LOCUS       NM_001415697            1841 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus LIM zinc finger domain containing 2 (Lims2),
            transcript variant 2, mRNA.
ACCESSION   NM_001415697 XM_006254596
VERSION     NM_001415697.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1841)
  AUTHORS   Porcheri,C., Suter,U. and Jessberger,S.
  TITLE     Dissecting integrin-dependent regulation of neural stem cell
            proliferation in the adult brain
  JOURNAL   J Neurosci 34 (15), 5222-5232 (2014)
   PUBMED   24719101
REFERENCE   2  (bases 1 to 1841)
  AUTHORS   Donthamsetty,S., Bhave,V.S., Mars,W.M., Bowen,W.C., Orr,A.,
            Haynes,M.M., Wu,C. and Michalopoulos,G.K.
  TITLE     Role of PINCH and its partner tumor suppressor Rsu-1 in regulating
            liver size and tumorigenesis
  JOURNAL   PLoS One 8 (9), e74625 (2013)
   PUBMED   24058607
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1841)
  AUTHORS   Kuo,J.C., Han,X., Hsiao,C.T., Yates,J.R. 3rd and Waterman,C.M.
  TITLE     Analysis of the myosin-II-responsive focal adhesion proteome
            reveals a role for beta-Pix in negative regulation of focal
            adhesion maturation
  JOURNAL   Nat Cell Biol 13 (4), 383-393 (2011)
   PUBMED   21423176
REFERENCE   4  (bases 1 to 1841)
  AUTHORS   Liang,X., Sun,Y., Ye,M., Scimia,M.C., Cheng,H., Martin,J., Wang,G.,
            Rearden,A., Wu,C., Peterson,K.L., Powell,H.C., Evans,S.M. and
            Chen,J.
  TITLE     Targeted ablation of PINCH1 and PINCH2 from murine myocardium
            results in dilated cardiomyopathy and early postnatal lethality
  JOURNAL   Circulation 120 (7), 568-576 (2009)
   PUBMED   19652092
REFERENCE   5  (bases 1 to 1841)
  AUTHORS   Legate,K.R., Montanez,E., Kudlacek,O. and Fassler,R.
  TITLE     ILK, PINCH and parvin: the tIPP of integrin signalling
  JOURNAL   Nat Rev Mol Cell Biol 7 (1), 20-31 (2006)
   PUBMED   16493410
  REMARK    Review article
REFERENCE   6  (bases 1 to 1841)
  AUTHORS   Braun,A., Bordoy,R., Stanchi,F., Moser,M., Kostka,G. G, Ehler,E.,
            Brandau,O. and Fassler,R.
  TITLE     PINCH2 is a new five LIM domain protein, homologous to PINCHand
            localized to focal adhesions
  JOURNAL   Exp Cell Res 284 (2), 239-250 (2003)
   PUBMED   12651156
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000018.1.
            
            On Dec 23, 2022 this sequence version replaced XM_006254596.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643296.37363.1,
                                           SRR26643295.55774.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-216               JAXUCZ010000018.1  23837704-23837919
            217-376             JAXUCZ010000018.1  23848907-23849066
            377-443             JAXUCZ010000018.1  23851675-23851741
            444-564             JAXUCZ010000018.1  23851992-23852112
            565-714             JAXUCZ010000018.1  23861953-23862102
            715-865             JAXUCZ010000018.1  23862746-23862896
            866-958             JAXUCZ010000018.1  23864009-23864101
            959-1007            JAXUCZ010000018.1  23864726-23864774
            1008-1083           JAXUCZ010000018.1  23865006-23865081
            1084-1841           JAXUCZ010000018.1  23865606-23866363
FEATURES             Location/Qualifiers
     source          1..1841
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="18"
                     /map="18p12"
     gene            1..1841
                     /gene="Lims2"
                     /note="LIM zinc finger domain containing 2"
                     /db_xref="GeneID:361303"
                     /db_xref="RGD:1305273"
     exon            1..216
                     /gene="Lims2"
                     /inference="alignment:Splign:2.1.0"
     CDS             206..1231
                     /gene="Lims2"
                     /note="isoform 2 is encoded by transcript variant 2; LIM
                     and senescent cell antigen-like-containing domain protein
                     2; LIM and senescent cell antigen like domains 2; LIM-type
                     zinc finger domains 2"
