LOCUS       NM_001191858            2954 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus limb development membrane protein 1 (Lmbr1),
            mRNA.
ACCESSION   NM_001191858 XM_342608
VERSION     NM_001191858.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2954)
  AUTHORS   Clark,R.M., Marker,P.C., Roessler,E., Dutra,A., Schimenti,J.C.,
            Muenke,M. and Kingsley,D.M.
  TITLE     Reciprocal mouse and human limb phenotypes caused by gain- and
            loss-of-function mutations affecting Lmbr1
  JOURNAL   Genetics 159 (2), 715-726 (2001)
   PUBMED   11606546
REFERENCE   2  (bases 1 to 2954)
  AUTHORS   Ianakiev,P., van Baren,M.J., Daly,M.J., Toledo,S.P.,
            Cavalcanti,M.G., Neto,J.C., Silveira,E.L., Freire-Maia,A.,
            Heutink,P., Kilpatrick,M.W. and Tsipouras,P.
  TITLE     Acheiropodia is caused by a genomic deletion in C7orf2, the human
            orthologue of the Lmbr1 gene
  JOURNAL   Am J Hum Genet 68 (1), 38-45 (2001)
   PUBMED   11090342
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Oct 7, 2014 this sequence version replaced NM_001191858.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the Celera
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.17753.1,
                                           SRR26643298.20983.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-213               JAXUCZ010000004.1  6649881-6650093
            214-286             JAXUCZ010000004.1  6682442-6682514
            287-326             JAXUCZ010000004.1  6685280-6685319
            327-466             JAXUCZ010000004.1  6687925-6688064
            467-570             JAXUCZ010000004.1  6732872-6732975
            571-697             JAXUCZ010000004.1  6746782-6746908
            698-766             JAXUCZ010000004.1  6747517-6747585
            767-831             JAXUCZ010000004.1  6748362-6748426
            832-904             JAXUCZ010000004.1  6758240-6758312
            905-985             JAXUCZ010000004.1  6778753-6778833
            986-1062            JAXUCZ010000004.1  6783338-6783414
            1063-1140           JAXUCZ010000004.1  6783968-6784045
            1141-1214           JAXUCZ010000004.1  6787038-6787111
            1215-1305           JAXUCZ010000004.1  6787324-6787414
            1306-1372           JAXUCZ010000004.1  6788675-6788741
            1373-1534           JAXUCZ010000004.1  6817278-6817439
            1535-2954           JAXUCZ010000004.1  6819104-6820523
FEATURES             Location/Qualifiers
     source          1..2954
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q11"
     gene            1..2954
                     /gene="Lmbr1"
                     /gene_synonym="RGD1563910"
                     /note="limb development membrane protein 1"
                     /db_xref="GeneID:362295"
                     /db_xref="RGD:1563910"
     exon            1..213
                     /gene="Lmbr1"
                     /gene_synonym="RGD1563910"
                     /inference="alignment:Splign:2.1.0"
     CDS             148..1620
                     /gene="Lmbr1"
                     /gene_synonym="RGD1563910"
                     /note="limb region 1 homolog"
                     /codon_start=1
                     /product="limb region 1 protein homolog"
                     /protein_id="NP_001178787.1"
                     /db_xref="GeneID:362295"
                     /db_xref="RGD:1563910"
                     /translation="MEGQDEVSAREQHFHSQVRESTICFLLFAILYVLSYFIITRYKR
