LOCUS       NM_021758                759 bp    mRNA    linear   ROD 26-APR-2024
DEFINITION  Rattus norvegicus lin-7 homolog B, crumbs cell polarity complex
            component (Lin7b), mRNA.
ACCESSION   NM_021758
VERSION     NM_021758.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 759)
  AUTHORS   Hu,H.T. and Hsueh,Y.P.
  TITLE     Calcium influx and postsynaptic proteins coordinate the dendritic
            filopodium-spine transition
  JOURNAL   Dev Neurobiol 74 (10), 1011-1029 (2014)
   PUBMED   24753440
REFERENCE   2  (bases 1 to 759)
  AUTHORS   Bohl,J., Brimer,N., Lyons,C. and Vande Pol,S.B.
  TITLE     The stardust family protein MPP7 forms a tripartite complex with
            LIN7 and DLG1 that regulates the stability and localization of DLG1
            to cell junctions
  JOURNAL   J Biol Chem 282 (13), 9392-9400 (2007)
   PUBMED   17237226
REFERENCE   3  (bases 1 to 759)
  AUTHORS   Hong,C.J. and Hsueh,Y.P.
  TITLE     CASK associates with glutamate receptor interacting protein and
            signaling molecules
  JOURNAL   Biochem Biophys Res Commun 351 (3), 771-776 (2006)
   PUBMED   17084383
REFERENCE   4  (bases 1 to 759)
  AUTHORS   Olsen,O., Moore,K.A., Fukata,M., Kazuta,T., Trinidad,J.C.,
            Kauer,F.W., Streuli,M., Misawa,H., Burlingame,A.L., Nicoll,R.A. and
            Bredt,D.S.
  TITLE     Neurotransmitter release regulated by a MALS-liprin-alpha
            presynaptic complex
  JOURNAL   J Cell Biol 170 (7), 1127-1134 (2005)
   PUBMED   16186258
REFERENCE   5  (bases 1 to 759)
  AUTHORS   Leonoudakis,D., Conti,L.R., Radeke,C.M., McGuire,L.M. and
            Vandenberg,C.A.
  TITLE     A multiprotein trafficking complex composed of SAP97, CASK, Veli,
            and Mint1 is associated with inward rectifier Kir2 potassium
            channels
  JOURNAL   J Biol Chem 279 (18), 19051-19063 (2004)
   PUBMED   14960569
  REMARK    GeneRIF: specific Veli isoforms participate in forming distinct
            protein complexes in brain, where Veli-1 stably associates with
            CASK and SAP97, Veli-2 associates with CASK and Mint1, and Veli-3
            associates with CASK, SAP97, and Mint1.
REFERENCE   6  (bases 1 to 759)
  AUTHORS   Hori,K., Konno,D., Maruoka,H. and Sobue,K.
  TITLE     MALS is a binding partner of IRSp53 at cell-cell contacts
  JOURNAL   FEBS Lett 554 (1-2), 30-34 (2003)
   PUBMED   14596909
REFERENCE   7  (bases 1 to 759)
  AUTHORS   Jo,K., Derin,R., Li,M. and Bredt,D.S.
  TITLE     Characterization of MALS/Velis-1, -2, and -3: a family of mammalian
            LIN-7 homologs enriched at brain synapses in association with the
            postsynaptic density-95/NMDA receptor postsynaptic complex
  JOURNAL   J Neurosci 19 (11), 4189-4199 (1999)
   PUBMED   10341223
REFERENCE   8  (bases 1 to 759)
  AUTHORS   Irie,M., Hata,Y., Deguchi,M., Ide,N., Hirao,K., Yao,I., Nishioka,H.
            and Takai,Y.
