LOCUS       NM_012732               3230 bp    mRNA    linear   ROD 04-AUG-2024
DEFINITION  Rattus norvegicus lipase A, lysosomal acid type (Lipa), mRNA.
ACCESSION   NM_012732
VERSION     NM_012732.3
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3230)
  AUTHORS   Zschenker,O., Oezden,D. and Ameis,D.
  TITLE     Lysosomal acid lipase as a preproprotein
  JOURNAL   J Biochem 136 (1), 65-72 (2004)
   PUBMED   15269241
REFERENCE   2  (bases 1 to 3230)
  AUTHORS   Lian,X., Yan,C., Yang,L., Xu,Y. and Du,H.
  TITLE     Lysosomal acid lipase deficiency causes respiratory inflammation
            and destruction in the lung
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 286 (4), L801-L807 (2004)
   PUBMED   14644759
REFERENCE   3  (bases 1 to 3230)
  AUTHORS   Lakowska,H., Maciejewski,R., Szkodziak,P. and Staskiewicz,G.
  TITLE     Changes in the activity of lysosomal enzymes in rat kidneys in the
            course of acute pancreatitis
  JOURNAL   Med Sci Monit 7 (6), 1193-1197 (2001)
   PUBMED   11687729
REFERENCE   4  (bases 1 to 3230)
  AUTHORS   Inoue,Y., Ose,T., Mukai,S., Ehira,S., Yonekura,M., Hou,D.X. and
            Fujii,M.
  TITLE     Inhibition of the acid lipase activity by apolipoprotein A-I in the
            presence of lysosomal proteases
  JOURNAL   Biosci Biotechnol Biochem 63 (5), 937-939 (1999)
   PUBMED   10419291
REFERENCE   5  (bases 1 to 3230)
  AUTHORS   Ries,S., Buchler,C., Schindler,G., Aslanidis,C., Ameis,D.,
            Gasche,C., Jung,N., Schambach,A., Fehringer,P., Vanier,M.T.,
            Belli,D.C., Greten,H. and Schmitz,G.
  TITLE     Different missense mutations in histidine-108 of lysosomal acid
            lipase cause cholesteryl ester storage disease in unrelated
            compound heterozygous and hemizygous individuals
  JOURNAL   Hum Mutat 12 (1), 44-51 (1998)
   PUBMED   9633819
REFERENCE   6  (bases 1 to 3230)
  AUTHORS   Anderson,R.A. and Sando,G.N.
  TITLE     Cloning and expression of cDNA encoding human lysosomal acid
            lipase/cholesteryl ester hydrolase. Similarities to gastric and
            lingual lipases
  JOURNAL   J Biol Chem 266 (33), 22479-22484 (1991)
   PUBMED   1718995
REFERENCE   7  (bases 1 to 3230)
  AUTHORS   Fontaine,R.N., Carter,C.P. and Hui,D.Y.
  TITLE     Structure of the rat pancreatic cholesterol esterase gene
  JOURNAL   Biochemistry 30 (28), 7008-7014 (1991)
   PUBMED   2069957
REFERENCE   8  (bases 1 to 3230)
  AUTHORS   Amanuma,K., Okada,J., Imanaka,T., Ohkuma,S. and Takano,T.
  TITLE     Subcellular localization of acid lipase in rat liver
  JOURNAL   Biochem Int 11 (3), 349-355 (1985)
   PUBMED   4062953
REFERENCE   9  (bases 1 to 3230)
  AUTHORS   Hoeg,J.M., Demosky,S.J. Jr., Pescovitz,O.H. and Brewer,H.B. Jr.
  TITLE     Cholesteryl ester storage disease and Wolman disease: phenotypic
            variants of lysosomal acid cholesteryl ester hydrolase deficiency
  JOURNAL   Am J Hum Genet 36 (6), 1190-1203 (1984)
   PUBMED   6097111
REFERENCE   10 (bases 1 to 3230)
  AUTHORS   Warner,T.G., Dambach,L.M., Shin,J.H. and O'Brien,J.S.
  TITLE     Purification of the lysosomal acid lipase from human liver and its
            role in lysosomal lipid hydrolysis
  JOURNAL   J Biol Chem 256 (6), 2952-2957 (1981)
   PUBMED   7204383
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC072532.1.
