LOCUS       NM_012859               3704 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus lipase E, hormone sensitive type (Lipe), mRNA.
ACCESSION   NM_012859 XM_346538
VERSION     NM_012859.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3704)
  AUTHORS   Shajari,S., Saeed,A., Smith-Cortinez,N.F., Heegsma,J., Sydor,S. and
            Faber,K.N.
  TITLE     Hormone-sensitive lipase is a retinyl ester hydrolase in human and
            rat quiescent hepatic stellate cells
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1864 (9), 1258-1267
            (2019)
   PUBMED   31150775
  REMARK    GeneRIF: HSL regulates vitamin A metabolism in quiescent hepatic
            stellate cells.
REFERENCE   2  (bases 1 to 3704)
  AUTHORS   Gertz,K., Uhlemann,R., Foryst-Ludwig,A., Barrientos,R.M.,
            Kappert,K., Thone-Reineke,C., Djoufack,P., Kirschbaum,C.,
            Fink,K.B., Heinz,A., Kintscher,U., Endres,M. and Kronenberg,G.
  TITLE     The cytoskeleton in 'couch potato-ism': Insights from a murine
            model of impaired actin dynamics
  JOURNAL   Exp Neurol 306, 34-44 (2018)
   PUBMED   29684438
REFERENCE   3  (bases 1 to 3704)
  AUTHORS   Ogasawara,J., Izawa,T., Sakurai,T., Shirato,K., Ishibashi,Y.,
            Ohira,Y., Ishida,H., Ohno,H. and Kizaki,T.
  TITLE     Habitual exercise training acts as a physiological stimulator for
            constant activation of lipolytic enzymes in rat primary white
            adipocytes
  JOURNAL   Biochem Biophys Res Commun 464 (1), 348-353 (2015)
   PUBMED   26141235
  REMARK    GeneRIF: Habitual exercise training acts as a physiological
            stimulator for constant activation of lipolytic enzymes, HSL and
            ATGL, in rat primary white adipocytes.
REFERENCE   4  (bases 1 to 3704)
  AUTHORS   Stelmanska,E., Szrok,S. and Swierczynski,J.
  TITLE     Progesterone-induced down-regulation of hormone sensitive lipase
            (Lipe) and up-regulation of G0/G1 switch 2 (G0s2) genes expression
            in inguinal adipose tissue of female rats is reflected by
            diminished rate of lipolysis
  JOURNAL   J Steroid Biochem Mol Biol 147, 31-39 (2015)
   PUBMED   25448749
  REMARK    GeneRIF: The findings suggest that progesterone, acting in a
            progesterone receptor-dependent manner, down-regulates Lipe gene
            expression but exerts no effect on Pnpla2 gene expression in the
            inguinal white adipose tissue of females.
REFERENCE   5  (bases 1 to 3704)
  AUTHORS   Macpherson,R.E., Vandenboom,R., Roy,B.D. and Peters,S.J.
  TITLE     Skeletal muscle PLIN3 and PLIN5 are serine phosphorylated at rest
            and following lipolysis during adrenergic or contractile
            stimulation
  JOURNAL   Physiol Rep 1 (4), e00084 (2013)
   PUBMED   24303154
REFERENCE   6  (bases 1 to 3704)
  AUTHORS   Jansa,P., Mason,S.W., Hoffmann-Rohrer,U. and Grummt,I.
  TITLE     Cloning and functional characterization of PTRF, a novel protein
            which induces dissociation of paused ternary transcription
            complexes
  JOURNAL   EMBO J 17 (10), 2855-2864 (1998)
   PUBMED   9582279
REFERENCE   7  (bases 1 to 3704)
  AUTHORS   Wei,S., Lai,K., Patel,S., Piantedosi,R., Shen,H., Colantuoni,V.,
            Kraemer,F.B. and Blaner,W.S.
  TITLE     Retinyl ester hydrolysis and retinol efflux from BFC-1beta
            adipocytes
  JOURNAL   J Biol Chem 272 (22), 14159-14165 (1997)
   PUBMED   9162045
REFERENCE   8  (bases 1 to 3704)
  AUTHORS   Holst,L.S., Langin,D., Mulder,H., Laurell,H., Grober,J., Bergh,A.,
            Mohrenweiser,H.W., Edgren,G. and Holm,C.
