LOCUS       NM_001402442            1301 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus LIM domain only 1 (Lmo1), transcript variant 1,
            mRNA.
ACCESSION   NM_001402442
VERSION     NM_001402442.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1301)
  AUTHORS   Kusy,S., Gerby,B., Goardon,N., Gault,N., Ferri,F., Gerard,D.,
            Armstrong,F., Ballerini,P., Cayuela,J.M., Baruchel,A., Pflumio,F.
            and Romeo,P.H.
  TITLE     NKX3.1 is a direct TAL1 target gene that mediates proliferation of
            TAL1-expressing human T cell acute lymphoblastic leukemia
  JOURNAL   J Exp Med 207 (10), 2141-2156 (2010)
   PUBMED   20855495
REFERENCE   2  (bases 1 to 1301)
  AUTHORS   Susa,T., Ishikawa,A., Cai,L.Y., Kato,T., Matsumoto,K., Kitahara,K.,
            Kurokawa,R., Ono,T. and Kato,Y.
  TITLE     The highly related LIM factors, LMO1, LMO3 and LMO4, play different
            roles in the regulation of the pituitary glycoprotein hormone
            alpha-subunit (alpha GSU) gene
  JOURNAL   Biosci Rep 30 (1), 51-58 (2009)
   PUBMED   19228115
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1301)
  AUTHORS   Chervinsky,D.S., Zhao,X.F., Lam,D.H., Ellsworth,M., Gross,K.W. and
            Aplan,P.D.
  TITLE     Disordered T-cell development and T-cell malignancies in SCL LMO1
            double-transgenic mice: parallels with E2A-deficient mice
  JOURNAL   Mol Cell Biol 19 (7), 5025-5035 (1999)
   PUBMED   10373552
REFERENCE   4  (bases 1 to 1301)
  AUTHORS   Ono,Y., Fukuhara,N. and Yoshie,O.
  TITLE     TAL1 and LIM-only proteins synergistically induce retinaldehyde
            dehydrogenase 2 expression in T-cell acute lymphoblastic leukemia
            by acting as cofactors for GATA3
  JOURNAL   Mol Cell Biol 18 (12), 6939-6950 (1998)
   PUBMED   9819382
REFERENCE   5  (bases 1 to 1301)
  AUTHORS   McGuire,E.A., Rintoul,C.E., Sclar,G.M. and Korsmeyer,S.J.
  TITLE     Thymic overexpression of Ttg-1 in transgenic mice results in T-cell
            acute lymphoblastic leukemia/lymphoma
  JOURNAL   Mol Cell Biol 12 (9), 4186-4196 (1992)
   PUBMED   1508213
REFERENCE   6  (bases 1 to 1301)
  AUTHORS   McGuire,E.A., Davis,A.R. and Korsmeyer,S.J.
  TITLE     T-cell translocation gene 1 (Ttg-1) encodes a nuclear protein
            normally expressed in neural lineage cells
  JOURNAL   Blood 77 (3), 599-606 (1991)
   PUBMED   1703797
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.662257.1,
                                           SRR22399489.3956773.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-550               JAXUCZ010000001.1  172597984-172598533 c
            551-764             JAXUCZ010000001.1  172571995-172572208 c
            765-890             JAXUCZ010000001.1  172569132-172569257 c
            891-1301            JAXUCZ010000001.1  172567156-172567566 c
FEATURES             Location/Qualifiers
     source          1..1301
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q33"
     gene            1..1301
                     /gene="Lmo1"
                     /gene_synonym="Dat1"
                     /note="LIM domain only 1"
                     /db_xref="GeneID:245979"
                     /db_xref="RGD:621166"
     exon            1..550
                     /gene="Lmo1"
                     /gene_synonym="Dat1"
                     /inference="alignment:Splign:2.1.0"
     CDS             526..996
                     /gene="Lmo1"
                     /gene_synonym="Dat1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     neuronal-specific transcription factor DAT1;
                     dopamine-inducible LIM-domain transcription factor DAT1;
                     LIM domain only protein 1; LIM domain only protein 3"
                     /codon_start=1
                     /product="LIM domain only protein 3 isoform 1"
                     /protein_id="NP_001389371.1"
                     /db_xref="GeneID:245979"
                     /db_xref="RGD:621166"
                     /translation="MMVLDKEDGVPMLSVQPKGKQKGCAGCNRKIKDRYLLKALDKYW
                     HEDCLKCACCDCRLGEVGSTLYTKANLILCRRDYLRLFGTTGNCAACSKLIPAFEMVM
                     RARDNVYHLDCFACQLCNQRFCVGDKFFLKNNMILCQMDYEEGHLNGTFESQVQ"
     exon            551..764
                     /gene="Lmo1"
                     /gene_synonym="Dat1"
                     /inference="alignment:Splign:2.1.0"
     exon            765..890
                     /gene="Lmo1"
                     /gene_synonym="Dat1"
                     /inference="alignment:Splign:2.1.0"
     exon            891..1301
                     /gene="Lmo1"
                     /gene_synonym="Dat1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atacattgag ggagaaaggc agcgggagtc ggccgccgag attcccccat ctctttgaat
       61 ataatttcag attgagattc agattaaatc cgaggggaaa acactttatg aggctgaaag
      121 ctgtgtcgtt gccagagcca gggttatgag ctatcaaatg caattacatt aagacagatt
      181 atactgggca aattgagcca tttagaaggt gagaatcaaa gaaacggctc tgatcctctc
      241 ttcccccttc tctctccctc tccctctctc tctttctctc taaattgcag ttcgtagttc
      301 cttgcaattc tgaggcacaa aagtaggtga gactgctttt gtatctgcga agtgcttcac
      361 tcctgaatgt aattctagct gagtgcaatc taggttaaga gccggacaag cgggtaatta
      421 gagcccgctt gctgccggag gaccggccgc ccagccgaag tgcgcccgga gtcggcgccc
      481 ttttcccggc cgagccgagc agcggctgga cacggagtgc ccgagatgat ggtgctggac
      541 aaggaggacg gtgtgccgat gctctccgtc caacctaagg ggaagcagaa gggctgtgca
      601 ggctgcaacc gaaagatcaa ggaccggtac ctgctgaagg ccctggacaa gtactggcat
      661 gaggactgcc tcaagtgtgc ctgctgtgac tgtcgcctgg gcgaggtggg ctccactctc
      721 tacaccaagg ctaacctcat cctgtgccgg cgcgactacc tgaggctttt tggcaccaca
      781 ggaaactgtg ctgcctgcag caagctgatc ccagctttcg agatggtgat gcgggcccgg
      841 gacaatgtct atcaccttga ctgcttcgcc tgccaactct gcaatcagag attttgcgtg
      901 ggagacaaat tcttcctgaa gaacaacatg atcttgtgcc agatggacta tgaggagggg
      961 catctcaatg gcacctttga atcccaagtt cagtaacgcc caacatctgg cctccaggtc
     1021 catctgtccg tctgcccacc tgaccatctg cctggcaggc cggccggcca gccactctgc
     1081 ctgcgcgggc tggccagccg ctgtcctaca agttagaact tcatcctcaa cgtgaaggtg
     1141 gtttttctcc accaccgccg cccatttccg tgggaccctc ctggggccag gctcggcctg
     1201 tacagtctgt cttctgtata taaatgggaa catttatttt atgagaaatg taatgcgatt
     1261 ttattactgg cgcggattaa acttatgaat gtttccgggg a
//
