LOCUS       NM_053905               2856 bp    mRNA    linear   ROD 07-APR-2024
DEFINITION  Rattus norvegicus lamin B1 (Lmnb1), mRNA.
ACCESSION   NM_053905 XM_346512 XM_347355
VERSION     NM_053905.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2856)
  AUTHORS   Bedrosian,T.A., Houtman,J., Eguiguren,J.S., Ghassemzadeh,S.,
            Rund,N., Novaresi,N.M., Hu,L., Parylak,S.L., Denli,A.M.,
            Randolph-Moore,L., Namba,T., Gage,F.H. and Toda,T.
  TITLE     Lamin B1 decline underlies age-related loss of adult hippocampal
            neurogenesis
  JOURNAL   EMBO J 40 (3), e105819 (2021)
   PUBMED   33300615
  REMARK    GeneRIF: Lamin B1 decline underlies age-related loss of adult
            hippocampal neurogenesis.
REFERENCE   2  (bases 1 to 2856)
  AUTHORS   Du,Z., Chen,J. and Chu,H.
  TITLE     Differential Expression of LaminB1 in the Developing Rat Cochlea
  JOURNAL   J Int Adv Otol 15 (1), 106-111 (2019)
   PUBMED   30924780
  REMARK    GeneRIF: the current research provided direct evidence that LaminB1
            was expressed in the developing cochlea and developmentally
            regulated in cochlear tissues, suggesting a possible role of
            LaminB1 in cochlear development. the result provided a theoretical
            basis for further study about the physiological function of LaminB1
            in the peripheral auditory system.
REFERENCE   3  (bases 1 to 2856)
  AUTHORS   Whitton,H., Singh,L.N., Patrick,M.A., Price,A.J., Osorio,F.G.,
            Lopez-Otin,C. and Bochkis,I.M.
  TITLE     Changes at the nuclear lamina alter binding of pioneer factor Foxa2
            in aged liver
  JOURNAL   Aging Cell 17 (3), e12742 (2018)
   PUBMED   29484800
REFERENCE   4  (bases 1 to 2856)
  AUTHORS   Karmodiya,K., Anamika,K., Muley,V., Pradhan,S.J., Bhide,Y. and
            Galande,S.
  TITLE     Camello, a novel family of Histone Acetyltransferases that
            acetylate histone H4 and is essential for zebrafish development
  JOURNAL   Sci Rep 4, 6076 (2014)
   PUBMED   25123547
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2856)
  AUTHORS   Shiraki,A., Saito,F., Akane,H., Takeyoshi,M., Imatanaka,N.,
            Itahashi,M., Yoshida,T. and Shibutani,M.
  TITLE     Expression alterations of genes on both neuronal and glial
            development in rats after developmental exposure to
            6-propyl-2-thiouracil
  JOURNAL   Toxicol Lett 228 (3), 225-234 (2014)
   PUBMED   24780913
REFERENCE   6  (bases 1 to 2856)
  AUTHORS   Chen,Q.M., Alexander,D., Sun,H., Xie,L., Lin,Y., Terrand,J.,
            Morrissy,S. and Purdom,S.
  TITLE     Corticosteroids inhibit cell death induced by doxorubicin in
            cardiomyocytes: induction of antiapoptosis, antioxidant, and
            detoxification genes
  JOURNAL   Mol Pharmacol 67 (6), 1861-1873 (2005)
   PUBMED   15755911
REFERENCE   7  (bases 1 to 2856)
  AUTHORS   Burns,K.H., Viveiros,M.M., Ren,Y., Wang,P., DeMayo,F.J.,
            Frail,D.E., Eppig,J.J. and Matzuk,M.M.
  TITLE     Roles of NPM2 in chromatin and nucleolar organization in oocytes
            and embryos
  JOURNAL   Science 300 (5619), 633-636 (2003)
   PUBMED   12714744
REFERENCE   8  (bases 1 to 2856)
  AUTHORS   Barboro,P., D'Arrigo,C., Diaspro,A., Mormino,M., Alberti,I.,
            Parodi,S., Patrone,E. and Balbi,C.
  TITLE     Unraveling the organization of the internal nuclear matrix:
            RNA-dependent anchoring of NuMA to a lamin scaffold
  JOURNAL   Exp Cell Res 279 (2), 202-218 (2002)
   PUBMED   12243746
REFERENCE   9  (bases 1 to 2856)
  AUTHORS   Ko,Y.G., Kang,Y.S., Kim,E.K., Park,S.G. and Kim,S.
