LOCUS       NM_001100722            2510 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus leucine rich repeat and Ig domain containing 1
            (Lingo1), mRNA.
ACCESSION   NM_001100722 XM_001068291 XM_001070567 XM_001070615 XM_236268
VERSION     NM_001100722.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2510)
  AUTHORS   Wu H, Ding L, Wang Y, Zou TB, Wang T, Fu W, Lin Y, Zhang X, Chen K,
            Lei Y, Zhong C and Luo C.
  TITLE     MiR-615 Regulates NSC Differentiation In Vitro and Contributes to
            Spinal Cord Injury Repair by Targeting LINGO-1
  JOURNAL   Mol Neurobiol 57 (7), 3057-3074 (2020)
   PUBMED   32462552
  REMARK    GeneRIF: MiR-615 Regulates NSC Differentiation In Vitro and
            Contributes to Spinal Cord Injury Repair by Targeting LINGO-1.
REFERENCE   2  (bases 1 to 2510)
  AUTHORS   Youssef AEH, Dief AE, El Azhary NM, Abdelmonsif DA and El-Fetiany
            OS.
  TITLE     LINGO-1 siRNA nanoparticles promote central remyelination in
            ethidium bromide-induced demyelination in rats
  JOURNAL   J Physiol Biochem 75 (1), 89-99 (2019)
   PUBMED   30759305
  REMARK    GeneRIF: LINGO-1 siRNA nanoparticles silencing promoted central
            remyelination in ethidium bromide-induced demyelination in rats.
REFERENCE   3  (bases 1 to 2510)
  AUTHORS   Song XJ, Han W, He R, Li TY, Xie LL, Cheng L, Chen HS and Jiang L.
  TITLE     Alterations of Hippocampal Myelin Sheath and Axon Sprouting by
            Status Convulsion and Regulating Lingo-1 Expression with RNA
            Interference in Immature and Adult Rats
  JOURNAL   Neurochem Res 43 (3), 721-735 (2018)
   PUBMED   29383653
  REMARK    GeneRIF: in both immature and adult brains, Lingo-1 signaling plays
            important roles in seizure-induced damage to myelin sheaths and
            axon growth
REFERENCE   4  (bases 1 to 2510)
  AUTHORS   Shao Z, Lee X, Huang G, Sheng G, Henderson CE, Louvard D, Sohn J,
            Pepinsky B and Mi S.
  TITLE     LINGO-1 Regulates Oligodendrocyte Differentiation through the
            Cytoplasmic Gelsolin Signaling Pathway
  JOURNAL   J Neurosci 37 (12), 3127-3137 (2017)
   PUBMED   28193690
  REMARK    GeneRIF: Myelin loss and subsequent axon degeneration contributes
            to a variety of neurological diseases, such as multiple sclerosis
            (MS).
REFERENCE   5  (bases 1 to 2510)
  AUTHORS   Meabon JS, de Laat R, Ieguchi K, Serbzhinsky D, Hudson MP, Huber
            BR, Wiley JC and Bothwell M.
  TITLE     Intracellular LINGO-1 negatively regulates Trk neurotrophin
            receptor signaling
  JOURNAL   Mol Cell Neurosci 70, 1-10 (2016)
   PUBMED   26546150
  REMARK    GeneRIF: We propose that LINGO-1 functions as a negative feedback
            regulator of signaling by cognate receptor tyrosine kinases
            including TrkA, TrkB and TrkC.
REFERENCE   6  (bases 1 to 2510)
  AUTHORS   Fu QL, Li X, Yip HK, Shao Z, Wu W, Mi S and So KF.
  TITLE     Combined effect of brain-derived neurotrophic factor and LINGO-1
            fusion protein on long-term survival of retinal ganglion cells in
            chronic glaucoma
  JOURNAL   Neuroscience 162 (2), 375-382 (2009)
   PUBMED   19422885
REFERENCE   7  (bases 1 to 2510)
  AUTHORS   Zhao XH, Jin WL, Wu J, Mi S and Ju G.
  TITLE     Inactivation of glycogen synthase kinase-3beta and up-regulation of
            LINGO-1 are involved in LINGO-1 antagonist regulated survival of
            cerebellar granular neurons
  JOURNAL   Cell Mol Neurobiol 28 (5), 727-735 (2008)
   PUBMED   18183482
  REMARK    GeneRIF: Taken together, these results suggest a new mechanism of
            LINGO-1 antagonist regulated neuronal survival involving protein
            synthesis of LINGO-1 and inactivation of GSK-3 pathway.
