LOCUS       NM_001112737            3796 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus LIM domain containing 1 (Limd1), mRNA.
ACCESSION   NM_001112737 XM_001078972 XM_236734
VERSION     NM_001112737.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3796)
  AUTHORS   Landry,N.M., Rattan,S.G., Filomeno,K.L., Meier,T.W., Meier,S.C.,
            Foran,S.J., Meier,C.F., Koleini,N., Fandrich,R.R., Kardami,E.,
            Duhamel,T.A. and Dixon,I.M.C.
  TITLE     SKI activates the Hippo pathway via LIMD1 to inhibit cardiac
            fibroblast activation
  JOURNAL   Basic Res Cardiol 116 (1), 25 (2021)
   PUBMED   33847835
  REMARK    GeneRIF: SKI activates the Hippo pathway via LIMD1 to inhibit
            cardiac fibroblast activation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3796)
  AUTHORS   Foxler,D.E., Bridge,K.S., James,V., Webb,T.M., Mee,M., Wong,S.C.,
            Feng,Y., Constantin-Teodosiu,D., Petursdottir,T.E., Bjornsson,J.,
            Ingvarsson,S., Ratcliffe,P.J., Longmore,G.D. and Sharp,T.V.
  TITLE     The LIMD1 protein bridges an association between the prolyl
            hydroxylases and VHL to repress HIF-1 activity
  JOURNAL   Nat Cell Biol 14 (2), 201-208 (2012)
   PUBMED   22286099
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3796)
  AUTHORS   Bai,S.W., Herrera-Abreu,M.T., Rohn,J.L., Racine,V., Tajadura,V.,
            Suryavanshi,N., Bechtel,S., Wiemann,S., Baum,B. and Ridley,A.J.
  TITLE     Identification and characterization of a set of conserved and new
            regulators of cytoskeletal organization, cell morphology and
            migration
  JOURNAL   BMC Biol 9, 54 (2011)
   PUBMED   21834987
  REMARK    Erratum:[BMC Biol. 2024 Oct 10;22(1):228. doi:
            10.1186/s12915-024-02036-3.. PMID: 39390519]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3796)
  AUTHORS   James,V., Zhang,Y., Foxler,D.E., de Moor,C.H., Kong,Y.W.,
            Webb,T.M., Self,T.J., Feng,Y., Lagos,D., Chu,C.Y., Rana,T.M.,
            Morley,S.J., Longmore,G.D., Bushell,M. and Sharp,T.V.
  TITLE     LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for
            microRNA-mediated gene silencing
  JOURNAL   Proc Natl Acad Sci U S A 107 (28), 12499-12504 (2010)
   PUBMED   20616046
REFERENCE   5  (bases 1 to 3796)
  AUTHORS   Das Thakur,M., Feng,Y., Jagannathan,R., Seppa,M.J., Skeath,J.B. and
            Longmore,G.D.
  TITLE     Ajuba LIM proteins are negative regulators of the Hippo signaling
            pathway
  JOURNAL   Curr Biol 20 (7), 657-662 (2010)
   PUBMED   20303269
REFERENCE   6  (bases 1 to 3796)
  AUTHORS   Luderer,H.F., Bai,S. and Longmore,G.D.
  TITLE     The LIM protein LIMD1 influences osteoblast differentiation and
            function
  JOURNAL   Exp Cell Res 314 (15), 2884-2894 (2008)
   PUBMED   18657804
REFERENCE   7  (bases 1 to 3796)
  AUTHORS   Huggins,C.J. and Andrulis,I.L.
  TITLE     Cell cycle regulated phosphorylation of LIMD1 in cell lines and
            expression in human breast cancers
  JOURNAL   Cancer Lett 267 (1), 55-66 (2008)
   PUBMED   18439753
REFERENCE   8  (bases 1 to 3796)
  AUTHORS   Ayyanathan,K., Peng,H., Hou,Z., Fredericks,W.J., Goyal,R.K.,
            Langer,E.M., Longmore,G.D. and Rauscher,F.J. 3rd.
