LOCUS       NP_001100649             595 aa            linear   ROD 06-MAY-2024
DEFINITION  leiomodin-1 [Rattus norvegicus].
ACCESSION   NP_001100649 XP_001062822 XP_008767784 XP_222660
VERSION     NP_001100649.2
DBSOURCE    REFSEQ: accession NM_001107179.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 595)
  AUTHORS   Boczkowska,M., Rebowski,G., Kremneva,E., Lappalainen,P. and
            Dominguez,R.
  TITLE     How Leiomodin and Tropomodulin use a common fold for different
            actin assembly functions
  JOURNAL   Nat Commun 6, 8314 (2015)
   PUBMED   26370058
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 595)
  AUTHORS   Nanda,V. and Miano,J.M.
  TITLE     Leiomodin 1, a new serum response factor-dependent target gene
            expressed preferentially in differentiated smooth muscle cells
  JOURNAL   J Biol Chem 287 (4), 2459-2467 (2012)
   PUBMED   22157009
  REMARK    GeneRIF: Lmod1 is a new SMC-restricted SRF/MYOCD target gene.
REFERENCE   3  (residues 1 to 595)
  AUTHORS   Conley,C.A. and Fowler,V.M.
  TITLE     Localization of the human 64kD autoantigen D1 to myofibrils in a
            subset of extraocular muscle fibers
  JOURNAL   Curr Eye Res 19 (4), 313-322 (1999)
   PUBMED   10520227
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On or before Nov 27, 2020 this sequence version replaced
            XP_008767784.1, NP_001100649.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643285.36267.1,
                                           SRR26643299.51946.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..595
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q13"
     Protein         1..595
                     /product="leiomodin-1"
                     /note="leiomodin 1 (smooth muscle); SM-Lmod; smooth muscle
                     leiomodin"
                     /calculated_mol_wt=66085
     Region          1..322
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot
                     (A0A0G2K0D3.1)"
     Site            12
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K0D3.1)"
     Region          13..>95
                     /region_name="Tropomodulin"
                     /note="pfam03250"
                     /db_xref="CDD:460862"
     Region          <73..326
                     /region_name="PTZ00121"
                     /note="MAEBL; Provisional"
                     /db_xref="CDD:173412"
     Site            85
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K0D3.1)"
     Site            135
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K0D3.1)"
     Region          165..288
                     /region_name="8 X approximate tandem repeats.
                     /evidence=ECO:0000305"
                     /note="propagated from UniProtKB/Swiss-Prot
                     (A0A0G2K0D3.1)"
     Region          <335..>445
                     /region_name="RNA1"
                     /note="Ran GTPase-activating protein (RanGAP) involved in
                     mRNA processing and transport [Translation, ribosomal
                     structure and biogenesis]; COG5238"
                     /db_xref="CDD:444072"
     Region          467..568
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot
                     (A0A0G2K0D3.1)"
     Region          503..522
                     /region_name="5 X 4 AA approximate tandem repeats.
                     /evidence=ECO:0000305"
                     /note="propagated from UniProtKB/Swiss-Prot
                     (A0A0G2K0D3.1)"
     Site            550
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (A0A0G2K0D3.1)"
     CDS             1..595
                     /gene="Lmod1"
                     /coded_by="NM_001107179.3:221..2008"
                     /db_xref="GeneID:304816"
                     /db_xref="RGD:1307236"
ORIGIN      
        1 mskvakyrrq vsedpdidsl lstlspeeme elekeldvvd pdgsipvglr qrnqtdkqps
       61 gsfnreamln fcekeskkii qremsvdesk qvgrktdakn gedkgsnasr kalgprqdsd
      121 vgkepkkgvl kksfsrdree adsrgsekpk eekvirgidk grvraavdrk eagkdgreer
      181 aaattkkeee ktgsvrnagl srdkdkkree vkepskkeev kltaenrstv grqedgkqke
      241 sredrdkkpe vkgigcgsrd srkedekvkk eetqpdkgvr eegktrekqp psgpskpsdg
      301 qaraeeeaap sifdeplekv knndpemtev nvnnsdcitn eilvrfteal efntvvkvfa
      361 lantraddhv afaiaimlka nktitslnld snhitgkgil aifrallqnn tltelrfhnq
      421 rhicggktem eiakllkent tllklgyhfe lagprmtvtn llsrnmdkqr qkrlqeqkqa
      481 qeasgekkdr levpkvgalp kgspkpspqp spksapknsp kkagvpaapp ppppplappl
      541 imenlknsls patqrkmgdk vlpaqeknsr dqllaairss nlkqlkkvev pkllq
//
