LOCUS       NM_021851               4261 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus lin-7 homolog C, crumbs cell polarity complex
            component (Lin7c), mRNA.
ACCESSION   NM_021851
VERSION     NM_021851.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4261)
  AUTHORS   Monastyrskaya,K., Sanchez-Freire,V., Hashemi Gheinani,A.,
            Klumpp,D.J., Babiychuk,E.B., Draeger,A. and Burkhard,F.C.
  TITLE     miR-199a-5p regulates urothelial permeability and may play a role
            in bladder pain syndrome
  JOURNAL   Am J Pathol 182 (2), 431-448 (2013)
   PUBMED   23201090
REFERENCE   2  (bases 1 to 4261)
  AUTHORS   Yang,X., Xie,X., Chen,L., Zhou,H., Wang,Z., Zhao,W., Tian,R.,
            Zhang,R., Tian,C., Long,J. and Shen,Y.
  TITLE     Structural basis for tandem L27 domain-mediated polymerization
  JOURNAL   FASEB J 24 (12), 4806-4815 (2010)
   PUBMED   20702775
REFERENCE   3  (bases 1 to 4261)
  AUTHORS   Srinivasan,K., Roosa,J., Olsen,O., Lee,S.H., Bredt,D.S. and
            McConnell,S.K.
  TITLE     MALS-3 regulates polarity and early neurogenesis in the developing
            cerebral cortex
  JOURNAL   Development 135 (10), 1781-1790 (2008)
   PUBMED   18403412
  REMARK    GeneRIF: MALS-3 plays a role in maintaining apicobasal polarity and
            is required for normal neurogenesis in the developing cortex.
REFERENCE   4  (bases 1 to 4261)
  AUTHORS   Holmes,W.B. and Moncman,C.L.
  TITLE     Nebulette interacts with filamin C
  JOURNAL   Cell Motil Cytoskeleton 65 (2), 130-142 (2008)
   PUBMED   17987659
REFERENCE   5  (bases 1 to 4261)
  AUTHORS   Morokuma,Y., Nakamura,N., Kato,A., Notoya,M., Yamamoto,Y.,
            Sakai,Y., Fukuda,H., Yamashina,S., Hirata,Y. and Hirose,S.
  TITLE     MARCH-XI, a novel transmembrane ubiquitin ligase implicated in
            ubiquitin-dependent protein sorting in developing spermatids
  JOURNAL   J Biol Chem 282 (34), 24806-24815 (2007)
   PUBMED   17604280
REFERENCE   6  (bases 1 to 4261)
  AUTHORS   Hong,C.J. and Hsueh,Y.P.
  TITLE     CASK associates with glutamate receptor interacting protein and
            signaling molecules
  JOURNAL   Biochem Biophys Res Commun 351 (3), 771-776 (2006)
   PUBMED   17084383
REFERENCE   7  (bases 1 to 4261)
  AUTHORS   Olsen,O., Moore,K.A., Fukata,M., Kazuta,T., Trinidad,J.C.,
            Kauer,F.W., Streuli,M., Misawa,H., Burlingame,A.L., Nicoll,R.A. and
            Bredt,D.S.
  TITLE     Neurotransmitter release regulated by a MALS-liprin-alpha
            presynaptic complex
  JOURNAL   J Cell Biol 170 (7), 1127-1134 (2005)
   PUBMED   16186258
REFERENCE   8  (bases 1 to 4261)
  AUTHORS   Leonoudakis,D., Conti,L.R., Anderson,S., Radeke,C.M., McGuire,L.M.,
            Adams,M.E., Froehner,S.C., Yates,J.R. 3rd and Vandenberg,C.A.
  TITLE     Protein trafficking and anchoring complexes revealed by proteomic
            analysis of inward rectifier potassium channel (Kir2.x)-associated
            proteins
  JOURNAL   J Biol Chem 279 (21), 22331-22346 (2004)
   PUBMED   15024025
REFERENCE   9  (bases 1 to 4261)
  AUTHORS   Leonoudakis,D., Conti,L.R., Radeke,C.M., McGuire,L.M. and
            Vandenberg,C.A.
  TITLE     A multiprotein trafficking complex composed of SAP97, CASK, Veli,
            and Mint1 is associated with inward rectifier Kir2 potassium
            channels
  JOURNAL   J Biol Chem 279 (18), 19051-19063 (2004)
   PUBMED   14960569
  REMARK    GeneRIF: specific Veli isoforms participate in forming distinct
            protein complexes in brain, where Veli-1 stably associates with
            CASK and SAP97, Veli-2 associates with CASK and Mint1, and Veli-3
            associates with CASK, SAP97, and Mint1.
REFERENCE   10 (bases 1 to 4261)
  AUTHORS   Irie,M., Hata,Y., Deguchi,M., Ide,N., Hirao,K., Yao,I., Nishioka,H.
            and Takai,Y.
