LOCUS       NM_001408921            5833 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus lin-7 homolog A, crumbs cell polarity complex
            component (Lin7a), mRNA.
ACCESSION   NM_001408921 XM_039080116
VERSION     NM_001408921.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5833)
  AUTHORS   Lu,C.C., Appler,J.M., Houseman,E.A. and Goodrich,L.V.
  TITLE     Developmental profiling of spiral ganglion neurons reveals insights
            into auditory circuit assembly
  JOURNAL   J Neurosci 31 (30), 10903-10918 (2011)
   PUBMED   21795542
REFERENCE   2  (bases 1 to 5833)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   3  (bases 1 to 5833)
  AUTHORS   Samuels,B.A., Hsueh,Y.P., Shu,T., Liang,H., Tseng,H.C., Hong,C.J.,
            Su,S.C., Volker,J., Neve,R.L., Yue,D.T. and Tsai,L.H.
  TITLE     Cdk5 promotes synaptogenesis by regulating the subcellular
            distribution of the MAGUK family member CASK
  JOURNAL   Neuron 56 (5), 823-837 (2007)
   PUBMED   18054859
REFERENCE   4  (bases 1 to 5833)
  AUTHORS   Morokuma,Y., Nakamura,N., Kato,A., Notoya,M., Yamamoto,Y.,
            Sakai,Y., Fukuda,H., Yamashina,S., Hirata,Y. and Hirose,S.
  TITLE     MARCH-XI, a novel transmembrane ubiquitin ligase implicated in
            ubiquitin-dependent protein sorting in developing spermatids
  JOURNAL   J Biol Chem 282 (34), 24806-24815 (2007)
   PUBMED   17604280
REFERENCE   5  (bases 1 to 5833)
  AUTHORS   Bohl,J., Brimer,N., Lyons,C. and Vande Pol,S.B.
  TITLE     The stardust family protein MPP7 forms a tripartite complex with
            LIN7 and DLG1 that regulates the stability and localization of DLG1
            to cell junctions
  JOURNAL   J Biol Chem 282 (13), 9392-9400 (2007)
   PUBMED   17237226
REFERENCE   6  (bases 1 to 5833)
  AUTHORS   Karnak,D., Lee,S. and Margolis,B.
  TITLE     Identification of multiple binding partners for the amino-terminal
            domain of synapse-associated protein 97
  JOURNAL   J Biol Chem 277 (48), 46730-46735 (2002)
   PUBMED   12351654
REFERENCE   7  (bases 1 to 5833)
  AUTHORS   Straight,S.W., Karnak,D., Borg,J.P., Kamberov,E., Dare,H.,
            Margolis,B. and Wade,J.B.
  TITLE     mLin-7 is localized to the basolateral surface of renal epithelia
            via its NH(2) terminus
  JOURNAL   Am J Physiol Renal Physiol 278 (3), F464-F475 (2000)
   PUBMED   10710551
REFERENCE   8  (bases 1 to 5833)
  AUTHORS   Jo,K., Derin,R., Li,M. and Bredt,D.S.
  TITLE     Characterization of MALS/Velis-1, -2, and -3: a family of mammalian
            LIN-7 homologs enriched at brain synapses in association with the
            postsynaptic density-95/NMDA receptor postsynaptic complex
  JOURNAL   J Neurosci 19 (11), 4189-4199 (1999)
   PUBMED   10341223
REFERENCE   9  (bases 1 to 5833)
  AUTHORS   Irie,M., Hata,Y., Deguchi,M., Ide,N., Hirao,K., Yao,I., Nishioka,H.
            and Takai,Y.
  TITLE     Isolation and characterization of mammalian homologues of
            Caenorhabditis elegans lin-7: localization at cell-cell junctions
  JOURNAL   Oncogene 18 (18), 2811-2817 (1999)
   PUBMED   10362251
REFERENCE   10 (bases 1 to 5833)
  AUTHORS   Butz,S., Okamoto,M. and Sudhof,T.C.
