LOCUS       NM_001012741            1865 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus lipase G, endothelial type (Lipg), mRNA.
ACCESSION   NM_001012741 XM_225720
VERSION     NM_001012741.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1865)
  AUTHORS   Essalmani,R., Susan-Resiga,D., Chamberland,A., Asselin,M.C.,
            Canuel,M., Constam,D., Creemers,J.W., Day,R., Gauthier,D., Prat,A.
            and Seidah,N.G.
  TITLE     Furin is the primary in vivo convertase of angiopoietin-like 3 and
            endothelial lipase in hepatocytes
  JOURNAL   J Biol Chem 288 (37), 26410-26418 (2013)
   PUBMED   23918928
REFERENCE   2  (bases 1 to 1865)
  AUTHORS   Wu,X., Huang,H., Tang,F., Le,K., Xu,S. and Liu,P.
  TITLE     Regulated expression of endothelial lipase in atherosclerosis
  JOURNAL   Mol Cell Endocrinol 315 (1-2), 233-238 (2010)
   PUBMED   19931348
  REMARK    GeneRIF: Data show that endothelial lipase (EL) was upregulated in
            rat atherosclerosis and taht lipopolysaccharide stimulates EL
            expression in vitro through NFkappaB activation.
REFERENCE   3  (bases 1 to 1865)
  AUTHORS   Griffon,N., Jin,W., Petty,T.J., Millar,J., Badellino,K.O.,
            Saven,J.G., Marchadier,D.H., Kempner,E.S., Billheimer,J.,
            Glick,J.M. and Rader,D.J.
  TITLE     Identification of the active form of endothelial lipase, a
            homodimer in a head-to-tail conformation
  JOURNAL   J Biol Chem 284 (35), 23322-23330 (2009)
   PUBMED   19567873
REFERENCE   4  (bases 1 to 1865)
  AUTHORS   Nijstad,N., Wiersma,H., Gautier,T., van der Giet,M., Maugeais,C.
            and Tietge,U.J.
  TITLE     Scavenger receptor BI-mediated selective uptake is required for the
            remodeling of high density lipoprotein by endothelial lipase
  JOURNAL   J Biol Chem 284 (10), 6093-6100 (2009)
   PUBMED   19136670
REFERENCE   5  (bases 1 to 1865)
  AUTHORS   Jin,W., Wang,X., Millar,J.S., Quertermous,T., Rothblat,G.H.,
            Glick,J.M. and Rader,D.J.
  TITLE     Hepatic proprotein convertases modulate HDL metabolism
  JOURNAL   Cell Metab 6 (2), 129-136 (2007)
   PUBMED   17681148
REFERENCE   6  (bases 1 to 1865)
  AUTHORS   Bonne,A.C., Den Bieman,M.G., Van Lith,H.A. and Van Zutphen,B.F.
  TITLE     Sequencing and chromosomal assignment of the rat
            endothelial-derived lipase gene (Lipg)
  JOURNAL   DNA Seq 12 (4), 285-287 (2001)
   PUBMED   11924532
REFERENCE   7  (bases 1 to 1865)
  AUTHORS   Stevenson,F.T., Shearer,G.C. and Atkinson,D.N.
  TITLE     Lipoprotein-stimulated mesangial cell proliferation and gene
            expression are regulated by lipoprotein lipase
  JOURNAL   Kidney Int 59 (6), 2062-2068 (2001)
   PUBMED   11380807
REFERENCE   8  (bases 1 to 1865)
  AUTHORS   Hirata,K., Dichek,H.L., Cioffi,J.A., Choi,S.Y., Leeper,N.J.,
            Quintana,L., Kronmal,G.S., Cooper,A.D. and Quertermous,T.
  TITLE     Cloning of a unique lipase from endothelial cells extends the
            lipase gene family
  JOURNAL   J Biol Chem 274 (20), 14170-14175 (1999)
   PUBMED   10318835
REFERENCE   9  (bases 1 to 1865)
  AUTHORS   Jaye,M., Lynch,K.J., Krawiec,J., Marchadier,D., Maugeais,C.,
            Doan,K., South,V., Amin,D., Perrone,M. and Rader,D.J.
