LOCUS       NM_001304613            4261 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus LLGL scribble cell polarity complex component 1
            (Llgl1), mRNA.
ACCESSION   NM_001304613 XM_006246518
VERSION     NM_001304613.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4261)
  AUTHORS   Shi,N., Tian,C., Liang,X., Jiang,P., Liang,L., Zhou,L., Shu,Y.,
            Chen,P. and Wang,Y.
  TITLE     Proteome analysis of actin filament-associated proteins in the
            postnatal rat cerebellum
  JOURNAL   Neuroscience 227, 90-101 (2012)
   PUBMED   23032931
  REMARK    GeneRIF: This study demonistrated that demonstrated that the
            actin-associated proteins Lethal(2) giant larvae protein homolog 1
            (LLGL1) was specifically upregulated in granule neurons and
            Purkinje cells during morphogenesis of axons and dendrites.
REFERENCE   2  (bases 1 to 4261)
  AUTHORS   Tao,H., Inoue,K., Kiyonari,H., Bassuk,A.G., Axelrod,J.D.,
            Sasaki,H., Aizawa,S. and Ueno,N.
  TITLE     Nuclear localization of Prickle2 is required to establish cell
            polarity during early mouse embryogenesis
  JOURNAL   Dev Biol 364 (2), 138-148 (2012)
   PUBMED   22333836
REFERENCE   3  (bases 1 to 4261)
  AUTHORS   Wang,T., Liu,Y., Xu,X.H., Deng,C.Y., Wu,K.Y., Zhu,J., Fu,X.Q.,
            He,M. and Luo,Z.G.
  TITLE     Lgl1 activation of rab10 promotes axonal membrane trafficking
            underlying neuronal polarization
  JOURNAL   Dev Cell 21 (3), 431-444 (2011)
   PUBMED   21856246
REFERENCE   4  (bases 1 to 4261)
  AUTHORS   Ozcelik,M., Cotter,L., Jacob,C., Pereira,J.A., Relvas,J.B.,
            Suter,U. and Tricaud,N.
  TITLE     Pals1 is a major regulator of the epithelial-like polarization and
            the extension of the myelin sheath in peripheral nerves
  JOURNAL   J Neurosci 30 (11), 4120-4131 (2010)
   PUBMED   20237282
REFERENCE   5  (bases 1 to 4261)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
REFERENCE   6  (bases 1 to 4261)
  AUTHORS   Klezovitch,O., Fernandez,T.E., Tapscott,S.J. and Vasioukhin,V.
  TITLE     Loss of cell polarity causes severe brain dysplasia in Lgl1
            knockout mice
  JOURNAL   Genes Dev 18 (5), 559-571 (2004)
   PUBMED   15037549
REFERENCE   7  (bases 1 to 4261)
  AUTHORS   Kim,Y.S., Chung,H.M. and Baek,K.H.
  TITLE     WD-40 repeat containing rat lethal giant larvae recessive oncogene,
            but not m-tomosyn, restores the salt sensitivity in Saccharomyces
            cerevisiae
  JOURNAL   Int J Oncol 23 (1), 229-233 (2003)
   PUBMED   12792798
  REMARK    GeneRIF: expression of the rgl-1 cDNA, but not m-tomosyn, restored
            partially salt sensitivity in yeast, indicating that rgl-1 is a
            homologue of lgl family members
REFERENCE   8  (bases 1 to 4261)
  AUTHORS   Kim,Y.S., Baek,K.H., Lee,K.Y., Chung,H.M., Lee,K.A., Ko,J.J. and
            Cha,K.Y.
  TITLE     The rgl-1 is a legitimate homologue of lethal giant larvae
            recessive oncogene in rat
  JOURNAL   Int J Oncol 20 (6), 1219-1225 (2002)
   PUBMED   12012002
REFERENCE   9  (bases 1 to 4261)
  AUTHORS   Strand,D., Unger,S., Corvi,R., Hartenstein,K., Schenkel,H.,
            Kalmes,A., Merdes,G., Neumann,B., Krieg-Schneider,F., Coy,J.F. et
            al.