  TITLE     A tripartite protein complex with the potential to couple synaptic
            vesicle exocytosis to cell adhesion in brain
  JOURNAL   Cell 94 (6), 773-782 (1998)
   PUBMED   9753324
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Jul 1, 2022 this sequence version replaced XM_039080116.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.38861.1,
                                           SRR26643286.22510.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-100               JAXUCZ010000007.1  44473568-44473667
            101-219             JAXUCZ010000007.1  44534050-44534168
            220-291             JAXUCZ010000007.1  44578245-44578316
            292-501             JAXUCZ010000007.1  44580749-44580958
            502-714             JAXUCZ010000007.1  44616805-44617017
            715-5833            JAXUCZ010000007.1  44623956-44629074
FEATURES             Location/Qualifiers
     source          1..5833
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q21"
     gene            1..5833
                     /gene="Lin7a"
                     /gene_synonym="lin-7-Ba; MALS-1; Veli1"
                     /note="lin-7 homolog A, crumbs cell polarity complex
                     component"
                     /db_xref="GeneID:85327"
                     /db_xref="RGD:621256"
     exon            1..100
                     /gene="Lin7a"
                     /gene_synonym="lin-7-Ba; MALS-1; Veli1"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..714
                     /gene="Lin7a"
                     /gene_synonym="lin-7-Ba; MALS-1; Veli1"
                     /note="veli-1 protein; vertebrate lin-7 homolog 1;
                     mammalian lin-seven protein 1; protein lin-7 homolog
                     A-like"
                     /codon_start=1
                     /product="protein lin-7 homolog A"
                     /protein_id="NP_001395850.1"
                     /db_xref="GeneID:85327"
                     /db_xref="RGD:621256"
                     /translation="MLKPSVTSAPTADMATLTVVQPLTLDRDVARAIELLEKLQESGE
                     VPVHKLQSLKKVLQSEFCTAIREVYQYMHETITVNGCPEFRARATAKATVAAFAASEG
                     HSHPRVVELPKTDEGLGFNVMGGKEQNSPIYISRIIPGGVAERHGGLKRGDQLLSVNG
                     VSVEGEHHEKAVELLKAAKDSVKLVVRYTPKVLEEMEARFEKLRTARRRQQQQLLIQQ
                     QQQQQQPQQNHMS"
     exon            101..219
                     /gene="Lin7a"
                     /gene_synonym="lin-7-Ba; MALS-1; Veli1"
                     /inference="alignment:Splign:2.1.0"
     exon            220..291
                     /gene="Lin7a"
                     /gene_synonym="lin-7-Ba; MALS-1; Veli1"
                     /inference="alignment:Splign:2.1.0"
     exon            292..501
                     /gene="Lin7a"
                     /gene_synonym="lin-7-Ba; MALS-1; Veli1"
                     /inference="alignment:Splign:2.1.0"
     exon            502..714
                     /gene="Lin7a"
                     /gene_synonym="lin-7-Ba; MALS-1; Veli1"
                     /inference="alignment:Splign:2.1.0"
     exon            715..5833
                     /gene="Lin7a"
                     /gene_synonym="lin-7-Ba; MALS-1; Veli1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cactacaagc ggttgctgat gctgaagccg agcgtcactt cggctcccac ggcagacatg
       61 gcgacattga cagtggtcca gccgcttact ctggacagag atgttgcaag agcaatcgaa
      121 ctactagaaa agctacaaga atccggagaa gtaccagtgc acaagctgca gtctctcaaa
      181 aaggtgcttc agagtgagtt ttgtacagca atccgagagg tgtatcaata catgcatgaa