  TITLE     Isolation and characterization of mammalian homologues of
            Caenorhabditis elegans lin-7: localization at cell-cell junctions
  JOURNAL   Oncogene 18 (18), 2811-2817 (1999)
   PUBMED   10362251
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Oct 7, 2022 this sequence version replaced NM_021758.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BQ194324.1, AF090133.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760386,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-89                JAXUCZ010000001.1  104985990-104986078 c
            90-208              JAXUCZ010000001.1  104985595-104985713 c
            209-280             JAXUCZ010000001.1  104985382-104985453 c
            281-490             JAXUCZ010000001.1  104984592-104984801 c
            491-654             JAXUCZ010000001.1  104983776-104983939 c
            655-759             JAXUCZ010000001.1  104983368-104983472 c
FEATURES             Location/Qualifiers
     source          1..759
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..759
                     /gene="Lin7b"
                     /gene_synonym="MALS2; Veli1a; Veli2"
                     /note="lin-7 homolog B, crumbs cell polarity complex
                     component"
                     /db_xref="GeneID:60377"
                     /db_xref="RGD:620730"
     exon            1..89
                     /gene="Lin7b"
                     /gene_synonym="MALS2; Veli1a; Veli2"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..676
                     /gene="Lin7b"
                     /gene_synonym="MALS2; Veli1a; Veli2"
                     /note="MALS-2; lin-7B; veli-2 protein; vertebrate lin-7
                     homolog 2; mammalian lin-seven protein 2; lin 7 homolog b;
                     vertebrate homolog of C. elegans Lin-7 type 2; lin-7-A"
                     /codon_start=1
                     /product="protein lin-7 homolog B"
                     /protein_id="NP_068526.1"
                     /db_xref="GeneID:60377"
                     /db_xref="RGD:620730"
                     /translation="MAALVEPLGLERDVSRAVELLERLQRSGELPPQKLQALQRVLQS
                     RFCSAIREVYEQLYDTLDITGSAEVRAHATAKATVAAFTASEGHAHPRVVELPKTDEG
                     LGFNIMGGKEQNSPIYISRVIPGGVADRHGGLKRGDQLLSVNGVSVEGEHHEKAVELL
                     KAAQGSVKLVVRYTPRVLEEMEARFEKMRSARRRQQHHSYSSLESRG"
     exon            90..208
                     /gene="Lin7b"
                     /gene_synonym="MALS2; Veli1a; Veli2"
                     /inference="alignment:Splign:2.1.0"
     exon            209..280
                     /gene="Lin7b"
                     /gene_synonym="MALS2; Veli1a; Veli2"
                     /inference="alignment:Splign:2.1.0"
     exon            281..490
                     /gene="Lin7b"
                     /gene_synonym="MALS2; Veli1a; Veli2"
                     /inference="alignment:Splign:2.1.0"
     exon            491..654
                     /gene="Lin7b"
                     /gene_synonym="MALS2; Veli1a; Veli2"
                     /inference="alignment:Splign:2.1.0"
     exon            655..759
                     /gene="Lin7b"
                     /gene_synonym="MALS2; Veli1a; Veli2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcattgcacc tcctcgcgga cgccggggcg ggtggcttgc attagaggag atatggctgc
       61 gctggtggag ccgctggggc tggagcggga cgtgtcccgg gctgtggagc tgctagagcg
      121 gctgcagcgt agcggagaac tgcccccgca gaagctgcag gccctgcagc gggtcctgca
      181 gagccgcttc tgctccgcca tccgcgaggt gtatgaacag ctctatgaca cgctggacat
      241 cactggcagc gccgaggtgc gggctcatgc cacagccaag gctacagtgg ctgctttcac
      301 agccagtgag ggccatgccc atcccagggt cgtggaacta ccgaagactg atgagggttt
      361 gggcttcaac atcatgggcg gcaaagagca gaactcgccc atctatatct ctcgagtcat
      421 ccccggaggt gtggctgatc gccatggtgg cctcaagagg ggagaccagc tgctgtctgt
      481 gaatggtgtg agtgtggaag gcgaacacca tgaaaaggca gtggaactcc tgaaggccgc
      541 ccagggctca gtgaaactgg tggtgcgcta cacccctcgg gtgctggagg agatggaagc
      601 ccgcttcgag aagatgcgat ctgcccgtcg gcgccagcag caccacagct actcgtcctt
      661 ggagtctcga ggctgaaatc acagagcagg acccgcctcc tcccctgtac agtattattt
      721 attgtcactg gctccttatt taaagatctt taaccctca
//
