LOCUS       NM_031727               3290 bp    mRNA    linear   ROD 26-APR-2024
DEFINITION  Rattus norvegicus LIM domain kinase 1 (Limk1), mRNA.
ACCESSION   NM_031727 XM_346433 XM_347352
VERSION     NM_031727.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3290)
  AUTHORS   Chen,Y., Song,D., Gao,J., Zhang,X. and Chen,X.
  TITLE     Circ-Zfp644 acts as a pro-hypertrophic mediator in an Ang-II
            induced in vitro myocardial hypertrophy model
  JOURNAL   Cell Biol Int 45 (6), 1260-1268 (2021)
   PUBMED   33559936
  REMARK    GeneRIF: Circ-Zfp644 acts as a pro-hypertrophic mediator in an
            Ang-II induced in vitro myocardial hypertrophy model.
REFERENCE   2  (bases 1 to 3290)
  AUTHORS   Chen,B., Lin,W., Qi,W., Li,S., Hong,Z. and Zhao,H.
  TITLE     Cofilin Inhibition by Limk1 Reduces Rod Formation and Cell
            Apoptosis after Ischemic Stroke
  JOURNAL   Neuroscience 444, 64-75 (2020)
   PUBMED   32697981
  REMARK    GeneRIF: Cofilin Inhibition by Limk1 Reduces Rod Formation and Cell
            Apoptosis after Ischemic Stroke.
REFERENCE   3  (bases 1 to 3290)
  AUTHORS   Liu,W., Wu,J., Huang,J., Zhuo,P., Lin,Y., Wang,L., Lin,R., Chen,L.
            and Tao,J.
  TITLE     Electroacupuncture Regulates Hippocampal Synaptic Plasticity via
            miR-134-Mediated LIMK1 Function in Rats with Ischemic Stroke
  JOURNAL   Neural Plast 2017, 9545646 (2017)
   PUBMED   28116173
  REMARK    GeneRIF: MiR-134-mediated LIM domain kinase was involved in
            Regulates Hippocampal Synaptic Plasticity via miR-134-mediated
            LIMK1 function in rats with ischemic stroke induced hippocampal
            synaptic plasticity, which served as a contributor to improving
            learning and memory during the recovery stage of ischemic stroke.
REFERENCE   4  (bases 1 to 3290)
  AUTHORS   Yu,Y., Zhang,P., Yan,J., Sun,Y., Wu,X., Xi,S., Zhang,L., Sun,Y.,
            Hu,R. and Jiang,H.
  TITLE     Sevoflurane induces cognitive impairments via the
            MiR-27b/LIMK1-signaling pathway in developing rats
  JOURNAL   Inhal Toxicol 28 (14), 731-738 (2016)
   PUBMED   27973945
  REMARK    GeneRIF: We demonstrated that LIMK1, as one target of miR-27b,
            might mediate sevoflurane-induced synapse deficits in the
            hippocampus. These results emphasize the potential role of LIMK1 in
            cognitive dysfunction in rats.
REFERENCE   5  (bases 1 to 3290)
  AUTHORS   George,J., Soares,C., Montersino,A., Beique,J.C. and Thomas,G.M.
  TITLE     Palmitoylation of LIM Kinase-1 ensures spine-specific actin
            polymerization and morphological plasticity
  JOURNAL   Elife 4, e06327 (2015)
   PUBMED   25884247
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3290)
  AUTHORS   Rosso,S., Bollati,F., Bisbal,M., Peretti,D., Sumi,T., Nakamura,T.,
            Quiroga,S., Ferreira,A. and Caceres,A.
  TITLE     LIMK1 regulates Golgi dynamics, traffic of Golgi-derived vesicles,
            and process extension in primary cultured neurons
  JOURNAL   Mol Biol Cell 15 (7), 3433-3449 (2004)
   PUBMED   15090620
REFERENCE   7  (bases 1 to 3290)
  AUTHORS   Foletta,V.C., Moussi,N., Sarmiere,P.D., Bamburg,J.R. and Bernard,O.
