LOCUS       NM_001109269            3520 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus lin-28 homolog A (Lin28a), mRNA.
ACCESSION   NM_001109269 XM_001066291 XM_575928
VERSION     NM_001109269.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3520)
  AUTHORS   Hou,D., Pei,C., Yu,D. and Yang,G.
  TITLE     miR-188-5p silencing improves cerebral ischemia/reperfusion injury
            by targeting Lin28a
  JOURNAL   Metab Brain Dis 38 (7), 2327-2338 (2023)
   PUBMED   37572229
  REMARK    GeneRIF: miR-188-5p silencing improves cerebral
            ischemia/reperfusion injury by targeting Lin28a.
REFERENCE   2  (bases 1 to 3520)
  AUTHORS   Cai,L., Gao,Z. and Gu,Z.
  TITLE     Lin28A alleviates ovariectomy-induced osteoporosis through
            activation of the AMP-activated protein kinase pathway in rats
  JOURNAL   Int J Rheum Dis 25 (12), 1416-1423 (2022)
   PUBMED   36106579
  REMARK    GeneRIF: Lin28A alleviates ovariectomy-induced osteoporosis through
            activation of the AMP-activated protein kinase pathway in rats.
REFERENCE   3  (bases 1 to 3520)
  AUTHORS   Hwang,Y.J., Jung,G.S., Jeon,W. and Lee,K.M.
  TITLE     Lin28a ameliorates glucotoxicity-induced beta-cell dysfunction and
            apoptosis
  JOURNAL   BMB Rep 54 (4), 215-220 (2021)
   PUBMED   33691905
  REMARK    GeneRIF: Lin28a ameliorates glucotoxicity-induced beta-cell
            dysfunction and apoptosis.
REFERENCE   4  (bases 1 to 3520)
  AUTHORS   Frasson,L.T., Dalmaso,B., Akamine,P.S., Kimura,E.T., Hamassaki,D.E.
            and Del Debbio,C.B.
  TITLE     Let-7, Lin28 and Hmga2 Expression in Ciliary Epithelium and Retinal
            Progenitor Cells
  JOURNAL   Invest Ophthalmol Vis Sci 62 (3), 31 (2021)
   PUBMED   33749722
  REMARK    GeneRIF: Let-7, Lin28 and Hmga2 Expression in Ciliary Epithelium
            and Retinal Progenitor Cells.
REFERENCE   5  (bases 1 to 3520)
  AUTHORS   Zou,Z., Zhou,X., Zhang,R., Zhang,Q., Jiang,S., Xu,C., Zhang,R.,
            Xie,T., Zhu,H., Gong,P., Zhang,D., Ma,H., Liao,L. and Dong,J.
  TITLE     Lin28a up-regulation is associated with the formation of restenosis
            via promoting proliferation and migration of vascular smooth muscle
            cells
  JOURNAL   J Cell Mol Med 24 (17), 9682-9691 (2020)
   PUBMED   32710472
  REMARK    GeneRIF: Lin28a up-regulation is associated with the formation of
            restenosis via promoting proliferation and migration of vascular
            smooth muscle cells.
REFERENCE   6  (bases 1 to 3520)
  AUTHORS   Rybak,A., Fuchs,H., Smirnova,L., Brandt,C., Pohl,E.E., Nitsch,R.
            and Wulczyn,F.G.
  TITLE     A feedback loop comprising lin-28 and let-7 controls pre-let-7
            maturation during neural stem-cell commitment
  JOURNAL   Nat Cell Biol 10 (8), 987-993 (2008)
   PUBMED   18604195
REFERENCE   7  (bases 1 to 3520)
  AUTHORS   Viswanathan,S.R., Daley,G.Q. and Gregory,R.I.
  TITLE     Selective blockade of microRNA processing by Lin28
  JOURNAL   Science 320 (5872), 97-100 (2008)
   PUBMED   18292307
REFERENCE   8  (bases 1 to 3520)
  AUTHORS   Polesskaya,A., Cuvellier,S., Naguibneva,I., Duquet,A., Moss,E.G.
            and Harel-Bellan,A.
  TITLE     Lin-28 binds IGF-2 mRNA and participates in skeletal myogenesis by
            increasing translation efficiency
  JOURNAL   Genes Dev 21 (9), 1125-1138 (2007)
   PUBMED   17473174
REFERENCE   9  (bases 1 to 3520)
  AUTHORS   Balzer,E. and Moss,E.G.