  TITLE     A novel endothelial-derived lipase that modulates HDL metabolism
  JOURNAL   Nat Genet 21 (4), 424-428 (1999)
   PUBMED   10192396
REFERENCE   10 (bases 1 to 1865)
  AUTHORS   Peinado-Onsurbe,J., Soler,C., Galan,X., Poveda,B., Soley,M.,
            Llobera,M. and Ramirez,I.
  TITLE     Involvement of catecholamines in the effect of fasting on hepatic
            endothelial lipase activity in the rat
  JOURNAL   Endocrinology 129 (5), 2599-2606 (1991)
   PUBMED   1935790
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Dec 7, 2020 this sequence version replaced NM_001012741.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY916123.1, SRR26643297.50654.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676785 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-373               JAXUCZ010000018.1  70810887-70811259   c
            374-561             JAXUCZ010000018.1  70807016-70807203   c
            562-741             JAXUCZ010000018.1  70805213-70805392   c
            742-853             JAXUCZ010000018.1  70803895-70804006   c
            854-1075            JAXUCZ010000018.1  70797529-70797750   c
            1076-1318           JAXUCZ010000018.1  70796361-70796603   c
            1319-1439           JAXUCZ010000018.1  70795602-70795722   c
            1440-1658           JAXUCZ010000018.1  70794391-70794609   c
            1659-1763           JAXUCZ010000018.1  70792063-70792167   c
            1764-1865           JAXUCZ010000018.1  70790077-70790178   c
FEATURES             Location/Qualifiers
     source          1..1865
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18q12.2"
     gene            1..1865
                     /gene="Lipg"
                     /gene_synonym="lipase"
                     /note="lipase G, endothelial type"
                     /db_xref="GeneID:291437"
                     /db_xref="RGD:1310740"
     exon            1..373
                     /gene="Lipg"
                     /gene_synonym="lipase"
                     /inference="alignment:Splign:2.1.0"
     CDS             277..1758
                     /gene="Lipg"
                     /gene_synonym="lipase"
                     /EC_number="3.1.1.3"
                     /EC_number="3.1.1.32"
                     /note="endothelial lipase; endothelial-derived lipase;
                     EDL; lipase, endothelial; phospholipase A1"
                     /codon_start=1
                     /product="endothelial lipase precursor"
                     /protein_id="NP_001012759.1"
                     /db_xref="GeneID:291437"
                     /db_xref="RGD:1310740"
                     /translation="MRDPVFLLGFWSLYCCFPAGSLTTLRPQGSLRDEHHKPTGVPVT
                     ITTKPSVTFNIRTSKDPEHEGCNLSLGDSKLLENCGFNMTAKTFFIIHGWTMSGMFES
                     WLHKLVSALQTREKEANVVVVDWLPLAHQLYIDAVSNTRVVGRRVAGMLNWLQEKGEF
                     SLGDVHLIGYSLGAHVAGYAGNFVKGTVGRITGLDPAGPMFEGVDINRRLSPDDADFV
                     DVLHTYTLSFGLSIGIRMPVGHIDIYPNGGDFQPGCGFNDVMGSFAYGTISEMVKCEH
                     ERAVHLFVDSLVNQDKPSFAFQCTDPNRFKRGICLSCRKNRCNNIGYNAKKMRKKRNS
                     KMYLKTRAGMPFRVYHYQLKVHMFSYKNSGDIQPDLYITLYGSNADSQNLPLEIVEKI
                     ELNATNTFLVYTEEYLGDLFKIRLTWEGVSSSWYNLWNEFRSYLSQPSSPSRELHIRR
                     IRVKSGETQRKVAFCVQDPMKNSISPGQELWFYKCQNDCRVKN"
     exon            374..561
                     /gene="Lipg"
                     /gene_synonym="lipase"
                     /inference="alignment:Splign:2.1.0"
     exon            562..741
                     /gene="Lipg"
