LOCUS       NP_001094034             749 aa            linear   ROD 15-JUN-2024
DEFINITION  protein lin-54 homolog isoform 1 [Rattus norvegicus].
ACCESSION   NP_001094034 XP_001056268 XP_001061440 XP_223187
VERSION     NP_001094034.1
DBSOURCE    REFSEQ: accession NM_001100564.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 749)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
REFERENCE   2  (residues 1 to 749)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On or before Jan 20, 2008 this sequence version replaced
            XP_001056268.1, XP_223187.3, XP_001061440.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643288.50880.1,
                                           SRR21887620.1685037.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..749
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     Protein         1..749
                     /product="protein lin-54 homolog isoform 1"
                     /note="protein lin-54 homolog"
                     /calculated_mol_wt=79130
     Region          <165..480
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Site            244
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q6MZP7; propagated from
                     UniProtKB/Swiss-Prot (Q641Z1.2)"
     Site            249
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:Q6MZP7; propagated from
                     UniProtKB/Swiss-Prot (Q641Z1.2)"
     Site            264
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q6MZP7; propagated from
                     UniProtKB/Swiss-Prot (Q641Z1.2)"
     Site            282
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q6MZP7; propagated from
                     UniProtKB/Swiss-Prot (Q641Z1.2)"
     Site            310
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q641Z1.2)"
     Site            314
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q641Z1.2)"
     Region          522..>545
                     /region_name="TCR"
                     /note="Tesmin/TSO1-like CXC domain, cysteine-rich domain;
                     pfam03638"
                     /db_xref="CDD:461001"
     Region          523..536
                     /region_name="DNA-binding.
                     /evidence=ECO:0000250|UniProtKB:Q6MZP7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q641Z1.2)"
     Site            536
                     /site_type="other"
                     /note="Critical for interaction with target DNA.
                     /evidence=ECO:0000250|UniProtKB:Q6MZP7; propagated from
                     UniProtKB/Swiss-Prot (Q641Z1.2)"
     Site            574
                     /site_type="other"
                     /note="Interaction with DNA.
                     /evidence=ECO:0000250|UniProtKB:Q6MZP7; propagated from
                     UniProtKB/Swiss-Prot (Q641Z1.2)"
     Region          583..596
                     /region_name="Linker.
                     /evidence=ECO:0000250|UniProtKB:Q6MZP7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q641Z1.2)"
     Region          596..631
                     /region_name="TCR"
                     /note="Tesmin/TSO1-like CXC domain, cysteine-rich domain;
                     pfam03638"
                     /db_xref="CDD:461001"
     Region          599..612
                     /region_name="DNA-binding.
                     /evidence=ECO:0000250|UniProtKB:Q6MZP7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q641Z1.2)"
     Site            610
                     /site_type="other"
                     /note="Critical for interaction with target DNA.
                     /evidence=ECO:0000250|UniProtKB:Q6MZP7; propagated from
                     UniProtKB/Swiss-Prot (Q641Z1.2)"
     Site            635
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q6MZP7; propagated from
                     UniProtKB/Swiss-Prot (Q641Z1.2)"
     CDS             1..749
                     /gene="Lin54"
                     /gene_synonym="RGD1311361"
                     /coded_by="NM_001100564.2:193..2442"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="GeneID:305171"
                     /db_xref="RGD:1311361"
ORIGIN      
        1 mevvpaevns llpddimdta itlvdedsie avivsspipm eteleeivsi nstgdstatp
       61 istepitvys nhtnqvavnt tvskadsntt vkpafpsglq klgaqtpvti sanqiilnkv
      121 sqtsdlklgn qtlkpdgqkl ilttlgksgs pivlalphsq lpqaqkvtaq aqpgdaklpp
      181 qqikvvtigg rpevkpaigv saltpgsqli ntttqpsvlq tqqlktvqia kkprtptsgp
      241 vitklifakp inskavtgqt tqasppvvtg rvlsqsapgt psktitises gvigstlnst
      301 tqtpnkiais plkspnktvk savqtitvgg mstsqfktii plaaapnvqp iqvpgskfhy
      361 vrlvtattag ssappvsqsp svntqplqqa kpvvvnttpv rmsvpfvqaq avkqvvpkpi
      421 nstsqivtts qpqqrlimpa tplpqiqpnl tnlppgtvla papgtgnvgy avlpaqyvtq
      481 lqqssyvsia gnsnftgtsg iqtqarvsfn giipsesasr prkpcnctks lclklycdcf
      541 angefcnncn ctncynnleh enerqkaika cldrnpeafk pkigkgkege sdrrhskgcn
      601 ckrsgclkny cecyeakimc ssickcigck nfeesperkt lmhladaaev rvqqqtaakt
      661 klssqisdll trptpalnsg ggklpftfvt kevaeatcnc llaqaeqadk kgkskaaaer
      721 mileefgrcl msvinsagka ksdpcamhc
//
