LOCUS       NM_001105735            2257 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus lipopolysaccharide-induced TNF factor (Litaf),
            mRNA.
ACCESSION   NM_001105735 XM_001078236 XM_343856
VERSION     NM_001105735.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2257)
  AUTHORS   Qin,W., Wunderley,L., Barrett,A.L., High,S. and Woodman,P.G.
  TITLE     The Charcot Marie Tooth disease protein LITAF is a zinc-binding
            monotopic membrane protein
  JOURNAL   Biochem J 473 (21), 3965-3978 (2016)
   PUBMED   27582497
REFERENCE   2  (bases 1 to 2257)
  AUTHORS   Merrill,J.C., You,J., Constable,C., Leeman,S.E. and Amar,S.
  TITLE     Whole-body deletion of LPS-induced TNF-alpha factor (LITAF)
            markedly improves experimental endotoxic shock and inflammatory
            arthritis
  JOURNAL   Proc Natl Acad Sci U S A 108 (52), 21247-21252 (2011)
   PUBMED   22160695
REFERENCE   3  (bases 1 to 2257)
  AUTHORS   Bixler,G.V., Vanguilder,H.D., Brucklacher,R.M., Kimball,S.R.,
            Bronson,S.K. and Freeman,W.M.
  TITLE     Chronic insulin treatment of diabetes does not fully normalize
            alterations in the retinal transcriptome
  JOURNAL   BMC Med Genomics 4, 40 (2011)
   PUBMED   21575160
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2257)
  AUTHORS   Zhou,J., Yang,Z., Tsuji,T., Gong,J., Xie,J., Chen,C., Li,W.,
            Amar,S. and Luo,Z.
  TITLE     LITAF and TNFSF15, two downstream targets of AMPK, exert inhibitory
            effects on tumor growth
  JOURNAL   Oncogene 30 (16), 1892-1900 (2011)
   PUBMED   21217782
REFERENCE   5  (bases 1 to 2257)
  AUTHORS   Van Kirk,C.A., VanGuilder,H.D., Young,M., Farley,J.A., Sonntag,W.E.
            and Freeman,W.M.
  TITLE     Age-related alterations in retinal neurovascular and inflammatory
            transcripts
  JOURNAL   Mol Vis 17, 1261-1274 (2011)
   PUBMED   21633715
REFERENCE   6  (bases 1 to 2257)
  AUTHORS   Matsuda,A., Suzuki,Y., Honda,G., Muramatsu,S., Matsuzaki,O.,
            Nagano,Y., Doi,T., Shimotohno,K., Harada,T., Nishida,E., Hayashi,H.
            and Sugano,S.
  TITLE     Large-scale identification and characterization of human genes that
            activate NF-kappaB and MAPK signaling pathways
  JOURNAL   Oncogene 22 (21), 3307-3318 (2003)
   PUBMED   12761501
REFERENCE   7  (bases 1 to 2257)
  AUTHORS   Tang,X., Fenton,M.J. and Amar,S.
  TITLE     Identification and functional characterization of a novel binding
            site on TNF-alpha promoter
  JOURNAL   Proc Natl Acad Sci U S A 100 (7), 4096-4101 (2003)
   PUBMED   12655064
REFERENCE   8  (bases 1 to 2257)
  AUTHORS   Hamano,H., Noguchi,M., Fukui,H., Issiki,A. and Watanabe,Y.
  TITLE     Regulation of brain cell environment on neuronal protection: role
            of TNFalpha in glia cells
  JOURNAL   Life Sci 72 (4-5), 565-574 (2002)
   PUBMED   12467897
  REMARK    GeneRIF: cerebral TNFalpha is mainly produced in glia cells and
            that its production is dependently regulated by each stimulant
REFERENCE   9  (bases 1 to 2257)
  AUTHORS   Moriwaki,Y., Begum,N.A., Kobayashi,M., Matsumoto,M., Toyoshima,K.
            and Seya,T.
  TITLE     Mycobacterium bovis Bacillus Calmette-Guerin and its cell wall
            complex induce a novel lysosomal membrane protein, SIMPLE, that
            bridges the missing link between lipopolysaccharide and
            p53-inducible gene, LITAF(PIG7), and estrogen-inducible gene, EET-1
  JOURNAL   J Biol Chem 276 (25), 23065-23076 (2001)
   PUBMED   11274176
REFERENCE   10 (bases 1 to 2257)
  AUTHORS   Everett,L.M., Li,A., Devaraju,G., Caperell-Grant,A. and Bigsby,R.M.
