LOCUS       NM_001145456            1254 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus LIM zinc finger domain containing 1 (Lims1),
            transcript variant 1, mRNA.
ACCESSION   NM_001145456 XM_001053331 XM_574766
VERSION     NM_001145456.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1254)
  AUTHORS   Jia,L., Li,X., Gu,Y. and Cui,W.
  TITLE     Early Activation of PINCH/ Glycogen-Synthase Kinase 3beta/ERK
            Pathway in Obstructive Nephropathy Rat Model
  JOURNAL   Am J Nephrol 44 (5), 396-403 (2016)
   PUBMED   27771700
  REMARK    GeneRIF: PINCH/GSK3beta/ERK pathway induced in kidney in unilateral
            ureteral obstruction
REFERENCE   2  (bases 1 to 1254)
  AUTHORS   Porcheri,C., Suter,U. and Jessberger,S.
  TITLE     Dissecting integrin-dependent regulation of neural stem cell
            proliferation in the adult brain
  JOURNAL   J Neurosci 34 (15), 5222-5232 (2014)
   PUBMED   24719101
REFERENCE   3  (bases 1 to 1254)
  AUTHORS   Donthamsetty,S., Bhave,V.S., Mars,W.M., Bowen,W.C., Orr,A.,
            Haynes,M.M., Wu,C. and Michalopoulos,G.K.
  TITLE     Role of PINCH and its partner tumor suppressor Rsu-1 in regulating
            liver size and tumorigenesis
  JOURNAL   PLoS One 8 (9), e74625 (2013)
   PUBMED   24058607
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1254)
  AUTHORS   Kuo,J.C., Han,X., Hsiao,C.T., Yates,J.R. 3rd and Waterman,C.M.
  TITLE     Analysis of the myosin-II-responsive focal adhesion proteome
            reveals a role for beta-Pix in negative regulation of focal
            adhesion maturation
  JOURNAL   Nat Cell Biol 13 (4), 383-393 (2011)
   PUBMED   21423176
REFERENCE   5  (bases 1 to 1254)
  AUTHORS   Wang,D., Li,Y., Wu,C. and Liu,Y.
  TITLE     PINCH1 is transcriptional regulator in podocytes that interacts
            with WT1 and represses podocalyxin expression
  JOURNAL   PLoS One 6 (2), e17048 (2011)
   PUBMED   21390327
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1254)
  AUTHORS   Legate,K.R., Montanez,E., Kudlacek,O. and Fassler,R.
  TITLE     ILK, PINCH and parvin: the tIPP of integrin signalling
  JOURNAL   Nat Rev Mol Cell Biol 7 (1), 20-31 (2006)
   PUBMED   16493410
  REMARK    Review article
REFERENCE   7  (bases 1 to 1254)
  AUTHORS   Li,S., Bordoy,R., Stanchi,F., Moser,M., Braun,A., Kudlacek,O.,
            Wewer,U.M., Yurchenco,P.D. and Fassler,R.
  TITLE     PINCH1 regulates cell-matrix and cell-cell adhesions, cell polarity
            and cell survival during the peri-implantation stage
  JOURNAL   J Cell Sci 118 (Pt 13), 2913-2921 (2005)
   PUBMED   15976450
REFERENCE   8  (bases 1 to 1254)
  AUTHORS   Liang,X., Zhou,Q., Li,X., Sun,Y., Lu,M., Dalton,N., Ross,J. Jr. and
            Chen,J.
  TITLE     PINCH1 plays an essential role in early murine embryonic
            development but is dispensable in ventricular cardiomyocytes
  JOURNAL   Mol Cell Biol 25 (8), 3056-3062 (2005)
   PUBMED   15798193
REFERENCE   9  (bases 1 to 1254)
  AUTHORS   Braun,A., Bordoy,R., Stanchi,F., Moser,M., Kostka,G. G, Ehler,E.,
            Brandau,O. and Fassler,R.
  TITLE     PINCH2 is a new five LIM domain protein, homologous to PINCHand
            localized to focal adhesions
  JOURNAL   Exp Cell Res 284 (2), 239-250 (2003)
   PUBMED   12651156
REFERENCE   10 (bases 1 to 1254)
  AUTHORS   Zhang,Y., Chen,K., Tu,Y., Velyvis,A., Yang,Y., Qin,J. and Wu,C.
