LOCUS       NM_139189               2576 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus LMBR1 domain containing 1 (Lmbrd1), mRNA.
ACCESSION   NM_139189
VERSION     NM_139189.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2576)
  AUTHORS   Kawaguchi,K., Okamoto,T., Morita,M. and Imanaka,T.
  TITLE     Translocation of the ABC transporter ABCD4 from the endoplasmic
            reticulum to lysosomes requires the escort protein LMBD1
  JOURNAL   Sci Rep 6, 30183 (2016)
   PUBMED   27456980
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2576)
  AUTHORS   Tseng,L.T., Lin,C.L., Tzen,K.Y., Chang,S.C. and Chang,M.F.
  TITLE     LMBD1 protein serves as a specific adaptor for insulin receptor
            internalization
  JOURNAL   J Biol Chem 288 (45), 32424-32432 (2013)
   PUBMED   24078630
  REMARK    GeneRIF: LMBD1 plays an imperative role in mediating and regulating
            the endocytosis of the IR.
REFERENCE   3  (bases 1 to 2576)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC078723.1.
            
            On Aug 8, 2004 this sequence version replaced NM_139189.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078723.1, AY093598.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2576
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q21"
     gene            1..2576
                     /gene="Lmbrd1"
                     /gene_synonym="LMBD1"
                     /note="LMBR1 domain containing 1"
                     /db_xref="GeneID:246046"
                     /db_xref="RGD:708471"
     exon            1..148
                     /gene="Lmbrd1"
                     /gene_synonym="LMBD1"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..1702
                     /gene="Lmbrd1"
                     /gene_synonym="LMBD1"
                     /note="probable lysosomal cobalamin transporter; LMBR1
                     domain-containing protein 1; liver regeneration p-53
                     related protein"
                     /codon_start=1
                     /product="lysosomal cobalamin transport escort protein
                     LMBD1"
                     /protein_id="NP_631928.2"
                     /db_xref="GeneID:246046"
                     /db_xref="RGD:708471"
                     /translation="MAAAAADLVIGWCIFGLLLLAILAFCWVYVRKYQSQRESEVVST
                     VTAIFSLAVALITSALLPVDIFLVSYMKNQNGTFKDWANANVTVQIENTVLYGYYTLY
                     SVILFCVFFWIPFVYFYYEEKDDDDTSKCTQVKTALKYTLGFVVICALLLLVGAFVPL
                     NLPNNNNSTEWEKVKLLFEDLGTGQGLAALSFSISSLTLIGMLAAITYTAYGMSALPL
                     NLIKGTRSTAYERLENTEDIEEVEQHIQTIRSKSKDGRPLSARDRRTLKQCEERLRTL
                     RKRERHLEFIENSWWTKFCGALRPLKIIWGIFFILVALLFVISLFLSNLDKALHSAGI
                     DSGFIVFGTNLSNPLNMLLPLLQTVFPLDYILITIIIMYFIFTSMAGIRNIGIWFFWI
                     RLYKIRRGRTRPQALLFLCMILLLIVLHTSYMIYSLAPQYVMYGSQNYLIESNITSDA
                     HKGNSTLAVPKRCDADAPKDQCTVTRTYVFLHKFWFFSAAYYFGNWAFLVVFLIGLIV
                     SCCKGKKSVIEGVDEDSDLSDDEPSAYSA"
     exon            149..325
                     /gene="Lmbrd1"
                     /gene_synonym="LMBD1"
                     /inference="alignment:Splign:2.1.0"
     exon            326..386
                     /gene="Lmbrd1"
                     /gene_synonym="LMBD1"
                     /inference="alignment:Splign:2.1.0"
     exon            387..484
                     /gene="Lmbrd1"
                     /gene_synonym="LMBD1"
                     /inference="alignment:Splign:2.1.0"
     exon            485..552
                     /gene="Lmbrd1"
                     /gene_synonym="LMBD1"
                     /inference="alignment:Splign:2.1.0"
     exon            553..641
                     /gene="Lmbrd1"
                     /gene_synonym="LMBD1"
                     /inference="alignment:Splign:2.1.0"
     exon            642..715
                     /gene="Lmbrd1"
                     /gene_synonym="LMBD1"
                     /inference="alignment:Splign:2.1.0"
     exon            716..841
                     /gene="Lmbrd1"
                     /gene_synonym="LMBD1"
                     /inference="alignment:Splign:2.1.0"
     exon            842..994
                     /gene="Lmbrd1"