  TITLE     LIM kinase 1, a key regulator of actin dynamics, is widely
            expressed in embryonic and adult tissues
  JOURNAL   Exp Cell Res 294 (2), 392-405 (2004)
   PUBMED   15023529
REFERENCE   8  (bases 1 to 3290)
  AUTHORS   Yang,E., Kim,H., Lee,J., Shin,J.S., Yoon,H., Kim,S.J. and Choi,I.H.
  TITLE     Overexpression of LIM kinase 1 renders resistance to apoptosis in
            PC12 cells by inhibition of caspase activation
  JOURNAL   Cell Mol Neurobiol 24 (2), 181-192 (2004)
   PUBMED   15176434
  REMARK    GeneRIF: PC12 cells overexpressing the wild-type LIMK1 were more
            resistant to cell death and the level of caspase 3 activation in
            these cells was lower than in the control PC12 cells or than in the
            PC12 cells expressing a mutant LIMK1 lacking the kinase domain.
REFERENCE   9  (bases 1 to 3290)
  AUTHORS   Geneste,O., Copeland,J.W. and Treisman,R.
  TITLE     LIM kinase and Diaphanous cooperate to regulate serum response
            factor and actin dynamics
  JOURNAL   J Cell Biol 157 (5), 831-838 (2002)
   PUBMED   12034774
  REMARK    GeneRIF: LIM kinase and Diaphanous cooperate to regulate serum
            response factor and actin dynamics.
REFERENCE   10 (bases 1 to 3290)
  AUTHORS   Nunoue,K., Ohashi,K., Okano,I. and Mizuno,K.
  TITLE     LIMK-1 and LIMK-2, two members of a LIM motif-containing protein
            kinase family
  JOURNAL   Oncogene 11 (4), 701-710 (1995)
   PUBMED   7651734
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB726578.1, BF565872.1, CB702103.1, AW529884.1, CB691076.1,
            AC091000.2 and CV112377.1.
            
            On Oct 12, 2007 this sequence version replaced NM_031727.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments and orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-296               CB726578.1         1-296
            297-349             BF565872.1         63-115
            350-355             CB726578.1         350-355
            356-375             BF565872.1         122-141
            376-455             CB726578.1         376-455
            456-610             BF565872.1         222-376
            611-856             CB702103.1         21-266
            857-1189            AW529884.1         6-338               c
            1190-1462           CB691076.1         9-281
            1463-1463           AC091000.2         133466-133466       c
            1464-1490           CB691076.1         283-309
            1491-1521           CB691076.1         311-341
            1522-2094           CV112377.1         152-724
            2095-3290           AC091000.2         125122-126317       c
FEATURES             Location/Qualifiers
     source          1..3290
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="12"
                     /map="12q12"
     gene            1..3290
                     /gene="Limk1"
                     /note="LIM domain kinase 1"
                     /db_xref="GeneID:65172"
                     /db_xref="RGD:62055"
     exon            1..238
                     /gene="Limk1"
                     /inference="alignment:Splign:2.1.0"
     CDS             184..2127
                     /gene="Limk1"
                     /EC_number="2.7.11.1"
                     /note="LIM-domain containing, protein kinase 1; LIMK-1;
                     LIM motif-containing protein kinase 1"
                     /codon_start=1
