LOCUS       NM_001002016            3112 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Rattus norvegicus lamin A/C (Lmna), mRNA.
ACCESSION   NM_001002016 XM_006232747
VERSION     NM_001002016.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3112)
  AUTHORS   Lachaize,V., Pena,B., Ciubotaru,C., Cojoc,D., Chen,S.N.,
            Taylor,M.R.G., Mestroni,L. and Sbaizero,O.
  TITLE     Compromised Biomechanical Properties, Cell-Cell Adhesion and
            Nanotubes Communication in Cardiac Fibroblasts Carrying the Lamin
            A/C D192G Mutation
  JOURNAL   Int J Mol Sci 22 (17), 9193 (2021)
   PUBMED   34502098
  REMARK    GeneRIF: Compromised Biomechanical Properties, Cell-Cell Adhesion
            and Nanotubes Communication in Cardiac Fibroblasts Carrying the
            Lamin A/C D192G Mutation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3112)
  AUTHORS   Li,H.P., Liu,J.T., Chen,Y.X., Wang,W.B., Han,Y., Yao,Q.P. and
            Qi,Y.X.
  TITLE     Suppressed nuclear envelope proteins activate autophagy of vascular
            smooth muscle cells during cyclic stretch application
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1868 (1), 118855 (2021)
   PUBMED   32926941
  REMARK    GeneRIF: Suppressed nuclear envelope proteins activate autophagy of
            vascular smooth muscle cells during cyclic stretch application.
REFERENCE   3  (bases 1 to 3112)
  AUTHORS   Bao,H., Li,H.P., Shi,Q., Huang,K., Chen,X.H., Chen,Y.X., Han,Y.,
            Xiao,Q., Yao,Q.P. and Qi,Y.X.
  TITLE     Lamin A/C negatively regulated by miR-124-3p modulates apoptosis of
            vascular smooth muscle cells during cyclic stretch application in
            rats
  JOURNAL   Acta Physiol (Oxf) 228 (3), e13374 (2020)
   PUBMED   31495066
  REMARK    GeneRIF: Lamin A/C negatively regulated by miR-124-3p modulates
            apoptosis of vascular smooth muscle cells during cyclic stretch
            application in rats.
REFERENCE   4  (bases 1 to 3112)
  AUTHORS   Borin,D., Pena,B., Taylor,M.R.G., Mestroni,L., Lapasin,R. and
            Sbaizero,O.
  TITLE     Viscoelastic behavior of cardiomyocytes carrying LMNA mutations
  JOURNAL   Biorheology 57 (1), 1-14 (2020)
   PUBMED   32083564
  REMARK    GeneRIF: Viscoelastic behavior of cardiomyocytes carrying LMNA
            mutations.
REFERENCE   5  (bases 1 to 3112)
  AUTHORS   Perepelina,K., Dmitrieva,R., Ignatieva,E., Borodkina,A.,
            Kostareva,A. and Malashicheva,A.
  TITLE     Lamin A/C mutation associated with lipodystrophy influences
            adipogenic differentiation of stem cells through interaction with
            Notch signaling
  JOURNAL   Biochem Cell Biol 96 (3), 342-348 (2018)
   PUBMED   29040816
  REMARK    GeneRIF: lamin A/C interacts with Notch signaling, thereby
            influencing cellular differentiation, and point mutation in LMNA
            could halt this interaction
REFERENCE   6  (bases 1 to 3112)
  AUTHORS   Fatkin,D., MacRae,C., Sasaki,T., Wolff,M.R., Porcu,M.,
            Frenneaux,M., Atherton,J., Vidaillet,H.J. Jr., Spudich,S., De
            Girolami,U., Seidman,J.G., Seidman,C., Muntoni,F., Muehle,G.,
            Johnson,W. and McDonough,B.
