LOCUS       NM_001244779            1529 bp    mRNA    linear   ROD 01-FEB-2021
DEFINITION  Rattus norvegicus LIM domain only 2 (Lmo2), transcript variant 2,
            mRNA.
ACCESSION   NM_001244779
VERSION     NM_001244779.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1529)
  AUTHORS   Gamper I, Koh KR, Ruau D, Ullrich K, Bartunkova J, Piroth D, Hacker
            C, Bartunek P and Zenke M.
  TITLE     GAR22: a novel target gene of thyroid hormone receptor causes
            growth inhibition in human erythroid cells
  JOURNAL   Exp. Hematol. 37 (5), 539-548 (2009)
   PUBMED   19375645
REFERENCE   2  (bases 1 to 1529)
  AUTHORS   Tripic T, Deng W, Cheng Y, Zhang Y, Vakoc CR, Gregory GD, Hardison
            RC and Blobel GA.
  TITLE     SCL and associated proteins distinguish active from repressive GATA
            transcription factor complexes
  JOURNAL   Blood 113 (10), 2191-2201 (2009)
   PUBMED   19011221
REFERENCE   3  (bases 1 to 1529)
  AUTHORS   Landry JR, Kinston S, Knezevic K, de Bruijn MF, Wilson N,
            Nottingham WT, Peitz M, Edenhofer F, Pimanda JE, Ottersbach K and
            Gottgens B.
  TITLE     Runx genes are direct targets of Scl/Tal1 in the yolk sac and fetal
            liver
  JOURNAL   Blood 111 (6), 3005-3014 (2008)
   PUBMED   18184866
REFERENCE   4  (bases 1 to 1529)
  AUTHORS   Han C, Liu H, Liu J, Yin K, Xie Y, Shen X, Wang Y, Yuan J, Qiang B,
            Liu YJ and Peng X.
  TITLE     Human Bex2 interacts with LMO2 and regulates the transcriptional
            activity of a novel DNA-binding complex
  JOURNAL   Nucleic Acids Res. 33 (20), 6555-6565 (2005)
   PUBMED   16314316
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1529)
  AUTHORS   Manaia A, Lemarchandel V, Klaine M, Max-Audit I, Romeo P,
            Dieterlen-Lievre F and Godin I.
  TITLE     Lmo2 and GATA-3 associated expression in intraembryonic hemogenic
            sites
  JOURNAL   Development 127 (3), 643-653 (2000)
   PUBMED   10631184
REFERENCE   6  (bases 1 to 1529)
  AUTHORS   Visvader JE, Mao X, Fujiwara Y, Hahm K and Orkin SH.
  TITLE     The LIM-domain binding protein Ldb1 and its partner LMO2 act as
            negative regulators of erythroid differentiation
  JOURNAL   Proc. Natl. Acad. Sci. U.S.A. 94 (25), 13707-13712 (1997)
   PUBMED   9391090
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DY319476.1 and BC105772.1.
            
            Transcript Variant: This variant (2) has an alternate 5' exon,
            which results in a downstream AUG start codon, compared to variant
            1. The resulting isoform (2) is shorter at the N-terminus than
            isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DY319476.1, CK469988.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-633               DY319476.1         2-634
            634-1529            BC105772.1         744-1639
FEATURES             Location/Qualifiers
     source          1..1529
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q32"
     gene            1..1529
                     /gene="Lmo2"
                     /note="LIM domain only 2"
                     /db_xref="GeneID:362176"
                     /db_xref="RGD:1307101"
     CDS             298..774
                     /gene="Lmo2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     rhombotin-2"
                     /codon_start=1
                     /product="rhombotin-2 isoform 2"
                     /protein_id="NP_001231708.1"
                     /db_xref="GeneID:362176"
                     /db_xref="RGD:1307101"
                     /translation="MSSAIERKSLDPSEEPVDEVLQIPPSLLTCGGCQQNIGDRYFLK
                     AIDQYWHEDCLSCDLCGCRLGEVGRRLYYKLGRKLCRRDYLRLFGQDGLCASCDKRIR
                     AYEMTMRVKDKVYHLECFKCAACQKHFCVGDRYLLINSDIVCEQDIYEWTKINGII"
ORIGIN      
        1 aacaccacca ctcacacaaa tgcatactct tctctcctga ctgcttaaac tgagttcctg
       61 acattttctg gaaagagggc atttctacct ggatgtgcag tgacctgtgg agaggcaggg
      121 agcgcggtga ctgtccttga gcgtggaggg gcgagctcgc cggccgagcg accgagcaag
      181 aggaggcgca ggagcggcgg cgcccgagca cccgaggggg tccgagtcca ggcagctagc
      241 cagccacgcg ccacaaaggg agcgcccccg ccgcccggca cgcctccccc ctccccaatg
      301 tcctcggcca tcgaaaggaa gagcctggac ccgtctgagg aacccgtgga tgaggtgctg
      361 cagatccccc catccctgct gacatgtggt ggctgccagc agaacatagg ggaccgctac
      421 ttcctgaaag ccatcgacca gtactggcac gaggattgcc tcagctgtga cctctgtggg
      481 tgtcggctgg gagaggtggg ccggcgcctc tactacaagc tgggacggaa gctgtgcagg
      541 cgagactatc tcaggctttt tggacaagat ggcctctgtg cttcctgtga caagcggatc
      601 cgtgcctatg agatgacgat gcgcgtgaaa gacaaagtgt atcacctgga gtgtttcaag
      661 tgcgctgcct gccagaagca tttctgtgta ggtgacagat accttctcat caactccgac
      721 atagtgtgtg aacaagacat ctacgagtgg accaagatca atgggatcat ctaggccaga
      781 gtcccaggca cctgtgggga ggtgttcagt ggagacgctg gctccgcggt cttcgggctt
      841 aggcactttg ggaacctgag ggtgggtgag gcatttctta ggagactatg gactcttcct
      901 gggcactaaa gacatagcaa tcacatgaca taatgcagag gccgaggctt cagtgatgaa
      961 aaggaccagc cctaggagag aatttatggt cacaggctag ctatagtaac tgacaaggtt
     1021 agtggaggaa atctttgaga accagcatgc cactgtgcca tcatgataac atttcccaga
     1081 taggcagtct tgggtaaaga ttagatgtga ccttggtgtt catggactag agttgtggaa
     1141 ttaatttctt cctggctttg gtaactaccc tgttctagtc accgtccttc acactaggaa
     1201 aggaaagaga gaagaaatag tcgctttttt tttttctttc tttttttcct tggtcatctt
     1261 cccgtggcct acagctctgg agccaaggga aactgcatag aggtacattt cagttgggaa
     1321 tgaaatatac atctttcaac cagacaaata tttatagcag tgttgatgaa tcactgtttt
     1381 tagacacctt catttgaggt gaggcgcccc acagattgtt tctatacaaa tgtaaatctt
     1441 aaaaaaagaa gtcaaagttg ttcaactatt ttattatctt agattatatc aaagtatttg
     1501 ttgtgtgtca ttaaaaaaaa aaaaaaaaa
//