  TITLE     Molecular cloning, genomic organization, and expression of a
            testicular isoform of hormone-sensitive lipase
  JOURNAL   Genomics 35 (3), 441-447 (1996)
   PUBMED   8812477
REFERENCE   9  (bases 1 to 3704)
  AUTHORS   Holm,C., Kirchgessner,T.G., Svenson,K.L., Lusis,A.J., Belfrage,P.
            and Schotz,M.C.
  TITLE     Nucleotide sequence of rat adipose hormone sensitive lipase cDNA
  JOURNAL   Nucleic Acids Res 16 (20), 9879 (1988)
   PUBMED   3186461
REFERENCE   10 (bases 1 to 3704)
  AUTHORS   Fredrikson,G. and Belfrage,P.
  TITLE     Positional specificity of hormone-sensitive lipase from rat adipose
            tissue
  JOURNAL   J Biol Chem 258 (23), 14253-14256 (1983)
   PUBMED   6643478
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from U40001.1.
            
            On Dec 17, 2003 this sequence version replaced XM_346538.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U40001.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3704
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..3704
                     /gene="Lipe"
                     /gene_synonym="HSL; REH"
                     /note="lipase E, hormone sensitive type"
                     /db_xref="GeneID:25330"
                     /db_xref="RGD:3010"
     exon            1..1073
                     /gene="Lipe"
                     /gene_synonym="HSL; REH"
                     /inference="alignment:Splign:2.1.0"
     CDS             194..3400
                     /gene="Lipe"
                     /gene_synonym="HSL; REH"
                     /EC_number="3.1.1.79"
                     /EC_number="3.1.1.23"
                     /note="lipase, hormone sensitive; retinyl ester hydrolase;
                     monoacylglycerol lipase LIPE"
                     /codon_start=1
                     /product="hormone-sensitive lipase"
                     /protein_id="NP_036991.1"
                     /db_xref="GeneID:25330"
                     /db_xref="RGD:3010"
                     /translation="MKPRRPISFTREITAMEPSSTSVSRPEWRPEAQQTLTDYPGSRE
                     LQEFGIPQKQSLPNEATAQQGAEFQQEQGVQQSTLLQKLLTPLAFPVPQQSFPSHKVH
                     SDQQEATSQNGPGAGKVHTTQKELEHRDEHVGTAESGPAEPPPATEVEATSIAQAVSG
                     PDKKLPTQTDLVSQERAEQSDPTAQQTPLVQGVKSDQGSLIESGILARLQKLAIQQPS
                     QEWKTFLDCVTESDMEKYLNSSSKSNPPEPSGGTVIPGTLPSKQKPDCGKMSGYGGKL
                     PHGKKGILQKHKHYWDTASAFSHSMDLRTMTQSLVALAEDNMAFFSSQGPGETARRLS
                     NVFAGVREQALGLEPTLGQLLGVAHHFDLDTETPANGYRSLVHTARCCLAHLLHKSRY
                     VASNRRSIFFRASHNLAELEAYLAALTQLRALAYYAQRLLTINRPGVLFFEGDEGLSA
                     DFLQDYVTLHKGCFYGRCLGFQFTPAIRPFLQTLSIGLVSFGEHYKRNETGLSVTASS
                     LFTGGRFAIDPELRGAEFERIIQNLDVHFWKAFWNITEIEVLSSLANMASTTVRVSRL
                     LSLPPEAFEMPLTSDPKLTVTISPPLAHTGPGPVLARLISYDLREGQDSKMLNSLAKS
                     EGPRLELRPRPQQAPRSRALVVHIHGGGFVAQTSKSHEPYLKNWAQELGVPIISIDYS
                     LAPEAPFPRALEECFFAYCWAVKHCELLGSTGERICLAGDSAGGNLCITVSLRAAAYG
                     VRVPDGIMAAYPVTTLQSSASPSRLLSLMDPLLPLSVLSKCVSAYSGTETEDHFDSDQ
                     KALGVMGLVQRDTSLFLRDLRLGASSWLNSFLELSGRKPHKTPLPATETLRPTDSGRL