  TITLE     Isolation and characterization of mammalian homologues of
            Caenorhabditis elegans lin-7: localization at cell-cell junctions
  JOURNAL   Oncogene 18 (18), 2811-2817 (1999)
   PUBMED   10362251
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Oct 27, 2022 this sequence version replaced NM_021851.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ212254.1, SRR26643294.14399.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-62                JAXUCZ010000003.1  116861384-116861445
            63-181              JAXUCZ010000003.1  116864863-116864981
            182-253             JAXUCZ010000003.1  116865548-116865619
            254-463             JAXUCZ010000003.1  116867734-116867943
            464-4261            JAXUCZ010000003.1  116868566-116872363
FEATURES             Location/Qualifiers
     source          1..4261
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q34"
     gene            1..4261
                     /gene="Lin7c"
                     /gene_synonym="MALS-3; Veli3"
                     /note="lin-7 homolog C, crumbs cell polarity complex
                     component"
                     /db_xref="GeneID:60442"
                     /db_xref="RGD:621164"
     exon            1..62
                     /gene="Lin7c"
                     /gene_synonym="MALS-3; Veli3"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..619
                     /gene="Lin7c"
                     /gene_synonym="MALS-3; Veli3"
                     /note="veli-3 protein; vertebrate lin-7 homolog 3;
                     mammalian lin-seven protein 3"
                     /codon_start=1
                     /product="protein lin-7 homolog C"
                     /protein_id="NP_068623.1"
                     /db_xref="GeneID:60442"
                     /db_xref="RGD:621164"
                     /translation="MAALGEPVRLERDICRAIELLEKLQRSGEVPPQKLQALQRVLQS
                     EFCNAVREVYEHVYETVDISSSPEVRANATAKATVAAFAASEGHSHPRVVELPKTEEG
                     LGFNIMGGKEQNSPIYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEGEHHEKAVELL
                     KAAQGKVKLVVRYTPKVLEEMESRFEKMRSAKRRQQT"
     exon            63..181
                     /gene="Lin7c"
                     /gene_synonym="MALS-3; Veli3"
                     /inference="alignment:Splign:2.1.0"
     exon            182..253
                     /gene="Lin7c"
                     /gene_synonym="MALS-3; Veli3"
                     /inference="alignment:Splign:2.1.0"
     exon            254..463
                     /gene="Lin7c"
                     /gene_synonym="MALS-3; Veli3"
                     /inference="alignment:Splign:2.1.0"
     exon            464..4261
                     /gene="Lin7c"
                     /gene_synonym="MALS-3; Veli3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgggtctgg accgcggaag agaagatggc ggcgctggga gaacctgtcc ggctggagag
       61 ggatatctgc agagcaattg aattgttgga gaaattacag aggagtggag aggtgccgcc
      121 acagaaactt caggctttgc aaagagtcct ccagagtgag ttctgcaatg ctgtcagaga
      181 ggtatacgaa catgtttatg agactgtgga catcagtagc agccctgaag tgagagctaa
      241 tgcaactgca aaggctaccg ttgctgcgtt tgctgccagt gaagggcact ctcatccccg
      301 agttgttgag ctacccaaaa cagaagaggg ccttggattc aatatcatgg gaggcaaaga
      361 acaaaactca ccaatctata tatcccggat aattccaggt ggaattgctg acagacatgg
      421 aggcctcaaa cgaggagatc agctcctttc tgttaatgga gtgagtgttg aaggagagca
      481 ccatgagaaa gcggtggagc tactgaaagc agcccaaggc aaggtgaagt tagtcgtccg
      541 gtacacacca aaagtcctgg aagaaatgga gtcccgcttt gagaaaatga gatcagcaaa
      601 acgcagacaa cagacctaat cgtttaaaaa ctctatgttc cttttgcttt tagctaggaa
      661 agttacttgt gacctactga tggtcttgat gccagtgatt gtaaaacacc agaaacttcc
      721 gtgaactctt cttgccattt tataaatgcc tgttttagca tcactatggt tgtagagaag
      781 catacacttt ttttctcacg agaaaaagtc aaagttgatg agggcagttc tgtcctgctg
      841 tttttacagg cctttttcaa acacagattt tgtcacaaag ttgttataga tttttaataa
      901 tgctttttta atattaaaat gtacttttac attcttaatc tttttttaaa aagaggtttc
      961 tttatttggc gacttattta caaataacag atctccaata tttccttttg cttactgcaa