  TITLE     A novel estrogen-enhanced transcript identified in the rat uterus
            by differential display
  JOURNAL   Endocrinology 138 (9), 3836-3841 (1997)
   PUBMED   9275072
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Nov 24, 2020 this sequence version replaced NM_001105735.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U53184.1, DV216106.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-59                JAXUCZ010000010.1  5163258-5163316
            60-284              JAXUCZ010000010.1  5189962-5190186
            285-441             JAXUCZ010000010.1  5194161-5194317
            442-2257            JAXUCZ010000010.1  5198115-5199930
FEATURES             Location/Qualifiers
     source          1..2257
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q11"
     gene            1..2257
                     /gene="Litaf"
                     /gene_synonym="EET-1; Pig7"
                     /note="lipopolysaccharide-induced TNF factor"
                     /db_xref="GeneID:65161"
                     /db_xref="RGD:69294"
     exon            1..59
                     /gene="Litaf"
                     /gene_synonym="EET-1; Pig7"
                     /inference="alignment:Splign:2.1.0"
     exon            60..284
                     /gene="Litaf"
                     /gene_synonym="EET-1; Pig7"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..550
                     /gene="Litaf"
                     /gene_synonym="EET-1; Pig7"
                     /note="LPS-induced TNF-alpha factor homolog;
                     estrogen-enhanced transcript protein 1;
                     estrogen-responsive uterine transcript; LPS-induced TN
                     factor"
                     /codon_start=1
                     /product="lipopolysaccharide-induced tumor necrosis
                     factor-alpha factor homolog"
                     /protein_id="NP_001099205.1"
                     /db_xref="GeneID:65161"
                     /db_xref="RGD:69294"
                     /translation="MSAPGPYQAAAGPSVMPTAPPTYEETVGVNSYYPTPPAPQPGPA
                     TGLITGPDGKGMNPPSYYTQPVPVPNANAIAVQTVYVQQPISFYDRPIQMCCPSCNKM
                     IVTQLSYNAGALTWLSCGSLCLLGCVAGCCFIPFCVDALQDVDHYCPNCKALLGTYKR
                     L"
     exon            285..441
                     /gene="Litaf"
                     /gene_synonym="EET-1; Pig7"
                     /inference="alignment:Splign:2.1.0"
     exon            442..2257
                     /gene="Litaf"
                     /gene_synonym="EET-1; Pig7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccggcccgc gcgcgcggcc agcgcagacc tcccggctcc actggcggcg cgggcggcgg
       61 taaaatgtcg gctccaggac cttaccaagc agctgcaggc ccttctgtaa tgcctactgc
      121 acccccaacc tatgaagaaa cagtgggtgt caacagttac tacccaacgc ccccagcacc
      181 tcagccggga ccagccacag ggctcattac gggcccggat gggaagggca tgaatccacc
      241 ttcgtactac acccagcccg tgcctgtccc caacgccaac gcaattgcag tgcagacggt
      301 ttatgtgcag cagcccatct ccttctacga ccgccccatc cagatgtgct gtccttcctg
      361 caacaagatg atcgtgaccc agttgtccta caatgcagga gccctcacct ggctctcctg
      421 tggcagtctg tgtctgctgg gatgcgtcgc tggctgctgc ttcattccgt tttgcgtgga
      481 cgccctgcag gatgtggacc attactgccc caactgcaaa gcgctcctgg gcacctacaa
      541 acgtttgtag gactcggcca gccacagggg aggtagacaa gtgctcccgg aagtcaccca
      601 acccttgccc agcgcagcca gaagacgtcc cttccttgat ctcttcatga gctcgtcttc
      661 gtgtctttta gggggtgggg aaagtcggaa aagtaacaaa cccccaaacc cagaaactgc
      721 tgctggagtt gtgccctgca catgcaaaga cgtggacctt gggtgttgct ttaagggttt
      781 accgcctgat ctcgttaccc cactaactgt gattgttact ccatttgcat ctcgtctgct
      841 gatttgccac tgcctgcccc ctcttcctca agaagaggcc ttcctggtgc caggctcaaa
      901 acccgaagct acagtttgcc ttatttttca ctgtttggct tgatctgtac catctctccc
      961 agccctaatg acagagacct tgccttaaag actttgcggt tctgtaattg cagacttctc
     1021 cagcactcag aatcacttta attccataga gttgttcctc tccacacaca cccctccccc
     1081 ggtgcacaga agggctgccg acacccacca gactcataca gagaaggtca caagtactaa
     1141 atgaaaggct cccagcccac cttgtctcag cccctgtcct gtgaagggac tccttcctca
     1201 cacagtttct gtgacttcct tttgttctta aacacatgga agttacttgg cagggagaca
     1261 tttctagaat aatttttgtg atcacgatac acccttcatt ctccgtttgc tggtatgttt
     1321 ttagttggtt tggttttagt tttccacata cagtctagct cgtggccagc cttgagctcc
     1381 gaggagatcc tccatcttct cctctcaaat acccagggcc cagacatttg cctctgcacc
     1441 tgctgggctt tttctctcat ttttccttaa cagaaaaaca aacgggtaat ttcatcgact
     1501 gcctatgtag gtttggtgtg gttttgaaaa ccttgtttcc atggggcccc tttgggggag
     1561 tcagggggcc cctgcacgag cccatgcttc aatgccgaga gattggctgc tggaaccccc
     1621 tgaagcatga tttcatgttt tagagatgag cttctgtggt acggtcatca tggtctccaa
     1681 catcaacaga caaggtagaa ggatgtcaac gacaaagata agttcagggc tctttctagg
     1741 gtcaccactc tgtcctgtgt aacactgaca cagtctggcc agcctttcag gaggtcctgg
     1801 ctccctccta aacccatgta ggatctgctg caagtaacag tgtatgaagt caacctgacc
     1861 tggaacagaa gtctgcatat tggttaagat acagcctatg tatcttcata caacgatcca
     1921 gaagtactag acatcatttt tgcagtgaat tatgggtacc atacatgact ttgatgatat
     1981 ctgcttttaa acaaataaaa tctttgatca ctcagtgaac aattcagttc acctgttagg
     2041 aagaaaggcc ttgtgttgtg tttccaggag ttgcccaaag aatcttgggc tgctctgttc
     2101 cactaggaag tctttcctga cccacctcag gcttcagcca cagcaagatg accgttgcta
     2161 acgagttgca ttcgaaggtt tggcagtcgg agcccatggc tgtcactgat ggcagcaagc
     2221 cacggctttc aagttttaat aaaacgccaa gaagaaa
//