  TITLE     Missense mutations in the rod domain of the lamin A/C gene as
            causes of dilated cardiomyopathy and conduction-system disease
  JOURNAL   N Engl J Med 341 (23), 1715-1724 (1999)
   PUBMED   10580070
REFERENCE   7  (bases 1 to 3112)
  AUTHORS   Bonne,G., Di Barletta,M.R., Varnous,S., Becane,H.M., Hammouda,E.H.,
            Merlini,L., Muntoni,F., Greenberg,C.R., Gary,F., Urtizberea,J.A.,
            Duboc,D., Fardeau,M., Toniolo,D. and Schwartz,K.
  TITLE     Mutations in the gene encoding lamin A/C cause autosomal dominant
            Emery-Dreifuss muscular dystrophy
  JOURNAL   Nat Genet 21 (3), 285-288 (1999)
   PUBMED   10080180
REFERENCE   8  (bases 1 to 3112)
  AUTHORS   Alsheimer,M. and Benavente,R.
  TITLE     Change of karyoskeleton during mammalian spermatogenesis:
            expression pattern of nuclear lamin C2 and its regulation
  JOURNAL   Exp Cell Res 228 (2), 181-188 (1996)
   PUBMED   8912709
REFERENCE   9  (bases 1 to 3112)
  AUTHORS   Furukawa,K., Inagaki,H., Naruge,T., Tabata,S., Tomida,T.,
            Yamaguchi,A., Yoshikuni,M., Nagahama,Y. and Hotta,Y.
  TITLE     cDNA cloning and functional characterization of a meiosis-specific
            protein (MNS1) with apparent nuclear association
  JOURNAL   Chromosome Res 2 (2), 99-113 (1994)
   PUBMED   8032679
REFERENCE   10 (bases 1 to 3112)
  AUTHORS   Ozaki,T. and Sakiyama,S.
  TITLE     Lamin A gene expression is specifically suppressed in
            v-src-transformed cells
  JOURNAL   FEBS Lett 312 (2-3), 165-168 (1992)
   PUBMED   1426247
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1, FM031779.1, DN934590.1, CA338388.1 and
            FM060776.1.
            
            On or before Apr 15, 2014 this sequence version replaced
            XM_006232747.1, NM_001002016.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X66870.1, SRR26643298.11824.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 JAXUCZ010000002.1  176258228-176258235 c
            9-591               FM031779.1         1-583
            592-1025            DN934590.1         332-765
            1026-1703           CA338388.1         11-688
            1704-2015           FM060776.1         241-552
            2016-2174           JAXUCZ010000002.1  176238751-176238909 c
            2175-3112           JAXUCZ010000002.1  176237564-176238501 c
FEATURES             Location/Qualifiers
     source          1..3112
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..3112
                     /gene="Lmna"
                     /note="lamin A/C"
                     /db_xref="GeneID:60374"
                     /db_xref="RGD:620456"
     exon            1..559
                     /gene="Lmna"
                     /inference="alignment:Splign:2.1.0"
     CDS             204..2201
                     /gene="Lmna"
                     /note="lamin C2; lamin A"
                     /codon_start=1
                     /product="prelamin-A/C"
                     /protein_id="NP_001002016.2"
                     /db_xref="GeneID:60374"
                     /db_xref="RGD:620456"
