LOCUS       NM_017341               1377 bp    mRNA    linear   ROD 19-AUG-2024
DEFINITION  Rattus norvegicus lipase F, gastric type (Lipf), mRNA.
ACCESSION   NM_017341
VERSION     NM_017341.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1377)
  AUTHORS   Lemarie,F., Cavalier,J.F., Garcia,C., Boissel,F., Point,V.,
            Catheline,D., Legrand,P., Carriere,F. and Rioux,V.
  TITLE     Effect of preduodenal lipase inhibition in suckling rats on dietary
            octanoic acid (C8:0) gastric absorption and plasma octanoylated
            ghrelin concentration
  JOURNAL   Biochim Biophys Acta 1861 (9 Pt A), 1111-1120 (2016)
   PUBMED   27317984
  REMARK    GeneRIF: Lipase inhibition did not modify plasma octanoylated
            ghrelin concentration.
REFERENCE   2  (bases 1 to 1377)
  AUTHORS   Chow,K.M., Ma,Z., Cai,J., Pierce,W.M. and Hersh,L.B.
  TITLE     Nardilysin facilitates complex formation between mitochondrial
            malate dehydrogenase and citrate synthase
  JOURNAL   Biochim Biophys Acta 1723 (1-3), 292-301 (2005)
   PUBMED   15809022
REFERENCE   3  (bases 1 to 1377)
  AUTHORS   Kawai,T. and Fushiki,T.
  TITLE     Importance of lipolysis in oral cavity for orosensory detection of
            fat
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 285 (2), R447-R454 (2003)
   PUBMED   12702486
  REMARK    GeneRIF: significance of lingual lipase in the perception of a fat
            taste by using orlistat, a potent lipase inhibitor
REFERENCE   4  (bases 1 to 1377)
  AUTHORS   Roussel,A., Miled,N., Berti-Dupuis,L., Riviere,M., Spinelli,S.,
            Berna,P., Gruber,V., Verger,R. and Cambillau,C.
  TITLE     Crystal structure of the open form of dog gastric lipase in complex
            with a phosphonate inhibitor
  JOURNAL   J Biol Chem 277 (3), 2266-2274 (2002)
   PUBMED   11689574
REFERENCE   5  (bases 1 to 1377)
  AUTHORS   Roussel,A., Canaan,S., Egloff,M.P., Riviere,M., Dupuis,L.,
            Verger,R. and Cambillau,C.
  TITLE     Crystal structure of human gastric lipase and model of lysosomal
            acid lipase, two lipolytic enzymes of medical interest
  JOURNAL   J Biol Chem 274 (24), 16995-17002 (1999)
   PUBMED   10358049
REFERENCE   6  (bases 1 to 1377)
  AUTHORS   Carriere,F., Raphel,V., Moreau,H., Bernadac,A., Devaux,M.A.,
            Grimaud,R., Barrowman,J.A., Benicourt,C., Junien,J.L., Laugier,R.
            et al.
  TITLE     Dog gastric lipase: stimulation of its secretion in vivo and
            cytolocalization in mucous pit cells
  JOURNAL   Gastroenterology 102 (5), 1535-1545 (1992)
   PUBMED   1568562
REFERENCE   7  (bases 1 to 1377)
  AUTHORS   Carriere,F., Moreau,H., Raphel,V., Laugier,R., Benicourt,C.,
            Junien,J.L. and Verger,R.
  TITLE     Purification and biochemical characterization of dog gastric lipase
  JOURNAL   Eur J Biochem 202 (1), 75-83 (1991)
   PUBMED   1935982
REFERENCE   8  (bases 1 to 1377)
  AUTHORS   Rogalska,E., Ransac,S. and Verger,R.
  TITLE     Stereoselectivity of lipases. II. Stereoselective hydrolysis of
            triglycerides by gastric and pancreatic lipases
  JOURNAL   J Biol Chem 265 (33), 20271-20276 (1990)
   PUBMED   2243091
REFERENCE   9  (bases 1 to 1377)
  AUTHORS   Docherty,A.J., Bodmer,M.W., Angal,S., Verger,R., Riviere,C.,
            Lowe,P.A., Lyons,A., Emtage,J.S. and Harris,T.J.
  TITLE     Molecular cloning and nucleotide sequence of rat lingual lipase
            cDNA
  JOURNAL   Nucleic Acids Res 13 (6), 1891-1903 (1985)
   PUBMED   3839077
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1, X02309.1 and AA998080.1.