            
            On Oct 20, 2005 this sequence version replaced NM_012732.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC072532.1, SRR8487231.157702.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..3230
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q53"
     gene            1..3230
                     /gene="Lipa"
                     /gene_synonym="Chole; Chole2; LAL; Lip1"
                     /note="lipase A, lysosomal acid type"
                     /db_xref="GeneID:25055"
                     /db_xref="RGD:3008"
     exon            1..138
                     /gene="Lipa"
                     /gene_synonym="Chole; Chole2; LAL; Lip1"
                     /inference="alignment:Splign:2.1.0"
     exon            139..391
                     /gene="Lipa"
                     /gene_synonym="Chole; Chole2; LAL; Lip1"
                     /inference="alignment:Splign:2.1.0"
     CDS             287..1480
                     /gene="Lipa"
                     /gene_synonym="Chole; Chole2; LAL; Lip1"
                     /EC_number="3.1.1.13"
                     /note="pancreatic cholesterol esterase; sterol esterase;
                     acid cholesteryl ester hydrolase; cholesteryl esterase;
                     lipase A, lysosomal acid, cholesterol esterase; lysosomal
                     acid lipase/cholesteryl ester hydrolase; lysosomal acid
                     lipase 1; Cholesterol esterase (pancreatic) see D3Wox12
                     D3Wox13 D3Wox26 and D3Mgh25; lysosomal acid lipase A;
                     diacylglycerol lipase; triacylglycerol lipase;
                     triacylglycerol ester hydrolase"
                     /codon_start=1
                     /product="lysosomal acid lipase/cholesteryl ester
                     hydrolase precursor"
                     /protein_id="NP_036864.3"
                     /db_xref="GeneID:25055"
                     /db_xref="RGD:3008"
                     /translation="MQLLGRVICFVVGILLSGGPTGTISAVDPEANMNVTEIIMHWGY
                     PGEEHSVQTGDGYILGVHRIPHGRKNQFDKGPKPVVYLQHGFLADSSNWVTNIDNNSL
                     GFILADAGFDVWMGNSRGNTWSRKHKTLSVSQDEYWAFSFDEMAKYDLPASINYILNK
                     TGQEQLYYVGHSQGCTIGFIAFSQMPELAKKVKMFFALAPVLSLNFASGPMVKLGRLP
                     DLLLEDLFGQKQFLPQSAMVKWLSTHICTHVIMKELCANIFFLICGFNEKNLNMSRVD
                     VYTTHCPAGTSVQNMVHWTQVVKYHKLQAFDWGSSDKNYFHYNQSYPPLYSIKDMQLP
                     TALWSGGKDWLADTSDINILLTEIPTLVYHKNIPEWDHLDFIWGLDAPWRLYNEVVSL
                     MKKYQ"
     exon            392..509
                     /gene="Lipa"
                     /gene_synonym="Chole; Chole2; LAL; Lip1"
                     /inference="alignment:Splign:2.1.0"
     exon            510..708
                     /gene="Lipa"
                     /gene_synonym="Chole; Chole2; LAL; Lip1"
                     /inference="alignment:Splign:2.1.0"
     exon            709..818
                     /gene="Lipa"
                     /gene_synonym="Chole; Chole2; LAL; Lip1"
                     /inference="alignment:Splign:2.1.0"
     exon            819..955
                     /gene="Lipa"
                     /gene_synonym="Chole; Chole2; LAL; Lip1"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1102
                     /gene="Lipa"
                     /gene_synonym="Chole; Chole2; LAL; Lip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1174
                     /gene="Lipa"
                     /gene_synonym="Chole; Chole2; LAL; Lip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1246
                     /gene="Lipa"
                     /gene_synonym="Chole; Chole2; LAL; Lip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..3202
                     /gene="Lipa"
                     /gene_synonym="Chole; Chole2; LAL; Lip1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcctcgggcc tgctctgtgc agcggtctcg ggagctggtg ccctgcggat cgccaggcct
       61 gggagaggag cccccaccac gatctctggt caccagttgc tctgctcccg gagcatgttc