      241 acgattactg ttaatggctg ccctgaattc cgtgcgaggg ccacagcaaa ggcaacagtt
      301 gcggcttttg cagccagcga aggccactcc caccctcggg tagtcgaact gccaaagact
      361 gatgaaggcc tgggttttaa cgtgatggga ggaaaggaac agaattctcc aatttacatc
      421 tcccgcatca tccctggagg ggtggctgaa agacacggag gcctcaaaag aggagaccag
      481 ttgctatcag tgaacggagt gagcgtggaa ggggaacatc acgagaaagc tgtagaactt
      541 ctcaaggctg ctaaggacag tgtgaagctg gtcgtcagat acaccccaaa agtcctggag
      601 gagatggagg ctcgttttga aaagctgagg acagctcggc gtcggcaaca gcaacagttg
      661 cttattcagc agcagcagca gcagcagcag ccacaacaaa accacatgtc ataggccctt
      721 gaagaaaagc tagcaggtca atcatccaac agtcacaaat ttggaacccg tgctccggaa
      781 tcccagcaca tagaaaaagg aaaagaaaac accagtaaac acctgtcaca aaactgtgaa
      841 cacatggtgt atccatcctt taccaagaca attcgacatc ttcctcctct gggcaccagc
      901 ccccgttcat tgctttttta cctactcaga ccttccattc atggcagtgg aaatgcagtg
      961 tgttgaggga gagaagtatt ccagtctgca gactgaaaga gtgtaagaat aaagtctgtg
     1021 acttttgaac aaatcacctg ggctaggatt aagtgaatct ttggtcaagg ctcttccaga
     1081 gattagcaaa cccttcatta ggctatagtt caaactgcat cagttcaagg ttgtggccac
     1141 ttgaaaggaa cctcatatcg acctctgccc taaccctttc cacagtctat gttgctgagc
     1201 tgtctgaatt ggaatttgat tcagttacaa actcaacctc cattctcctc ttgaaaatgc
     1261 caagttctta ttctatataa tctgttctga acttggaaac agttggcttt ttagttttca
     1321 ttcctaccaa tatccaaaca catcaactga agttttttat tttagaatat tttagctgaa
     1381 cttttaattt attagaagtg caggttggaa cttaatgctg tcctttttta gaaagttaag
     1441 tattgcctgt atctattatt agtttagaca gactacaatg tatatttgtt ccaaaatata
     1501 tatataagac cagagtacac tggttataac ttggttcttt gtttgccaag ggtcactact
     1561 ctggtaagag attctctaga ctttatggat tccttctcat ttgatatatg taagctgccc
     1621 tcaatatttt cttgttaaat tttatttatt catttccact gatgaacttt ggagaagtct
     1681 aaacccatcc tgcacacatt gatgtacttt catagaaatc tatttgatat tttaaatctt
     1741 ggagatttat aatactgaac tataacatgt gcacatagat atacatcaaa agggatatct
     1801 cacacaaagt ttagatcggt aaccctaaat acaaatttta tttttttggc agtctaagat
     1861 caaaggtact ggccctttta tattgacata tgtggaaccc agtgatacca atattgtaaa
     1921 tgacagatac tgctttctcc aagggaaaat cgatttcaat ttgcatattc ccacttgtaa
     1981 ataagcaatc agatttgttc agctttcata aagatctgtt agcacctcct gtacacacaa
     2041 ttttttttta aattttgagt aaatctagac acataatctg gttttccata atgtaatgaa
     2101 tagacactta aacaccttaa gcacaaaaat gtacacagac acacacagac acacacaccc
     2161 aaaagaataa ctgcctagtt aaagcaagca gatgggtcat caaaacagag tccactagtt
     2221 taatatgtcc attctttttt gcaaaagcag aaaatggttc cccaagctac aaagaatttg
     2281 gtatttcaga tagtcctcta gcatagaaat ttgtgaagtt cagcttacaa gccatcttcc
     2341 tgaaactaaa caaaaccaat tagacatacc cagcatgttt tgtctcgcac catcgggtgg
     2401 tactactgtc aagagcaatg tcttactgct ttagatagtg cattgcccac cggatgacaa
     2461 acagccagaa aaccaagagc tacaccaatt tatttcaacc ctatcctgtt atggtaacag
     2521 attcccatcc tcaaaaatat atcctttttt tttttactag agaaaggttg gggggagggg
     2581 tcagtgagga gccagaatgt tatataaaat aggccaataa aagggacaag catgacaaaa
     2641 agaaataagt gcagattata agtattattc agtttgaaag atagttctca tttttataaa
     2701 aaatgtaata aacatatatt ttagttatca tttaagaaag aaatattaaa gctattcagg
     2761 agatgccaca aaactctcat aaaaggaaat catctcaccc ttataatgag aaaatggtca
     2821 tttcaacgag tttcagtaca ttgtataaat ttggagctta agacgattat gttttccctt
     2881 agctgttacg tgtttagtta ataccaaact taatatatgg tttcacatca gtacaagtat
     2941 tgtcagaagc cactatgaaa taagcaggta ctttttaagc tggtgttttc tagaagtctt
     3001 tgaattttat gcttcatctg tacaacgtgt agcgctgata aatgtatgcc aggttgtttg