            
            On Mar 24, 2010 this sequence version replaced NM_017341.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X02309.1, CF111067.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN14984027
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                JAXUCZ010000001.1  240906706-240906741
            37-1354             X02309.1           38-1355
            1355-1377           AA998080.1         1-23                c
FEATURES             Location/Qualifiers
     source          1..1377
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q52"
     gene            1..1377
                     /gene="Lipf"
                     /gene_synonym="RNLIP; Rnlp"
                     /note="lipase F, gastric type"
                     /db_xref="GeneID:50682"
                     /db_xref="RGD:708441"
     exon            1..36
                     /gene="Lipf"
                     /gene_synonym="RNLIP; Rnlp"
                     /inference="alignment:Splign:2.1.0"
     exon            37..149
                     /gene="Lipf"
                     /gene_synonym="RNLIP; Rnlp"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..1235
                     /gene="Lipf"
                     /gene_synonym="RNLIP; Rnlp"
                     /EC_number="3.1.1.3"
                     /note="gastric triacylglycerol lipase; prelingual lipase;
                     GL; gastric lipase; lingual lipase; lipase, gastric"
                     /codon_start=1
                     /product="gastric triacylglycerol lipase precursor"
                     /protein_id="NP_059037.1"
                     /db_xref="GeneID:50682"
                     /db_xref="RGD:708441"
                     /translation="MWLLLITSVISTFGGAHGLFGKLGPGNPEANMNISQMITYWGYP
                     CQEYEVVTEDGYILGVYRIPHGKNNSENIGKRPVVYLQHGLIASATNWIANLPNNSLA
                     FMLADAGYDVWLGNSRGNTWSRKNVYYSPDSVEFWAFSFDEMAKYDLPATINFIVQKT
                     GQEKIHYVGHSQGTTIGFIAFSTNPTLAKKIKTFYALAPVATVKYTQSPLKKISFIPT
                     FLFKLMFGKKMFLPHTYFDDFLGTEVCSREVLDLLCSNTLFIFCGFDKKNLNVSRFDV
                     YLGHNPAGTSVQDFLHWAQLVRSGKFQAFNWGSPSQNMLHYNQKTPPEYDVSAMTVPV
                     AVWNGGNDILADPQDVAMLLPKLSNLLFHKEILAYNHLDFIWAMDAPQEVYNEMISMM
                     AED"
     exon            150..267
                     /gene="Lipf"
                     /gene_synonym="RNLIP; Rnlp"
                     /inference="alignment:Splign:2.1.0"
     exon            268..466
                     /gene="Lipf"
                     /gene_synonym="RNLIP; Rnlp"
                     /inference="alignment:Splign:2.1.0"
     exon            467..576
                     /gene="Lipf"
                     /gene_synonym="RNLIP; Rnlp"
                     /inference="alignment:Splign:2.1.0"
     exon            577..713
                     /gene="Lipf"
                     /gene_synonym="RNLIP; Rnlp"
                     /inference="alignment:Splign:2.1.0"
     exon            714..860
                     /gene="Lipf"
                     /gene_synonym="RNLIP; Rnlp"
                     /inference="alignment:Splign:2.1.0"
     exon            861..932
                     /gene="Lipf"
                     /gene_synonym="RNLIP; Rnlp"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1004
                     /gene="Lipf"
                     /gene_synonym="RNLIP; Rnlp"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1360
                     /gene="Lipf"
                     /gene_synonym="RNLIP; Rnlp"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caaccagaga agcagaatct tgtttctgag ggcactagca gtacaagatg tggctgttat
       61 taataacaag tgtgatatca acattcggag gtgcacatgg cctatttgga aaactgggtc
      121 ctggaaaccc tgaagcaaat atgaatatta gtcagatgat aacttactgg ggatatccat
      181 gtcaagaata tgaagttgtt actgaagatg gctacattct gggggtctac agaattcctc
      241 atgggaagaa taattctgaa aatataggca agagacctgt ggtgtatttg cagcatggtt
      301 tgatcgcatc agccacaaac tggattgcaa atctaccaaa caacagcctg gcctttatgc
      361 tagcagacgc tggctatgat gtgtggctgg ggaacagtcg aggaaataca tggtccagga
      421 aaaatgtata ctactcacca gactcagttg aattctgggc tttcagcttt gatgaaatgg
      481 ctaaatatga ccttcccgcc acaataaact tcattgtaca gaaaactgga caagagaaga
      541 tacactatgt tggtcattct cagggcacca ctattggttt cattgccttt tctaccaatc
      601 ctacactggc caaaaaaatc aagacgtttt atgcattagc tccagttgct accgtgaagt
      661 atacacaaag tcccttgaaa aagatttcat ttattcctac atttcttttc aagcttatgt
      721 ttggcaagaa aatgttcctg ccccacacct actttgatga ctttcttggt accgaagtgt
      781 gctcacggga ggttctagat cttctctgca gcaacacttt attcatcttc tgtggatttg
      841 acaagaaaaa cttaaatgtg agtcgttttg atgtgtatct agggcataat ccagcaggga
      901 catctgttca agactttctc cactgggcac agcttgttag atctgggaaa tttcaagcct
      961 tcaactgggg aagcccatcc cagaacatgt tacactacaa ccagaaaacg cctcctgaat
     1021 atgatgtgtc agccatgact gtgccagttg cagtgtggaa cggtggcaat gacatcctgg
     1081 ctgatcccca agatgtcgcc atgctgcttc ccaaactctc caacctcctg ttccataagg
     1141 agattcttgc ctacaatcac ctggacttca tctgggcaat ggatgcccct caagaggttt
     1201 acaatgagat gatttccatg atggcagaag actaaaagaa tcaattatcc acatccattc
     1261 caaaatcttt tcccctttca tacagttttt ccagtgttta aaaatgtaat acatattact
     1321 gtaattttga ctttagaaat atattggcat cagcaaagtt aaaaaaaaaa aaaaaaa
//
