LOCUS       NM_001305235            3563 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus lamin B2 (Lmnb2), mRNA.
ACCESSION   NM_001305235 XM_001076027 XM_216850
VERSION     NM_001305235.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3563)
  AUTHORS   Borrego-Pinto,J., Jegou,T., Osorio,D.S., Aurade,F., Gorjanacz,M.,
            Koch,B., Mattaj,I.W. and Gomes,E.R.
  TITLE     Samp1 is a component of TAN lines and is required for nuclear
            movement
  JOURNAL   J Cell Sci 125 (Pt 5), 1099-1105 (2012)
   PUBMED   22349700
REFERENCE   2  (bases 1 to 3563)
  AUTHORS   Wakabayashi,T., Mori,T., Hirahara,Y., Koike,T., Kubota,Y.,
            Takamori,Y. and Yamada,H.
  TITLE     Nuclear lamins are differentially expressed in retinal neurons of
            the adult rat retina
  JOURNAL   Histochem Cell Biol 136 (4), 427-436 (2011)
   PUBMED   21842415
  REMARK    GeneRIF: This differential expression pattern of lamin b2 in
            retinal neurons suggests that they may be involved in cellular
            differentiation and expression of cell-specific genes in individual
            retinal neurons.
REFERENCE   3  (bases 1 to 3563)
  AUTHORS   Kim,C.E., Perez,A., Perkins,G., Ellisman,M.H. and Dauer,W.T.
  TITLE     A molecular mechanism underlying the neural-specific defect in
            torsinA mutant mice
  JOURNAL   Proc Natl Acad Sci U S A 107 (21), 9861-9866 (2010)
   PUBMED   20457914
REFERENCE   4  (bases 1 to 3563)
  AUTHORS   Goodchild,R.E., Kim,C.E. and Dauer,W.T.
  TITLE     Loss of the dystonia-associated protein torsinA selectively
            disrupts the neuronal nuclear envelope
  JOURNAL   Neuron 48 (6), 923-932 (2005)
   PUBMED   16364897
REFERENCE   5  (bases 1 to 3563)
  AUTHORS   Furukawa,K., Inagaki,H., Naruge,T., Tabata,S., Tomida,T.,
            Yamaguchi,A., Yoshikuni,M., Nagahama,Y. and Hotta,Y.
  TITLE     cDNA cloning and functional characterization of a meiosis-specific
            protein (MNS1) with apparent nuclear association
  JOURNAL   Chromosome Res 2 (2), 99-113 (1994)
   PUBMED   8032679
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On or before Mar 5, 2015 this sequence version replaced
            XM_216850.8, XM_001076027.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments and orthologous data.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ212316.1, SRR22582424.163415.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-303               JAXUCZ010000007.1  9443308-9443610
            304-440             JAXUCZ010000007.1  9450968-9451104
            441-597             JAXUCZ010000007.1  9452621-9452777
            598-723             JAXUCZ010000007.1  9452885-9453010
            724-894             JAXUCZ010000007.1  9455252-9455422
            895-1020            JAXUCZ010000007.1  9455493-9455618
            1021-1241           JAXUCZ010000007.1  9455728-9455948
            1242-1521           JAXUCZ010000007.1  9456143-9456422
            1522-1629           JAXUCZ010000007.1  9456500-9456607
            1630-1749           JAXUCZ010000007.1  9456974-9457093
            1750-1860           JAXUCZ010000007.1  9457239-9457349
            1861-3563           JAXUCZ010000007.1  9457640-9459342
FEATURES             Location/Qualifiers
     source          1..3563
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..3563
                     /gene="Lmnb2"
                     /gene_synonym="RGD1563803"
                     /note="lamin B2"
                     /db_xref="GeneID:299625"
                     /db_xref="RGD:1563803"
     exon            1..303
                     /gene="Lmnb2"
                     /gene_synonym="RGD1563803"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..1902