  TITLE     A human homologue of the Drosophila tumour suppressor gene l(2)gl
            maps to 17p11.2-12 and codes for a cytoskeletal protein that
            associates with nonmuscle myosin II heavy chain
  JOURNAL   Oncogene 11 (2), 291-301 (1995)
   PUBMED   7542763
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Feb 5, 2015 this sequence version replaced XM_006246518.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582416.316684.1,
                                           SRR26643294.39604.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-92                JAXUCZ010000010.1  45879094-45879185
            93-190              JAXUCZ010000010.1  45882000-45882097
            191-272             JAXUCZ010000010.1  45883824-45883905
            273-403             JAXUCZ010000010.1  45883992-45884122
            404-559             JAXUCZ010000010.1  45885164-45885319
            560-722             JAXUCZ010000010.1  45885400-45885562
            723-858             JAXUCZ010000010.1  45885645-45885780
            859-913             JAXUCZ010000010.1  45885955-45886009
            914-1068            JAXUCZ010000010.1  45886164-45886318
            1069-1292           JAXUCZ010000010.1  45886393-45886616
            1293-1360           JAXUCZ010000010.1  45886796-45886863
            1361-1514           JAXUCZ010000010.1  45887757-45887910
            1515-1619           JAXUCZ010000010.1  45887999-45888103
            1620-1912           JAXUCZ010000010.1  45888652-45888944
            1913-2060           JAXUCZ010000010.1  45889165-45889312
            2061-2214           JAXUCZ010000010.1  45889484-45889637
            2215-2510           JAXUCZ010000010.1  45890529-45890824
            2511-2775           JAXUCZ010000010.1  45891301-45891565
            2776-2890           JAXUCZ010000010.1  45891702-45891816
            2891-3012           JAXUCZ010000010.1  45891927-45892048
            3013-3133           JAXUCZ010000010.1  45892271-45892391
            3134-4261           JAXUCZ010000010.1  45892482-45893609
FEATURES             Location/Qualifiers
     source          1..4261
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q22"
     gene            1..4261
                     /gene="Llgl1"
                     /gene_synonym="LLGL; Llglh; Mgl1; Rgl-1; Rgl1"
                     /note="LLGL scribble cell polarity complex component 1"
                     /db_xref="GeneID:54265"
                     /db_xref="RGD:3012"
     exon            1..92
                     /gene="Llgl1"
                     /gene_synonym="LLGL; Llglh; Mgl1; Rgl-1; Rgl1"
                     /inference="alignment:Splign:2.1.0"
     CDS             12..3215
                     /gene="Llgl1"
                     /gene_synonym="LLGL; Llglh; Mgl1; Rgl-1; Rgl1"
                     /note="lethal giant larvae homolog 1, scribble cell
                     polarity complex component; LLGL1, scribble cell polarity
                     complex component"
                     /codon_start=1
                     /product="lethal(2) giant larvae protein homolog 1"
                     /protein_id="NP_001291542.1"
                     /db_xref="GeneID:54265"
                     /db_xref="RGD:3012"
                     /translation="MMKFRFRRQGADPQREKLKQELFAFHKTVEHGFPNQPSALAFDP
                     ELRIMAIGTRSGAVKIYGAPGVEFTGLHRDAATVTQMHFLPGQGRLLTLLDDSSLHLW
