LOCUS       NM_001127549            3555 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus LLGL scribble cell polarity complex component 2
            (Llgl2), mRNA.
ACCESSION   NM_001127549 XM_001073376 XM_001081717 XM_001081718 XM_573224
VERSION     NM_001127549.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3555)
  AUTHORS   Saito,Y., Li,L., Coyaud,E., Luna,A., Sander,C., Raught,B.,
            Asara,J.M., Brown,M. and Muthuswamy,S.K.
  TITLE     LLGL2 rescues nutrient stress by promoting leucine uptake in ER+
            breast cancer
  JOURNAL   Nature 569 (7755), 275-279 (2019)
   PUBMED   30996345
REFERENCE   2  (bases 1 to 3555)
  AUTHORS   Sripathy,S., Lee,M. and Vasioukhin,V.
  TITLE     Mammalian Llgl2 is necessary for proper branching morphogenesis
            during placental development
  JOURNAL   Mol Cell Biol 31 (14), 2920-2933 (2011)
   PUBMED   21606200
REFERENCE   3  (bases 1 to 3555)
  AUTHORS   Yasumi,M., Sakisaka,T., Hoshino,T., Kimura,T., Sakamoto,Y.,
            Yamanaka,T., Ohno,S. and Takai,Y.
  TITLE     Direct binding of Lgl2 to LGN during mitosis and its requirement
            for normal cell division
  JOURNAL   J Biol Chem 280 (8), 6761-6765 (2005)
   PUBMED   15632202
REFERENCE   4  (bases 1 to 3555)
  AUTHORS   Yamanaka,T., Horikoshi,Y., Sugiyama,Y., Ishiyama,C., Suzuki,A.,
            Hirose,T., Iwamatsu,A., Shinohara,A. and Ohno,S.
  TITLE     Mammalian Lgl forms a protein complex with PAR-6 and aPKC
            independently of PAR-3 to regulate epithelial cell polarity
  JOURNAL   Curr Biol 13 (9), 734-743 (2003)
   PUBMED   12725730
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC166481.1.
            
            On or before May 23, 2008 this sequence version replaced
            XM_001073376.1, XM_573224.2, XM_001081717.1, XM_001081718.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166481.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..3555
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.1"
     gene            1..3555
                     /gene="Llgl2"
                     /gene_synonym="RGD1560307"
                     /note="LLGL scribble cell polarity complex component 2"
                     /db_xref="GeneID:360661"
                     /db_xref="RGD:1560307"
     exon            1..140
                     /gene="Llgl2"
                     /gene_synonym="RGD1560307"
                     /inference="alignment:Splign:2.1.0"
     exon            141..245
                     /gene="Llgl2"
                     /gene_synonym="RGD1560307"
                     /inference="alignment:Splign:2.1.0"
     CDS             171..3251
                     /gene="Llgl2"
                     /gene_synonym="RGD1560307"
                     /note="lethal(2) giant larvae protein homolog 2; lethal
                     giant larvae homolog 2, scribble cell polarity complex
                     component; LLGL2, scribble cell polarity complex
                     component"
                     /codon_start=1
                     /product="LLGL scribble cell polarity complex component 2"
                     /protein_id="NP_001121021.1"
                     /db_xref="GeneID:360661"
                     /db_xref="RGD:1560307"
                     /translation="MRRFLRTGHDPARERLKRDLFQFNKTVEHGFPHQPSALGYSPSL