  TITLE     The Ajuba LIM domain protein is a corepressor for SNAG domain
            mediated repression and participates in nucleocytoplasmic Shuttling
  JOURNAL   Cancer Res 67 (19), 9097-9106 (2007)
   PUBMED   17909014
REFERENCE   9  (bases 1 to 3796)
  AUTHORS   Feng,Y., Zhao,H., Luderer,H.F., Epple,H., Faccio,R., Ross,F.P.,
            Teitelbaum,S.L. and Longmore,G.D.
  TITLE     The LIM protein, Limd1, regulates AP-1 activation through an
            interaction with Traf6 to influence osteoclast development
  JOURNAL   J Biol Chem 282 (1), 39-48 (2007)
   PUBMED   17092936
REFERENCE   10 (bases 1 to 3796)
  AUTHORS   Sharp,T.V., Munoz,F., Bourboulia,D., Presneau,N., Darai,E.,
            Wang,H.W., Cannon,M., Butcher,D.N., Nicholson,A.G., Klein,G.,
            Imreh,S. and Boshoff,C.
  TITLE     LIM domains-containing protein 1 (LIMD1), a tumor suppressor
            encoded at chromosome 3p21.3, binds pRB and represses E2F-driven
            transcription
  JOURNAL   Proc Natl Acad Sci U S A 101 (47), 16531-16536 (2004)
   PUBMED   15542589
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001112737.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC168666.1, SRR26643295.34167.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1757              JAXUCZ010000008.1  131999911-132001667
            1758-1859           JAXUCZ010000008.1  132020575-132020676
            1860-1927           JAXUCZ010000008.1  132035349-132035416
            1928-1990           JAXUCZ010000008.1  132036108-132036170
            1991-2121           JAXUCZ010000008.1  132041480-132041610
            2122-2173           JAXUCZ010000008.1  132042054-132042105
            2174-2242           JAXUCZ010000008.1  132042646-132042714
            2243-3796           JAXUCZ010000008.1  132043623-132045176
FEATURES             Location/Qualifiers
     source          1..3796
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..3796
                     /gene="Limd1"
                     /note="LIM domain containing 1"
                     /db_xref="GeneID:316101"
                     /db_xref="RGD:1309830"
     exon            1..1757
                     /gene="Limd1"
                     /inference="alignment:Splign:2.1.0"
     CDS             389..2380
                     /gene="Limd1"
                     /note="LIM domains containing 1"
                     /codon_start=1
                     /product="LIM domain-containing protein 1"
                     /protein_id="NP_001106208.1"
                     /db_xref="GeneID:316101"
                     /db_xref="RGD:1309830"
                     /translation="MDKYDDLGLEASKFIEDLNMYEASKDGLFRVDKGASNNPEFEET
                     RRVFATKMAKIHLQQQQQQQLLQEEALPRAGRSPINGGNRQGVSSKLAADGAAKPPLA
                     VPTVAPGLATTTMAVQSSYPPQEQRTRPSAHGARPGSQNCGSREGPVSSQRPALHGLG
                     PCEDPSCLTHGDYYDNFSLASPQWGDKPEESPSMSLSVGSGWPGCPGNDSLSHRSCGD
                     SHPYHPQLSMCSGRSFESGQDSGIGGHSSEKPTGLWSTASSQRVNLGFSSTGLENGTP