                     /gene_synonym="LMBD1"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1059
                     /gene="Lmbrd1"
                     /gene_synonym="LMBD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1162
                     /gene="Lmbrd1"
                     /gene_synonym="LMBD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1267
                     /gene="Lmbrd1"
                     /gene_synonym="LMBD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1417
                     /gene="Lmbrd1"
                     /gene_synonym="LMBD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1418..1496
                     /gene="Lmbrd1"
                     /gene_synonym="LMBD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1497..1588
                     /gene="Lmbrd1"
                     /gene_synonym="LMBD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1589..2550
                     /gene="Lmbrd1"
                     /gene_synonym="LMBD1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tttaggctgc gcagttccgg gtccctcttg gtcctgtccc gtcccttccc tcccctcccc
       61 tttgggttta tcgggaccgg aagcgaagat ggcggcggcg gctgccgatc tggtgatcgg
      121 ctggtgcatc ttcggcctct tgctcctggc tattttggcc ttttgctggg tatacgttcg
      181 taaataccag agccaacggg aaagtgaggt cgtctccact gtgacagcca ttttttcact
      241 ggctgtcgcg cttatcacat cagcgctcct gccagtggat atatttttgg tttcttacat
      301 gaaaaatcaa aatggcacat tcaaggactg ggctaatgcc aatgtcactg tacagattga
      361 gaacacagtt ctgtatggct actatactct gtactccgtc atcctgttct gtgtgttctt
      421 ctggatcccc tttgtctact tctactatga ggagaaggac gacgacgaca ccagcaagtg
      481 cacccaagtt aaaacggcgc tcaagtacac actgggattt gttgtgatct gcgcgctgct
      541 gctccttgtt ggtgcctttg tgccgctgaa tctgcccaac aacaacaatt ctacggagtg
      601 ggaaaaggtg aagctcctgt ttgaagatct cggaactggt caaggtctgg ccgcgctgtc
      661 cttctccatc agctctctga ccttgattgg gatgctggcg gccataacat acacagcgta
      721 tggcatgtcg gcattacctt taaacctgat aaaaggcact aggagcactg cctacgaacg
      781 cctggagaac actgaggaca tcgaggaggt ggagcagcac atccagacga ttcgatcaaa
      841 gagcaaagat ggccgacctt tgtccgcgag ggatagacgt accttaaagc aatgtgaaga
      901 aagattaaga acacttagga aaagagaacg gcacttagaa ttcattgaaa acagctggtg
      961 gacaaaattc tgtggtgccc tgcgccccct gaagattatt tggggaatat ttttcatcct
     1021 ggttgcattg ctgtttgtaa tttctctctt cctgtcaaat ttagataaag ctcttcactc
     1081 agcgggaata gattcgggtt tcatcgtctt tggaactaac ctgagcaatc cattgaacat
     1141 gcttttgcct ttgttacaaa ccgtgttccc tcttgattat attcttataa caattattat
     1201 tatgtacttt atttttactt cgatggcagg aattcgaaat attggcattt ggttcttttg
     1261 gattagacta tataaaatca gaagaggacg aaccaggcct caggcgctct tatttctctg
     1321 catgattctt ctgctgattg tcctccacac cagctacatg atctatagtc ttgctcctca
     1381 gtacgtgatg tacggaagcc agaattactt aatagagagc aatataactt ctgatgccca
     1441 taaaggcaac tcaacgcttg ctgtgccaaa gagatgtgat gcagatgccc caaaagatca
     1501 gtgtactgtc acccgaacat acgtattcct ccacaagttc tggttcttca gcgccgcata
     1561 ctactttggt aactgggcct ttctggtggt gttcttgatc ggattgattg tatcctgctg
     1621 taaagggaag aagtcagtca tagaaggagt ggatgaagat tcagacttaa gcgatgacga
     1681 accgtccgcc tactctgcat gaacagcctt ctgtctgtcc tagggcttaa tgaagttggt
     1741 cgaatatctg ttatgcattt tcaaaggctt aaagtaacat taaaatgaac tgtctagctt
     1801 tcatcaaaaa tgagagcatg gccattaaaa agaactatat tttttatgtt tcctgaagta
     1861 acattattgt atcatagatt aacatttaaa attgctataa tgctgtgtaa atacaaagtt
     1921 tccaggtttg tgagggaatg tctgtggaaa ttttctttat tgtataatag tgttaaattt
     1981 attaaaatct tacagaatgt acattccctt tgttgctttt taaaaatgta agaagtcact
     2041 tgtcttgtgc cttagggttt ctggagtaat gtgaaacttt taagtatctt cctgattgac
     2101 taaacaatgc cgcgtattgc ttgtggataa gcggaactct catggcagct tgctttcaat
     2161 tttttccata aaattatgag tctgactcaa gtagagttca tgaaaattat taagctgctt
     2221 aagaccatgg tcttctaaga tgtggtccag gttttattgt tcaaatctta atccacagag
     2281 tgttgctgtc tctacaggaa tataccagga atatacccgt ccatgtagat atgatttgtt
     2341 ttatacaaga ctttgaaact tggattatcg tgagtggaaa tatcaagaat aatgaatact
     2401 gaaggatgag tttatggagc gttgtaagtt acatgacgtc atactcagct gcttttcatt
     2461 gaaagtattt ggaaacctgt aaaagaaaat gaaagttgtg tgacttctga ctgtgttctg
     2521 ggcgatgaaa ataaagtctt aatatgctaa aaaaaaaaaa aaaaaaaaaa aaaaaa
//