  TITLE     Assembly of the PINCH-ILK-CH-ILKBP complex precedes and is
            essential for localization of each component to cell-matrix
            adhesion sites
  JOURNAL   J Cell Sci 115 (Pt 24), 4777-4786 (2002)
   PUBMED   12432066
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000020.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001145456.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FJ640984.1, SRR26643297.53222.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-166               JAXUCZ010000020.1  26911404-26911569
            167-326             JAXUCZ010000020.1  26936575-26936734
            327-393             JAXUCZ010000020.1  26945098-26945164
            394-514             JAXUCZ010000020.1  26946275-26946395
            515-664             JAXUCZ010000020.1  26946819-26946968
            665-815             JAXUCZ010000020.1  26948630-26948780
            816-908             JAXUCZ010000020.1  26950259-26950351
            909-957             JAXUCZ010000020.1  26952551-26952599
            958-1033            JAXUCZ010000020.1  26954229-26954304
            1034-1254           JAXUCZ010000020.1  26958610-26958830
FEATURES             Location/Qualifiers
     source          1..1254
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20q11"
     gene            1..1254
                     /gene="Lims1"
                     /gene_synonym="Pinch1; RGD1560732"
                     /note="LIM zinc finger domain containing 1"
                     /db_xref="GeneID:499443"
                     /db_xref="RGD:1560732"
     exon            1..166
                     /gene="Lims1"
                     /gene_synonym="Pinch1; RGD1560732"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..1148
                     /gene="Lims1"
                     /gene_synonym="Pinch1; RGD1560732"
                     /note="isoform 1 is encoded by transcript variant 1; LIM
                     and senescent cell antigen-like-containing domain protein
                     1; LIM and senescent cell antigen-like domains 1; LIM-type
                     zinc finger domains 1"
                     /codon_start=1
                     /product="LIM and senescent cell antigen-like-containing
                     domain protein 1 isoform 1"
                     /protein_id="NP_001138928.1"
                     /db_xref="GeneID:499443"
                     /db_xref="RGD:1560732"
                     /translation="MTALQLKELSQSGLYRRRRERPDSLRVNGLPEEELSNMANALAS
                     ATCERCKGGFDPAEKIVNSNGELYHEQCFVCAQCFQQFPEGLFYEFEGRKYCEHDFQM
                     LFAPCCHQCGEFIIGRVIKAMNNSWHPECFRCDLCQEVLADIGFVKNAGRHLCRPCHN
                     REKARGLGKYICQKCHAIIDEQPLIFKNDPYHPDHFNCANCGKELTADARELKGELYC
                     LPCHDKMGVPICGACRRPIEGRVVNAMGKQWHVEHFVCAKCEKPFLGHRHYERKGLAY
                     CETHYNQLFGDVCFHCNRVIEGDVVSALNKAWCVSCFACSTCNTKLTLKNKFVEFDMK
                     PVCKKCYEKFPLELKKRLKKLSETLGRK"
     exon            167..326
                     /gene="Lims1"
                     /gene_synonym="Pinch1; RGD1560732"
                     /inference="alignment:Splign:2.1.0"
     exon            327..393
                     /gene="Lims1"
                     /gene_synonym="Pinch1; RGD1560732"
                     /inference="alignment:Splign:2.1.0"
     exon            394..514
                     /gene="Lims1"
                     /gene_synonym="Pinch1; RGD1560732"
                     /inference="alignment:Splign:2.1.0"
     exon            515..664
                     /gene="Lims1"
                     /gene_synonym="Pinch1; RGD1560732"
                     /inference="alignment:Splign:2.1.0"
     exon            665..815
                     /gene="Lims1"
                     /gene_synonym="Pinch1; RGD1560732"
                     /inference="alignment:Splign:2.1.0"
     exon            816..908
                     /gene="Lims1"
                     /gene_synonym="Pinch1; RGD1560732"
                     /inference="alignment:Splign:2.1.0"
     exon            909..957
                     /gene="Lims1"
                     /gene_synonym="Pinch1; RGD1560732"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1033
                     /gene="Lims1"
                     /gene_synonym="Pinch1; RGD1560732"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1254
                     /gene="Lims1"
                     /gene_synonym="Pinch1; RGD1560732"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttctgagctg gcaacactcg cctagcacaa gtatccttaa ttgctgtgca gagaaaacta
       61 tgaccgcact acagcttaag gagctttcac agtcgggcct ctaccggaga aggcgagagc
      121 gtcctgatag tctgagagtc aatgggctcc cagaggaaga gctgagcaac atggccaatg
      181 ctttggccag tgccacgtgt gaacgctgca aggggggctt tgaccctgct gagaagatcg
      241 tgaacagtaa tggtgagctg taccatgaac agtgtttcgt gtgtgctcag tgcttccagc
      301 agttcccaga aggactcttt tatgagtttg aaggaagaaa gtactgtgag catgatttcc
      361 agatgctctt tgctccctgc tgccaccagt gtggtgaatt catcattggc agggttatca
      421 aagccatgaa caacagctgg catcctgagt gcttcagatg tgacctctgc caggaagtgc
      481 tggcagacat agggtttgtc aagaatgctg gcagacacct gtgtcgccca tgtcataatc
      541 gtgaaaaggc cagaggcctt ggaaaataca tctgccagaa atgccatgcc atcattgatg
      601 aacagccttt gattttcaag aacgaccctt accacccaga ccacttcaac tgtgccaact
      661 gcgggaagga gctaactgct gatgctcggg agctgaaagg ggagctatac tgtctgccat
      721 gtcatgataa gatgggggtc cctatctgtg gcgcctgccg gaggcccatt gaagggcgag
      781 tagtgaatgc catgggcaag caatggcatg tggagcattt tgtttgtgcc aaatgtgaaa
      841 aaccatttct tggacatcgc cattatgaga ggaagggctt ggcctattgt gagactcact
      901 ataatcagct atttggtgat gtttgtttcc attgcaaccg tgtcatagaa ggtgacgtgg
      961 tctctgccct caacaaggcc tggtgtgtga gctgctttgc ctgttccact tgcaatacca
     1021 aactaacact caagaataaa tttgtggagt ttgacatgaa accagtctgt aagaagtgct
     1081 acgagaaatt tcctttggag ctgaagaaaa gacttaagaa actatctgag accttaggaa
     1141 ggaaataact tttggtgtct tttttctctt tcttttaacc aatattactt aacctgatcc
     1201 accctcatct acttttgctt aaaactgtat caaagcatta gagagaatgg ttct
//
