LOCUS       NP_001008562             365 aa            linear   ROD 18-APR-2023
DEFINITION  LIM and cysteine-rich domains protein 1 [Rattus norvegicus].
ACCESSION   NP_001008562 XP_342734
VERSION     NP_001008562.1
DBSOURCE    REFSEQ: accession NM_001008562.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 365)
  AUTHORS   Govatati S, Pichavaram P, Janjanam J, Guo L, Virmani R and Rao GN.
  TITLE     Myristoylation of LMCD1 Leads to Its Species-Specific Derepression
            of E2F1 and NFATc1 in the Modulation of CDC6 and IL-33 Expression
            During Development of Vascular Lesions
  JOURNAL   Arterioscler Thromb Vasc Biol 40 (5), 1256-1274 (2020)
   PUBMED   32160773
REFERENCE   2  (residues 1 to 365)
  AUTHORS   Didangelos A, Yin X, Mandal K, Baumert M, Jahangiri M and Mayr M.
  TITLE     Proteomics characterization of extracellular space components in
            the human aorta
  JOURNAL   Mol Cell Proteomics 9 (9), 2048-2062 (2010)
   PUBMED   20551380
REFERENCE   3  (residues 1 to 365)
  AUTHORS   Luosujarvi H, Aro J, Tokola H, Leskinen H, Tenhunen O, Skoumal R,
            Szokodi I, Ruskoaho H and Rysa J.
  TITLE     A novel p38 MAPK target dyxin is rapidly induced by mechanical load
            in the heart
  JOURNAL   Blood Press 19 (1), 54-63 (2010)
   PUBMED   20175653
  REMARK    GeneRIF: A novel p38 MAPK target dyxin may play an important role
            in regulating hypertrophic process.
REFERENCE   4  (residues 1 to 365)
  AUTHORS   Bian ZY, Huang H, Jiang H, Shen DF, Yan L, Zhu LH, Wang L, Cao F,
            Liu C, Tang QZ and Li H.
  TITLE     LIM and cysteine-rich domains 1 regulates cardiac hypertrophy by
            targeting calcineurin/nuclear factor of activated T cells signaling
  JOURNAL   Hypertension 55 (2), 257-263 (2010)
   PUBMED   20026769
REFERENCE   5  (residues 1 to 365)
  AUTHORS   Rath N, Wang Z, Lu MM and Morrisey EE.
  TITLE     LMCD1/Dyxin is a novel transcriptional cofactor that restricts
            GATA6 function by inhibiting DNA binding
  JOURNAL   Mol Cell Biol 25 (20), 8864-8873 (2005)
   PUBMED   16199866
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079071.1.
            
            On Jan 12, 2005 this sequence version replaced XP_342734.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079071.1, SRR8487230.33412.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..365
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q41"
     Protein         1..365
                     /product="LIM and cysteine-rich domains protein 1"
                     /note="dyxin"
                     /calculated_mol_wt=40954
     Region          116..203
                     /region_name="PET_testin"
                     /note="The PET domain of Testin; cd09829"
                     /db_xref="CDD:193604"
     Region          243..300
                     /region_name="LIM1_Testin_like"
                     /note="The first LIM domain of Testin-like family;
                     cd09340"
                     /db_xref="CDD:188726"
     Site            order(243,246,269,272,275,278,296,299)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:188726"
     Region          306..359
                     /region_name="LIM"
                     /note="LIM is a small protein-protein interaction domain,
                     containing two zinc fingers; cl02475"
                     /db_xref="CDD:413332"
     Site            order(308,311,329,332,335,338,356,359)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:259829"
     CDS             1..365
                     /gene="Lmcd1"
                     /gene_synonym="LIMD1"
                     /coded_by="NM_001008562.1:109..1206"
                     /db_xref="GeneID:494021"
                     /db_xref="RGD:1308963"
ORIGIN      
        1 makvakdlnp rvqkmslgqq qsargvaclr ckgmcsgfep hswrkicksc kcsqeehcls
       61 sdleddrkig rllmdskyat ltarvkggdg iriykrnrmi mtnpiatgkd ptfdtityew
      121 appgvtqklg lqymelipke kqpvtgtega lyrrrqlmhq lpiydqdpsr crglvenelk
      181 ameefvkqyk sealgvgeva lpgqgglpke enktqekpeg tettapttng slgdpskeve
      241 yvcelckgva padspvvyad ragyskqwhp tcflcikcse plvdliyfwk dgapwcgrhy
      301 ceslrprcsg cdeiifsedy qrvedlawhr khficegceq llsgrayiit kgqllcptcs
      361 kskrs
//