                     RILAIGTRSGAVKLYGAPGVEFMGLHKENNAVLQIHFLPGQCQLVTLLDDNSLHLWSL
                     KVKGGVSELQEEESFTLRGPPGAAPSATQITEILPHSSGELLYLGTESGSVFVVRLPG
                     FCALHDRTISSDEVLQWLPEEARHRRVFEMVEALQEHPRDPNQILIGYSRGLVVIWDL
                     RASRVLSHFLSHQQLENVSWQRDGCLIVTCHSDGSHCQWSVPSDTQSPEPLRSSVPYG
                     PFPCKAITKIFWLTTRQGLPFTIFQGGMPRASYGDRHCISVVHNGQQTAFDFTSRVID
                     FTVLMEADPVAAFDDPYALVVLAEEELVVIDLQTPGWPPVQLPYLASLHCSAITCSHH
                     VSNIPLKLWERIIAAGSRQNSHFSTMEWPIDGGTSLAPPPPQRDLLLTGHEDGTVRFW
                     DASGVCLRLLYKLSTVRVFLTDTDLSENLSAQGEDEWPPLRKVGSFDPYSDDPRLGIQ
                     KIFLCKYSGYLAVAGTAGQVLVLELNDEAAEHAVEQVEADLLQDQEGYRWKGHERLAA
                     RPGPVRFEAGFQPFVLVQCQPPAVVTSLALHSEWRLVAFGTSHGFGLFDHQQRRQVFV
                     KCTLHPSDQLALEGPLSRVKSLKKSLRQSFRRMRRSRASSHKRRPGGPTGEAQAQAVN
                     TKAERTGLQNMELAPVQRKIEARSAEDSFTGFVRTLYFADTYLRDSSRHCPSLWAGTN
                     GGTVYAFSLRVPPAERRADEPVRAEQAKEIQLMHRAPVVGILVLDGHNVPLPEPLEVA
                     HDLSKSPDMQGSHQLLVVSEEQFKVFTLPKVSAKLKLKLTALEGSRVRRVGVAHFGSC
                     RAEDYGEHHLAVLTNLGDIQVVSVPLLKPQVRYSCIRREDVSGIASCVFTKYGQGFYL
                     ISPSEFERFSLSTKWLVEPRCLVDSAKARNHNRPSNGNSTGPKRTSGQVRNSRSQSDG
                     AETKPGPVMEHALLSDAWVLKEVQSTLEGDQGSCGNWRSHRVAVGCRLSNGEAE"
     exon            246..343
                     /gene="Llgl2"
                     /gene_synonym="RGD1560307"
                     /inference="alignment:Splign:2.1.0"
     exon            344..425
                     /gene="Llgl2"
                     /gene_synonym="RGD1560307"
                     /inference="alignment:Splign:2.1.0"
     exon            426..541
                     /gene="Llgl2"
                     /gene_synonym="RGD1560307"
                     /inference="alignment:Splign:2.1.0"
     exon            542..700
                     /gene="Llgl2"
                     /gene_synonym="RGD1560307"
                     /inference="alignment:Splign:2.1.0"
     exon            701..863
                     /gene="Llgl2"
                     /gene_synonym="RGD1560307"
                     /inference="alignment:Splign:2.1.0"
     exon            864..996
                     /gene="Llgl2"
                     /gene_synonym="RGD1560307"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1051
                     /gene="Llgl2"
                     /gene_synonym="RGD1560307"
                     /inference="alignment:Splign:2.1.0"
     exon            1052..1206
                     /gene="Llgl2"
                     /gene_synonym="RGD1560307"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1424
                     /gene="Llgl2"
                     /gene_synonym="RGD1560307"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..1492
                     /gene="Llgl2"
                     /gene_synonym="RGD1560307"
                     /inference="alignment:Splign:2.1.0"
     exon            1493..1646
                     /gene="Llgl2"
                     /gene_synonym="RGD1560307"
                     /inference="alignment:Splign:2.1.0"
     exon            1647..1751
                     /gene="Llgl2"
                     /gene_synonym="RGD1560307"