REFERENCE   8  (bases 1 to 2510)
  AUTHORS   Inoue H, Lin L, Lee X, Shao Z, Mendes S, Snodgrass-Belt P, Sweigard
            H, Engber T, Pepinsky B, Yang L, Beal MF, Mi S and Isacson O.
  TITLE     Inhibition of the leucine-rich repeat protein LINGO-1 enhances
            survival, structure, and function of dopaminergic neurons in
            Parkinson's disease models
  JOURNAL   Proc Natl Acad Sci U S A 104 (36), 14430-14435 (2007)
   PUBMED   17726113
REFERENCE   9  (bases 1 to 2510)
  AUTHORS   Lee X, Yang Z, Shao Z, Rosenberg SS, Levesque M, Pepinsky RB, Qiu
            M, Miller RH, Chan JR and Mi S.
  TITLE     NGF regulates the expression of axonal LINGO-1 to inhibit
            oligodendrocyte differentiation and myelination
  JOURNAL   J Neurosci 27 (1), 220-225 (2007)
   PUBMED   17202489
REFERENCE   10 (bases 1 to 2510)
  AUTHORS   Mi S, Miller RH, Lee X, Scott ML, Shulag-Morskaya S, Shao Z, Chang
            J, Thill G, Levesque M, Zhang M, Hession C, Sah D, Trapp B, He Z,
            Jung V, McCoy JM and Pepinsky RB.
  TITLE     LINGO-1 negatively regulates myelination by oligodendrocytes
  JOURNAL   Nat Neurosci 8 (6), 745-751 (2005)
   PUBMED   15895088
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BE108045.1, BF547075.1 and BC092632.1.
            
            On or before Nov 22, 2008 this sequence version replaced
            XM_001070615.1, XM_001070567.1, XM_236268.4, XM_001068291.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BE108045.1, BF414924.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132284, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-467               BE108045.1         1-467
            468-841             BF547075.1         8-381               c
            842-2510            BC092632.1         301-1969
FEATURES             Location/Qualifiers
     source          1..2510
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..2510
                     /gene="Lingo1"
                     /gene_synonym="Lrrn6a"
                     /note="leucine rich repeat and Ig domain containing 1"
                     /db_xref="GeneID:315691"
                     /db_xref="RGD:1308668"
     exon            1..239
                     /gene="Lingo1"
                     /gene_synonym="Lrrn6a"
                     /inference="alignment:Splign:2.1.0"
     CDS             234..2096
                     /gene="Lingo1"
                     /gene_synonym="Lrrn6a"
                     /note="leucine rich repeat neuronal 6A; leucine-rich
                     repeat and immunoglobulin-like domain-containing nogo
                     receptor-interacting protein 1"
                     /codon_start=1
                     /product="leucine-rich repeat and immunoglobulin-like
                     domain-containing nogo receptor-interacting protein 1
                     precursor"
                     /protein_id="NP_001094192.1"
                     /db_xref="GeneID:315691"
                     /db_xref="RGD:1308668"
                     /translation="MQVSERMLAGGMRSMPSPLLACWQPILLLVLGSVLSGSATGCPP
                     RCECSAQDRAVLCHRKRFVAVPEGIPTETRLLDLGKNRIKTLNQDEFASFPHLEELEL
                     NENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKIVILLD
                     YMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGLI
                     VLRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDTMTPNCLYGLNLTSLSITHCNLT
                     AVPYLAVRHLVYLRFLNLSYNPIGTIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGL
                     NYLRVLNVSGNQLTTLEESAFHSVGNLETLILDSNPLACDCRLLWVFRRRWRLNFNRQ