                     KSDEQEDEDAVVNRISLFLSTFTLAVSAGAVLLLPFSIISNEILLAFPQNYYIQWLNG
                     SLIHGLWNLASLFSNLCLFVLMPFAFFFLESEGFAGLKKGIRARILETLVMLLLLALL
                     ILGIVWVASALIDSDAASMESLYDLWEFYLPYLYSCISLMGCLLLLLCTPVGLSRMFT
                     VMGQLLVKPAILEDLDEQIYMITLEEEALQRRLHGLSSSAEYNVMELEQELENVKTLK
                     TKLERRKKASAWERNLVYPAVMVLLLIETSISVLLVACNILCLLVDETAMPKGTRGPG
                     IGSASLSTFGFVGAALEIILIFYLMVSSVVGFYSLRVFGNFTPKKDDTTMTKIIGNCV
                     SILVLSSALPVMSRTLGITRFDLLGDFGRFNWLGNFYIVLSYNLLFAIVTTLCLIRKF
                     TSAVREELFKALGLHKLHLSDTSRDSETTKPSANGHQKAL"
     exon            214..286
                     /gene="Lmbr1"
                     /gene_synonym="RGD1563910"
                     /inference="alignment:Splign:2.1.0"
     exon            287..326
                     /gene="Lmbr1"
                     /gene_synonym="RGD1563910"
                     /inference="alignment:Splign:2.1.0"
     exon            327..466
                     /gene="Lmbr1"
                     /gene_synonym="RGD1563910"
                     /inference="alignment:Splign:2.1.0"
     exon            467..570
                     /gene="Lmbr1"
                     /gene_synonym="RGD1563910"
                     /inference="alignment:Splign:2.1.0"
     exon            571..697
                     /gene="Lmbr1"
                     /gene_synonym="RGD1563910"
                     /inference="alignment:Splign:2.1.0"
     exon            698..766
                     /gene="Lmbr1"
                     /gene_synonym="RGD1563910"
                     /inference="alignment:Splign:2.1.0"
     exon            767..831
                     /gene="Lmbr1"
                     /gene_synonym="RGD1563910"
                     /inference="alignment:Splign:2.1.0"
     exon            832..904
                     /gene="Lmbr1"
                     /gene_synonym="RGD1563910"
                     /inference="alignment:Splign:2.1.0"
     exon            905..985
                     /gene="Lmbr1"
                     /gene_synonym="RGD1563910"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1062
                     /gene="Lmbr1"
                     /gene_synonym="RGD1563910"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1140
                     /gene="Lmbr1"
                     /gene_synonym="RGD1563910"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1214
                     /gene="Lmbr1"
                     /gene_synonym="RGD1563910"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1305
                     /gene="Lmbr1"
                     /gene_synonym="RGD1563910"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1372
                     /gene="Lmbr1"
                     /gene_synonym="RGD1563910"
                     /inference="alignment:Splign:2.1.0"
     exon            1373..1534
                     /gene="Lmbr1"
                     /gene_synonym="RGD1563910"
                     /inference="alignment:Splign:2.1.0"
     exon            1535..2954
                     /gene="Lmbr1"
                     /gene_synonym="RGD1563910"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tctgagctga ggcggcgttt tctgagcctg ctgcggtcta ggtagtgttc cggtccggcc
       61 acgagagact gtgtagcccc ggcgccgcgg gcaatggtgc ggcggagcgc gcggacgcgg
      121 gcggccctgc ggcgggcatg aaggaggatg gaagggcagg acgaggtgtc ggcgcgggag
