LOCUS       NM_053886               1743 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus lectin, mannose-binding, 1 (Lman1), mRNA.
ACCESSION   NM_053886
VERSION     NM_053886.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1743)
  AUTHORS   Gurth,C.M., Dankovich,T.M., Rizzoli,S.O. and D'Este,E.
  TITLE     Synaptic activity and strength are reflected by changes in the
            post-synaptic secretory pathway
  JOURNAL   Sci Rep 10 (1), 20576 (2020)
   PUBMED   33239744
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1743)
  AUTHORS   Hasson,S.A., Kane,L.A., Yamano,K., Huang,C.H., Sliter,D.A.,
            Buehler,E., Wang,C., Heman-Ackah,S.M., Hessa,T., Guha,R.,
            Martin,S.E. and Youle,R.J.
  TITLE     High-content genome-wide RNAi screens identify regulators of parkin
            upstream of mitophagy
  JOURNAL   Nature 504 (7479), 291-295 (2013)
   PUBMED   24270810
REFERENCE   3  (bases 1 to 1743)
  AUTHORS   Zhang,B., Zheng,C., Zhu,M., Tao,J., Vasievich,M.P., Baines,A.,
            Kim,J., Schekman,R., Kaufman,R.J. and Ginsburg,D.
  TITLE     Mice deficient in LMAN1 exhibit FV and FVIII deficiencies and liver
            accumulation of alpha1-antitrypsin
  JOURNAL   Blood 118 (12), 3384-3391 (2011)
   PUBMED   21795745
REFERENCE   4  (bases 1 to 1743)
  AUTHORS   Scrivens,P.J., Noueihed,B., Shahrzad,N., Hul,S., Brunet,S. and
            Sacher,M.
  TITLE     C4orf41 and TTC-15 are mammalian TRAPP components with a role at an
            early stage in ER-to-Golgi trafficking
  JOURNAL   Mol Biol Cell 22 (12), 2083-2093 (2011)
   PUBMED   21525244
REFERENCE   5  (bases 1 to 1743)
  AUTHORS   Valkova,C., Albrizio,M., Roder,I.V., Schwake,M., Betto,R.,
            Rudolf,R. and Kaether,C.
  TITLE     Sorting receptor Rer1 controls surface expression of muscle
            acetylcholine receptors by ER retention of unassembled
            alpha-subunits
  JOURNAL   Proc Natl Acad Sci U S A 108 (2), 621-625 (2011)
   PUBMED   21187406
REFERENCE   6  (bases 1 to 1743)
  AUTHORS   Nakajima,K., Takei,Y., Tanaka,Y., Nakagawa,T., Nakata,T., Noda,Y.,
            Setou,M. and Hirokawa,N.
  TITLE     Molecular motor KIF1C is not essential for mouse survival and
            motor-dependent retrograde Golgi apparatus-to-endoplasmic reticulum
            transport
  JOURNAL   Mol Cell Biol 22 (3), 866-873 (2002)
   PUBMED   11784862
REFERENCE   7  (bases 1 to 1743)
  AUTHORS   Garver,W.S., Heidenreich,R.A., Erickson,R.P., Thomas,M.A. and
            Wilson,J.M.
  TITLE     Localization of the murine Niemann-Pick C1 protein to two distinct
            intracellular compartments
  JOURNAL   J Lipid Res 41 (5), 673-687 (2000)
   PUBMED   10787428
REFERENCE   8  (bases 1 to 1743)
  AUTHORS   Nichols,W.C., Terry,V.H., Wheatley,M.A., Yang,A., Zivelin,A.,
            Ciavarella,N., Stefanile,C., Matsushita,T., Saito,H., de
            Bosch,N.B., Ruiz-Saez,A., Torres,A., Thompson,A.R., Feinstein,D.I.,
            White,G.C., Negrier,C., Vinciguerra,C., Aktan,M., Kaufman,R.J.,
            Ginsburg,D. and Seligsohn,U.