                     QPTCATPEFVQGKEFKDFPDVLLPNYFTCRRAHIRDRKAQQVFVDEGHTVQFVCRADG
                     DPPPAILWLSPRKHLVSAKSNGRLTVFPDGTLEVRYAQVQDNGTYLCIAANAGGNDSM
                     PAHLHVRSYSPDWPHQPNKTFAFISNQPGEGEANSTRATVPFPFDIKTLIIATTMGFI
                     SFLGVVLFCLVLLFLWSRGKGNTKHNIEIEYVPRKSDAGISSADAPRKFNMKMI"
     exon            240..2484
                     /gene="Lingo1"
                     /gene_synonym="Lrrn6a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggccgcggc ctcagcctcc gcccccgact cctgagctcc tgccctaggg ccggctgggc
       61 tcccgcccgc gtgggacaga cagacggaaa gccagccctg cgagggcgcg cggaccgggc
      121 ggaggtgttg taggaggaga cggaggaggg gggctgggct ggggctgggg ccgcgccggc
      181 aagagagaca tgcgattggt gaccaagccg agcggacgga cagcgcgccc gagatgcagg
      241 tgagcgagag gatgctggca gggggtatga gaagcatgcc cagccccctc ctggcctgct
      301 ggcagcccat cctcctgctg gtcctgggct ctgtgctgtc aggctccgcc accggctgcc
      361 cgccccgctg cgagtgctca gcgcaggacc gagcagtgct ctgtcaccgc aagcgctttg
      421 tggcggtgcc cgagggcatc cccaccgaga ctcgcctgct ggacctgggc aaaaaccgca
      481 tcaagacact caaccaggac gagtttgcca gtttcccaca cctggaggag ctagaactca
      541 atgagaacat tgtgagcgct gtggagccgg gcgccttcaa caacctcttc aacctgagga
      601 cgctggggct tcgcagcaac cgcctgaagc tcatcccgct gggcgtcttc accggcctca
      661 gcaacttgac caagctggac atcagcgaga acaagatcgt catcctgcta gactacatgt
      721 tccaagacct atacaacctc aagtcgctgg aggtcggcga caatgacctc gtctacatct
      781 cccatcgagc cttcagcggc ctcaacagcc tggaacagct gacgctggag aaatgcaatc
      841 tgacctccat ccccactgag gcactctccc acctgcatgg cctcatcgtc ctgcggctac
      901 gacacctcaa catcaatgcc atacgggact actccttcaa gaggctgtac cgactcaagg
      961 tcttagagat ctcccactgg ccctacctgg acaccatgac ccccaactgc ctctacggcc
     1021 tcaacctgac atccctatct atcacgcact gcaacctgac agccgtgccc tatctggcag
     1081 tgcgccacct ggtctatctc cgtttcctca atctttccta caaccccatc ggtacaatcg
     1141 agggctccat gctgcatgag ctgctgcggt tgcaagagat ccaactggtg ggcgggcagc
     1201 tggccgtggt ggagccctac gcctttcgtg ggctcaatta cctgcgtgtg ctcaatgttt
     1261 ctggcaacca gctgaccacc ctggaggagt cagccttcca ctcggtgggc aacctggaga
     1321 cgctcattct ggactccaac ccactggcct gtgactgccg gctgctgtgg gtgttccggc
     1381 gccgctggcg gctcaacttc aacaggcagc agcctacctg cgccacacct gagttcgtcc
     1441 agggcaagga gttcaaggac ttccccgatg tgctcctacc caactacttc acctgccgcc
     1501 gggcccacat ccgggaccgc aaggcacagc aggtgtttgt agatgagggc cacacggtgc
     1561 agttcgtatg ccgggcagat ggcgaccctc caccagctat cctttggctc tcaccccgca
     1621 agcacttggt ctcagccaag agcaatgggc ggctcacagt cttccctgat ggcacgctgg
     1681 aggtgcgcta cgcccaggta caggacaacg gcacgtacct gtgcatcgca gccaatgcag
     1741 gcggcaacga ctccatgccc gcccacttgc atgtgcgcag ctactcgcct gactggcccc
     1801 atcaacccaa caagaccttc gccttcatct ccaaccagcc aggcgaggga gaggccaaca
     1861 gcacccgcgc cactgtgcct ttccccttcg acatcaagac gctcatcatc gccaccacca
     1921 tgggcttcat ctccttcctg ggcgtggtcc tattctgcct ggtgctgctg tttctatgga
     1981 gccggggcaa aggcaacaca aagcacaaca tcgaaattga atatgtgccc cggaaatcgg
     2041 acgcaggcat cagctcagct gatgcacccc gcaagttcaa catgaagatg atatgaggat
     2101 ggggcagggt gggggcgcag ggacccccca cttccggggg aacactgggc agggaaggtg
     2161 cctggctgct gcccactcac ccccaggcct tcccaccttt ccctgccctc ctcacacact
     2221 ctcccctccc cccacgcgcc cccgctgcca cgccagcctc gccctcaccg cctgccctcc
     2281 ttctaccagg atttcagaag gccaggcctg aggaccccgc ctacataggg gccagagttg
     2341 acagacgaat ccaaagccga cgaaccacgc ggcagagtca ataattcaat taaaaaaaaa
     2401 gttacaaact tcctctgtaa cttgggtttc aataattaat ggatttttat gaaaacttga
     2461 aataataaaa aaagaaaaaa actaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