                     /codon_start=1
                     /product="LIM and senescent cell antigen-like-containing
                     domain protein 2 isoform 2"
                     /protein_id="NP_001402626.1"
                     /db_xref="GeneID:361303"
                     /db_xref="RGD:1305273"
                     /translation="MTGSNMSECLADAMCQRCQARFAPTERIVNSNGELYHEHCFVCA
                     QCFRPFPEGLFYEFEGRKYCEHDFQMLFAPCCGFCGEFVIGRVIKAMNANWHPGCFRC
                     ELCDVELADLGFVKNAGRHLCRPCHNREKAKGLGKFICQRCHLAIDEQPLMFKNDPYH
                     PDHFSCSHCGKELTSDARELKGELYCLPCHDKMGIPICGACRRPIEGRVVNALGKQWH
                     VEHFVCAKCEKPFLGHRHYEKKGLAYCETHYNQLFGDVCYNCSHVIEGDVVSALSKAW
                     CVNCFSCSACNMKLTLKNKFVEFDMKPVCKRCYERFPLELKKRLKKLSDLSSRKAQPK
                     PVGVNSV"
     exon            217..376
                     /gene="Lims2"
                     /inference="alignment:Splign:2.1.0"
     exon            377..443
                     /gene="Lims2"
                     /inference="alignment:Splign:2.1.0"
     exon            444..564
                     /gene="Lims2"
                     /inference="alignment:Splign:2.1.0"
     exon            565..714
                     /gene="Lims2"
                     /inference="alignment:Splign:2.1.0"
     exon            715..865
                     /gene="Lims2"
                     /inference="alignment:Splign:2.1.0"
     exon            866..958
                     /gene="Lims2"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1007
                     /gene="Lims2"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1083
                     /gene="Lims2"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1841
                     /gene="Lims2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcagtccct agtgttccca gggttgacac tagcaccggc atcccctgtg ccccttgaag
       61 ctgtcccctg cactcctctt cccagctgca ggctgggtgg agccgccctc gcggtttggg
      121 cgtgttcttc cctgtgccgg gaccctgcgt cctctgtcag ggacccagca gtggactgct
      181 gacgggtgct aggcgcgcgg ccaccatgac gggaagcaac atgtcagaat gtctggcgga
      241 tgccatgtgc cagcggtgcc aagcccggtt tgcccccaca gagcgcatcg tcaacagtaa
      301 tggggagctc taccatgagc actgctttgt gtgtgcacag tgcttccggc cgtttcccga
      361 ggggctcttc tatgagtttg agggccggaa gtactgtgaa cacgacttcc aaatgctgtt
      421 cgctccatgc tgcggattct gtggtgagtt tgtcatcggc cgcgtgatca aggccatgaa
      481 cgccaactgg catccgggct gcttccgctg tgagctgtgc gacgtggagc tggctgacct
      541 gggctttgtg aagaacgcag gcaggcacct ctgccggcct tgccacaacc gtgagaaggc
      601 caagggcctg ggcaaattca tctgccagag gtgtcacctc gccattgatg agcagcccct
      661 catgttcaag aatgatccct accacccgga ccacttcagc tgctcccact gtgggaagga
      721 gctgacctct gatgcccgag agctgaaggg tgagctctac tgcctgcctt gccacgacaa
      781 gatgggcatt cccatctgtg gggcttgccg ccggcccatt gagggccgtg tggtcaatgc
      841 gctgggcaaa cagtggcacg tggagcactt cgtctgcgcc aagtgtgaga agccattctt
      901 ggggcaccgg cactatgaga agaaaggcct agcatactgt gagacccact acaaccagct
      961 ctttggggat gtctgctaca actgcagtca tgtgattgag ggtgacgtgg tgtcggccct
     1021 cagcaaagcc tggtgtgtga actgcttctc ctgttccgcc tgcaacatga agctcactct
     1081 gaagaacaag tttgtggagt tcgatatgaa gcctgtgtgt aagaggtgct atgaaaggtt
     1141 ccccctggaa ctgaagaaga ggttgaagaa gctgtccgac ctgagctccc gcaaggccca
     1201 gcccaagcct gtgggcgtca actcagtctg aaggtccttg gcctccttgc ctgcctgcag
     1261 aaccttagcc ctcaccctct gccccaagtc ctgctagcca cctcccactt ctgctccaat
     1321 gcagcccctc ctccgggggc attctgtttc cagtccactt cgggctatgt agtcctctct
     1381 tctgtgctga ggcctggccc acgtcacaag catttccttc cagacccaca acctccaggg
     1441 actgggacaa actggggcag gatgatttgc cacttgcttg gcccgctgat cccagcccga
     1501 tacctctcct ctctactctc ccaggagact ctcaggccca gtgtgaccct ggggcttggc
     1561 tgagaagctg acccagcccc agggccagca ccacgcagac agaggcttca ggggagtacc
     1621 cttcagttat tcaaccacag taggtagctt gtgcttacac tgtgtcagca aacccagcta
     1681 gagggctggg acccccattg cctttgccac tcagaagacc tcatagaaag cttcccagct
     1741 gcccacccag cttgggtccc atttcccagg agcacattgc cctggccgtc tcagacccaa
     1801 aagtggtgac atacttgcac aatgaaggct gattcacatt c
//