  TITLE     ERGIC-53 gene structure and mutation analysis in 19 combined
            factors V and VIII deficiency families
  JOURNAL   Blood 93 (7), 2261-2266 (1999)
   PUBMED   10090935
REFERENCE   9  (bases 1 to 1743)
  AUTHORS   Nichols,W.C., Seligsohn,U., Zivelin,A., Terry,V.H., Hertel,C.E.,
            Wheatley,M.A., Moussalli,M.J., Hauri,H.P., Ciavarella,N.,
            Kaufman,R.J. and Ginsburg,D.
  TITLE     Mutations in the ER-Golgi intermediate compartment protein ERGIC-53
            cause combined deficiency of coagulation factors V and VIII
  JOURNAL   Cell 93 (1), 61-70 (1998)
   PUBMED   9546392
REFERENCE   10 (bases 1 to 1743)
  AUTHORS   Lahtinen,U., Hellman,U., Wernstedt,C., Saraste,J. and
            Pettersson,R.F.
  TITLE     Molecular cloning and expression of a 58-kDa cis-Golgi and
            intermediate compartment protein
  JOURNAL   J Biol Chem 271 (8), 4031-4037 (1996)
   PUBMED   8626736
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from U44129.1.
            
            On Feb 21, 2013 this sequence version replaced NM_053886.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U44129.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1743              U44129.1           1-1743
FEATURES             Location/Qualifiers
     source          1..1743
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.1"
     gene            1..1743
                     /gene="Lman1"
                     /gene_synonym="p58"
                     /note="lectin, mannose-binding, 1"
                     /db_xref="GeneID:116666"
                     /db_xref="RGD:71020"
     exon            1..248
                     /gene="Lman1"
                     /gene_synonym="p58"
                     /inference="alignment:Splign:2.1.0"
     CDS             11..1564
                     /gene="Lman1"
                     /gene_synonym="p58"
                     /note="protein ERGIC-53; ER-Golgi intermediate compartment
                     53 kDa protein; endoplasmic reticulum-golgi intermediate
                     compartment protein 53"
                     /codon_start=1
                     /product="protein ERGIC-53 precursor"
                     /protein_id="NP_446338.1"
                     /db_xref="GeneID:116666"
                     /db_xref="RGD:71020"
                     /translation="MAVSRRRGPQAGAQSFFCALLLSFSQFVGSDGMGGDAAAPGAAG
                     TQAELPHRRFEYKYSFKGPHLVQSDGTVPFWAHAGNAIPSADQIRIAPSLKSQRGSVW
                     TKTKAAFENWEVEVTFRVTGRGRIGADGLAIWYTENQGLDGPVFGSADMWNGVGIFFD
                     SFDNDGKKNNPAIVVVGNNGQINYDHQNDGATQALASCQRDFRNKPYPVRAKITYYQK
                     TLTVMINNGFTPDKNDYEFCAKVENMVIPTQGHFGISAATGGLADDHDVLSFLTFQLT
                     EPGKEPPTPEKDISEKEKEKYQEEFEHFQQELDKKKEEFQKGHPDLQGQPADDIFESI
                     GDRELRQVFEGQNRIHLEIKQLNRQLDMILDEQRRYVSSLTEEISRRGAGTPGQPGQV
                     SQQELDTVVRTQLEILRQVNEMKNSMRETMRLVSGVQHPGSAGVYETTQHFMDIKEHL
                     HIVKRDIDSLAQRSMSSNEKPKCPDLPAFPSCLSTVHFVIFIVVQTVLFIGYIMYRTQ
                     QEAAAKKFF"
     exon            249..403
                     /gene="Lman1"
                     /gene_synonym="p58"
                     /inference="alignment:Splign:2.1.0"
     exon            404..511
                     /gene="Lman1"
                     /gene_synonym="p58"
                     /inference="alignment:Splign:2.1.0"
     exon            512..573
                     /gene="Lman1"
                     /gene_synonym="p58"
                     /inference="alignment:Splign:2.1.0"
     exon            574..673
                     /gene="Lman1"