                     /translation="METPSQRRATRSGAQASSTPLSPTRITRLQEKEDLQELNDRLAV
                     YIDRVRSLETENAGLRLRITESEEVVSREVSGIKAAYEAELGDARKTLDSVAKERARL
                     QLELSKVREEFKELKARNTKKEGDLLAAQARLKDLEALLNSKEAALSTALSEKRTLEG
                     ELHDLRGQVAKLEAALGEAKKQLQDEMLRRVDAENRLQTLKEELDFQKNIYSEELRET
                     KRRHETRLVEIDNGKQREFESRLADALQELRAQHEDQVEQYKKELEKTYSAKLDNARQ
                     SAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKEAKLRDLEDSLARERDTS
                     RRLLAEKEREMAEMRARMQQQLDEYQELLDIKLALDMEIHAYRKLLEGEEERLRLSPS
                     PTSQRSRGRASSHSSQSQGGGSVTKKRKLESSESRSSFSQHARTSGRVAVEEVDEEGK
                     FVRLRNKSNEDQSMGNWQIRRQNGDDPLMTYRFPPKFTLKAGQVVTIWASGAGATHSP
                     PTDLVWKAQNTWGCGSSLRTALINATGEEVAMRKLVRSLTMVEDNDDEEEDGDELLHH
                     HRGSHCSSSGDPAEYNLRSRTVLCGTCGQPADKAASGSGAQVGGSISSGSSASSVTVT
                     RSFRSVGGSGGGSFGDNLVTRSYLLGNSSPRTQSSQNCSIM"
     exon            560..716
                     /gene="Lmna"
                     /inference="alignment:Splign:2.1.0"
     exon            717..842
                     /gene="Lmna"
                     /inference="alignment:Splign:2.1.0"
     exon            843..1013
                     /gene="Lmna"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1139
                     /gene="Lmna"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1360
                     /gene="Lmna"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1583
                     /gene="Lmna"
                     /inference="alignment:Splign:2.1.0"
     exon            1584..1691
                     /gene="Lmna"
                     /inference="alignment:Splign:2.1.0"
     exon            1692..1811
                     /gene="Lmna"
                     /inference="alignment:Splign:2.1.0"
     exon            1812..1907
                     /gene="Lmna"
                     /inference="alignment:Splign:2.1.0"
     exon            1908..2174
                     /gene="Lmna"
                     /inference="alignment:Splign:2.1.0"
     exon            2175..3112
                     /gene="Lmna"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgttcgcg ggaacgctgc ctcagcctca acaccagcca acccagatcc cgaggtgcgc
       61 cagcgcccag cccagatctc cacgcctgcc aggagcgagc ttcgccggct cgctgtcccc
      121 cgagcagcct ctgtccttct gtccgagtcc cgcgcccttc tcgggacccc tgcccagcgg
      181 gcagcactgc caccctgccg gccatggaga ccccgtctca gcggcgcgcc acccgcagtg
      241 gggcgcaggc cagctctacc ccgctgtcgc ccactcggat cacacggctg caggagaagg
      301 aggacctgca ggagctcaat gaccgtctgg ccgtgtacat cgatcgcgtg cgctccctgg
      361 agacggagaa cgcggggctg cgccttcgca tcactgagtc tgaagaggtg gtcagccgag
      421 aggtgtccgg catcaaggcg gcctacgagg ccgagctggg ggatgcccgc aagaccctcg
      481 actctgtggc caaggagcgc gcccgcctcc agttggagct gagcaaagtg cgtgaggagt
      541 tcaaggagct gaaggcgcgc aataccaaga aggaggggga tttgttggct gcgcaggccc
      601 ggctcaagga cctggaggct cttctcaact ccaaggaggc tgccctgagc actgctctca