                     /inference="alignment:Splign:2.1.0"
     exon            1752..2044
                     /gene="Llgl2"
                     /gene_synonym="RGD1560307"
                     /inference="alignment:Splign:2.1.0"
     exon            2045..2195
                     /gene="Llgl2"
                     /gene_synonym="RGD1560307"
                     /inference="alignment:Splign:2.1.0"
     exon            2196..2352
                     /gene="Llgl2"
                     /gene_synonym="RGD1560307"
                     /inference="alignment:Splign:2.1.0"
     exon            2353..2469
                     /gene="Llgl2"
                     /gene_synonym="RGD1560307"
                     /inference="alignment:Splign:2.1.0"
     exon            2470..2636
                     /gene="Llgl2"
                     /gene_synonym="RGD1560307"
                     /inference="alignment:Splign:2.1.0"
     exon            2637..2901
                     /gene="Llgl2"
                     /gene_synonym="RGD1560307"
                     /inference="alignment:Splign:2.1.0"
     exon            2902..3061
                     /gene="Llgl2"
                     /gene_synonym="RGD1560307"
                     /inference="alignment:Splign:2.1.0"
     exon            3062..3090
                     /gene="Llgl2"
                     /gene_synonym="RGD1560307"
                     /inference="alignment:Splign:2.1.0"
     exon            3091..3138
                     /gene="Llgl2"
                     /gene_synonym="RGD1560307"
                     /inference="alignment:Splign:2.1.0"
     exon            3139..3181
                     /gene="Llgl2"
                     /gene_synonym="RGD1560307"
                     /inference="alignment:Splign:2.1.0"
     exon            3182..3243
                     /gene="Llgl2"
                     /gene_synonym="RGD1560307"
                     /inference="alignment:Splign:2.1.0"
     exon            3244..3530
                     /gene="Llgl2"
                     /gene_synonym="RGD1560307"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaacaggtgt ctggcgtggc tgggtgcggg gggggacaca gtgagcagag acaccgttcc
       61 gggacccttg tgcgaggggc ctcgacgcag aacccgacga cccggcttcc tgtgacccgg
      121 cgtcgccagc ggcgtctggg gtctgtcgtg ggggccacca actaagcaag atgaggcggt
      181 tcctgagaac tggacatgac cctgcccggg aaaggctaaa gcgggatctg ttccagttca
      241 acaagacagt ggagcatggc ttcccacacc agcccagcgc cctcggctat agtccttcac
      301 tgcgcatcct ggccatcggt acccgctctg gagctgtcaa actatatggt gcccccgggg
      361 tagagttcat ggggcttcac aaagagaaca acgctgtgtt gcagatccac ttcctgcctg
      421 gtcagtgtca gctggtcact ctgctggatg acaacagcct gcacctgtgg agcctgaagg
      481 tcaagggtgg ggtgtcagag ctgcaggaag aagagagctt cactttgcgt ggccccccag
      541 gggcggcccc cagtgccacg cagatcactg agatcctacc tcactcctcc ggagaactgc
      601 tctacctggg caccgagagc ggcagtgtgt ttgtggtgcg gctgcctggg ttctgcgcac
      661 tgcacgacag gaccatcagt tcagacgagg tgctgcaatg gttgccagag gaggcccggc
      721 accggcgagt gttcgagatg gtggaggctc tgcaggagca ccctagagac cccaaccaaa
      781 tcctcattgg ctacagccga ggcctcgtcg tcatctggga ccttcgggcc agtcgagtgc
      841 tcagccactt cctgagccac cagcaactgg agaacgtcag ctggcagcgg gatggctgcc
      901 tgattgtcac ctgccactct gacggcagcc actgccagtg gtccgtgccc agtgacaccc