  TITLE     Localization of the developmental timing regulator Lin28 to mRNP
            complexes, P-bodies and stress granules
  JOURNAL   RNA Biol 4 (1), 16-25 (2007)
   PUBMED   17617744
REFERENCE   10 (bases 1 to 3520)
  AUTHORS   Moss,E.G. and Tang,L.
  TITLE     Conservation of the heterochronic regulator Lin-28, its
            developmental expression and microRNA complementary sites
  JOURNAL   Dev Biol 258 (2), 432-442 (2003)
   PUBMED   12798299
  REMARK    Erratum:[Dev Biol. 2003 Oct 15;262(2):361]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473968.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_575928.2, XM_001066291.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132291,
                              SAMD00132294 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3520
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..3520
                     /gene="Lin28a"
                     /gene_synonym="Lin28; RGD1566408"
                     /note="lin-28 homolog A"
                     /db_xref="GeneID:500562"
                     /db_xref="RGD:1566408"
     exon            1..106
                     /gene="Lin28a"
                     /gene_synonym="Lin28; RGD1566408"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..705
                     /gene="Lin28a"
                     /gene_synonym="Lin28; RGD1566408"
                     /note="protein lin-28 homolog A-like"
                     /codon_start=1
                     /product="protein lin-28 homolog A"
                     /protein_id="NP_001102739.1"
                     /db_xref="GeneID:500562"
                     /db_xref="RGD:1566408"
                     /translation="MGSVSNQQFAGGCAKAAEKAPEEAPADAARAADEPQLLHGAGIC
                     KWFNVRMGFGFLSMTARAGVALDPPVDVFVHQSKLHMEGFRSLKEGEAVEFTFKKSAK
                     GLESIRVTGPGGVFCIGSERRPKGKSMQKRRSKGDRCYNCGGLDHHAKECKLPPQPKK
                     CHFCQSISHMVASCPLKAQQGPSSQGKPVYFREEEEEIHSPTLLPEAQN"
     exon            107..303
                     /gene="Lin28a"
                     /gene_synonym="Lin28; RGD1566408"
                     /inference="alignment:Splign:2.1.0"
     exon            304..488
                     /gene="Lin28a"
                     /gene_synonym="Lin28; RGD1566408"
                     /inference="alignment:Splign:2.1.0"
     exon            489..3520
                     /gene="Lin28a"
                     /gene_synonym="Lin28; RGD1566408"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctttgcctc cggacttctc tggggccagc agccgcccga cctggggccc ggggccacgg
       61 gctcagccga cgaccatggg ctcggtgtcc aaccagcagt ttgcaggtgg ctgcgccaag
      121 gcagcggaga aggcgccaga agaggcgccg gctgacgcgg cccgagcggc agacgagccg
      181 cagctgctgc acggggccgg catctgtaag tggttcaacg tgcgcatggg gttcggcttc
      241 ctgtctatga ccgcccgtgc cggggtcgcg ctcgaccccc cggtggacgt ctttgtgcac
      301 cagagcaagc tgcacatgga aggtttccga agcctcaagg agggtgaggc agtggagttc
      361 acctttaaga agtctgccaa gggtctagag tccatccgcg tcactggccc tggtggcgtg
      421 ttctgtattg ggagtgagcg acggccaaag gggaagagca tgcagaaacg aagatccaaa
      481 ggagacaggt gctacaactg tggtgggcta gaccaccatg ccaaggaatg caagctgcca
      541 ccccagccca agaagtgcca cttttgccaa agcatcagcc atatggtggc ctcatgtcca
      601 ctgaaggccc agcagggccc cagttctcag ggaaaacctg tctacttccg ggaggaggaa
      661 gaagagatcc acagccctac cctgctccca gaagcccaga attgaggccc aggagtaggg
      721 gttattcttt ggctaatggg gagtttcagg gaggaggcat caatccgcag agtggagaaa