     3061 tcgaaatgaa gcaatccatc atatgtacag aagccaaggg ataggttata cgtcttcacg
     3121 gtcttacata caaatggctg gttctcttta gcgaagttta tctcattaaa atgtaagcat
     3181 ttccctggaa ttttaatcaa aagtgacacc cccaaagact tacagaagcc gctggtgcat
     3241 ctctgaagtt tcactgaagc aaaattgaaa aggaagaaca aatccaccat gatttgtact
     3301 gaacttctct attcccaaga atcacaaaca aagcctctca catggctgat gtcatccatt
     3361 aaaagaaaag gcatcgtacg tagactggac ttccatgcag ttcaatataa atataataaa
     3421 tggggtgtta aaagttagga agaaatggtt gtgacaggaa cctgatggag tgaatctcag
     3481 ctccctccct tggtcaagtg caagtaactc tctctgcacc ttttccctgc tatgatacta
     3541 aggcaagcac aaaaggtaaa agaaatcctg aaccttttca ctggagcatt tacattttga
     3601 ttctgcagtc atttgcaaca gaacatctgc agggagataa tgagcttaaa ttacaattga
     3661 ctttggaaga ataacagact cttgtgttcc tcaatcttgt aatcaatagg gaattctcta
     3721 gcaatgagag agccaccgct atctttcaag acaatgctaa gatctaagta aaaaaaaagt
     3781 ctagcattca ggggtttgtt aagaatggga gtttgtcact aaaaaacttg gctagagaca
     3841 aattatacct atttacaaat gtggttctca aacatggcat caaggatctt atttcctttt
     3901 acctagctgt acattcagga ctctaaatgt ggtacactgc tttcaacatc tattactatt
     3961 tgtgggtgtg ggaatgagtc cctggatttc ttacctttta gctgggcttt gcttgtaagc
     4021 actcctattc tatacttaag cttcaaacaa gatgtcgaca cagacacaga gtattctccg
     4081 aggtttctgg gacccctatg agtaagacct tccagggcat cctatccttc tttaaaccca
     4141 aacactataa gaccaagtaa tgtgactctg gtcctgcaga cgtgctggca ctctccaggc
     4201 actcagtgaa tatttgttga atgaatgaat tactgaagag gatggtaaat gaattaattt
     4261 tgacttctga ctaacatata ttggcattat aattttataa ttttgcatgt catagccaga
     4321 gccagaattt cctctaagat acatcctgga atcaaattaa attaaatatc tcaaagattc
     4381 aaggaccttt aagtcagaag caatgcttgg gaaatataca tatatatata tatatatata
     4441 tatatatata ttctgaactt tatatataat gagtaaaact ctctagttct ttacaaaagc
     4501 acatggataa tttggcatgc aggcttcaaa atagaacttt atttctaaag tttacagaac
     4561 actatgcttt aggctttttt aaacagttat atcatcaaac atatattacc ctatgacacg
     4621 tgtatttttc aaaggatcca tggtcattga aagcgccatt tctaaacttc tgcttccaaa
     4681 tgccccctct ttcatcattg actcctagaa tatacctgag ctaaaaatta ctcacttgtc
     4741 acctccctcc caaacttttc cgtgtattta tttatttaac aaatatgtct gtgttcctgg
     4801 cacatgctag attctagaaa tgcgatgcga aacaagtcaa atgtaatcca atcctaaagt
     4861 atactatgag gaactcttac tctggctaac tagtttatcg ttgactgggt tctcatcaca
     4921 catgctcgag caacagcagc aacaagaagc cctcactgca gcatgggaac cattcaatac
     4981 ttcccacgta gacttatgtg agcttgcctt tctgaacata acccctcaaa tttaccccgt
     5041 agtttagcca taaagcagag ttacagccca gggaagtagg ctattttaaa atttcatcag
     5101 tatctaccag gtttcagctt cagagctttt cccacccaag ctctattaac agggctccat
     5161 ttatacacag aagaactgaa gcacagatcc atgacttttc caaggtcatc cggttagctg
     5221 gtggagttgg gggtttgaac ccaagaagtc caacacagtg gtccatgtgc ctaaggatta
     5281 tccataggct ttggggagtc actcctgtat taaagcgaat gaatcattgt atatagaaat
     5341 atcttgagtt tgtagtgagt aaaaaaaata ttagtaaatt atatttcatt atagccaaca
     5401 aatcacatca gaaactatgt gatcaggact atacctgagt cttacatgat ggcctcatga
     5461 gctacaatac atcaagccag ggacatgcat acaagttcag atccagaaaa tttctacttg
     5521 tgaaaatgtt tcgatgactt cagaattatt cattgtcagc cactgtgtct atttggtgct
     5581 acaaacaaaa aaaaaatgaa agaacaaacc cctgatccaa gggcttataa atacacagtg
     5641 tggagatgaa ccaagggcat ttcatattta tagggaagga ttggccaact gttccatttc
     5701 tcaccattgc atgtacattg tgtctttcca attgtttgcg ttgtttttat gaaagagctg
     5761 caaaattgtg cagtggttca acatgaccaa agtggtatta tgctgctggg aagtaaacgt
     5821 attagatacc aga
//