                     /gene_synonym="lipase"
                     /inference="alignment:Splign:2.1.0"
     exon            742..853
                     /gene="Lipg"
                     /gene_synonym="lipase"
                     /inference="alignment:Splign:2.1.0"
     exon            854..1075
                     /gene="Lipg"
                     /gene_synonym="lipase"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1318
                     /gene="Lipg"
                     /gene_synonym="lipase"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..1439
                     /gene="Lipg"
                     /gene_synonym="lipase"
                     /inference="alignment:Splign:2.1.0"
     exon            1440..1658
                     /gene="Lipg"
                     /gene_synonym="lipase"
                     /inference="alignment:Splign:2.1.0"
     exon            1659..1763
                     /gene="Lipg"
                     /gene_synonym="lipase"
                     /inference="alignment:Splign:2.1.0"
     exon            1764..1865
                     /gene="Lipg"
                     /gene_synonym="lipase"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgacagcgg cgagtcccgg cttcactgca ggtccgggcg aggacaggtc gagctgggca
       61 gcgtgtccct ccacccgctc cctttccccc tcgccgctcg cagcgctacc aaccttccag
      121 gttgtaactt ctgctcccgc tgcccacccc atcaccttct ggccgggacc cggcctgtcc
      181 acttctaggc tcaggaggtt ttagtggctt caaaacaaaa caaaacccca aaccaaaaaa
      241 aaacctgctt gagaggaggg ggcgtggcgg ggaaggatgc gagacccggt tttcctgctc
      301 ggcttctgga gcctctattg ttgcttcccg gcgggaagtc tcacaacctt acgtccccag
      361 gggtcgctgc gagatgagca ccataaaccc accggagtac cagttaccat taccaccaaa
      421 ccctcggtga cttttaacat ccgcacttct aaggacccag agcacgaagg gtgtaatctc
      481 tcccttggtg acagcaaact cttagaaaac tgtggcttca acatgacagc caaaaccttc
      541 ttcatcattc atggatggac gatgagtggc atgtttgaaa gctggctgca taaactcgtg
      601 tcagccctgc agacgagaga gaaagaggca aacgtagtgg tggttgactg gctgcccctg
      661 gctcaccagc tgtacataga tgccgtcagt aacaccagag tggtgggacg tagagtggct
      721 gggatgctaa actggctgca ggagaaggga gagttttctc ttggggatgt tcacttgatt
      781 ggctacagcc tgggagcaca cgtggctgga tacgctggca actttgtgaa gggaacagtg
      841 ggcaggatca ctggattgga tcccgccgga cccatgtttg aaggggtgga catcaacagg
      901 aggctgtccc cggacgatgc ggactttgtg gatgtcctgc atacctacac gctgtctttt
      961 ggcttgagca ttgggattcg gatgcccgtg ggtcacattg acatctatcc caatggtggt
     1021 gacttccagc ccggctgcgg attcaacgat gtcatgggat ctttcgcgta tggaacaatc
     1081 tcagagatgg tgaaatgtga gcacgagcga gccgtacacc tctttgtcga ttctctggtg
     1141 aatcaggaca agccgagctt cgctttccag tgcacggacc ccaaccgctt caaaaggggc
     1201 atttgtctca gctgcaggaa gaaccgttgt aacaacattg gctacaatgc taagaaaatg
     1261 agaaagaaga ggaatagcaa gatgtattta aaaacccggg cgggcatgcc tttcagagtt
     1321 taccattatc agctgaaagt tcacatgttc tcttacaaga acagcggaga catccagccc
     1381 gacctctaca ttaccctgta tggtagcaac gcagactccc agaacctgcc cttggagatc
     1441 gtggagaaga ttgagctgaa tgccacaaac accttcctgg tctacactga ggagtacttg
     1501 ggtgatctct tcaagatcag acttacctgg gagggagtat ccagttcctg gtacaacctg
     1561 tggaatgagt ttcgtagcta cctgtcacaa cccagcagcc cctcgaggga gctgcacatc
     1621 cgacgaatcc gtgtcaagtc tggggaaacc cagcgaaaag tggcattttg cgttcaagac
     1681 cctatgaaga atagcatctc ccctggccag gagctgtggt tttacaagtg tcagaatgac
     1741 tgtagagtga aaaactaaac cagtcccttt gtggagctgg cctgagggcc caagaagtcc
     1801 tgatgtccac acccacaccc tactgtccat atacatggag gaacgttact gctgaagacc
     1861 cactg
//