      781 gtgggaatcg ggtgggttgc gtgggtagct tgcactgtca tatgacatct caggccgggg
      841 ttcccagtgt caccctgtct ttccttggag ggaaggaaag ggtgaggcaa aggaactcct
      901 accacgctcc atctagaagc aagtgaaagc ttttgtgggg aaccacccta gaatctgcat
      961 gctttatctg aggctctaat gggctctgct gagtggctgt tacaggggag aagcccttct
     1021 gtagaaggct gtgtgacagt tcccttgcta gacaggatgt gaaacaagtg tcaaaccaag
     1081 attaatgaac ctaaccctcc agcttctatg ttctgtagaa gagactctca ggttatttcc
     1141 acagggcgct tcctcataac ccagtcctgc catgctgtgc tgggaagagt ccctagcaac
     1201 gggttgtgat cacaggcaaa gagggtggtt ggggggacaa ctgcagacct gctgctccca
     1261 cctcactccc agccctttct gggccaatgg gattttaatt tatttgctcc cttgggtaac
     1321 tgcaccttgg gtcccacttt ctccaggatg ccaactgcac tatctatgtg cgaatgacgt
     1381 atcttgtgcg tttttttttc cttaatataa atattgggtt tgtatttttg tatattttaa
     1441 tcttaaggcc ctcattcctg cactgtgttc tcaggtacat gagcaatctc agggataagt
     1501 ccgtagcagc tccaggtctg cacagcagga atacttaact ttgttttgat caccatggag
     1561 accaaccatt tggagtgcac agcctgttga actacctcat ttttgccgat tacagctgcc
     1621 ttttctgcca tagcgtcctt gaaaaatgtc tcacaggttt tgattgagct gccccgagac
     1681 ttgatctggt tttggcaaaa cataggaaat cagtctaaac cggaaagggt ggtacagaga
     1741 cattaaaaag ccgggccagg gattggggat ttagctcagt ggtagagcgc ttgcctagga
     1801 agcgcaaggc cctgggttag gtccccagct ctggaaaaaa aagaaccaaa aaaaaaaaaa
     1861 aaaaaaaaaa aagctgggcc agtgaaaggc gcaagagtaa ctttccatac caaattcatc
     1921 cttttgccag attaatctaa gcctgccatg cacagcaggg tgtgtttgtg tgtgtgtatg
     1981 ttgatttttt ttcaatgcaa atttatgagg aagaggtgtt tttttattgt ttgattgctt
     2041 tttttatact ggggattgaa ccatgggctt catttatgct aggaagtacc ctgccactga
     2101 gttatcctgg taaggatgca atttaagacc aatatcttat tcccacattg tgctgtccag
     2161 gtatgggaac atgaggcaag gactcaaatc cttagccttt cacaatcttg gcttccagag
     2221 agactcaacg agtgtgggcc tctgtggcaa gtgtcctgcc ctgctgtagt gtgatggttg
     2281 atagctaacg aggggggggg ggtaaagttt cgtttacgta cttagagatc accacaaacc
     2341 tacctcactg tgttgaaacg ggacaaatgc aatagaacac attgggaggt gtgtgtgtgt
     2401 ctgatcctgg tttcttgttt cccccaaatg ctgcccccac ccctagttaa ttgtattcgt
     2461 ctggcctttg taggacttta ctgtctgagt tggtgactgc taggtggtct agttgtgtaa
     2521 atataaatgt gttggtcttc atgttctttt ggggttttat tgtttacaaa acttttgtcg
     2581 tattgagaga aaaataggca aagcatcttt gacagaaagt tctgcaccag actacaccat
     2641 ctgaaaccga aatgtggggt cctcttccca aagtgagcat ctgggaacca atggctttcc
     2701 ctcctgtgat ccttctgtct cccactctgg accacaatga ccttacaacc agcccctctt
     2761 ctccctcata agaaaactca ggctcagtta cttctttgag cttctctaca gcttttgaaa
     2821 gacctatgta aaagttctga agaagccatg aacttcatac tctctccccc ttgttcccta
     2881 actcagtgag gagttttggt tggtgctttt gagaccgggt ctcaggttcc tggctatcct
     2941 ccggcctcag actcctctgt gcagggactg caggtgagcc ccttctccct ggcaagacca
     3001 tttcatggtg tgatttacct ttggacagat ccaaccaacg taatctgtca cccttaggta
     3061 gagagaagca gttgtggggc cttccatgta gaaggtggaa ttcaaagttc aggaagggac
     3121 tatgaatgta cgtaaagttg agacactcag gaacttaatg ccggtgcaag aaacttatgt
     3181 caaagtggcc acaagattgt tactaggaga cggacgaatg tatctccatg tttactgcta
     3241 gaaaccaaag ctttgtgaga aatcttgaat ttatggggag ggtgggaaag tgtgtacttg
     3301 cctgtccttt ccctgatatc tttcctgaac tgcaggagac taagccccct ggggctttgg
     3361 tgaccccacc cctggggtgt tttatttcat ggttgagttt tgctgtcccc gggtacttat
     3421 attcctatcg tataatcatt ttgtaacaca tgctgacttt accttccctt ctcttccctg
     3481 ggaaaaataa agacttattg gtactccaaa attggtactg
//
