LOCUS       NM_001037358            1639 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus LIM domain only 2 (Lmo2), transcript variant 1,
            mRNA.
ACCESSION   NM_001037358
VERSION     NM_001037358.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1639)
  AUTHORS   Gamper I, Koh KR, Ruau D, Ullrich K, Bartunkova J, Piroth D, Hacker
            C, Bartunek P and Zenke M.
  TITLE     GAR22: a novel target gene of thyroid hormone receptor causes
            growth inhibition in human erythroid cells
  JOURNAL   Exp Hematol 37 (5), 539-548 (2009)
   PUBMED   19375645
REFERENCE   2  (bases 1 to 1639)
  AUTHORS   Tripic T, Deng W, Cheng Y, Zhang Y, Vakoc CR, Gregory GD, Hardison
            RC and Blobel GA.
  TITLE     SCL and associated proteins distinguish active from repressive GATA
            transcription factor complexes
  JOURNAL   Blood 113 (10), 2191-2201 (2009)
   PUBMED   19011221
REFERENCE   3  (bases 1 to 1639)
  AUTHORS   Landry JR, Kinston S, Knezevic K, de Bruijn MF, Wilson N,
            Nottingham WT, Peitz M, Edenhofer F, Pimanda JE, Ottersbach K and
            Gottgens B.
  TITLE     Runx genes are direct targets of Scl/Tal1 in the yolk sac and fetal
            liver
  JOURNAL   Blood 111 (6), 3005-3014 (2008)
   PUBMED   18184866
REFERENCE   4  (bases 1 to 1639)
  AUTHORS   Han C, Liu H, Liu J, Yin K, Xie Y, Shen X, Wang Y, Yuan J, Qiang B,
            Liu YJ and Peng X.
  TITLE     Human Bex2 interacts with LMO2 and regulates the transcriptional
            activity of a novel DNA-binding complex
  JOURNAL   Nucleic Acids Res 33 (20), 6555-6565 (2005)
   PUBMED   16314316
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1639)
  AUTHORS   Manaia A, Lemarchandel V, Klaine M, Max-Audit I, Romeo P,
            Dieterlen-Lievre F and Godin I.
  TITLE     Lmo2 and GATA-3 associated expression in intraembryonic hemogenic
            sites
  JOURNAL   Development 127 (3), 643-653 (2000)
   PUBMED   10631184
REFERENCE   6  (bases 1 to 1639)
  AUTHORS   Visvader JE, Mao X, Fujiwara Y, Hahm K and Orkin SH.
  TITLE     The LIM-domain binding protein Ldb1 and its partner LMO2 act as
            negative regulators of erythroid differentiation
  JOURNAL   Proc Natl Acad Sci U S A 94 (25), 13707-13712 (1997)
   PUBMED   9391090
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC105772.1.
            
            On Oct 1, 2011 this sequence version replaced NM_001037358.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC105772.1, FN804312.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1639              BC105772.1         1-1639
FEATURES             Location/Qualifiers
     source          1..1639
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q32"
     gene            1..1639
                     /gene="Lmo2"
                     /note="LIM domain only 2"
                     /db_xref="GeneID:362176"
                     /db_xref="RGD:1307101"
     exon            1..228
                     /gene="Lmo2"
                     /inference="alignment:Splign:2.1.0"
     CDS             222..884
                     /gene="Lmo2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     rhombotin-2"
                     /codon_start=1
                     /product="rhombotin-2 isoform 1"
                     /protein_id="NP_001032435.2"
                     /db_xref="GeneID:362176"
                     /db_xref="RGD:1307101"
                     /translation="MEGSAVTVLERGGASSPAERPSKRRRRSGGARAPEGVRVQAASQ
                     PRATKGAPPPPGTPPPSPMSSAIERKSLDPSEEPVDEVLQIPPSLLTCGGCQQNIGDR
                     YFLKAIDQYWHEDCLSCDLCGCRLGEVGRRLYYKLGRKLCRRDYLRLFGQDGLCASCD
                     KRIRAYEMTMRVKDKVYHLECFKCAACQKHFCVGDRYLLINSDIVCEQDIYEWTKING
                     II"
     exon            229..448
                     /gene="Lmo2"
                     /inference="alignment:Splign:2.1.0"
     exon            449..664
                     /gene="Lmo2"
                     /inference="alignment:Splign:2.1.0"
     exon            665..1639
                     /gene="Lmo2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggaagctga gcgaaaatag accttcgcga gagaggaggg agccccggga gagccgcgcg
       61 gtccgctccc cgcccccagg ccgccgcccc ctctctgccc tcggcgcccc gaccccagcg
      121 aaggtgcgag gggttcgggg cggccgggcg gagccggcga ctgcgcgcga tcgggaccgg
      181 gcggcggcgg cggcggctgt ggtgacggca gcgggaccgg gatggaaggg agcgcggtga
      241 ctgtccttga gcgtggaggg gcgagctcgc cggccgagcg accgagcaag aggaggcgca
      301 ggagcggcgg cgcccgagca cccgaggggg tccgagtcca ggcagctagc cagccacgcg
      361 ccacaaaggg agcgcccccg ccgcccggca cgcctccccc ctccccaatg tcctcggcca
      421 tcgaaaggaa gagcctggac ccgtctgagg aacccgtgga tgaggtgctg cagatccccc
      481 catccctgct gacatgtggt ggctgccagc agaacatagg ggaccgctac ttcctgaaag
      541 ccatcgacca gtactggcac gaggattgcc tcagctgtga cctctgtggg tgtcggctgg
      601 gagaggtggg ccggcgcctc tactacaagc tgggacggaa gctgtgcagg cgagactatc
      661 tcaggctttt tggacaagat ggcctctgtg cttcctgtga caagcggatc cgtgcctatg
      721 agatgacgat gcgcgtgaaa gacaaagtgt atcacctgga gtgtttcaag tgcgctgcct
      781 gccagaagca tttctgtgta ggtgacagat accttctcat caactccgac atagtgtgtg
      841 aacaagacat ctacgagtgg accaagatca atgggatcat ctaggccaga gtcccaggca
      901 cctgtgggga ggtgttcagt ggagacgctg gctccgcggt cttcgggctt aggcactttg
      961 ggaacctgag ggtgggtgag gcatttctta ggagactatg gactcttcct gggcactaaa
     1021 gacatagcaa tcacatgaca taatgcagag gccgaggctt cagtgatgaa aaggaccagc
     1081 cctaggagag aatttatggt cacaggctag ctatagtaac tgacaaggtt agtggaggaa
     1141 atctttgaga accagcatgc cactgtgcca tcatgataac atttcccaga taggcagtct
     1201 tgggtaaaga ttagatgtga ccttggtgtt catggactag agttgtggaa ttaatttctt
     1261 cctggctttg gtaactaccc tgttctagtc accgtccttc acactaggaa aggaaagaga
     1321 gaagaaatag tcgctttttt tttttctttc tttttttcct tggtcatctt cccgtggcct
     1381 acagctctgg agccaaggga aactgcatag aggtacattt cagttgggaa tgaaatatac
     1441 atctttcaac cagacaaata tttatagcag tgttgatgaa tcactgtttt tagacacctt
     1501 catttgaggt gaggcgcccc acagattgtt tctatacaaa tgtaaatctt aaaaaaagaa
     1561 gtcaaagttg ttcaactatt ttattatctt agattatatc aaagtatttg ttgtgtgtca
     1621 ttaaaaaaaa aaaaaaaaa
//
