LOCUS       NM_001107179            3949 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus leiomodin 1 (Lmod1), mRNA.
ACCESSION   NM_001107179 XM_001062822 XM_008769562 XM_222660
VERSION     NM_001107179.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3949)
  AUTHORS   Boczkowska,M., Rebowski,G., Kremneva,E., Lappalainen,P. and
            Dominguez,R.
  TITLE     How Leiomodin and Tropomodulin use a common fold for different
            actin assembly functions
  JOURNAL   Nat Commun 6, 8314 (2015)
   PUBMED   26370058
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3949)
  AUTHORS   Nanda,V. and Miano,J.M.
  TITLE     Leiomodin 1, a new serum response factor-dependent target gene
            expressed preferentially in differentiated smooth muscle cells
  JOURNAL   J Biol Chem 287 (4), 2459-2467 (2012)
   PUBMED   22157009
  REMARK    GeneRIF: Lmod1 is a new SMC-restricted SRF/MYOCD target gene.
REFERENCE   3  (bases 1 to 3949)
  AUTHORS   Conley,C.A. and Fowler,V.M.
  TITLE     Localization of the human 64kD autoantigen D1 to myofibrils in a
            subset of extraocular muscle fibers
  JOURNAL   Curr Eye Res 19 (4), 313-322 (1999)
   PUBMED   10520227
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            [WARNING] On May 3, 2024 this sequence was replaced by
            NM_001107179.3.
            
            On or before Nov 27, 2020 this sequence version replaced
            XM_008769562.2, NM_001107179.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643285.36267.1,
                                           SRR26643299.51946.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-466               JAXUCZ010000013.1  49305845-49306310
            467-1966            JAXUCZ010000013.1  49343526-49345025
            1967-3949           JAXUCZ010000013.1  49345988-49347970
FEATURES             Location/Qualifiers
     source          1..3949
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q13"
     gene            1..3949
                     /gene="Lmod1"
                     /note="leiomodin 1"
                     /db_xref="GeneID:304816"
                     /db_xref="RGD:1307236"
     exon            1..466
                     /gene="Lmod1"
                     /inference="alignment:Splign:2.1.0"
     CDS             206..1993
                     /gene="Lmod1"
                     /note="leiomodin 1 (smooth muscle); SM-Lmod; smooth muscle
                     leiomodin"
                     /codon_start=1
                     /product="leiomodin-1"
                     /protein_id="NP_001100649.2"
                     /db_xref="GeneID:304816"
                     /db_xref="RGD:1307236"
                     /translation="MSKVAKYRRQVSEDPDIDSLLSTLSPEEMEELEKELDVVDPDGS
                     IPVGLRQRNQTDKQPSGSFNREAMLNFCEKESKKIIQREMSVDESKQVGRKTDAKNGE
                     DKGSNASRKALGPRQDSDVGKEPKKGVLKKSFSRDREEADSRGSEKPKEEKVIRGIDK