                     TESMRRSVSEAALAQPEGLLGTDSLKKLTIKDLSFKGNSEPSDSPEMSQSMETLGPST
                     PSDVNFFLRSGNSQEEAETRDDISPMDGIPRVRAAFPDGFHPRRSSQGVLHMPLYSSP
                     IVKNPFMSPLLAPDVMLKTLPPVHLVACALDPMLDDSVMFARRLKDLGQPVTLKVVED
                     LPHGFLSLAALCRETRQAAELCVQRIRLILTPPAAPLT"
     exon            1074..1609
                     /gene="Lipe"
                     /gene_synonym="HSL; REH"
                     /inference="alignment:Splign:2.1.0"
     exon            1610..1700
                     /gene="Lipe"
                     /gene_synonym="HSL; REH"
                     /inference="alignment:Splign:2.1.0"
     exon            1701..1846
                     /gene="Lipe"
                     /gene_synonym="HSL; REH"
                     /inference="alignment:Splign:2.1.0"
     exon            1847..2032
                     /gene="Lipe"
                     /gene_synonym="HSL; REH"
                     /inference="alignment:Splign:2.1.0"
     exon            2033..2324
                     /gene="Lipe"
                     /gene_synonym="HSL; REH"
                     /inference="alignment:Splign:2.1.0"
     exon            2325..2552
                     /gene="Lipe"
                     /gene_synonym="HSL; REH"
                     /inference="alignment:Splign:2.1.0"
     exon            2553..2729
                     /gene="Lipe"
                     /gene_synonym="HSL; REH"
                     /inference="alignment:Splign:2.1.0"
     exon            2730..3187
                     /gene="Lipe"
                     /gene_synonym="HSL; REH"
                     /inference="alignment:Splign:2.1.0"
     exon            3188..3704
                     /gene="Lipe"
                     /gene_synonym="HSL; REH"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tagccctaac ccctctccca aagtaagagg cacagagtga tcacttggcg aggagtgggg
       61 accagcagtg aaaaacccgc ggaccagctc taaagaaaga ccaggaatgc caggacaaaa
      121 gattagagcc caaagggagg tgccatcatg aaagatctgt gaagaggaag cctgaagggt
      181 agggggcaga aggatgaaac ctaggagacc aatttctttc acaagggaaa taacagctat
      241 ggagccaagt tctacctctg tgtctaggcc agaatggaga cctgaggcac agcagaccct
      301 cacagactac ccaggatcaa gggaactgca ggaatttggt atcccacaga aacaaagtct
      361 cccaaatgag gccactgccc agcaaggagc tgaattccag caagaacagg gagttcaaca
      421 atctactctg ctccagaaac ttctcacccc attagccttc cctgtaccac agcaatcatt
      481 cccaagccac aaagtgcact cggatcaaca ggaagccacc tcccagaatg gacctggggc
      541 ggggaaagtg catacaactc aaaaggaact agaacacaga gatgaacacg tggggacagc
      601 agaatctgga ccagcagaac cacctccagc tacagaagta gaggctacat ctatagccca
      661 ggccgtatct ggaccggaca agaaactccc tacccaaact gacttggtct cccaagagag
      721 agctgagcag tcagacccta cagcccagca aacacctcta gtccaaggag tcaagtctga
      781 ccagggatct ttgatagagt cagggatttt agcaagactg cagaaactag ccatacagca
      841 gccctcccaa gagtggaaga catttcttga ttgtgttaca gagtctgaca tggagaaata
      901 cctgaattca tcctcaaagt caaaccctcc agagccaagt ggtgggacag tgatcccagg
      961 aacgctgccc tccaaacaga aacccgattg tggaaagatg tcaggatatg gtgggaaatt
     1021 accacatggg aagaaaggca tcctccagaa acacaagcac tactgggata cagcctcggc
     1081 attctcacac agcatggatt tacgcacaat gacacagtcg ctggtggcgc tcgcagaaga