                     AQPKGTTVSAPMVPSSTSQGACLRRDSSLGYEAPGRVFKPLVDTQPWLQDGPKSYLSV
                     SAPLSSTTSKDNAQTGMTAGLDPKLGCVESGTSPKPSPTSNVHPVMSAPSELSCKESP
                     PSWSTDSSLGPVLPESPTPSRVRLPCQTLTPGPELGPSTAELKLEALTQRLEREMDAH
                     PKADYFGACVKCSKGVFGAGQACQAMGDLYHDACFTCAACSRKLRGKAFYFVNGKVFC
                     EEDFLYSGFQQSADRCFLCGHLIMDMILQALGKSYHPGCFRCVICNECLDGVPFTVDS
                     ENKIYCVRDYHKVLAPKCAACGLPILPPEGSDETIRVVSMDRDYHVECYHCEDCGLEL
                     NDEDGHRCYPLEDHLFCHSCHVKRLEKGPSPASLHQHHF"
     exon            1758..1859
                     /gene="Limd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1860..1927
                     /gene="Limd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1928..1990
                     /gene="Limd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1991..2121
                     /gene="Limd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2122..2173
                     /gene="Limd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2174..2242
                     /gene="Limd1"
                     /inference="alignment:Splign:2.1.0"
     exon            2243..3796
                     /gene="Limd1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgtccagc gcgtttgcaa gttcggttgc ccgacgtgga tgtgagttta ctttttctgt
       61 gtacattctc tgtcttcttt cgcctgtttt tggttttgtg acttagagga gagaactttt
      121 ctaagcaggc cgggcacgac tgaaggctac tctgccccca cgtggacgct cccctgggga
      181 aaagaagtct gaaagtaaac ttagcctcgc cggcctgaag gcctcaactt tggctggact
      241 gtaagtttcg gagtcatgac cttctcgctg ggcaggtggg aatctttatc tatcttgggc
      301 tggacctgaa acctcagtca gcacccaaat ctcccccacc ccattcacac tttgtaccag
      361 gggtaggccc cggacactga tctacaacat ggataaatat gatgatctgg gccttgaggc
      421 cagtaagttc attgaggacc tgaacatgta cgaggcctcc aaggatgggc tcttccgggt
      481 ggacaagggt gctagcaaca accccgaatt tgaggaaact cgaagggtgt tcgcgaccaa
      541 gatggccaaa atccacctcc agcagcagca acagcagcag ctcctacagg aggaggccct
      601 acctagggca ggcagaagcc ccatcaacgg tgggaaccgt cagggtgtga gcagcaagct
      661 ggctgcagat ggggccgcta agcctcctct tgctgtgcca acagtagcac ctggactagc
      721 taccaccact atggcggtgc agtcctcata cccacctcag gagcagagga ccaggccatc
      781 tgcccacggt gcaaggcctg gcagtcagaa ctgtggttcc agggaggggc ctgtgagttc
      841 ccagagacct gctttacacg gtctgggtcc ctgtgaagac ccttcctgcc tcactcacgg
      901 agactattac gacaatttct ctttggcaag cccacagtgg ggtgataaac cagaagagtc
      961 ccctagcatg agtttgagtg tagggagtgg atggcctggt tgcccaggaa atgattccct
     1021 gtcgcacaga tcctgtgggg acagtcatcc ttaccaccca cagctctcca tgtgctctgg
     1081 caggtctttt gaaagtggtc aggacagtgg cattggtggc catagcagtg agaagccaac
     1141 aggcctttgg tccactgcct cctctcagag agtgaacctg ggcttttctt ccacgggctt
     1201 ggagaatggg accccagctc aacccaaggg cacaaccgtt tcagcaccaa tggtccctag
     1261 cagcactagc caaggcgctt gtctgagaag agattcgagt ctgggatatg aggctccagg
     1321 cagggtcttc aaacctcttg tggacactca gccttggctc caggatgggc ccaagtcgta
     1381 cctctctgtt tctgctccac tatcctcaac aaccagcaag gacaatgccc agacaggtat