      181 cagcacttcc acagccaagt gcgagagtcc acgatatgtt ttcttctttt tgccattctc
      241 tacgtccttt cttacttcat cattacaaga tacaagagaa aatcagatga acaagaagat
      301 gaggatgccg tagtcaacag gatatcgttg tttctgagca ccttcactct agcggtttca
      361 gctggtgctg ttttgctttt gcccttctcc atcatcagca atgagatcct gcttgctttt
      421 cctcaaaact actacattca gtggttgaat ggctccttga tccatggttt gtggaatctt
      481 gcgtctttat tttccaacct ttgtttattt gtgttgatgc cctttgcctt tttctttctg
      541 gaatcagaag gttttgcagg cctgaaaaag ggaatccgag cccgcatttt ggaaactctg
      601 gtcatgctgc tgctgcttgc gttgctgatt cttgggatag tgtgggtggc ttccgccctg
      661 attgacagtg atgctgccag tatggagtct ttatatgatc tctgggaatt ctacctgccc
      721 tatttgtatt cttgcatttc actgatggga tgcttgctgc ttctcttgtg taccccagtt
      781 ggcctgtccc gtatgttcac agtgatgggc cagttgctgg tgaagcctgc gattcttgaa
      841 gacctggatg aacaaattta tatgattact ctagaagaag aagcgctcca gagaagactg
      901 cacgggctgt cttcatcggc ggaatataat gtaatggaat tggagcaaga acttgagaat
      961 gtaaagaccc ttaagacaaa attagagagg cggaaaaaag cttcagcatg ggagagaaat
     1021 ttggtgtatc ctgctgttat ggttctcctc cttattgaaa catccatttc agtcctcctg
     1081 gtggcgtgta atattctttg cctgctggtt gatgagactg caatgccaaa gggaacaagg
     1141 ggccctggca taggaagcgc ctctctctcc acttttggct ttgtgggagc tgcacttgaa
     1201 atcattctga ttttctatct catggtatct tctgttgttg gtttctatag cctcagagtt
     1261 tttggaaact ttacacccaa gaaggatgac acaaccatga caaagatcat tgggaattgt
     1321 gtgtcaattt tagtcttgag ctctgctttg cctgtgatgt caagaacact ggggatcact
     1381 agatttgatc tacttggaga ctttggaaga tttaattggc tgggaaattt ctatattgta
     1441 ttatcctaca atttactctt tgctattgtg acaacattgt gtttgatcag aaaattcaca
     1501 tcagctgtac gagaagaact tttcaaggcc ctaggacttc ataaacttca cttgtctgat
     1561 acctcaaggg attcagaaac tacaaagcct tctgcaaacg ggcatcagaa agcactgtga
     1621 gacctgactg tctcagtagc actctatagc aagacctgac aactccctat ccatgacatt
     1681 cccatagaca ctggtcactc tggtgggcct gggccaaccc gccagtgccc cttctcataa
     1741 gcactgacaa cttggcactg cttatctgtg tctcctttga gtttcctgat tgactttata
     1801 gcttttggtt aaacctgagt cctagagact gaggaaaagc tgtgtgtcta cagcaggagc
     1861 catcaggatg cgaggtgtaa tgtgccaaga ggcagacttg gactttttat gttttgagaa
     1921 gtttggttct gcaggcagaa gcccgcctga aagtcatctg gtacccaaag catctcaggt
     1981 ggtcagaaac tgctgtacta gtaacaaact aactacattt tttatttcct taaaaaaaaa
     2041 aaccaaaagc agattttctg attcatgtta cagaatcttc attagacttt gagccagtgg
     2101 aaaatactag attcttttca cacttgagcc ttggtgggca gccccaggac tgtgtctttg
     2161 tggtaagctg cagtctgaag catgtgattg tagatttgaa cagtgtatgt ctgtgtacct
     2221 gataatactt ttcctagcac agtgccagtg ttgtacacat gtgtaactta gactttgcct
     2281 tataggctgt atgtacattc actttttaaa accctttttc aaaaacgact ccactctgtg
     2341 cttgttgtgc ctgtgaaacc caaagataga aattgctgct gcttcttcgt gtccctcagg
     2401 ctttggtgac tttcatatac accaccttaa gtctccacct caggaaggtt accagtgtga
     2461 tacctggaac ttaaaggttg ggttctccac gaaagggcag gtgaagtgta atatgagtcc
     2521 ttaactattc agttgtttag tttaattgtt aacagagatg gtttttcaac tcctgagtct
     2581 actgattaaa aagaaatgag cacatgctgc tgttgtttct aggtagcaca tatttcacag
     2641 gaatatagtg atgctcacat gcagtgtatg gatgacagaa caggctttgt gttcagaaaa
     2701 aaaagtaaag catttttttt caaattgttg aatttagttt ctttttgaga aatatgtgaa
     2761 aggttgtatc tgacactttt ttctactttg aaaaacaaga aaatttagct atgtttataa
     2821 gccattgatt caaggaaagg tcagagcagt tttctactgc agtcatttat agtgcacacc
     2881 atttgccaac acaaccaaac tgtaccttac tctgtaaggt aaggtgtctg aaaatttcat
     2941 aaaatactga actt
//