     1141 caacatggcc ttcttctcaa gccagggccc aggagagaca gcacggcggc tgtccaacgt
     1201 ctttgcaggt gttcgggaac aggcactggg gctagaacca actctaggtc agctcttggg
     1261 tgtggcacac catttcgacc tggacactga gacaccagcc aacggatacc gtagcttggt
     1321 gcacacagct cgttgctgcc tggcacacct actacacaaa tcccgctatg tggcctctaa
     1381 ccgcagaagt atcttcttcc gtgccagcca caacctagca gaactggagg cctacctggc
     1441 tgccctcacc cagctccgtg ctctagccta ctacgcccag cgcctgctga ccatcaaccg
     1501 accaggagtg ctcttctttg agggcgatga gggactcagc gctgacttcc tacaggacta
     1561 tgtcacgcta cataaaggct gcttttacgg tcgctgcctg ggcttccagt tcacacctgc
     1621 catccggccg ttcctgcaga ctctctccat cgggctggtg tccttcgggg aacactacaa
     1681 acgcaacgag acgggcctca gtgtgactgc aagttccctc tttacgggtg gccgattcgc
     1741 catagaccca gagttgcgtg gggctgaatt tgagcgcatc atacagaacc tggacgtgca
     1801 cttctggaaa gccttctgga atatcacgga gatcgaggtg ctatcgtctc tggccaacat
     1861 ggcatcaacc accgtgaggg taagccgcct gcttagcttg ccgcctgagg cctttgagat
     1921 gccactaacc tctgacccca agctcacagt taccatctca cctcccttgg cacacacggg
     1981 accaggccct gtgctagcca ggctcatctc ctatgacctg cgggaagggc aggacagcaa
     2041 gatgctcaac agcctggcaa aatctgaggg cccacgcctg gagctgcgcc cacggcctca
     2101 acaagccccc cgctcacgag ccctggttgt ccacattcac ggtggtggct ttgtggcaca
     2161 gacctccaaa tcccatgagc cctacctcaa gaactgggcc caggagctag gcgtccccat
     2221 catctccatc gactactccc tggcccctga ggcccccttc ccccgagcac tggaggagtg
     2281 tttttttgcc tactgctggg ctgtcaagca ctgtgaactg cttggttcaa ccggagagcg
     2341 gatatgcctt gcgggggaca gcgcaggtgg gaacctctgc atcaccgtgt cccttcgggc
     2401 agcagcctat ggggtgaggg tgccagatgg catcatggca gcctacccag ttaccaccct
     2461 gcagtcctct gcttctccct ctcgtctgct gagcctcatg gatcctcttc taccactgag
     2521 cgtactctcc aagtgtgtga gcgcctattc agggacagag acggaggacc attttgactc
     2581 agaccagaag gcattgggcg tgatggggct ggtgcagaga gacacgtccc tgttcctcag
     2641 agacctccgc ctgggcgcct cctcatggct caactccttc ctggagttaa gtgggcgcaa
     2701 gccccataag accccattgc ctgcaacaga gacactgcgc cccacggatt ctgggcgcct
     2761 tacggagtct atgcgcagga gtgtgtctga ggcagccctg gcccagcctg agggcttgct
     2821 gggcacagat tccttgaaga agctaacaat aaaggacttg agctttaagg gcaactcaga
     2881 gccatcagac agccccgaga tgtcacagtc aatggagaca cttggcccct ccacaccctc
     2941 ggatgtcaac ttttttctgc gatccgggaa ttcccaggaa gaggctgaaa ccagagatga
     3001 tataagcccc atggacggaa tcccccgcgt gcgcgctgcc ttccctgatg gtttccaccc
     3061 acggcgctca agccaaggtg tcctccacat gcccctctac tcgtcaccca tagtcaagaa
     3121 ccccttcatg tctcctctgc tggcccctga cgtcatgctg aagaccctgc cgcccgtgca
     3181 ccttgtggcg tgcgctctgg accccatgct ggatgactcg gtcatgttcg cgcggcgact
     3241 gaaggacctg ggccagcccg tgacgctgaa agtggtagag gacctgccgc atggtttcct
     3301 gagcttagca gccctgtgtc gtgagacccg gcaggccgcg gagttgtgcg tgcagcgcat
     3361 ccggctgatc ctcacccccc ctgctgcacc gctgacctga gctgggaacg gcggggggcg
     3421 gcactaaaag acctcttgca cccttctgcg cgggcttccg tgatgagtgc gctccgagtc
     3481 gggctctagg ccccctcggt cgggctgggc gggagggggc gggccgtgcc ttaaccataa
     3541 gtggggcggg gcaggggcca aaagctgaac ctgggggagg gggacgcaca cacacacacc
     3601 tgtcaccgag acagctggac ctgcactcta ccactgcctt ctactgctgc tgtgaccgac
     3661 caccgctagt cggttttgct ttttgtaaat aaaagttatt taat
//