                     /gene="Lmnb2"
                     /gene_synonym="RGD1563803"
                     /codon_start=1
                     /product="lamin-B2"
                     /protein_id="NP_001292164.1"
                     /db_xref="GeneID:299625"
                     /db_xref="RGD:1563803"
                     /translation="MSAPDPGSSADPPAAATAMASLPPRAGSATPLSPTRLSRLQEKE
                     ELRELNDRLAHYIDRVRALELENDKLLLRISEKEEVTTREVSGIKTLYESELADARRV
                     LDETARERARLQIEIGKVQAELEEAKKSAKKREGELTVARGRVKDLESLFHRSEAELA
                     AALGDKHVLETEVAELRAQLAKAEDGHAVAKKQLEKETLMRVDLENHCQSLQEELAFS
                     KSVFEEEVQETRRRHERHLVEVDSSRQQEYDFKIAQALEELRSQHDEQVRLYRLELEQ
                     TYQAKLDNTKLISDQNDKAARAAREELKEARMRVESLSYQLSGLQKQASAAEDHIREL
                     EEALAGERDKFRNMLDAKEQEMAEVRDAMQQQLAEYQELLDIKLALDMEICSYRKLLE
                     GEEERLKLSPSPSSRVTISLATSSSSSSSSSGVGMSLGRGRSKRQRLETEDTPGSPSS
                     ASSVSSGSRLAQQAGATGVVNIDEVDLEGRFVRLKNSSDKDQSLGNWRIKKQVLEGED
                     IAYKFTPKYVLRAGQTVTVWAAGAGATHSPPSTLVWKNQSSWGSGENFRTVLVNADGE
                     EVAVQAAKPPSVQGHESREEEEEAEAEFGEEDLFHQQGDPRTTSRGCRMM"
     exon            304..440
                     /gene="Lmnb2"
                     /gene_synonym="RGD1563803"
                     /inference="alignment:Splign:2.1.0"
     exon            441..597
                     /gene="Lmnb2"
                     /gene_synonym="RGD1563803"
                     /inference="alignment:Splign:2.1.0"
     exon            598..723
                     /gene="Lmnb2"
                     /gene_synonym="RGD1563803"
                     /inference="alignment:Splign:2.1.0"
     exon            724..894
                     /gene="Lmnb2"
                     /gene_synonym="RGD1563803"
                     /inference="alignment:Splign:2.1.0"
     exon            895..1020
                     /gene="Lmnb2"
                     /gene_synonym="RGD1563803"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1241
                     /gene="Lmnb2"
                     /gene_synonym="RGD1563803"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1521
                     /gene="Lmnb2"
                     /gene_synonym="RGD1563803"
                     /inference="alignment:Splign:2.1.0"
     exon            1522..1629
                     /gene="Lmnb2"
                     /gene_synonym="RGD1563803"
                     /inference="alignment:Splign:2.1.0"
     exon            1630..1749
                     /gene="Lmnb2"
                     /gene_synonym="RGD1563803"
                     /inference="alignment:Splign:2.1.0"
     exon            1750..1860
                     /gene="Lmnb2"
                     /gene_synonym="RGD1563803"
                     /inference="alignment:Splign:2.1.0"
     exon            1861..3563
                     /gene="Lmnb2"
                     /gene_synonym="RGD1563803"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaattccggc gcgctgcggg cggcggcgcc atcttccgcg gagcggattg aatgagcgcg
       61 ccggacccgg gtagctcagc ggatcctcct gccgccgcca ccgccatggc gtctctgccg
      121 ccccgtgcgg ggtccgccac gccgctgtcg cccacgcgcc tgtctcggct gcaggagaag
      181 gaggagctgc gcgagcttaa cgaccgcctg gcacactaca tcgaccgcgt ccgcgcgctg
      241 gagctggaaa atgataagct gctgctcaga atctccgaga aggaggaggt taccactcgt
      301 gaggtgagtg gtatcaagac cctgtacgag tcagagctgg ctgatgcccg gcgggtactg
      361 gatgagacag cccgtgaacg tgcccggctg cagattgaga tagggaaagt acaagcagag
      421 ctggaggagg ccaagaagag cgccaagaag agggaaggcg agctcacggt ggcccgggga
      481 cgagtgaagg acctggagtc cttattccac cgcagtgagg ctgagctggc cgcagccctc
      541 ggtgacaagc atgtcctgga gacggaggtg gcagagctcc gagcgcagct ggccaaggca