                     /gene_synonym="p58"
                     /inference="alignment:Splign:2.1.0"
     exon            674..797
                     /gene="Lman1"
                     /gene_synonym="p58"
                     /inference="alignment:Splign:2.1.0"
     exon            798..856
                     /gene="Lman1"
                     /gene_synonym="p58"
                     /inference="alignment:Splign:2.1.0"
     exon            857..989
                     /gene="Lman1"
                     /gene_synonym="p58"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1183
                     /gene="Lman1"
                     /gene_synonym="p58"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..1254
                     /gene="Lman1"
                     /gene_synonym="p58"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..1405
                     /gene="Lman1"
                     /gene_synonym="p58"
                     /inference="alignment:Splign:2.1.0"
     exon            1406..1527
                     /gene="Lman1"
                     /gene_synonym="p58"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..1594
                     /gene="Lman1"
                     /gene_synonym="p58"
                     /inference="alignment:Splign:2.1.0"
     exon            1595..1743
                     /gene="Lman1"
                     /gene_synonym="p58"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaatccaag atggcggtgt ccaggcggcg gggtccccag gctggagcgc agtcgttctt
       61 ctgcgccctg ctgctgtctt tcagccaatt cgtcgggagc gacggcatgg gaggagatgc
      121 tgcggctccc ggcgccgcag gcacccaggc cgagttgcca caccgccgtt tcgagtacaa
      181 atacagcttt aaggggccgc atctggtgca gagcgatggg accgtgccct tttgggccca
      241 cgcggggaat gctattccaa gtgcagatca gatccgaata gcaccgtcct taaagagcca
      301 aagaggttcc gtgtggacca aaacaaaagc agccttcgag aactgggaag tggaagtgac
      361 attccgagtg accggaagag gtcgaattgg agctgatggc ttagcaattt ggtatacaga
      421 aaaccaaggc ttggacggcc ctgtgtttgg atcagctgat atgtggaatg gtgttggaat
      481 attttttgat tcttttgaca atgacggaaa gaaaaacaat cctgctatag tagttgtagg
      541 caacaatgga caaatcaatt atgaccacca aaatgatggt gccactcaag ccttagcgag
      601 ttgtcagagg gacttccgta ataaacccta tcctgtccgg gcaaagatta cctattacca
      661 gaaaacactg acggtcatga tcaataatgg ctttacacca gataaaaatg attatgaatt
      721 ctgtgccaaa gtggaaaata tggttatccc cacgcaaggg cattttggga tatctgctgc
      781 aacaggaggt cttgcagatg accacgatgt tctctctttc ctgactttcc aactaaccga
      841 gcccggaaaa gagccaccta cgccagaaaa agacatttca gaaaaagaaa aggaaaagta
      901 tcaagaggag tttgaacact tccagcaaga attagacaag aagaaggagg aattccagaa
      961 gggccaccct gacctccagg ggcagccagc ggatgacatc tttgagagca taggggatcg
     1021 ggagctgaga caagtgtttg aaggacaaaa tcgcattcat ctggagatca agcaacttaa
     1081 ccggcagctg gatatgattc tcgatgaaca gaggagatac gtgtcttctc tgacagagga
     1141 gatttccagg agaggagcag ggaccccagg acagcctggg caggtctccc aacaggaact
     1201 ggacactgtt gtgaggaccc agctggagat tttgagacaa gtgaatgaga tgaagaactc
     1261 catgcgtgag accatgcggc tggttagtgg cgtccagcac ccaggctcgg ccggcgtcta
     1321 cgagacaacc cagcacttca tggacatcaa ggagcacctg cacatcgtga agagagatat
     1381 cgacagcctc gcgcagcgca gcatgtcatc taatgaaaaa ccaaaatgcc cagatctacc
     1441 agcattcccg tcgtgtctgt ccacagtcca ctttgtgata tttatagtgg tgcagacggt
     1501 gttgttcatt ggctacatca tgtacaggac tcagcaagaa gcagctgcca aaaaattctt
     1561 ctgaccttga ttttcctatg tgtacgtcat gtatctgggc tagactttcg ctggcttcaa
     1621 gacaatttac ctcttattaa agtaatggtc tcgtttgctt tgggatccag aacaacactg
     1681 tttagtatat atgctactaa attgttgtaa gcctttgtaa gtttcctctc agatgtcatt
     1741 tgg
//