                     EIIQRNGCAHLEEGLSFHPPSRPSFDNASFPAGLTRVTVVLLAAGDTVVLGTESGSIF
                     FLDVATLALLEGQTLSPDEVLRSVPDDYRCGKALGPVESLQGHLQDPSKILIGYSRGL
                     LVIWSQATQSVEHVFLGNQQLESLCWGRGGSNIISSHSDGSYAIWSTDTGSPPTLQPT
                     VVTTPYGPFPCKAINKILWRSCESGDHFIIFSGGMPRASYGDRHCVSVLRAETLVTLD
                     FTSRVIDFFTVHSTQPEDGFDNPQALAVLLEEELVVLDLQTPGWPAVPAPYLAPLHSS
                     AITCSAHVANVPSKLWARIVSAGERQSPQPASSALSWPITGGRNLAQEPSQRGLLLTG
                     HEDGTVRFWDASGVALRPLYKLSTAGLFQTDCEHADSLAQAVEDDWPPFRKVGCFDPY
                     SDDPRLGIQKVALCKYTAQMVVAGTAGQVLVLELSDVPGEHTVSVASVDLLQDREGFT
                     WKGHERLSPHTGPLPWPAGFQPRVLIQCLPPAAVTAVALHAEWSLVAFGTSHGFGLFD
                     YQRKSPVLARCTLHPNDSLAMEGPLSRVKSLKKSLRQSFRRIRKSRVSGKKRATTASS
                     KLQEANAQLAEQTCPHDVEMTPVQRRIEPRSADDSLSGVVRCLYFADTFLRDATHHGP
                     TMWAGTNSGSVFAYALEVPAATAGGEKRPEQAVEAVLGKEVQLMHRAPVVAIAVLDGR
                     GRPLPEPYEASRDLAQAPDMQGGHAVLIASEEQFKVFTLPKVSAKTKFKLTAHEGCRV
                     RKVALATFASVISEDYAETCLACLTNLGDVHVFSVPGLRPQVHYACIRKEDISGIASC
                     VFTRHGQGFYLISPSEFERFSLSARNITEPLCSLDISWSRNATQPSHRLQESPKLSQA
                     NGTRNIILAPESCEGSPRSPSSAHSKLADTTEPLEATLSPVSIDSAASGDTMLDTTGD
                     VTAEYVKDFLGSPEDSEKNLRNLGADDAGRAYTLLIE"
     exon            93..190
                     /gene="Llgl1"
                     /gene_synonym="LLGL; Llglh; Mgl1; Rgl-1; Rgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            191..272
                     /gene="Llgl1"
                     /gene_synonym="LLGL; Llglh; Mgl1; Rgl-1; Rgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            273..403
                     /gene="Llgl1"
                     /gene_synonym="LLGL; Llglh; Mgl1; Rgl-1; Rgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            404..559
                     /gene="Llgl1"
                     /gene_synonym="LLGL; Llglh; Mgl1; Rgl-1; Rgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            560..722
                     /gene="Llgl1"
                     /gene_synonym="LLGL; Llglh; Mgl1; Rgl-1; Rgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            723..858
                     /gene="Llgl1"
                     /gene_synonym="LLGL; Llglh; Mgl1; Rgl-1; Rgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            859..913
                     /gene="Llgl1"
                     /gene_synonym="LLGL; Llglh; Mgl1; Rgl-1; Rgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1068
                     /gene="Llgl1"
                     /gene_synonym="LLGL; Llglh; Mgl1; Rgl-1; Rgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1292
                     /gene="Llgl1"
                     /gene_synonym="LLGL; Llglh; Mgl1; Rgl-1; Rgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1360
                     /gene="Llgl1"
                     /gene_synonym="LLGL; Llglh; Mgl1; Rgl-1; Rgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1514
                     /gene="Llgl1"
                     /gene_synonym="LLGL; Llglh; Mgl1; Rgl-1; Rgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1515..1619
                     /gene="Llgl1"
                     /gene_synonym="LLGL; Llglh; Mgl1; Rgl-1; Rgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..1912
                     /gene="Llgl1"