      601 gaggatggtc acgctgtggc caagaagcag ttggagaagg agacgctgat gcgtgtggac
      661 ttggagaacc actgccagag tctgcaggag gagcttgctt tcagcaagag tgtgttcgag
      721 gaggaggtgc aggagacccg gcggaggcat gaacggcact tggtggaggt ggacagcagc
      781 cggcaacagg aatatgactt caagatagct caggccctgg aggagctgcg cagccagcac
      841 gacgagcaag tgcgtctgta ccggctggag ctggagcaga cctaccaggc taagctggac
      901 aacaccaagt tgatctcgga ccagaatgac aaggcagccc gtgctgcgcg ggaggagctc
      961 aaggaggccc gcatgcgcgt ggagtccctc agctaccagc tctcaggtct ccaaaagcag
     1021 gccagtgctg cagaggacca catccgcgag ctggaggagg ccttggctgg ggagcgtgac
     1081 aagttccgca acatgctgga tgcaaaggag caggagatgg cagaggtgcg cgacgccatg
     1141 cagcagcagc tggcggagta ccaggagctg ctggacatca agctggcctt ggacatggag
     1201 atatgctcct accgcaagct tctggagggc gaggaggaaa ggcttaagct gtcccccagc
     1261 ccttcatcac gggtcaccat ctctctggcc acttcaagca gcagcagcag cagcagcagt
     1321 ggggttggca tgtctttggg gcggggccga agcaagcgcc agcggctgga gacggaggac
     1381 actccaggct cacccagcag tgcctccagc gtgagcagcg gctctcgcct ggctcagcag
     1441 gctggggcca cgggtgttgt gaacatcgac gaggtggacc tggagggcag gttcgtgcgt
     1501 cttaagaact cttcagacaa ggatcaatct ttggggaact ggaggatcaa gaaacaggtt
     1561 ctggagggtg aggacatcgc ctacaagttc acacccaagt atgtcctgcg agccggccag
     1621 acggtcacgg tgtgggcagc tggcgcaggg gctacacaca gccccccatc aacccttgtg
     1681 tggaagaacc agagcagctg ggggtctggg gagaacttcc gcaccgtcct ggtcaatgcg
     1741 gacggcgagg aggtggccgt gcaggctgca aagccgccat ctgtccaggg gcacgagagc
     1801 agggaggagg aggaagaggc agaggcagag tttggtgaag aggacctttt ccaccagcag
     1861 ggggacccaa ggactacctc aaggggctgc cggatgatgt gaaacctgcc cacagtcacc
     1921 atggtcccca gagcccctga aattattttt ttatggtctg ctctcacgag tccttggtcc
     1981 atttctagat gacttgttaa gcaaccatga gaatgtgggt gggctctgct gggtttccga
     2041 gatggaagtg tcctctaccc acaggcctca cttgggcctg agctcatgcc catgctgtca
     2101 tgtcgtgatg tcatgtgatg tcatgctgtc atgtcgtgat gtcatgtgat gtcatgctgt
     2161 catgtcgtga tgtcatgtga tgtcgtgatg tcatgtcgtg atgatataga ggcctgggct
     2221 gggaacctgg aggctgtggg acttgggcct ggatctgggg caggagaatg cctgctagtt
     2281 cagggtggac cttgtatgac actggtgatt cagaggtttt ctttgaaact tttcaaatca
     2341 agtcagaatc catgtttgga tttaaggaaa tcaaattcag aaagagggct gtggggctca
     2401 ctagcctgtc aggttggtgg ctcataggac acaggacaga cgctcctctc ctggagttgt
     2461 tggcgcttgc agagcacctg aacccaggga cggtccagct ttgtgctctg agtctgaagg
     2521 gtttataata gtccctagct tgagggcatt cagaggcttc tctgggccca gattctaaaa
     2581 tgttctagtc ccttctaaag ctgagggctc agaaggaggg agctcactca cacatggggt
     2641 ggttcctccc atcctaagac tgaaggggac aggcagatcg tgggcgttgt gtattcagga
     2701 tcaaaggctg cggaatccca gccagtgact gctcacaggc gtgtggccag gctagctgtg
     2761 caactggcct cacgtgtatg taccctgcgc ggcccctctc tgaaccaccc tgaaaacgag
     2821 gcctggaaac ttgcttccct gcgactaaac gccaggagcc agccagtttt acctgtcacc
     2881 tccccaccaa tgacacatgg tattttttta aagaatattt atttttttac atcagtagcc
     2941 cagctcactg ggacgctgct ctgggagtgc aggcctggag ctgccacaac tgggggttac
     3001 ctatgacagc ttcctttacc gagctgtcgg gagtgctgtc tccctcctgg cacagctgat
     3061 ggtagtaggg agaattcagg cctagtcttc ccccaaggca agagctcttg gccacaggaa
     3121 gccaccactg ccaccgacct ccagaatcca ccagccacct cctgcttcta gatacctccg
     3181 ttttctttaa gtgaccggtg ttggatcctg gatagtggta gctgactgca gtcactgctg
     3241 ccttgctgcc ttgcccacag tgcaggtgct ctccagtgta ccgcgaactg gagctggctt
     3301 ccttgtggtt gaagagcagg tctagagtaa tctgcaggtc ctcagaggtc tgtttctggt
     3361 ccggccaggc gaggtggtta ccggagtggc acttctactg ggagccgcct gcactgcaca
     3421 cattgctcag cttctacaga tcctttcttt tataagatgc atgccaaacg tgttccactt
     3481 tttcttttct gcctatgatt tgtaatatac attttactac tgggaacttt tgtacactca
     3541 aataaacact gattttaact gca
//
