LOCUS       NM_012597               1742 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus lipase C, hepatic type (Lipc), mRNA.
ACCESSION   NM_012597
VERSION     NM_012597.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1742)
  AUTHORS   Park,H.S., Kim,I.J., Kim,E.G., Ryu,C.S., Lee,J.Y., Ko,E.J.,
            Park,H.W., Sung,J.H. and Kim,N.K.
  TITLE     A study of associations between CUBN, HNF1A, and LIPC gene
            polymorphisms and coronary artery disease
  JOURNAL   Sci Rep 10 (1), 16294 (2020)
   PUBMED   33004870
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1742)
  AUTHORS   Rotimi,O.A., Rotimi,S.O., Duru,C.U., Ebebeinwe,O.J., Abiodun,A.O.,
            Oyeniyi,B.O. and Faduyile,F.A.
  TITLE     Acute aflatoxin B1 - Induced hepatotoxicity alters gene expression
            and disrupts lipid and lipoprotein metabolism in rats
  JOURNAL   Toxicol Rep 4, 408-414 (2017)
   PUBMED   28959666
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1742)
  AUTHORS   Yang,P. and Subbaiah,P.V.
  TITLE     Regulation of hepatic lipase activity by sphingomyelin in plasma
            lipoproteins
  JOURNAL   Biochim Biophys Acta 1851 (10), 1327-1336 (2015)
   PUBMED   26193433
REFERENCE   4  (bases 1 to 1742)
  AUTHORS   Jobgen,W., Fu,W.J., Gao,H., Li,P., Meininger,C.J., Smith,S.B.,
            Spencer,T.E. and Wu,G.
  TITLE     High fat feeding and dietary L-arginine supplementation
            differentially regulate gene expression in rat white adipose tissue
  JOURNAL   Amino Acids 37 (1), 187-198 (2009)
   PUBMED   19212806
REFERENCE   5  (bases 1 to 1742)
  AUTHORS   Boualga,A., Prost,J., Taleb-Senouci,D., Krouf,D., Kharoubi,O.,
            Lamri-Senhadji,M., Belleville,J. and Bouchenak,M.
  TITLE     Purified chickpea or lentil proteins impair VLDL metabolism and
            lipoprotein lipase activity in epididymal fat, but not in muscle,
            compared to casein, in growing rats
  JOURNAL   Eur J Nutr 48 (3), 162-169 (2009)
   PUBMED   19165521
REFERENCE   6  (bases 1 to 1742)
  AUTHORS   Bohn,E., Gerke,V., Kresse,H., Loffler,B.M. and Kunze,H.
  TITLE     Annexin II inhibits calcium-dependent phospholipase A1 and
            lysophospholipase but not triacyl glycerol lipase activities of rat
            liver hepatic lipase
  JOURNAL   FEBS Lett 296 (3), 237-240 (1992)
   PUBMED   1531641
REFERENCE   7  (bases 1 to 1742)
  AUTHORS   Mao,J. and Hamosh,M.
  TITLE     Postnatal development of plasma-lipid-clearing enzymes (lipoprotein
            lipase, hepatic lipase and lecithin:cholesterol acyl transferase)
            and lipid profiles in suckling rats
  JOURNAL   Biol Neonate 62 (1), 1-9 (1992)
   PUBMED   1391269
REFERENCE   8  (bases 1 to 1742)
  AUTHORS   Kuusi,T., Nikkla,E.A., Virtanen,I. and Kinnunen,P.K.
  TITLE     Localization of the heparin-releasable lipase in situ in the rat
            liver
  JOURNAL   Biochem J 181 (1), 245-246 (1979)
   PUBMED   384999
REFERENCE   9  (bases 1 to 1742)
  AUTHORS   Nikkila,E.A., Huttunen,J.K. and Ehnholm,C.
  TITLE     Postheparin plasma lipoprotein lipase and hepatic lipase in
            diabetes mellitus. Relationship to plasma triglyceride metabolism
  JOURNAL   Diabetes 26 (1), 11-21 (1977)
   PUBMED   187516
REFERENCE   10 (bases 1 to 1742)
  AUTHORS   Kinnunen,P.K. and Ehnolm,C.
  TITLE     Effect of serum and C-apoproteins from very low density
            lipoproteins on human postheparin plasma hepatic lipase
  JOURNAL   FEBS Lett 65 (3), 354-357 (1976)
   PUBMED   182536
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC088160.1.