      121 tgtgtccggt atccaaagag acggctgcag tcgttcggtt cctgtctgcc ttccgtgtag
      181 gatttgattt ctcctaaact tggtttaaga cttttaaaga aggccctaat ttatcgaggc
      241 ctgtttgtga agtaaaattc ggctggctac tctcaacgga agaaagatgc aactgctagg
      301 ccgggtgatc tgtttcgtcg ttgggatcct gctttctggg ggcccaacgg ggaccatatc
      361 agctgtggac cctgaagcaa acatgaatgt gactgagata atcatgcact ggggatatcc
      421 tggcgaagag cactcagtac agacaggaga tggctacatt ctgggtgttc accgaatccc
      481 gcatgggcgg aagaaccagt ttgataaagg tcccaaacca gttgtgtatc ttcagcatgg
      541 cttcctggca gattctagta actgggtcac aaacattgac aacaacagcc tgggcttcat
      601 cctggcagat gctggctttg atgtgtggat gggaaacagc agaggaaaca cctggtctcg
      661 gaagcacaag actctgtcag tttctcagga tgaatactgg gccttcagtt ttgatgagat
      721 ggcaaaatat gacctccctg cttcaattaa ctacattttg aataaaactg gccaagaaca
      781 gctgtattat gtgggccact ctcaaggctg caccataggt tttatagcat tttcacagat
      841 gcctgaactg gcaaagaagg ttaaaatgtt ttttgccctg gctcctgtgt tgtctctcaa
      901 ttttgcttcg ggcccgatgg tcaaattggg acggttgccg gatctgcttc ttgaggactt
      961 gtttgggcag aagcaatttc ttcctcagag tgcaatggtg aaatggctaa gcactcacat
     1021 ttgcacgcac gtcatcatga aggagctttg cgccaacatc ttctttctga tatgtggctt
     1081 caatgagaag aatttaaaca tgtctagagt ggatgtgtat acaacacact gtcctgcggg
     1141 aacctctgtg caaaacatgg tacactggac ccaggttgtt aaataccata agcttcaagc
     1201 ttttgactgg ggaagcagtg acaagaatta ttttcattac aatcagagtt atccaccctt
     1261 gtacagcata aaagacatgc aactacccac tgctttatgg agcgggggca aggactggct
     1321 ggcagacacc agtgacatca atatcttact gactgaaatc cccacgttag tgtaccacaa
     1381 gaacattccc gagtgggacc atctggattt tatctggggt ttggatgccc cctggaggct
     1441 gtataatgaa gtagtcagtc taatgaagaa ataccagtga gtgccaagac ttgagatgct
     1501 tccccttcac taggggaaaa aaggacagat gtttgcttaa ttcctgcaaa atacttgtgt
     1561 tttcctggtc tagatcattt gtatttttta tgtgcaagaa aacgatgatg ttgaagacat
     1621 acatgggtct ggtcagtaag aagcacgctg gctgtcttct gcttcattct gactgacaag
     1681 ccagagtcac aaccagcgat gcctttgaag tttttagaaa gtatgggtgt tacgtgaaga
     1741 agccattgca atcctcttgt ttacttttta cggtcgtttt cggtgtctgc atgctgtgca
     1801 tatacatgcc tatgtgtgtg ccctgtgctg gccagagcct ccttgtgtgg aggtaagggc
     1861 tcacatcagg gtatcttcct cagacacttt ccactttact ttttgagacc tggtctctcg
     1921 acgaaccagt cagtagcttg ctattccagt tagactggct gaccagggag cctccagaat
     1981 ctgtccgtct ctaccttccc cctcaccagg tctacggagg gtgatgtccc agccagcatt
     2041 tttacactgg ttctagggac aggaactcag gttctcatgc ttgaatagca agccctttct
     2101 tcaccaaacc attgcctcaa accctctgtg atcgaaaagc tgctcaatta cctttatgtt
     2161 cccacccaat gcaagtgaac gagcacaaga catttcaagc tgttgtttgt gagcaaaaat
     2221 caatctgcca gtgacttgaa catgctagga gaaactcctc gctctgagct tgacaaacct
     2281 gcagtccagg ttctccagag attgagacag ggaggctgct gttacattta gggttcattt
     2341 ggagagtgag actttgtctc tacaaaacca aagacaaagg agaagaagaa aaaaaaaacc
     2401 ctaaagtact cagttctcat ctgttagcct cagagggctt agagagttcc tgtgtttacc
     2461 tatccgaaca acattttcat gtctttatgc agtagctacc tagtgaaatc cagtgttatc
     2521 ccagcttctc caggcgtaaa cattctctct tcaatctcat cagacctcag tagcaagcat
     2581 ttagtgaata tttagatttt tcaggccaag ccaagacaaa aatgaataga ataaaagaaa
     2641 aaagagccca gactcttgaa agcggtttgc actgatttaa aaataaaaaa aaagaatctt
     2701 gaagaatgac atgataaact gtgttggttc cgcatgtgta gtcggatccc ttttctgtgg
     2761 agaacgttct gtggagggac aaaccactaa tttgccccaa gtgaatgtgg ctgtagtgac
     2821 agcgacagtg cctctgatct gagaagcagg gctggctgcc ggtgacaagc atcccagttc
     2881 ctttccccag agatgaagcg gatgttttca gacagagctc ggctcaggaa tttcgcttgg
     2941 agaatcagtg tttatgtgca caatgtttta gtgagcctgc tctgcgcctg catatgggga
     3001 agccctcgac tgttcaccgg gctcgtgggc gacggctgcc gtcagctgga cagtggataa
     3061 gttttctgac gtagtcacca cagattcagg gatatcgctt tgtgtcgact cctaaggaag
     3121 gcaggacgat atgacttggt aacattgtaa aggttcacat ttaaactttt caataaatct
     3181 cagcctcaca ggcctgaaca tcaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
