LOCUS       NM_001009708            1650 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus LIM domain only 4 (Lmo4), mRNA.
ACCESSION   NM_001009708 XM_342353
VERSION     NM_001009708.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1650)
  AUTHORS   Baron,K.D., Al-Zahrani,K., Conway,J., Labreche,C., Storbeck,C.J.,
            Visvader,J.E. and Sabourin,L.A.
  TITLE     Recruitment and activation of SLK at the leading edge of migrating
            cells requires Src family kinase activity and the LIM-only protein
            4
  JOURNAL   Biochim Biophys Acta 1853 (7), 1683-1692 (2015)
   PUBMED   25882817
  REMARK    Erratum:[Biochim Biophys Acta. 2015 Oct;1853(10 Pt A):2754]
REFERENCE   2  (bases 1 to 1650)
  AUTHORS   Jamesdaniel,S.
  TITLE     Downstream targets of Lmo4 are modulated by cisplatin in the inner
            ear of Wistar rats
  JOURNAL   PLoS One 9 (12), e115263 (2014)
   PUBMED   25501662
  REMARK    GeneRIF: Authors provided the first evidence of in vivo nitration
            of Lmo4 in cisplatin ototoxicity.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1650)
  AUTHORS   Michell,A.C., Braganca,J., Broadbent,C., Joyce,B., Franklyn,A.,
            Schneider,J.E., Bhattacharya,S. and Bamforth,S.D.
  TITLE     A novel role for transcription factor Lmo4 in thymus development
            through genetic interaction with Cited2
  JOURNAL   Dev Dyn 239 (7), 1988-1994 (2010)
   PUBMED   20549734
REFERENCE   4  (bases 1 to 1650)
  AUTHORS   Song,M.R., Sun,Y., Bryson,A., Gill,G.N., Evans,S.M. and Pfaff,S.L.
  TITLE     Islet-to-LMO stoichiometries control the function of transcription
            complexes that specify motor neuron and V2a interneuron identity
  JOURNAL   Development 136 (17), 2923-2932 (2009)
   PUBMED   19666821
REFERENCE   5  (bases 1 to 1650)
  AUTHORS   Joshi,K., Lee,S., Lee,B., Lee,J.W. and Lee,S.K.
  TITLE     LMO4 controls the balance between excitatory and inhibitory spinal
            V2 interneurons
  JOURNAL   Neuron 61 (6), 839-851 (2009)
   PUBMED   19323994
REFERENCE   6  (bases 1 to 1650)
  AUTHORS   Chen,H.H., Schock,S.C., Xu,J., Safarpour,F., Thompson,C.S. and
            Stewart,A.F.
  TITLE     Extracellular ATP-dependent upregulation of the transcription
            cofactor LMO4 promotes neuron survival from hypoxia
  JOURNAL   Exp Cell Res 313 (14), 3106-3116 (2007)
   PUBMED   17524392
  REMARK    GeneRIF: Data reveal that LMO4 is a rapidly induced downstream
            effector of ATP signaling that promotes neuron survival from
            hypoxia.
REFERENCE   7  (bases 1 to 1650)
  AUTHORS   Yu,Z., Lin,K.K., Bhandari,A., Spencer,J.A., Xu,X., Wang,N., Lu,Z.,
            Gill,G.N., Roop,D.R., Wertz,P. and Andersen,B.
  TITLE     The Grainyhead-like epithelial transactivator Get-1/Grhl3 regulates
            epidermal terminal differentiation and interacts functionally with
            LMO4
  JOURNAL   Dev Biol 299 (1), 122-136 (2006)
   PUBMED   16949565
REFERENCE   8  (bases 1 to 1650)
  AUTHORS   Lee,S.K., Jurata,L.W., Nowak,R., Lettieri,K., Kenny,D.A.,
            Pfaff,S.L. and Gill,G.N.
  TITLE     The LIM domain-only protein LMO4 is required for neural tube
            closure
  JOURNAL   Mol Cell Neurosci 28 (2), 205-214 (2005)
   PUBMED   15691703
REFERENCE   9  (bases 1 to 1650)
  AUTHORS   Tse,E., Smith,A.J., Hunt,S., Lavenir,I., Forster,A., Warren,A.J.,
            Grutz,G., Foroni,L., Carlton,M.B., Colledge,W.H., Boehm,T. and
            Rabbitts,T.H.
  TITLE     Null mutation of the Lmo4 gene or a combined null mutation of the
            Lmo1/Lmo3 genes causes perinatal lethality, and Lmo4 controls
            neural tube development in mice
  JOURNAL   Mol Cell Biol 24 (5), 2063-2073 (2004)
   PUBMED   14966285
REFERENCE   10 (bases 1 to 1650)
  AUTHORS   Sugihara,T.M., Bach,I., Kioussi,C., Rosenfeld,M.G. and Andersen,B.