      961 agagcccaga acctctgcgc agttctgtac cttacggtcc ttttccttgc aaagctatca
     1021 ccaaaatctt ctggcttacc accaggcaag ggttgccctt caccatcttc cagggcggta
     1081 tgccccgggc cagctacggg gaccgccact gcatctcagt ggtccacaat ggccagcaga
     1141 cagcctttga cttcacctcc cgtgtcatcg acttcaccgt tctcatggag gctgaccctg
     1201 tggctgcctt tgatgacccc tacgccctgg tggtgcttgc cgaggaggaa ctggtggtga
     1261 ttgacctgca gacacccggc tggccgccag tccagctgcc ctacctggct tccctgcact
     1321 gttcagccat tacctgctcc catcatgtct ccaacatccc cctgaagctg tgggaacgaa
     1381 tcatcgctgc cggcagccgc cagaactcgc acttctccac catggagtgg cccatagatg
     1441 gtggtaccag cctggccccg cctccaccgc agagggacct gctgctcaca gggcacgagg
     1501 atggcacagt gcggttctgg gacgcctcgg gtgtctgttt acggctgctg tacaaactca
     1561 gtaccgtgag ggtgttcctt acagacacag acctcagcga gaacctcagc gcccagggtg
     1621 aggacgagtg gcccccactc cgcaaggtgg gctcctttga tccctacagt gatgatccac
     1681 ggctgggcat ccagaagatt ttcctctgca aatacagtgg ctacctggct gtggcaggca
     1741 cggcagggca ggtgctggtg ctggagctga acgatgaggc ggcagagcac gccgtggagc
     1801 aggtggaggc tgacctgctg caggaccagg agggctaccg ctggaagggc cacgagcgcc
     1861 tcgccgcccg ccccgggccc gtgcgctttg aggcaggctt tcagcccttt gtactggtgc
     1921 agtgccagcc cccagctgtg gtcacctccc tggccctgca ctctgagtgg cggcttgtgg
     1981 cctttggcac cagccacggt ttcggcctct tcgatcacca gcagcggcgg caggtctttg
     2041 tcaagtgcac acttcacccc agtgaccagc tggccttgga gggcccgctg tcccgcgtaa
     2101 agtccctcaa gaagtcccta cgtcagtcat tccgtcggat gcgccgcagc agggcgtcca
     2161 gtcataaacg gcggcctggt ggccccacgg gcgaggcgca ggctcaggct gtgaacacca
     2221 aggcagaacg gacagggctg cagaacatgg agctggcacc tgtacagcgc aagatcgagg
     2281 cccgctcagc agaggactcc ttcaccggct ttgttcggac cctctatttt gctgacacct
     2341 acctgaggga cagttcccgc cactgtccct cgctgtgggc tggcaccaat ggaggcaccg
     2401 tctatgcctt ctccctgcgc gtacctcctg cagaaaggag agcggatgag cctgtgcggg
     2461 cagagcaggc caaggagatc cagctgatgc atcgtgcacc tgtggtgggc atcctggtgc
     2521 ttgacggaca caacgtaccc cttcccgagc ccctggaagt agcccatgac ctgtccaaga
     2581 gcccagacat gcaaggaagc caccagctgc ttgtggtgtc agaggagcaa ttcaaggtgt
     2641 tcacgctgcc caaggtgagc gccaagctga agctgaagct gacggccctg gaaggctcgc
     2701 gggttcgacg agtcggggtt gcccacttcg gcagctgcag ggcggaggac tatggggagc
     2761 accacctggc agtgctcacc aatttgggtg acatccaagt ggtctcagtg cccctgctca
     2821 agccccaggt gcggtacagc tgcatccgcc gggaggatgt cagtggaata gcctcctgcg
     2881 tcttcaccaa gtacggccaa ggcttctacc tgatatcacc ttcggagttc gagcgctttt
     2941 ctctctccac caagtggctg gttgagcccc ggtgtttggt ggattcagcc aaagccagga
     3001 accacaaccg gcccagtaat ggcaatagca caggccccaa aaggacctcc ggccaagtca
     3061 ggaactcacg gagccagagt gatggagcag agacgaagcc cggcccagtg atggagcacg
     3121 cactgctcag tgacgcctgg gtcctaaagg aagtccagag cacgctagag ggggaccagg
     3181 ggagctgtgg caattggcgc tctcaccgtg tggctgtggg ttgcaggctg agcaatggcg
     3241 aagcagagtg aatgggacat catccaggct gtagaacgaa cacacactac tgagggcctt
     3301 tccagcccga gcccggccag gggctgcccg tgccctggtc accttcctgc tgctgctcca
     3361 ggctttagga gaggggagct cccacctgga ccgcccgccc ctcctgggcc ctgtctgtct
     3421 tgatcctttt atcaatgtcg cacagttttt atttccaccc ccttttgtag tgggctgggt
     3481 tttaaattat aaattttaac gcctctgagt aaaactgagt ttttaatgaa aaaaaaaaaa
     3541 aaaaaaaaaa aaaaa
//