            
            On Jan 2, 2005 this sequence version replaced NM_012597.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088160.1, M16235.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1742
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..1742
                     /gene="Lipc"
                     /note="lipase C, hepatic type"
                     /db_xref="GeneID:24538"
                     /db_xref="RGD:3009"
     exon            1..178
                     /gene="Lipc"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..1578
                     /gene="Lipc"
                     /EC_number="3.1.1.3"
                     /EC_number="3.1.1.5"
                     /EC_number="3.1.1.32"
                     /note="hepatic triacylglycerol lipase; HL; hepatic lipase;
                     lipase member C; lipase, hepatic; phospholipase A1;
                     lysophospholipase"
                     /codon_start=1
                     /product="hepatic triacylglycerol lipase precursor"
                     /protein_id="NP_036729.2"
                     /db_xref="GeneID:24538"
                     /db_xref="RGD:3009"
                     /translation="MGNHLQISVSLVLCIFIQSSACGQGVGTEPFGRNLGATEERKPL
                     QKPEIRFLLFKDESDRLGCQLRPQHPETLQECGFNSSHPLVMIIHGWSVDGLLETWIW
                     KIVGALKSRQSQPVNVGLVDWISLAYQHYAIAVRNTRVVGQEVAALLLWLEESMKFSR
                     SKVHLIGYSLGAHVSGFAGSSMGGKRKIGRITGLDPAGPMFEGTSPNERLSPDDANFV
                     DAIHTFTREHMGLSVGIKQPIAHYDFYPNGGSFQPGCHFLELYKHIAEHGLNAITQTI
                     KCAHERSVHLFIDSLQHSNLQNTGFQCSNMDSFSQGLCLNCKKGRCNSLGYDIRRDRP
                     RKSKTLFLITRAQSPFKVYHYQFKIQFINQMEKPIEPTFTMTLLGTKEEIKKIPITLG
                     EGITSNKTYSLLITLDKDIGELIMLKFKWENSAVWANVWNTVQTIMLWDTEPHYAGLI
                     LKTIWVKAGETQQRMTFCPDNVDDLQLHPTQEKVFVKCDLKSKD"
     exon            179..369
                     /gene="Lipc"
                     /inference="alignment:Splign:2.1.0"
     exon            370..552
                     /gene="Lipc"
                     /inference="alignment:Splign:2.1.0"
     exon            553..670
                     /gene="Lipc"
                     /inference="alignment:Splign:2.1.0"
     exon            671..904
                     /gene="Lipc"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1147
                     /gene="Lipc"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1265
                     /gene="Lipc"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1484
                     /gene="Lipc"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..1718
                     /gene="Lipc"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggccttcca caactaaata ccaagaagca ttctggtctc tttagttcta gacattaaca
       61 agaagacctc aggccccggg taagacgaga gacatgggaa atcacctcca aatctccgtt
      121 tccctggtgc tgtgcatctt tatccagtca agtgcctgtg gacaaggcgt gggaacagag
      181 ccctttggga gaaaccttgg agctactgaa gaaaggaaac cgttacagaa gccagagatc
      241 agattcctgc tcttcaaaga tgaaagtgac cgcctgggtt gtcagctcag acctcagcac
      301 ccggaaacac tgcaggagtg tggcttcaac agctcccatc cacttgtcat gatcatccac
      361 gggtggtcgg tggatggctt gctagaaacc tggatctgga agatagtggg tgccctgaag
      421 tcccgacagt cccaacccgt gaacgtggga ttagtggact ggatctccct ggcataccag
      481 cactatgcta ttgccgtgcg caacacccgt gttgtgggcc aggaggtggc tgctcttctc
      541 ctatggctgg aggaatctat gaagttttct cggagcaaag ttcacttaat tgggtacagc
      601 ctgggagcac acgtttcagg attcgcaggc agctccatgg gtgggaagcg caagatcgga
      661 agaatcacag ggctggaccc tgcaggacct atgtttgagg gaacttcccc caacgagcgc
      721 ctttctccag atgatgccaa ttttgtggat gctattcata cctttaccag ggagcacatg
      781 ggtctgagtg tgggcatcaa acagcccatt gcccactatg acttctaccc caacgggggc
      841 tccttccagc ctggctgcca cttcctggag ctctacaaac acattgcaga gcatggctta
      901 aatgccataa cccagaccat caaatgtgcc catgagcgtt ctgtgcacct cttcattgac
      961 tccttgcaac acagcaacct gcagaacaca ggcttccagt gcagcaacat ggacagcttc
     1021 agtcagggtc tatgtctgaa ctgcaagaag ggccgttgca acagtctggg ctatgacatc
     1081 cgcagggatc ggccacgcaa gagcaagaca ctcttcctca tcacccgagc ccagtccccc
     1141 ttcaaagttt atcattacca gttcaagatc cagttcatca atcaaatgga gaagccaata
     1201 gagcctactt ttaccatgac actgctgggg acaaaagaag aaataaagaa aattcccatc
     1261 accctgggcg aaggaattac cagcaataaa acctattcct tacttatcac actggacaaa
     1321 gacatcggcg agttgatcat gctcaagttc aagtgggaaa acagcgcagt gtgggccaat
     1381 gtctggaaca cagtgcagac cataatgcta tgggacacag agcctcacta cgcgggcctc
     1441 attctgaaga ccatctgggt caaagctgga gagacgcagc aaagaatgac attttgccct
     1501 gataatgtgg atgatctcca gcttcacccc acccaggaga aagtcttcgt gaaatgtgac
     1561 ctgaagtcaa aagactgaag aagcaaaaga gcagatgagt caagagaccc aagcacaaaa
     1621 taaatagact attctttatc tgtaatggtt gccttattcg gaagccaaat tacacaaagg
     1681 atcatgcata aacttaaata aagctgatat gtaaaggaaa aaaaaaaaaa aaaaaaaaaa
     1741 aa
//