     1021 tttctttgtg aaatttgttt tcatttttcc aagcaattaa acatagcagt cttgattgtg
     1081 gcggtttatc atgccgtgag tgttgccatc tctgctgcat tgtgtacttg gagcataaca
     1141 tatgagatca tataatcagt ggtaaatcat agcttccatg gaaccttttt atttttattt
     1201 aaacaatgta taacgtattc atttatactg atttataaaa gaaaggtttt aagcactgaa
     1261 gcaatcattg ctaaaatatg tatttcataa tatttaagca gtgaagcaag aggatataat
     1321 ttgattatta gcattaccaa ttaaatcctt tatttatatt taacagtcat aaattataca
     1381 tgcaaaaagc tcagatttca acttttcaaa tttttatgct attcatttgt atttaagtat
     1441 atttctcata gtttggttct ttcatgccta gacatgagtc ggttagtctg tgctggggag
     1501 aatggaagta ggacaaggta acaacttcaa cttttagagc ctgaagaacc atatattcct
     1561 actcccagct tcagtacaga cttgagatat gaagggcagg gaggatttgc ttaaggtaca
     1621 gaagctggcg gtttcctaag tctcacagtg agtggggctc aggatgacat atatcttgat
     1681 gattcagaga gcgagcgatg ggaatttgga gcagtacttt tcaccatttg tccactggat
     1741 gtcaccattt tcctaaaagg cagctattgg tacatgattg tgactgtggt cttctaaaag
     1801 ctgaagtcaa agtgattaat ttccagtcac agattacagg aacattttta aagggtttaa
     1861 gtgatgatgt taaatagaaa cagatgggtt gaaaatggaa ggatttgtca taattacgac
     1921 tattaccttt attttttaaa aatgggcatt ttgtaacatt ccttcaggaa gaatggaagt
     1981 gtgtatgttt ttctgcatgt gtgtgagcac tgtgagtctt acaagattac tgcagttttc
     2041 agtgattttc agagtaaaag tcaatcaaca tgttatttat catttaggac ttgaacactg
     2101 gattgtgcat ggttgaatgt ctttagtcca ctacaaaatg tgcttgatat tgatagaatc
     2161 atgctgaatt gtatattttc aaaattagct catgtgtttt taaaatgttg agaccaaagt
     2221 agtatagaag agtatgacgt attttaattt aattgtaaaa ttattagagg tatttgtttt
     2281 aaaactatat taaagaaaag tgttggtgca tatagaacag taccattatt gttatgctcg
     2341 tatttctgca tcccagggca agtaaaccct gaggaaccct tgtcttcgag tagctactgg
     2401 ggctgcagct gctcccgagg atgcaccagc gtcccactat gattacagct tcctggttca
     2461 tgtttcagct gttgcagaat ttcagccaag ttactttttt tccttaagta cgttgaaaaa
     2521 gctttttttt ttccttcttc ggtaactcac agtctgttct ttgtggccag cacctattta
     2581 taaagtctta agtaacacta cttaaaggag ccaaacacag agctcttctt ggtactgtta
     2641 agcatgagta gcagtagttg gctttcattg atgcaattct cctatctcag aattttaaat
     2701 aatgaccata ggaaaagtca gtggcaagtg tacagtagtc ttcttgtgta ctaaggaaat
     2761 gaatgaattt taatctaata aatggatgat ttgtggatta aaactaggca gtaaatataa
     2821 agggtatttg tttgacttgt aacttacaaa tgtaaatttc ccttagcccc agttttcaat
     2881 tttttttttc ttaaatattt caaaatgagt tgacttggtg attcatgacc ttggttgcat
     2941 gttagaatgc cctgcagatc ttaaaactca tctaggtccc ttcacataca gctgattcat
     3001 aatcatttct ttgtgattga catttcatat gacagtgtct accctctatt gtcttcagag
     3061 gctcattctg acacccaagc ttcagaagca ctagcccatg gactttctga ttatactgga
     3121 ctctgtttga aagtacattt aatctgaagc tatttaacga ttgattctac tccttagtat
     3181 ctttttatgg gcttaagaag tatttggcag tccttttttt tttttttttg gagaatctct
     3241 acatagttct ggctgtcctg gagctctctc tgtaaaccat gctggctttt gtattccctt
     3301 ttcttgttct ttaaaaaata agacctacca gtaattcaat tgtaaaatct tattagtgtt
     3361 tctccttctg tcccctttac ctttaaaaaa aattgcaggt tatcatttga aagagcatgt
     3421 ttaagcatcg ccgatgtgaa agcactatga ggaatgaatc tgtgccgtct agatatggct
     3481 cctttatcat tactgttcta ctacatggat ggagtcctgt tctgtagggt ctcacttttt
     3541 aagatcatct tcctgttgta aaagtttaag gcattttgct caagtacttt gtttacaatt
     3601 aaaatgaata gaacttaata gaagataagg ttatggctta ctggaaagca tcagcatgac
     3661 ttggtataga cttaaaagag tacatgtgat tatactgtgg aatgattatt gatatataag
     3721 gactctagta attgtacctc ctgaataaat gtccgtttgc gcattttcta acttacagtc
     3781 cattgtctgt tctggcaaca atctcgcttt gtagttttac tctccaaaat tcatgagtag
     3841 tgtttcttca aaggttgttg aagtaataat agttacataa tgggggaaag tcatttgatt
     3901 attaattttc aagaagtttt aaactaattt gtaactggac gtggttttta aaaatattgg
     3961 caaagatttg atacacttgt actcttttta gtttgagaaa attatttgga atgtgaaaca
     4021 gtgctttttc aatagatgaa tcatttagca attaaattct gactctaagg cttatttaaa
     4081 atatatttgt atgagtcgtg tttgtccttt gcatttgaca aaattgatac aattacaagt
     4141 tgaacgctgt atgtaaaata accgttacat aaagtaaaaa gcaaactccg tggtggttcc
     4201 tgaaatgaga cttcagattt ctgtattttg tttgcctttc ataaactata actaaaccaa
     4261 a
//
