LOCUS       NM_001008562            1699 bp    mRNA    linear   ROD 18-APR-2023
DEFINITION  Rattus norvegicus LIM and cysteine-rich domains 1 (Lmcd1), mRNA.
ACCESSION   NM_001008562 XM_342733
VERSION     NM_001008562.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1699)
  AUTHORS   Govatati S, Pichavaram P, Janjanam J, Guo L, Virmani R and Rao GN.
  TITLE     Myristoylation of LMCD1 Leads to Its Species-Specific Derepression
            of E2F1 and NFATc1 in the Modulation of CDC6 and IL-33 Expression
            During Development of Vascular Lesions
  JOURNAL   Arterioscler Thromb Vasc Biol 40 (5), 1256-1274 (2020)
   PUBMED   32160773
REFERENCE   2  (bases 1 to 1699)
  AUTHORS   Didangelos A, Yin X, Mandal K, Baumert M, Jahangiri M and Mayr M.
  TITLE     Proteomics characterization of extracellular space components in
            the human aorta
  JOURNAL   Mol Cell Proteomics 9 (9), 2048-2062 (2010)
   PUBMED   20551380
REFERENCE   3  (bases 1 to 1699)
  AUTHORS   Luosujarvi H, Aro J, Tokola H, Leskinen H, Tenhunen O, Skoumal R,
            Szokodi I, Ruskoaho H and Rysa J.
  TITLE     A novel p38 MAPK target dyxin is rapidly induced by mechanical load
            in the heart
  JOURNAL   Blood Press 19 (1), 54-63 (2010)
   PUBMED   20175653
  REMARK    GeneRIF: A novel p38 MAPK target dyxin may play an important role
            in regulating hypertrophic process.
REFERENCE   4  (bases 1 to 1699)
  AUTHORS   Bian ZY, Huang H, Jiang H, Shen DF, Yan L, Zhu LH, Wang L, Cao F,
            Liu C, Tang QZ and Li H.
  TITLE     LIM and cysteine-rich domains 1 regulates cardiac hypertrophy by
            targeting calcineurin/nuclear factor of activated T cells signaling
  JOURNAL   Hypertension 55 (2), 257-263 (2010)
   PUBMED   20026769
REFERENCE   5  (bases 1 to 1699)
  AUTHORS   Rath N, Wang Z, Lu MM and Morrisey EE.
  TITLE     LMCD1/Dyxin is a novel transcriptional cofactor that restricts
            GATA6 function by inhibiting DNA binding
  JOURNAL   Mol Cell Biol 25 (20), 8864-8873 (2005)
   PUBMED   16199866
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079071.1.
            
            On Jan 12, 2005 this sequence version replaced XM_342733.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079071.1, SRR8487230.33412.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1699
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q41"
     gene            1..1699
                     /gene="Lmcd1"
                     /gene_synonym="LIMD1"
                     /note="LIM and cysteine-rich domains 1"
                     /db_xref="GeneID:494021"
                     /db_xref="RGD:1308963"
     exon            1..150
                     /gene="Lmcd1"
                     /gene_synonym="LIMD1"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..1206
                     /gene="Lmcd1"
                     /gene_synonym="LIMD1"
                     /note="dyxin"
                     /codon_start=1
                     /product="LIM and cysteine-rich domains protein 1"
                     /protein_id="NP_001008562.1"
                     /db_xref="GeneID:494021"
                     /db_xref="RGD:1308963"
                     /translation="MAKVAKDLNPRVQKMSLGQQQSARGVACLRCKGMCSGFEPHSWR
                     KICKSCKCSQEEHCLSSDLEDDRKIGRLLMDSKYATLTARVKGGDGIRIYKRNRMIMT