                     GRVRAAVDRKEAGKDGREERAAATTKKEEEKTGSVRNAGLSRDKDKKREEVKEPSKKE
                     EVKLTAENRSTVGRQEDGKQKESREDRDKKPEVKGIGCGSRDSRKEDEKVKKEETQPD
                     KGVREEGKTREKQPPSGPSKPSDGQARAEEEAAPSIFDEPLEKVKNNDPEMTEVNVNN
                     SDCITNEILVRFTEALEFNTVVKVFALANTRADDHVAFAIAIMLKANKTITSLNLDSN
                     HITGKGILAIFRALLQNNTLTELRFHNQRHICGGKTEMEIAKLLKENTTLLKLGYHFE
                     LAGPRMTVTNLLSRNMDKQRQKRLQEQKQAQEASGEKKDRLEVPKVGALPKGSPKPSP
                     QPSPKSAPKNSPKKAGVPAAPPPPPPPLAPPLIMENLKNSLSPATQRKMGDKVLPAQE
                     KNSRDQLLAAIRSSNLKQLKKVEVPKLLQ"
     exon            467..1966
                     /gene="Lmod1"
                     /inference="alignment:Splign:2.1.0"
     exon            1967..3949
                     /gene="Lmod1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cactagcctt gggctgcagg gaggctgctg tgtcccccgg aacacctgta gtacagcagg
       61 gcccacggag ctgcagtgct cacctagctg gggctttgca ctcaagcccg ctcagttcta
      121 accagactag cgctccctgt cccttccctg cctaccacca gcaagcccgc cagacctggt
      181 aggagcaact gctcactttg ccaagatgtc caaggtagct aagtatcggc ggcaggtgag
      241 tgaagacccc gacatcgaca gcctgctgtc taccctctcc cctgaagaaa tggaagagct
      301 ggagaaggag ctggatgtgg tggaccctga tgggagcatt cccgtggggc tgcggcagag
      361 gaatcaaacg gacaaacagc cctccggctc gttcaaccgg gaagccatgc tcaacttctg
      421 tgaaaaggag agcaagaaaa ttattcagag ggagatgtct gtggatgaaa gcaagcaagt
      481 ggggaggaag actgatgcca agaacggaga ggacaagggc agcaatgcca gcagaaaggc
      541 cctaggcccc agacaggact cagacgtggg caaggagccg aagaagggcg ttttaaagaa
      601 aagcttctcc agggatcgag aggaggccga cagcagaggt agtgagaagc ccaaggagga
      661 gaaggtcatc aggggcattg acaagggcag ggtcagggct gcagtggaca ggaaggaagc
      721 cgggaaagat ggcagagaag aaagggcagc cgccaccacg aagaaggaag aggagaagac
      781 agggagtgtc aggaacgcag gcttgagcag agacaaagac aagaagagag aggaggtaaa
      841 ggagcccagc aagaaagagg aggtgaagct aacagcagag aacaggagca cagttgggag
      901 acaggaggac gggaagcaga aagagtcacg cgaagatagg gacaagaaac cagaggtcaa
      961 gggcatagga tgtgggagca gagactcgag aaaggaagac gaaaaagtga agaaggaaga
     1021 aacccaacct gataaaggag tcagagaaga gggcaagacc agagagaagc agccccccag
     1081 cggccccagc aagccctctg atgggcaagc cagggcagaa gaggaagcag ctcccagtat
     1141 atttgacgaa cctctggaga aagtgaagaa caatgaccca gagatgaccg aggtgaacgt
     1201 caacaactca gactgcatca ccaatgaaat cctagtccgg tttaccgagg ccttggagtt
     1261 caacaccgtg gtcaaggtgt ttgccttggc caacactcgg gccgacgacc acgtggcctt
     1321 tgccattgcc atcatgctga aggccaataa gaccatcacc agcctcaacc tggactccaa
     1381 tcacatcact ggcaaaggca tcctggccat cttccgggcc ctcctccaga acaacacgct
     1441 gacggagctg cgttttcaca accagaggca catctgtgga ggcaagacgg agatggagat
     1501 tgccaagctg ctcaaggaga acaccaccct actcaagctg ggctaccatt tcgagctggc
     1561 tggaccccgg atgactgtca ccaatctgct tagccgaaac atggacaagc agcgacagaa