     1441 gaccgctgga ctggatccta agcttggatg tgtggagtct ggcactagtc ccaagcccag
     1501 ccccaccagt aacgtccatc cggtaatgtc tgctccgtct gagttatctt gtaaagagag
     1561 tcctcccagc tggtccactg acagtagcct gggacctgtg ctcccagaga gccccacccc
     1621 ctccagggtg aggttgccct gccagaccct cacgccaggc cccgagcttg gaccctccac
     1681 tgcggaattg aagttggaag ccctcaccca gcgtctggag cgagagatgg atgctcaccc
     1741 caaagcagac tacttcggag cctgtgtgaa atgcagcaaa ggggtgtttg gagctggcca
     1801 ggcctgtcag gccatggggg atctctacca cgatgcctgc ttcacctgtg cagcctgcag
     1861 caggaagtta agaggaaagg ccttctattt tgtcaatggc aaagtattct gtgaggaaga
     1921 ctttttgtac tctggctttc agcagtctgc ggacagatgt tttctttgtg gacacctgat
     1981 tatggacatg atcctacagg ccctagggaa gtcctatcac cctggctgtt tccgctgcgt
     2041 catctgcaat gagtgtctag atggggttcc tttcaccgtg gactctgaga acaagatcta
     2101 ctgtgtccga gattatcaca aggtgctggc ccccaagtgt gcagcctgtg gccttcccat
     2161 tcttccacca gagggctcag atgagaccat cagagttgtg tccatggacc gagactacca
     2221 tgtagagtgc taccactgtg aggactgtgg tctggagctc aatgatgagg atggtcaccg
     2281 ctgctatcca ctggaggacc acctgttctg tcactcctgc catgtcaaga gactggagaa
     2341 aggaccctca cctgcatccc tccaccagca ccacttctag caaagagaca gtggggatgt
     2401 ggggccagcc tgcccaggga ggtgtctgtg tagcacttct gagcttcccc acagctgggg
     2461 cacaggaaga ggagggacag gaagttgagt tcctgtgtgt gtgaagggta tcattctttt
     2521 aaccacagca gtgtgcactc cccatcctgt ccgtgtgttt tccaagtgct tttctctatt
     2581 gccacactct cgccaaatca ctcaggaaga tgctccagct tgcacatgac acaagatggg
     2641 gtctgtgtaa ctggacacat cctactccct ggaaacaggt tttcagattg tgttgggcat
     2701 attccacagt gtccctaaag agaaacaatg gtggaggtga gcaggagaat gcctgcaccc
     2761 agataaccct cacacagcct gtgctgtgac ttcacagttc tgtccacttc agagctttag
     2821 ttcttctgag gatgcttcaa acccttaact gcattacagc aggaaagaag tactgcatat
     2881 atttgctttg taccttggag tttgcttggt gaaagagagc caagcttaga catctgggag
     2941 gctgggtctc cctgctgtgc ctctgcagtt cctgctgcac ctaaggcagt ggagctgggg
     3001 cagaggcctg ccctgccctg ccctgccctg ccctgtccta tatagccagc tcagagagaa
     3061 ctggtgcagg caccaggctt cttgtccatg cttggtgctg tgttttcatt gcttcctcca
     3121 gtctgtgaca ttggagttgc ttcctcaagg cgagtctgag gatctcatgc gctcagatcc
     3181 ctgtcaaagg ttgggaatcc tagtccatat cctgggagag agctccttcc agaaggaaag
     3241 tgttgtgtgt gagatctcaa agctagcacc agagggagtg cctgagcttg tttcacaggc
     3301 atctctctcg gccacctctc agcacagaca ttcgtttggt ttgatgaaac caatataagg
     3361 tacactgctt tagtctggtt tttattcctt tgttatttct ctctaccttt tcccacacac
     3421 aaaacatacc tcacagatag ttttcaccaa tcacagatca gagaggaatt catccatcat
     3481 atggagactg ttggtgtatc agcagtggcc agctccaact cttcactaca gctgagcagt
     3541 acagctgcag cacgaggcct tctgagagaa gaagcaactg aaatcaactc tctgcctcgt
     3601 gtgcctctgc attactggtc ctggggtagc caggctaaga gggagaccac atgctgacaa
     3661 cattaggacc acctccgagg tggatctgtg ggcatacctg tcctcccaac atttgagaag
     3721 ttgaagtttg tgaagtagaa gtttaaggct gtcctcaaat acatgaggcc atgacctcac
     3781 tcagaaaaac ttaaaa
//