                     NPIATGKDPTFDTITYEWAPPGVTQKLGLQYMELIPKEKQPVTGTEGALYRRRQLMHQ
                     LPIYDQDPSRCRGLVENELKAMEEFVKQYKSEALGVGEVALPGQGGLPKEENKTQEKP
                     EGTETTAPTTNGSLGDPSKEVEYVCELCKGVAPADSPVVYADRAGYSKQWHPTCFLCI
                     KCSEPLVDLIYFWKDGAPWCGRHYCESLRPRCSGCDEIIFSEDYQRVEDLAWHRKHFI
                     CEGCEQLLSGRAYIITKGQLLCPTCSKSKRS"
     exon            151..239
                     /gene="Lmcd1"
                     /gene_synonym="LIMD1"
                     /inference="alignment:Splign:2.1.0"
     exon            240..495
                     /gene="Lmcd1"
                     /gene_synonym="LIMD1"
                     /inference="alignment:Splign:2.1.0"
     exon            496..831
                     /gene="Lmcd1"
                     /gene_synonym="LIMD1"
                     /inference="alignment:Splign:2.1.0"
     exon            832..1047
                     /gene="Lmcd1"
                     /gene_synonym="LIMD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1663
                     /gene="Lmcd1"
                     /gene_synonym="LIMD1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctggaagcag gcaagggaat ctgaacttgg cccatcagca gcgctgtcca ttctgcgtgc
       61 cctctctccc ctgcctgaga agccaggtgc tagttctgca cccccaggat ggcaaaggta
      121 gccaaggacc tcaaccctcg agtgcaaaag atgtccctgg gccagcagca gtccgcaaga
      181 ggagtggctt gtctgcggtg caaggggatg tgctccggct tcgagccgca ttcatggagg
      241 aaaatatgca agtcttgtaa atgcagccag gaggagcact gcctaagctc tgacctggag
      301 gatgatcgga aaattgggcg cctgctgatg gactccaagt atgccactct tactgccagg
      361 gtgaaaggtg gagacggcat tcgcatctat aagagaaacc gcatgatcat gaccaacccc
      421 attgccactg gcaaagaccc cacctttgac actatcacct atgagtgggc tcccccagga
      481 gtcacccaga aactgggctt gcagtacatg gagctcatcc ccaaggagaa gcagcctgtg
      541 acaggtactg agggtgccct ctaccgccga cgccagctca tgcaccagct cccaatctat
      601 gatcaggacc cctctcgatg ccgcggactt gtggagaatg agctgaaagc tatggaagag
      661 ttcgtcaagc agtacaagag cgaggccctt ggggtgggcg aggtggccct cccagggcag
      721 ggaggcttgc ccaaggaaga aaacaagaca caggaaaagc cagagggcac agagaccact
      781 gccccaacca ccaatggcag cctgggtgat ccatccaagg aagtggaata tgtctgtgag
      841 ctctgcaagg gagtagcccc tgctgacagc cctgtggtct acgctgacag ggctggatac
      901 agcaagcagt ggcaccccac atgctttctg tgtatcaagt gctcagagcc actggtggac
      961 ctcatctact tctggaagga tggtgcaccc tggtgtgggc gccactactg cgagagcttg
     1021 cggccccggt gctcaggctg tgacgagatc atcttctcag aagactacca gcgtgtggaa
     1081 gacttagcct ggcatcggaa acacttcatt tgtgagggct gtgagcagct gctgagcggc
     1141 cgtgcataca tcatcaccaa gggtcagctc ctgtgcccca cttgcagcaa gtccaaacgc
     1201 tcctgaaggg ctgcccaccc acacccaaaa ccagcagagt caatcagatt tcaccaggag
     1261 actgaagcca tcctatgggg cggatgccac agccagcaag tgatgcatat tctaggtcga
     1321 gttgtggtag atctttgagg ttcagtagtt tcaaacccag aggtattcta agaaatctta
     1381 gaatggattt attgttccta gctgcagcca actaaagaca cactggtatc ctacaaggga
     1441 gctctaggag aaatttccca gaatgcactt ctgagggatc caatcaagta gatgtaggtt
     1501 atggtttttt tttctcgtgg acaagggatc tctcctgggg ggaaaggatg ggatttcaac
     1561 tctcatttgt ttgcctcttt ctcaagtgga atctgaatct tcaataaaca atgtttttgg
     1621 catgataagc atatcaataa aaggtttatg agtttcacac ataaaaaaaa aaaaaaaaaa
     1681 aaaaaaaaaa aaaaaaaaa
//