      661 gtgagaaacg cacgttggaa ggcgagctcc atgatctgcg ggggcaggta gccaagcttg
      721 aggcagccct gggtgaggct aagaagcaac tccaggatga gatgctgagg cgagtggatg
      781 ctgagaacag gctacagacc ctgaaggagg agctggattt ccagaagaac atttacagtg
      841 aggaactgcg tgagaccaag cgccggcacg agacccggct ggtggagatt gataatggga
      901 agcagcgaga gtttgagagc cggctggcag atgctctgca ggagctgcgg gcccagcatg
      961 aggaccaggt ggagcagtac aagaaggagc tagaaaagac atactctgcc aagctggata
     1021 atgcccggca gtctgccgag aggaacagca acctcgtggg agctgcccat gaggagctcc
     1081 agcagtctcg aatccgcatt gacagcctct cagcccagct cagccagctc cagaagcagt
     1141 tggcagccaa ggaggccaag ctgcgtgacc tggaggactc cctggcccgt gagcgggata
     1201 ccagccggcg cctgctggct gaaaaagagc gggagatggc tgagatgcgg gcaaggatgc
     1261 agcagcagct ggatgagtac caggaattgc tggacatcaa gctggccctg gacatggaga
     1321 tccatgccta ccgaaagctg ctggagggcg aggaggagag gctacgcctg tcccccagcc
     1381 ctacctcgca gcgcagccgt ggccgcgcct cctcccactc ctcccagtct cagggtggag
     1441 gcagcgtcac caaaaagcgc aagctggagt cttctgagag ccggagcagc ttctcgcagc
     1501 atgctcgcac tagcggccgt gtggccgtag aggaagtaga tgaagagggc aagttcgtgc
     1561 ggctgcgcaa caagtccaac gaggaccagt ccatgggcaa ctggcagatc aggcgtcaga
     1621 atggtgatga tcctttgatg acttatcgct tcccaccgaa gttcacccta aaggccgggc
     1681 aggtggtgac gatctgggct tcaggagctg gggccaccca tagcccccct actgacttgg
     1741 tgtggaaggc acagaacact tggggctgtg ggagcagcct tcgcacggct ctcatcaacg
     1801 ccactggaga agaagtggcc atgcgcaagc tggtgcgctc actgaccatg gttgaggaca
     1861 atgacgatga ggaagaggat ggagatgagc tgctccatca ccatcgtggc tcccactgca
     1921 gcagctcggg ggaccccgct gagtacaacc tgcgctcacg caccgtgctg tgcgggacat
     1981 gtgggcagcc tgctgacaag gctgccagtg gctcaggagc ccaggtgggc ggatccatct
     2041 cctctggctc ttctgcctcc agtgtcacag tcactcgaag cttccgcagt gtggggggca
     2101 gtgggggtgg cagcttcggg gacaacctag tcacccgctc ctacctcctg ggcaactcca
     2161 gtccccggac ccagagctcc cagaactgca gcatcatgta atctgggacc tgccaggcag
     2221 gggtgggggc agaggccacc tgctccctct tcaccacatg ccacctcctg ccctgttcct
     2281 tatgagagca ggtctgaagc caaagaaaac tatcccctgc ctttgggtgt ttttcttttt
     2341 tccttctatt ttttttctaa gagaagttat tttctacagt ggttttatac tgaaggaaaa
     2401 acacaagcaa aaaaaaaagt gtctttatct caatccttag tccttccctt ttccctgtat
     2461 ctgccttaaa ccaaagggct tctcatagga gcccagggaa aggactgctt ttgtagtcta
     2521 gatttttgtc ctgctgcctt ggctttgccc tcatcccagg accctgtgac acggtgcctg
     2581 agaggcaggc atggagttct ctttaccggc ctcctccaca gctggcccac tgccatgcca
     2641 gctgcaaaga aaaggggtgc agagagaatg actgaaaggt caagcccctc ctggctcact
     2701 acacttggcc gagactcctc tgcctgcctt accctcctgc cttcccgagc ctgggacgag
     2761 tggattccca gaggcaaatc tgccatgctt gcttttttct atattgtatt cagacaagag
     2821 atgggaaaga tggggaagga gaagggacgg tcagtttgaa cctacctttc ccccgtgcgt
     2881 acagcctgct ggtgggctct gtcctgtcgg tggagggcag tattaagtgg gattggggag
     2941 agagtgaggg aaaggctcct ggagattggg agaacctgct ggggccagtg agaagactag
     3001 agggtgtggt gattggtggc tacagcaaac actaaggaac ccttcatccc acttcccatc
     3061 tgcacctctg ctctcccccc aaatcaatac actagttgtt tccatcccgg at
//
