LOCUS       NM_001244780            1504 bp    mRNA    linear   ROD 01-FEB-2021
DEFINITION  Rattus norvegicus LIM domain only 2 (Lmo2), transcript variant 3,
            mRNA.
ACCESSION   NM_001244780
VERSION     NM_001244780.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1504)
  AUTHORS   Gamper I, Koh KR, Ruau D, Ullrich K, Bartunkova J, Piroth D, Hacker
            C, Bartunek P and Zenke M.
  TITLE     GAR22: a novel target gene of thyroid hormone receptor causes
            growth inhibition in human erythroid cells
  JOURNAL   Exp. Hematol. 37 (5), 539-548 (2009)
   PUBMED   19375645
REFERENCE   2  (bases 1 to 1504)
  AUTHORS   Tripic T, Deng W, Cheng Y, Zhang Y, Vakoc CR, Gregory GD, Hardison
            RC and Blobel GA.
  TITLE     SCL and associated proteins distinguish active from repressive GATA
            transcription factor complexes
  JOURNAL   Blood 113 (10), 2191-2201 (2009)
   PUBMED   19011221
REFERENCE   3  (bases 1 to 1504)
  AUTHORS   Landry JR, Kinston S, Knezevic K, de Bruijn MF, Wilson N,
            Nottingham WT, Peitz M, Edenhofer F, Pimanda JE, Ottersbach K and
            Gottgens B.
  TITLE     Runx genes are direct targets of Scl/Tal1 in the yolk sac and fetal
            liver
  JOURNAL   Blood 111 (6), 3005-3014 (2008)
   PUBMED   18184866
REFERENCE   4  (bases 1 to 1504)
  AUTHORS   Han C, Liu H, Liu J, Yin K, Xie Y, Shen X, Wang Y, Yuan J, Qiang B,
            Liu YJ and Peng X.
  TITLE     Human Bex2 interacts with LMO2 and regulates the transcriptional
            activity of a novel DNA-binding complex
  JOURNAL   Nucleic Acids Res. 33 (20), 6555-6565 (2005)
   PUBMED   16314316
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1504)
  AUTHORS   Manaia A, Lemarchandel V, Klaine M, Max-Audit I, Romeo P,
            Dieterlen-Lievre F and Godin I.
  TITLE     Lmo2 and GATA-3 associated expression in intraembryonic hemogenic
            sites
  JOURNAL   Development 127 (3), 643-653 (2000)
   PUBMED   10631184
REFERENCE   6  (bases 1 to 1504)
  AUTHORS   Visvader JE, Mao X, Fujiwara Y, Hahm K and Orkin SH.
  TITLE     The LIM-domain binding protein Ldb1 and its partner LMO2 act as
            negative regulators of erythroid differentiation
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 94 (25), 13707-13712 (1997)
   PUBMED   9391090
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CO559731.1 and BC105772.1.
            
            Transcript Variant: This variant (3) has an alternate 5' exon,
            which results in a downstream AUG start codon, compared to variant
            1. The resulting isoform (2) is shorter at the N-terminus than
            isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CO559731.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-608               CO559731.1         1-608
            609-1504            BC105772.1         744-1639
FEATURES             Location/Qualifiers
     source          1..1504
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q32"
     gene            1..1504
                     /gene="Lmo2"
                     /note="LIM domain only 2"
                     /db_xref="GeneID:362176"
                     /db_xref="RGD:1307101"
     CDS             273..749
                     /gene="Lmo2"
                     /note="isoform 2 is encoded by transcript variant 3;
                     rhombotin-2"
                     /codon_start=1
                     /product="rhombotin-2 isoform 2"
                     /protein_id="NP_001231709.1"
                     /db_xref="GeneID:362176"
                     /db_xref="RGD:1307101"
                     /translation="MSSAIERKSLDPSEEPVDEVLQIPPSLLTCGGCQQNIGDRYFLK
                     AIDQYWHEDCLSCDLCGCRLGEVGRRLYYKLGRKLCRRDYLRLFGQDGLCASCDKRIR
                     AYEMTMRVKDKVYHLECFKCAACQKHFCVGDRYLLINSDIVCEQDIYEWTKINGII"
ORIGIN      
        1 cacgaccgtg gtcttgggac ctcgaacccg agacgagcgc tcgctagcca gccactagca
       61 acgcttgcat ttctttcctg ctggaaccgc cagggagcgc ggtgactgtc cttgagcgtg
      121 gaggggcgag ctcgccggcc gagcgaccga gcaagaggag gcgcaggagc ggcggcgccc
      181 gagcacccga gggggtccga gtccaggcag ctagccagcc acgcgccaca aagggagcgc
      241 ccccgccgcc cggcacgcct cccccctccc caatgtcctc ggccatcgaa aggaagagcc
      301 tggacccgtc tgaggaaccc gtggatgagg tgctgcagat ccccccatcc ctgctgacat
      361 gtggtggctg ccagcagaac ataggggacc gctacttcct gaaagccatc gaccagtact
      421 ggcacgagga ttgcctcagc tgtgacctct gtgggtgtcg gctgggagag gtgggccggc
      481 gcctctacta caagctggga cggaagctgt gcaggcgaga ctatctcagg ctttttggac
      541 aagatggcct ctgtgcttcc tgtgacaagc ggatccgtgc ctatgagatg acgatgcgcg
      601 tgaaagacaa agtgtatcac ctggagtgtt tcaagtgcgc tgcctgccag aagcatttct
      661 gtgtaggtga cagatacctt ctcatcaact ccgacatagt gtgtgaacaa gacatctacg
      721 agtggaccaa gatcaatggg atcatctagg ccagagtccc aggcacctgt ggggaggtgt
      781 tcagtggaga cgctggctcc gcggtcttcg ggcttaggca ctttgggaac ctgagggtgg
      841 gtgaggcatt tcttaggaga ctatggactc ttcctgggca ctaaagacat agcaatcaca
      901 tgacataatg cagaggccga ggcttcagtg atgaaaagga ccagccctag gagagaattt
      961 atggtcacag gctagctata gtaactgaca aggttagtgg aggaaatctt tgagaaccag
     1021 catgccactg tgccatcatg ataacatttc ccagataggc agtcttgggt aaagattaga
     1081 tgtgaccttg gtgttcatgg actagagttg tggaattaat ttcttcctgg ctttggtaac
     1141 taccctgttc tagtcaccgt ccttcacact aggaaaggaa agagagaaga aatagtcgct
     1201 tttttttttt ctttcttttt ttccttggtc atcttcccgt ggcctacagc tctggagcca
     1261 agggaaactg catagaggta catttcagtt gggaatgaaa tatacatctt tcaaccagac
     1321 aaatatttat agcagtgttg atgaatcact gtttttagac accttcattt gaggtgaggc
     1381 gccccacaga ttgtttctat acaaatgtaa atcttaaaaa aagaagtcaa agttgttcaa
     1441 ctattttatt atcttagatt atatcaaagt atttgttgtg tgtcattaaa aaaaaaaaaa
     1501 aaaa
//
