                     KMEESSRPSTPQRSAHENLMEAIRGSSIRQLRRVEVPEALR"
     exon            416..1765
                     /gene="Lmod2"
                     /inference="alignment:Splign:2.1.0"
     exon            1766..2215
                     /gene="Lmod2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caccgctctt aaaaggttcc cgaggccact cctcacacca gctgccgacc agcctgaaag
       61 cttgctcgcc tctctgtctg cctctgcttg ccttgaatgc ctggttcttt aagctcttgg
      121 ggagtctgac aaggccggga ccatgtctac atttggctac agaaggggac ttagtaaata
      181 tgaatccatc gatgaggatg aacttctggc ctccctcaca gctgaagagc tgaaggagct
      241 tgagagggag ctggaagaca ttgaacctga tcgaaacctt cctgtggggc taagacaaaa
      301 gagtctgaca gagaaaaccc caaccggaaa cttcagccga gaggcgctga tggcgtactg
      361 ggaaaaggag tcccaaaaac ttttggagaa ggaacggctg ggggaatgtg gaaagcttgc
      421 agaagaagac aaggaagaga gtgaggagga actaatcttc acagagagca acagcgaagt
      481 ctccgaggag gtgtgtacgg aagaggagga ggagtctaca gaggaagagg aagaagagga
      541 ggaagaagac agtgaggaag aggaagtgac gacggaagtc acaaaacata ttaacggaac
      601 tgtaagccac aatggtgtta atcctgataa ctctaagcca aagacattta aaagccaaat
      661 agaaaatata aatttaacca acggcaacag tggaggaaca cagaggaaca cagagtcgcc
      721 agctgccatt cacccctgtg ggaatcccac tgttatcgag gatgctctgg aaaagattaa
      781 aaacaatgac cccgacacaa cagaagttaa tctgaacaat attgagaaca tcaccaccca
      841 gaccttatcc cgatttgctg aagctctcaa ggagaacaca gtagtgaaga cgttcagtct
      901 ggccaacacg cacgctgacg acgccgcggc gattgccatt gcggaaatgc tcaaggttaa
      961 cgagcacatt accagcgtaa acgtggagtc caacttcatc accggcaagg ggatcctggc
     1021 catcatgaga gcgctgcagc acaacacagt gctcaccgag ctgcgcttcc acaaccagag
     1081 gcacatcatg ggctcccagg tcgagatgga gattgtcaag ctgctcaagg agaataccac
     1141 gctgctgagg ctgggctacc attttgagct cccaggaccg agaatgagta tgacgagtat
     1201 tttaaccagg aatatggata aacagaggca aaaacgcatg caggagcaaa aacagcaaga
     1261 ggggcatgat ggaggagcta ctcttaggac caaagtctgg caaagaggga cgcctggctc
     1321 ttctccgtat gcatctccga ggcagtctcc atggtcgtct cctaaagtct ccaagaaagt
     1381 gcacaccggg aggagccgac ctccatctcc tgtggccccg cctccacccc ctcccccacc
     1441 tccccttcct ccccacatgc tgcctcctcc tcctcctccc cctgctcctc cactcccagg
     1501 gaaaaagctc atcaccagaa acattgcaga agtcattaaa caacaggaaa gcgcccagcg
     1561 ggccctacaa aatggacagc gaaagaaaaa agggaaaaag gttaagaaac aacccaacaa
     1621 tatcctaaag gaaattaaga attctctgag gtcagtgcaa gagaagaaaa tggaagaaag
     1681 ctcccggccc tctaccccac agagatcagc tcatgagaac ctcatggaag ccattcgggg
     1741 gagcagtata agacagctac ggagggtgga agttcccgaa gctctgagat agaatgatct
     1801 gtagaagagg actcggaagt gtttggtggt gtgacttgag gtgcattgtg agctgtttcc
     1861 aaaatgcctt ctttaatttg aaatatctcc cagcttcaga cactagtcac tatggaattc
     1921 caaggggaat tctaagaagc catgagcatg tttcttctgt aaatatgaaa ataaactttt
     1981 gtatgttgta agattcatcc gggcagcaag cctcagaaga tctctttgcc tctctggtat
     2041 ctcagttact gagctcaagt cacttagaga aatgtgctat tatttttgta atcccaataa
     2101 ccttagatta aagttttttt taaaagagaa actaatattt ttctgtgcat taatatatct
     2161 gctgggtatg tgttatattg ctaaatatta aaatccttac gttcttacac caaaaaaaaa
     2221 aaaaaaaaaa aaaaaaa
//