                     /gene_synonym="LLGL; Llglh; Mgl1; Rgl-1; Rgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1913..2060
                     /gene="Llgl1"
                     /gene_synonym="LLGL; Llglh; Mgl1; Rgl-1; Rgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2061..2214
                     /gene="Llgl1"
                     /gene_synonym="LLGL; Llglh; Mgl1; Rgl-1; Rgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2215..2510
                     /gene="Llgl1"
                     /gene_synonym="LLGL; Llglh; Mgl1; Rgl-1; Rgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2511..2775
                     /gene="Llgl1"
                     /gene_synonym="LLGL; Llglh; Mgl1; Rgl-1; Rgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2776..2890
                     /gene="Llgl1"
                     /gene_synonym="LLGL; Llglh; Mgl1; Rgl-1; Rgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            2891..3012
                     /gene="Llgl1"
                     /gene_synonym="LLGL; Llglh; Mgl1; Rgl-1; Rgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            3013..3133
                     /gene="Llgl1"
                     /gene_synonym="LLGL; Llglh; Mgl1; Rgl-1; Rgl1"
                     /inference="alignment:Splign:2.1.0"
     exon            3134..4261
                     /gene="Llgl1"
                     /gene_synonym="LLGL; Llglh; Mgl1; Rgl-1; Rgl1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgggcgcaa gatgatgaag tttcggttcc ggcggcaggg cgcagacccg cagcgcgaga
       61 agctcaagca ggagctcttc gccttccaca agactgtgga gcatggcttc cccaaccagc
      121 ccagcgcctt ggccttcgac ccggagcttc gcatcatggc catcggcacc agatctgggg
      181 ctgtcaagat ctatggggca cccggagtgg aatttacagg cctacaccgg gatgcggcca
      241 ctgtcaccca gatgcatttc ctgcctggtc agggccgact tctgaccctg ttagacgaca
      301 gcagcttaca tctgtgggaa atcatccagc gtaatggctg tgcccatctg gaggaagggc
      361 tcagcttcca cccacccagc cggcccagtt ttgacaatgc cagtttccct gccggtctaa
      421 cccgagtcac tgtggtcctg ctggcagctg gcgataccgt ggttctgggg accgagagtg
      481 gtagcatatt cttcctggat gtcgccaccc tggcactgct ggaggggcag actctcagcc
      541 cagatgaggt cctgcgcagc gtgccagatg actaccggtg tggaaaggcc ttgggccctg
      601 tggagtcact ccagggacat ctgcaagacc ccagcaagat ccttataggc tatagtcggg
      661 gcttactggt catctggagc caggccacac agtctgtgga gcacgttttc ctgggtaacc
      721 agcagctgga gagcctgtgt tgggggcgtg gtggcagcaa cattatcagc tcacatagtg
      781 atggcagcta tgccatctgg tccacagaca ctggcagccc cccaacgctt cagcccactg
      841 tagtgaccac accttatggc cccttcccct gcaaggccat caacaagatt ctgtggcgga
      901 gctgtgagtc aggagaccac tttatcatct tcagtggtgg catgcctcga gccagctatg
      961 gtgaccgcca ctgtgtgagt gtactgcggg cagagacact ggtgacccta gacttcacct
     1021 cccgtgtcat tgacttcttc acggtgcaca gcacacagcc agaggatggt tttgacaacc
     1081 cccaggccct agccgtgctt ctggaggaag agctggtggt gctggacctg cagacaccag
     1141 gctggccagc tgtgcctgcc ccttacctgg ctccactgca ttcatcagcg atcacctgct
     1201 ctgcccatgt tgccaatgtg cccagcaagc tgtgggcccg catcgtaagt gctggcgagc
     1261 ggcagagccc acagcctgcc tccagtgcct tgagttggcc cattactggg ggccggaact
     1321 tggcccagga accctcgcag cgtgggctac tgctgaccgg ccatgaggat ggcactgtgc
     1381 ggttctggga cgcctctggt gtggcgctaa ggccactcta caaactgagc acagctggcc
     1441 tctttcagac ggactgcgaa catgctgaca gcctggccca ggctgtggag gatgactggc
     1501 cgcccttccg caaggtgggc tgctttgatc cctacagtga tgatccccgg ctaggaatcc