  TITLE     Nucleolar localization of human methionyl-tRNA synthetase and its
            role in ribosomal RNA synthesis
  JOURNAL   J Cell Biol 149 (3), 567-574 (2000)
   PUBMED   10791971
REFERENCE   10 (bases 1 to 2856)
  AUTHORS   Furukawa,K., Inagaki,H., Naruge,T., Tabata,S., Tomida,T.,
            Yamaguchi,A., Yoshikuni,M., Nagahama,Y. and Hotta,Y.
  TITLE     cDNA cloning and functional characterization of a meiosis-specific
            protein (MNS1) with apparent nuclear association
  JOURNAL   Chromosome Res 2 (2), 99-113 (1994)
   PUBMED   8032679
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Dec 1, 2020 this sequence version replaced NM_053905.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U72353.1, SRR22582419.694776.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-683               JAXUCZ010000018.1  52373939-52374621
            684-840             JAXUCZ010000018.1  52395863-52396019
            841-966             JAXUCZ010000018.1  52396463-52396588
            967-1137            JAXUCZ010000018.1  52398051-52398221
            1138-1263           JAXUCZ010000018.1  52399907-52400032
            1264-1484           JAXUCZ010000018.1  52400905-52401125
            1485-1710           JAXUCZ010000018.1  52401769-52401994
            1711-1815           JAXUCZ010000018.1  52404073-52404177
            1816-1935           JAXUCZ010000018.1  52408656-52408775
            1936-2046           JAXUCZ010000018.1  52410246-52410356
            2047-2856           JAXUCZ010000018.1  52412475-52413284
FEATURES             Location/Qualifiers
     source          1..2856
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.1"
     gene            1..2856
                     /gene="Lmnb1"
                     /note="lamin B1"
                     /db_xref="GeneID:116685"
                     /db_xref="RGD:620522"
     exon            1..683
                     /gene="Lmnb1"
                     /inference="alignment:Splign:2.1.0"
     CDS             325..2088
                     /gene="Lmnb1"
                     /codon_start=1
                     /product="lamin-B1"
                     /protein_id="NP_446357.2"
                     /db_xref="GeneID:116685"
                     /db_xref="RGD:620522"
                     /translation="MATATPVQQRAGSRASAPATPLSPTRLSRLQEKEELRELNDRLA
                     VYIDKVRSLETENSALQLQVTEREEVRGRELTGLKALYETELADARRALDDTARERAK
                     LQIELGKFKAEHDQLLLNYAKKESDLSGAQIKLREYEAALNSKDAALATALGDKKSLE
                     GDLEDLKDQIAQLEASLSAAKKQLADETLLKVDLENRCQSLTEDLEFRKNMYEEEINE
                     TRRKHETRLVEVDSGRQIEYEYKLAQALHEMREQHDAQVRLYKEELEQTYHAKLENAR
                     LSSEMNTSTVNSAREELMESRMRIESLSSQLSNLQKESRACLERIQELEDMLAKERDN
                     SRRMLSDKEREMAEIRDQMQQQLNDYEQLLDVKLALDMEISAYRKLLEGEEERLKLSP
                     SPSSRVTVSRASSSRSVRTTRGKRKRVDVEESEASSSVSISHSASATGNVCIEEIDVD
                     GKFIRLKNTSEQDQPMGGWEMIRKIGDTSVSYKYTSRYVLKAGQTVTVWAANAGVTAS
                     PPTDLIWKNQNSWGTGEDVKVVLKNSQGEEVAQRSTVFKTTIPEEEEEEEEEPIGVAI
                     EEERFHQQGTPRASNKSCAIM"
     exon            684..840
                     /gene="Lmnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            841..966
                     /gene="Lmnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1137
                     /gene="Lmnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1263
                     /gene="Lmnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1484
                     /gene="Lmnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..1710
                     /gene="Lmnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1711..1815
                     /gene="Lmnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1816..1935
                     /gene="Lmnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1936..2046
