LOCUS       NM_001108917            1895 bp    mRNA    linear   ROD 02-APR-2024
DEFINITION  Rattus norvegicus lipoyl(octanoyl) transferase 2 (Lipt2), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_001108917 XM_001066655 XM_344924
VERSION     NM_001108917.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1895)
  AUTHORS   Habarou,F., Hamel,Y., Haack,T.B., Feichtinger,R.G., Lebigot,E.,
            Marquardt,I., Busiah,K., Laroche,C., Madrange,M., Grisel,C.,
            Pontoizeau,C., Eisermann,M., Boutron,A., Chretien,D.,
            Chadefaux-Vekemans,B., Barouki,R., Bole-Feysot,C., Nitschke,P.,
            Goudin,N., Boddaert,N., Nemazanyy,I., Delahodde,A., Kolker,S.,
            Rodenburg,R.J., Korenke,G.C., Meitinger,T., Strom,T.M.,
            Prokisch,H., Rotig,A., Ottolenghi,C., Mayr,J.A. and de Lonlay,P.
  TITLE     Biallelic Mutations in LIPT2 Cause a Mitochondrial Lipoylation
            Defect Associated with Severe Neonatal Encephalopathy
  JOURNAL   Am J Hum Genet 101 (2), 283-290 (2017)
   PUBMED   28757203
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473956.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_344924.3, XM_001066655.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FM062603.1, CB577976.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1895
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..1895
                     /gene="Lipt2"
                     /gene_synonym="RGD1305211"
                     /note="lipoyl(octanoyl) transferase 2"
                     /db_xref="GeneID:365314"
                     /db_xref="RGD:1305211"
     exon            1..471
                     /gene="Lipt2"
                     /gene_synonym="RGD1305211"
                     /inference="alignment:Splign:2.1.0"
     CDS             6..701
                     /gene="Lipt2"
                     /gene_synonym="RGD1305211"
                     /EC_number="2.3.1.181"
                     /note="putative lipoyltransferase 2, mitochondrial;
                     lipoyl(octanoyl) transferase 2 (putative)"
                     /codon_start=1
                     /product="octanoyl-[acyl-carrier-protein]:protein
                     N-octanoyltransferase LIPT2, mitochondrial"
                     /protein_id="NP_001102387.1"
                     /db_xref="GeneID:365314"
                     /db_xref="RGD:1305211"
                     /translation="MSLPAVRLLWLGRVHYSELLELQEHWLRQLQADPRPRTLSGTKA
                     GVLLVCEPAGPVYTGGLRGGLTPEETMRLRALGAEVRATGRGGLATFHGPGQLLCHPV
                     LDLRLLGLRLRTHVAALEACAVRLCELRGLRGARARPPPYTGVWLGERKICAIGVRCG
                     RHITSHGLALNCSTDLTWFEHIVPCGLVGTGVTSLSEALQRLVTVDEVMPSFLVAFKE
                     TFKCTLISEDRPS"
     exon            472..1895
                     /gene="Lipt2"
                     /gene_synonym="RGD1305211"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgcaatgtc gcttcccgcc gtccggctgc tttggctcgg gagggtgcac tactctgagt
       61 tgctggagct gcaggagcat tggctacggc agctacaggc cgaccctcgc ccccggaccc
      121 tgtcggggac caaagcgggc gtgctcttgg tctgcgagcc agcggggcca gtgtacacgg
      181 gcgggctacg cggcggcctg acacccgagg agactatgcg gctgagggcc ctgggagctg
      241 aggtgcgcgc cacgggccgc ggcggcctgg ccactttcca cggcccggga cagctgctct
      301 gccacccggt gcttgacctg cggcttctag gcctgcgcct gcgcacccac gtggcggcgc
      361 tggaggcgtg cgctgtgcgt ctgtgcgagc tccggggcct gcggggcgcc cgcgcgcggc
      421 cgccgcccta tactggcgtc tggctaggcg agcgcaagat ctgcgctatc ggagtccgct
      481 gtggaagaca catcacatcc cacggcctgg ctctgaattg ttctaccgac ctcacgtggt
      541 ttgagcacat cgtgccttgt ggactggttg ggactggagt cacttcactg agtgaggcac
      601 ttcagagact cgtcactgtg gatgaagtaa tgccatcttt ccttgtggcc ttcaaggaga
      661 ctttcaagtg cacgttaatc tcagaggaca ggcccagctg aaggacattc attcacctta
      721 gcctgggatg acggttctgc aatggaaagc ttctagtccg agtccctaga actactcttt
      781 gatttttctg accatgactg aggacagatc ctgagctatt gctgccgtat ctctccccac
      841 ctacctcagg ggtcgttatg gaaacactat gagaagtcac atgctacgta aagcatccct
      901 gtgacctgtt aacggagaca ctccagtgtt attataaact gccatttcct aattacttgc
      961 tactttttca gtgctgtatc taacagcaat tttggttgtt aggtctttga gttgcgtggg
     1021 aaccaaatct ctgtgaagag ataaagttac tttgttctca aaaaaaaaaa aaaaaaaaaa
     1081 acaacctgga tcttccttca ataaagggga aagcctcttc aaaaaatata tatttttttg
     1141 cctttctggg ttgaatgcct caaatttgat aattttacct gtttttgctt aaggtcaaca
     1201 gagatgggtt aaaggctttg taaagacaag agtataccct cattgagtac aaaggctata
     1261 gaggaaaggt ttccctaaat gggatccctg gttctgcatg aaggtcaagt ctgctaagaa
     1321 gaagaaactt ttgtgattcg agacagccaa ggaacacatt agctcaattc ttatggatca
     1381 ggaatttgga agaaatgtac ctaggttggt tggagtctta ccagagcttc catttaaagg
     1441 tgtcggttgt cattaggagg cttagctgtt gctgggaggt caatgtccaa aatggatgga
     1501 tcactccatt gtgcttgctt gcttgcttct agttgtcaat gagaagcctc agttctttac
     1561 catgcacact cttctgtaag gcggcagtga tattagaagg gctataggag ctctcatgtc
     1621 ttttatgagc tagctgtgga agtcacacat tcctttctgt agtctcccag atgagcctca
     1681 ttcagagcaa aaggaatatc ccattcactg caagagatgg agtttttagg agccatcttg
     1741 gttttgtcct cctagcttat gaaaggtaga gctttggctg aggctctggt ccacacttgg
     1801 agctgtggaa gtaagttatt tccctctctg ggcttcagtg ctgttcacac tgtatttccc
     1861 aggagcctca taaaaaggct ttaatggtta gtttt
//