     1561 agaaggttgc gctttgcaag tacacagccc agatggtggt ggctggcaca gcaggccagg
     1621 tgctggtgct ggagctcagt gacgtgccgg gagagcacac cgtcagtgtg gccagtgtgg
     1681 atcttctcca ggatcgggag ggcttcacgt ggaagggcca cgagcgactg agcccgcaca
     1741 cgggaccgtt gccttggcct gccgggttcc agcctcgcgt gctgatacag tgcctgccgc
     1801 ccgctgctgt tactgctgtt gcactccatg ctgagtggag cctcgtggcc tttgggacca
     1861 gtcatggctt tggccttttt gactaccagc gcaagagccc tgtgctggcc aggtgtaccc
     1921 ttcaccccaa tgactctctg gccatggagg ggccactgtc ccgggtgaag tccctcaaga
     1981 agtcactgcg acagtcattc cggcgtatcc gcaagagccg tgtctcaggc aaaaaacggg
     2041 ctaccactgc cagcagcaag ttgcaggagg ccaatgcaca gctggcagag cagacatgcc
     2101 cacacgacgt ggagatgaca cctgtgcagc gccgcatcga gcctcgctct gctgatgact
     2161 ccctttctgg tgttgtacgc tgcctctact ttgctgacac attccttcga gatgcgaccc
     2221 accatgggcc caccatgtgg gcaggcacca actcgggctc tgtatttgcc tatgcgctgg
     2281 aggttccagc agccacggca ggtggtgaaa agcggcctga gcaggcagtg gaggctgtgc
     2341 tgggcaagga ggtgcaacta atgcatcggg cacccgtggt ggccattgct gtgttggatg
     2401 gccgtggccg tccgctgcct gagccgtatg aggcttcccg ggacctagca caggcgcctg
     2461 acatgcaagg tgggcatgct gtgctcatcg catctgagga acagttcaag gtattcacac
     2521 tacccaaggt gagtgctaag accaaattca agctgacagc ccacgaaggc tgtcgtgtgc
     2581 ggaaggtagc cctggctaca tttgccagtg tgatatctga ggactatgct gagacctgcc
     2641 ttgcctgcct cactaacctg ggtgatgtcc acgtcttctc ggtgcctggc ctgaggcctc
     2701 aggtgcacta cgcctgtatc cggaaggagg acatcagtgg catcgcttcc tgtgtcttca
     2761 cacgccatgg gcagggcttt tacttgattt ctccatcgga atttgaacgc ttctcactga
     2821 gtgctcgcaa tatcacagaa ccactctgtt ctctggatat cagctggtcc cgaaatgcca
     2881 cccagcccag ccacaggctt caagagtcac ccaagctgag ccaggctaat ggaaccagaa
     2941 acatcattct ggccccagag agctgtgaag gaagcccaag aagccctagc tctgcccaca
     3001 gcaagctcgc tgataccaca gaaccactgg aggccacact ctcgcctgtg tccattgact
     3061 cagctgctag tggggatacc atgctggaca cgacagggga tgtcactgcg gaatatgtga
     3121 aggatttcct tggctctccc gaggactctg agaagaacct gcggaacctg ggagcagatg
     3181 atgctggtcg ggcctacacc cttctgattg aatgaggtgc tgtggggcag cttggcctta
     3241 tcacacagcg gctgccatcc ctccagctgg aaccctggca ggcttctatt atggcatcac
     3301 tcctggaagc ctagcagcct tcctctggct gttaggccta ggagacttag tcatgattat
     3361 cacagttcag tgctagaaag gacctggcct gtcagcattg aagtcctgtg cattagaagg
     3421 ccacctctga ccctgtgggt gtaggtgtag gagttgatgc tcctcttgtt cacagagccc
     3481 atttcacagg agtcactgag gctgataggt cttgcctatt gagccagcac atggaccata
     3541 tgtgccctga ccatatctta ctatggaccc agcctagctg gagactggag ctctctgggc
     3601 cttagtagct agtgcctcag cagcctacat tgggcataga taactaacca taccctcttc
     3661 tacgtggtac cctcctagat ccccagcaag cccatctcag gctgtcactg aaagggcctg
     3721 cctgccctgc gggctggagt agcctgggtt tgctcacctt agtgatcacc atctgtccgt
     3781 cgggcagtct tgccaagccc cttaacactg acccgtctta ctgatgctgg gccctgagca
     3841 cccccagctt taaggtcagc tggagggggt gtgcgaggct cctctctctt gcactccata
     3901 ctgtacttcc tttctcctca agcagagtat ttttctaacg cctggactgc actggccagt
     3961 catttctaaa gcagtttggt acttgctcct ggcctgtgtg tatgcgcatg tgactggaaa
     4021 ctgctgggca tcgtgactga agttggtcat cggggtgtgt gtgtgtgtgt gtgtgtgtgt
     4081 gtgtgtgtgt gtgtgtgtgt gcgcgcgcgc gtgtgcacgt gcacgtgtct ggcagtgagg
     4141 atgggcttcc ctgtagatgc caccttcggc ttttctcttt tttaaaaaac tagttgtttt
     4201 aatattaaaa gtactgattt tttaatattg aaaataaaag catttaatat cttttaaact
     4261 a
//