                     /gene="Lmnb1"
                     /inference="alignment:Splign:2.1.0"
     exon            2047..2856
                     /gene="Lmnb1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctccgcccc ccgcgcctcg cctcctaccc gcctctcgcc gccctcctcc ctggcccgcc
       61 tgccgctctg agcagcccga gaggaaacaa aagtgctacg ggcgggagac tcacgtccgc
      121 gacgcgcacc cgtttcggtc tccaggctgt cctggcctct tcccgcgcgc gtttgcgagt
      181 gagcgtgtac actcacaaag ggcgtctggc gggcgatcgc ggccctcccg cttcgctctt
      241 tgtgcggtag ccccgccgcc gccatcccag gtacactccg tcctcgccgg cctgtggttt
      301 gtaccttaga tcccgccgcc cgccatggcg accgcgaccc ccgtgcagca gcgggcgggc
      361 agccgcgcca gcgcccccgc cacgccgctc agccccacgc gcctgtcgcg gctgcaggag
      421 aaagaggagc tgcgcgagct caacgaccgt ctggcggtgt atattgacaa ggtgcgcagc
      481 ttggagacgg agaacagcgc gctgcagctg caggtgaccg agcgcgagga ggtgcgcggc
      541 cgcgagctca ccgggctcaa ggctctctac gagaccgagc tggccgacgc acgccgcgct
      601 ctagacgaca cggcccgcga gcgcgccaag ctacagatcg agctgggcaa gttcaaggcc
      661 gagcacgacc agctgctgct caattatgct aagaaggagt ctgatctcag tggagcccag
      721 atcaagcttc gagagtatga ggccgcgcta aactctaagg atgcagcact ggctactgcc
      781 cttggggaca aaaagagttt agagggagac ttggaggatc tgaaagacca gattgcccag
      841 ttggaagcat ccctatctgc cgccaaaaag cagttggcgg atgagacttt gcttaaagtg
      901 gatctggaga accgttgtca gagccttact gaggacttgg agttccgtaa aaatatgtat
      961 gaagaggaga tcaatgagac aagaaggaag catgagacgc gcctggtgga ggtggactcc
     1021 gggcgtcaga ttgagtatga gtacaagctg gctcaagccc tgcacgagat gagagagcag
     1081 cacgacgcgc aggtgaggct gtataaggaa gagctggagc agacctacca cgccaagctt
     1141 gagaatgcca ggctgtcatc agagatgaac acttccactg tcaacagtgc cagggaggaa
     1201 ttgatggaga gccggatgag gatcgagagc ctttcctctc agctttctaa cctgcagaaa
     1261 gagtctagag catgcttgga aaggattcaa gaattggagg acatgcttgc taaagagaga
     1321 gacaactcac gccgcatgct gtctgacaaa gagagagaga tggcggaaat aagggaccag
     1381 atgcagcagc agctgaatga ttacgaacag ctgcttgacg tgaagctggc cctggacatg
     1441 gagatcagcg cctacaggaa actcttggaa ggcgaagaag agcggttaaa gctctctcca
     1501 agtccttctt cccgagtgac cgtgtccaga gcctcatcca gccgcagtgt gcgcaccacc
     1561 agaggaaagc ggaagagagt tgatgtggaa gaatcagagg cgagcagtag tgttagcatt
     1621 tcccactctg cttcagccac ggggaatgtg tgcattgaag agatagatgt tgatgggaag
     1681 tttattcgct tgaagaacac ttctgaacag gatcaaccaa tgggaggctg ggagatgatc
     1741 agaaaaattg gagacacatc agtcagttac aaatatacct caagatatgt gctgaaggcc
     1801 ggccagactg ttacagtatg ggctgcaaat gctggagtca cagccagtcc tccaactgac
     1861 ctcatctgga agaaccagaa ctcttggggc actggcgagg atgtgaaggt tgtgttgaag
     1921 aattctcagg gagaggaggt tgctcagaga agcacagtct tcaaaactac catacctgag
     1981 gaggaagagg aggaggagga ggagcccatt ggagtggcca tcgaggagga acgtttccac
     2041 cagcagggaa ccccaagagc atccaataaa agctgtgcca ttatgtgaac ttgtcacgtc
     2101 acggtcttcc tggagctaga agcacggagt cctgtataca gtgcagagcc ttctcagaag
     2161 cacatatttt tgtatttcct ttatgtgaat ttttaagctg cgaatctgat ggccttaatt
     2221 tcctttttga cactgaaagt tttgtaaaag agatcctacc catacataca tgttgcagat
     2281 gtgaattatt gacactgagc taacgtactg tttggaaagg ggccctcaag tttttggcat
     2341 tttttttttc ttttttgtat gtgtgtatgt aatttttttt tttttaagtt cttttaagag
     2401 ggaacaggga gggtaagaaa accactgcgt gtccaggcat aattgaagat cgctctccct
     2461 agataggcga tctgctcttg atccttctct gctatatata aaatggtgct gtgtgggagg
     2521 ggggaaaggc gtttttcaat atatgaactt ttgtatggaa tttttttgta ataagtgatc
     2581 aaggttacct tttttttaaa tagaaaagag aagaaacgtt ttgtaggaag gcagtattgc
     2641 gccagccatc atgtaagcac tctggatgga cgtttcacag agccgtcgtt cagtcaactc
     2701 cttctcttag agtcttgatt cctgagggga atggggcagg cgggctaggg tgggggagac
     2761 tttctcttca cgtgcgctag ttgaggtttt taagatagtg taacatgctt aaatttctta
     2821 tcaacattaa caaataaaag gctgttttac tattaa
//