     1621 acggctgcaa gagcaaaagc aggcccagga agccagtggg gagaagaagg accggctgga
     1681 ggtacccaag gtcggggctc tgcccaaggg ctcccccaaa ccttcacccc agccatcccc
     1741 aaagtctgct ccaaagaact cacccaagaa agcgggtgtc ccagcagccc cgcctccccc
     1801 tccccctcca ctggccccac cccttatcat ggagaaccta aagaactcac tctcaccagc
     1861 cacccagagg aagatgggag acaaagtgct ccctgcccag gagaagaact cacgtgacca
     1921 actcctagct gccatccgtt ccagcaacct taagcagctg aagaaggtag aggtgcccaa
     1981 gctgcttcaa taggacaggc agccaggcat tggtaccaat gcctgactgc ctagactctt
     2041 gttccagggc tacacagacc cccgccaccc caccctggct gagctgctac agctgcccct
     2101 gtccaccatg ggagagctcg agacctgggc cgcgctcgag ggaggacacc tcatctcttc
     2161 tccctttcct tttcttgtct ctgaggctct tcaaaaattg ctttgaaacc tggagctgga
     2221 gtgaagtgtc gggacaagag gagtccttta agtacgtcac agagaagatg tctcccaggg
     2281 accacatatc caccccagcc tcactgcctc cagggccagg attcaggcct ctgaggagcc
     2341 cttggggcca agcggctggg ccagtggcac tccatggggc agaggtagaa agatggaggg
     2401 caagggagtc ggaaggcaga gcaggagggc tgggaacact ataaagcctc catctgatgt
     2461 gcctgggcag cggacatggt tggacagtac ctgagagaag gtaggctcca gctgggagta
     2521 gacagacaga cagcagctgg acctgaaggg ttgatgccaa agcagacgtt tccttcacac
     2581 cacctgctgc tgtataatag ctatatatct gtttttccat aagattttga taatatatac
     2641 aaacctttag ctgcgagtgg ctatacctca ccttttcttc atgtgttaat ggttctaatg
     2701 ttcaccccgg gttccctaga aggcctccaa aagctcaggg tccctgccaa accattcaag
     2761 gtgaccatag acagagaggg caatatgggg gaaagcttga actcttgaga caacctcccg
     2821 acctggtgtt gcaggtctgt tcctcgccag tctctttgcc tcgtatctgt gcccagagat
     2881 gttctcaggg gcagagagtc acacagggcc ctggcgatgg ctatataagg cacgttcagg
     2941 gatgaccatt ccgtgactct tcctactgta ggctcagggc cagttcttca cagcagttac
     3001 aggcgaagga aggcagagtg agtcagagtg actcagggag ggacaccagt gtgacttagg
     3061 gcatgctccc actggaggca tcactgggga tctatggaat actgttccaa ctagggatga
     3121 agcccagcgt cagctcccat gcctagcatg gaggccttgg tttccatctc caacatgatc
     3181 tctttctgac ttactggcct gaagattact gtgccaccat gaaattacca ccttggttct
     3241 gggtcacaga catctgtctg tctgtctgtc tgtctgtctg tctgtctgtc tctctctttc
     3301 tctctagaag cagagaggaa agcagttgga atatgggtgg ggtcccacct ccctaaggaa
     3361 gtaggatagc tgttgtaggt ctggctaaaa tcagagaggg cctactcata tcccagggta
     3421 ccttctgatt ccattccttc cccaccccat tactgcttaa gtaatgggct ggcccagggg
     3481 aggagatatc ccagcgctgg ctcccagatc tcaaagatcg tgatttggag ccaagcccac
     3541 gagcttgcat ctgatggtgc agggcactag gtagatcttt acagatggtt gtgagccacc
     3601 atgtggttac tgagatttga actcaggacc tgtggaagag cagtcagtgc tcttaaccgc
     3661 tgagccatct ctccagcccc cactaggtag atcttaaggg tgcttctgct tatcttccaa
     3721 ctctgcgagg tggaagccaa tagcctcact ggtttgcaga tagaaattaa tcagcttcac
     3781 atgggtacat ggctgataag aggcaggacc gaagtcttca ctcctctctg ctgctgaaaa
     3841 atggaccagt gatagttttt cacaatgaca ttggaagcca aacagaaata tagataggta
     3901 gatgataggt agatagatgt cgatgtagat atagatatct tcctcttct
//