                     /product="LIM domain kinase 1"
                     /protein_id="NP_113915.2"
                     /db_xref="GeneID:65172"
                     /db_xref="RGD:62055"
                     /translation="MRLTLLCCTWREERMGEEGSELPVCASCSQSIYDGQYLQALNAD
                     WHADCFRCCECSTSLSHQYYEKDGQLFCKKDYWARYGESCHGCSEHITKGLVMVAGEL
                     KYHPECFICLACGNFIGDGDTYTLVEHSKLYCGQCYYQTVVTPVIEQILPDSPGSHLP
                     HTVTLVSIPASAHGKRGLSVSIDPPHGPPGCGTEHSHTVRVQGVDPGCMSPDVKNSIH
                     IGDRILEINGTPIRNVPLDEIDLLIQETSRLLQLTLEHDPHDSLGHGPVSDPSPLASP
                     VHTPSGQAGSSARQKPVLRSCSIDTSPGAGSLVSPASQRKDLGRSESLRVVCRPHRIF
                     RPSDLIHGEVLGKGCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLE
                     HPNVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAY
                     LHSMNIIHRDLNSHNCLVRENRNVVVADFGLARLMIDEKGQSEDLRSLKKPDRKKRYT
                     VVGNPYWMAPEMINGRSYDEKVDVFSFGIVLCEIIGRVNADPDYLPRTMDFGLNVRGF
                     LDRYCPPNCPPSFFPITVRCCDLDPEKRPSFVKLEQWLETLRMHLAGHLPLGPQLEQL
                     ERGFWETYRRGESSLPAHPEVPD"
     exon            239..335
                     /gene="Limk1"
                     /inference="alignment:Splign:2.1.0"
     exon            336..474
                     /gene="Limk1"
                     /inference="alignment:Splign:2.1.0"
     exon            475..584
                     /gene="Limk1"
                     /inference="alignment:Splign:2.1.0"
     exon            585..791
                     /gene="Limk1"
                     /inference="alignment:Splign:2.1.0"
     exon            792..897
                     /gene="Limk1"
                     /inference="alignment:Splign:2.1.0"
     exon            898..1064
                     /gene="Limk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1248
                     /gene="Limk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1335
                     /gene="Limk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1467
                     /gene="Limk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1527
                     /gene="Limk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..1593
                     /gene="Limk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..1750
                     /gene="Limk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1751..1806
                     /gene="Limk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1807..1964
                     /gene="Limk1"
                     /inference="alignment:Splign:2.1.0"
     exon            1965..3290
                     /gene="Limk1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttcaagcct ggtgtgggag tgcagcggag catcatcgcc gaagccggag cggagcgctc
       61 ggctccggcc ccgcgctccc cgcctcccgc cttctcgggc cggcggcggg cgagctcgcg
      121 ggcccggccc cagctctcca gtgccccgcc ggttgccggc ggtccccgcc ccccgccgag
      181 tgcatgaggt tgacgctact ttgttgcacc tggagggaag aacgtatggg agaggaagga
      241 agcgagttgc ctgtgtgtgc gagctgtagc cagagtatct atgacggcca gtacctccag
      301 gccctgaatg ctgactggca tgcggattgc ttcaggtgct gcgagtgtag cacctccctt
      361 tcacaccagt actacgagaa ggatggacag ctcttctgca agaaggacta ctgggcccgc
      421 tatggcgagt cttgccacgg gtgctccgaa cacatcacca aagggctggt catggtggcc
      481 ggggagctga agtatcaccc cgagtgcttc atctgccttg cctgtggaaa cttcatcggt
      541 gatggggaca cctacacact ggtggagcac tccaagctgt actgcgggca gtgctactac