  TITLE     Mouse deformed epidermal autoregulatory factor 1 recruits a LIM
            domain factor, LMO-4, and CLIM coregulators
  JOURNAL   Proc Natl Acad Sci U S A 95 (26), 15418-15423 (1998)
   PUBMED   9860983
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC087700.1.
            
            On Jan 13, 2005 this sequence version replaced XM_342353.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087700.1, FQ233103.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760396, SAMN12840106
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1650
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q44"
     gene            1..1650
                     /gene="Lmo4"
                     /note="LIM domain only 4"
                     /db_xref="GeneID:362051"
                     /db_xref="RGD:1305670"
     exon            1..360
                     /gene="Lmo4"
                     /inference="alignment:Splign:2.1.0"
     exon            361..599
                     /gene="Lmo4"
                     /inference="alignment:Splign:2.1.0"
     CDS             364..861
                     /gene="Lmo4"
                     /codon_start=1
                     /product="LIM domain transcription factor LMO4"
                     /protein_id="NP_001009708.1"
                     /db_xref="GeneID:362051"
                     /db_xref="RGD:1305670"
                     /translation="MVNPGSSSQPPPVTAGSLSWKRCAGCGGKIADRFLLYAMDSYWH
                     SRCLKCSCCQAQLGDIGTSCYTKSGMILCRNDYIRLFGNSGACSACGQSIPASELVMR
                     AQGNVYHLKCFTCSTCRNRLVPGDRFHYINGSLFCEHDRPTALINGHLNSLQSNPLLP
                     DQKVC"
     exon            600..696
                     /gene="Lmo4"
                     /inference="alignment:Splign:2.1.0"
     exon            697..852
                     /gene="Lmo4"
                     /inference="alignment:Splign:2.1.0"
     exon            853..1629
                     /gene="Lmo4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcgattgca gcagtggctg ccgctgcgcc gcgcgggccg ggccgagggc gcctgcagct
       61 gctcctcgcg cgcagccggg ggctgaggac ccggaccctc gggctgagac ttgacacttc
      121 tgcgccgggc cgcctgccac ttagcgtggg gctccgtcta cccgccccag agccacgcga
      181 ttaaaaaaaa aaaaaaagca gcccttagcc ccctcctccc ctttcctgct tctgcgagaa
      241 ctccctccct ccctccagct ccgccagccc cggcgcccct gccctggaag ccgagcggct
      301 ccgctcgcat ttcgccgccg ccgccgcctc tcgcagtgtt gcaatatagg ggagaaacag
      361 accatggtga atccgggcag cagctcgcag ccgcccccgg tgacggccgg ctccctctcc
      421 tggaagcgct gcgcaggctg cgggggcaag attgcggacc gctttctgct ctatgccatg
      481 gacagctact ggcacagccg ctgcctcaag tgctcctgct gccaggcgca gctgggcgac
      541 atcggcacgt cctgttacac caagagcggc atgatccttt gcagaaatga ctacattagg
      601 ttatttggga acagtggtgc ctgcagtgcc tgtggacagt cgattcctgc gagtgaactc
      661 gtcatgaggg ctcaaggcaa cgtgtatcat ctcaagtgtt ttacatgctc tacctgccgg
      721 aatcgcctag tcccgggaga tcggtttcac tacatcaatg gcagtttatt ttgtgaacat
      781 gatagaccca cagctctcat caacggccat ttgaactcac ttcagagcaa tccactactg
      841 ccagaccaga aggtctgctg agaggtcaga gtgttgcaga atgcgtgcct tcatctcaga
      901 attgttcatc acaggtggat cccgtgcgtc tgctgtagac cagtcatctt cgtagccagc
      961 gccgtgccac accgcgcccc ctttagtctt gagtgccctt cctgcattta ttggtgtatt
     1021 aaaatgactg aatatgaaca ttaaggactc catgaacccg ggctaatggg agacggtagc
     1081 gagaatgaaa aaagatccac caaaggacat ctagggggga gggtgcttgg gggggagggc
     1141 aatgactaat gaagctaatt agaagaggca tcacgaatct gctttctacc ctcattaaca
     1201 attagcaggg caccggccgg agtgtgagcc ctgttttact cttaactaca ttctgtttgc
     1261 tctttgtata tttaagtgtt gtaatgagat gtgtttcaat caaacctgaa catgagttaa
     1321 aaaggaaaga gacgtggctt ttgtgatagt tctatcacag acacttttat tgtatctctg
     1381 taaaatacaa tgtatgtatg catgtgagtg ttcttgtcct gatgttgctc cgcccatgac
     1441 aaaggttaaa aaaaaagaaa agaagaaaaa aaaaatgagg ctcacagccg ctactatgta
     1501 gaaatccccc cctacttcta atttgctgaa tgaagaaaaa aaaatctttt atttgtgata
     1561 ttttcagaga catttgctct agtatggtgt atttaaataa taaaaactta aaagaaaaaa
     1621 tatccaacaa aaaaaaaaaa aaaaaaaaaa
//