      601 cagactgtgg taactccagt catcgaacag atcctccctg actcacccgg ctcccacctg
      661 ccccacacag tcaccctcgt gtctatccca gcctctgctc atggcaaacg aggcctgtct
      721 gtctccatcg acccccctca cggcccacca ggatgtggca cggagcattc gcacacggtc
      781 cgagtccaag gagtggaccc gggctgcatg agcccggatg tgaagaattc catccacatc
      841 ggagacagga tcttggaaat caacggcacg cccatccgga atgtgccgct ggacgagatc
      901 gacttgctga tccaggagac cagccgcctg ctccagctga ccctcgagca cgacccccat
      961 gactcactgg gccatgggcc agtgtcggat cccagccccc tggcctcccc ggtacacact
     1021 cccagcggac aggcaggcag ctctgcccgg cagaaacctg tcttgaggag ctgcagtatt
     1081 gacacgtccc cgggtgccgg ctcactagtc tcaccagcct cccagcgcaa ggacctgggt
     1141 cgctccgaat ccctccgagt ggtttgtcga ccacaccgca tcttccggcc gtctgacctc
     1201 atccatgggg aggtgttggg caagggctgt ttcggccagg ccatcaaggt gacacatcga
     1261 gaaacgggcg aggtgatggt gatgaaggaa ctcatccggt ttgacgagga gacccagagg
     1321 acattcctca aggaggtgaa ggtcatgcga tgcctggagc accctaacgt gctcaagttc
     1381 atcggcgtgc tgtacaagga caagcggctg aacttcatca ccgagtacat caagggcggc
     1441 accctgcggg gcatcatcaa gagcatggac agccagtacc cgtggagtca gagggtcagc
     1501 tttgccaagg acattgcatc agggatggcc tacctccatt cgatgaacat catccaccga
     1561 gacctcaact cccacaactg tctggtccgt gagaacagga acgtggtggt ggctgacttt
     1621 gggctggctc gactcatgat cgatgagaag ggtcagtctg aagacttgcg tagccttaag
     1681 aagccggacc gcaagaaacg gtacacagtg gtgggtaacc cctactggat ggcgccagag
     1741 atgatcaatg gtcgtagtta cgatgaaaag gtggacgtgt tttcctttgg aattgtcctt
     1801 tgtgagatta tcgggcgtgt gaatgcagac cctgactatc tgccccgcac tatggacttt
     1861 ggcctcaatg taaggggttt cctggaccgc tactgtccac caaactgtcc cccaagtttc
     1921 ttccccatca ctgtgcgctg ctgtgacctg gatcctgaga agaggccctc ttttgtaaag
     1981 ctggaacaat ggctagaaac acttcgcatg cacttggctg gtcacctgcc actgggccca
     2041 caactggaac aactggagcg gggcttctgg gagacctacc ggcggggcga gagctcgcta
     2101 cccgcccacc ccgaggtccc tgactgagcc cagtgggccc accatcttca tccccgcctc
     2161 tggagaatag accctcacca gattcctcag cagggggtgg cctaggcatg gagccctcag
     2221 ctggggcagt ggtgaccata tccgtacccc cagacctgcc ttttcccctc atgcagggtg
     2281 ccccccagcc tctctctgcc tctggccccc aagtcacaag gctgcacaca cacgtggttg
     2341 gtcacatcgc cctgccttac ctcccattgt gtggagccac cccctcactt gtctttgcat
     2401 gagctggagg gttggggaag ctgaacccat tccatgcaat gcctgcagct gtctgcacag
     2461 cgcacctgct ggcagctctt cccagcaagg ctgggccaga aggcagcttt agaagtgagc
     2521 cctgtaaggc caagggagag gctatgtgcc cgggaaccca agggcagtcc aggatccctt
     2581 ggggaaaatc taggtagcat caggtattga cagggatcta aatcccaaag cagagagaga
     2641 gagaggtcca gtcccatgtg gccaggcagt ggccttcgct cttgcttcgt gtccatctca
     2701 tttcttgatc aaagccactt tagtaagaag taggtaccag tcctcaggat gagccaggag
     2761 ccctcagggg agagggcgga tgatgcctgg gaacacagct gacagggagg gtccagccca
     2821 caccacagag gctaggcaga gggaatgagg tagccatcca ccagcacccc agccctcccg
     2881 gttcatctca gcacccttcc tgggcctctc cccgtggctg gagcagcccc accccctccc
     2941 tgggtgcatc tgccctctga gttctttctg tgtgatctat tttttaagaa gagtttgtat
     3001 tattttttca taacggctgt agcagcagct gctggggggg ggttgggggg gtttgttttg
     3061 ttgttttgtt ttaggtgggt gggggtggga gggccatctc ttcactctgc ttcagttgaa
     3121 cacctaggga cgtattaaaa ctgtgaagct ttctcagtgc actttgaaca tggaagagaa
     3181 tctgaacccc cgcgggacca ggactgaaag aggcaaggcc tgcttgcctc ggcccagtga
     3241 ccgtgatagg aatgaaccca aactcaataa aatcaattct gtgctcccca
//
