LOCUS       NM_001191615            4324 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus LIM domain and actin binding 1 (Lima1), mRNA.
ACCESSION   NM_001191615 XM_006257355 XM_217039
VERSION     NM_001191615.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4324)
  AUTHORS   Zhang,Y.Y., Fu,Z.Y., Wei,J., Qi,W., Baituola,G., Luo,J., Meng,Y.J.,
            Guo,S.Y., Yin,H., Jiang,S.Y., Li,Y.F., Miao,H.H., Liu,Y., Wang,Y.,
            Li,B.L., Ma,Y.T. and Song,B.L.
  TITLE     A LIMA1 variant promotes low plasma LDL cholesterol and decreases
            intestinal cholesterol absorption
  JOURNAL   Science 360 (6393), 1087-1092 (2018)
   PUBMED   29880681
REFERENCE   2  (bases 1 to 4324)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4324)
  AUTHORS   Tsurumi,H., Harita,Y., Kurihara,H., Kosako,H., Hayashi,K.,
            Matsunaga,A., Kajiho,Y., Kanda,S., Miura,K., Sekine,T., Oka,A.,
            Ishizuka,K., Horita,S., Hattori,M., Hattori,S. and Igarashi,T.
  TITLE     Epithelial protein lost in neoplasm modulates platelet-derived
            growth factor-mediated adhesion and motility of mesangial cells
  JOURNAL   Kidney Int 86 (3), 548-557 (2014)
   PUBMED   24694988
REFERENCE   4  (bases 1 to 4324)
  AUTHORS   Revenu,C., Ubelmann,F., Hurbain,I., El-Marjou,F., Dingli,F.,
            Loew,D., Delacour,D., Gilet,J., Brot-Laroche,E., Rivero,F.,
            Louvard,D. and Robine,S.
  TITLE     A new role for the architecture of microvillar actin bundles in
            apical retention of membrane proteins
  JOURNAL   Mol Biol Cell 23 (2), 324-336 (2012)
   PUBMED   22114352
REFERENCE   5  (bases 1 to 4324)
  AUTHORS   Kuo,J.C., Han,X., Hsiao,C.T., Yates,J.R. 3rd and Waterman,C.M.
  TITLE     Analysis of the myosin-II-responsive focal adhesion proteome
            reveals a role for beta-Pix in negative regulation of focal
            adhesion maturation
  JOURNAL   Nat Cell Biol 13 (4), 383-393 (2011)
   PUBMED   21423176
REFERENCE   6  (bases 1 to 4324)
  AUTHORS   Smith,T.C., Fang,Z. and Luna,E.J.
  TITLE     Novel interactors and a role for supervillin in early cytokinesis
  JOURNAL   Cytoskeleton (Hoboken) 67 (6), 346-364 (2010)
   PUBMED   20309963
REFERENCE   7  (bases 1 to 4324)
  AUTHORS   Han,M.Y., Kosako,H., Watanabe,T. and Hattori,S.
  TITLE     Extracellular signal-regulated kinase/mitogen-activated protein
            kinase regulates actin organization and cell motility by
            phosphorylating the actin cross-linking protein EPLIN
  JOURNAL   Mol Cell Biol 27 (23), 8190-8204 (2007)
   PUBMED   17875928
REFERENCE   8  (bases 1 to 4324)
  AUTHORS   Maul,R.S., Song,Y., Amann,K.J., Gerbin,S.C., Pollard,T.D. and
            Chang,D.D.
  TITLE     EPLIN regulates actin dynamics by cross-linking and stabilizing
            filaments
  JOURNAL   J Cell Biol 160 (3), 399-407 (2003)
   PUBMED   12566430
REFERENCE   9  (bases 1 to 4324)
  AUTHORS   Maul,R.S., Sachi Gerbin,C. and Chang,D.D.
  TITLE     Characterization of mouse epithelial protein lost in neoplasm
            (EPLIN) and comparison of mammalian and zebrafish EPLIN
  JOURNAL   Gene 262 (1-2), 155-160 (2001)
   PUBMED   11179679
REFERENCE   10 (bases 1 to 4324)
  AUTHORS   Maul,R.S. and Chang,D.D.
  TITLE     EPLIN, epithelial protein lost in neoplasm
  JOURNAL   Oncogene 18 (54), 7838-7841 (1999)
   PUBMED   10618726
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On or before Dec 15, 2022 this sequence version replaced
            XM_006257355.4, NM_001191615.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.944759.1,
                                           SRR26643289.22006.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760393,
                                           SAMN12840107 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-90                JAXUCZ010000007.1  132880254-132880343 c
            91-239              JAXUCZ010000007.1  132846376-132846524 c
            240-285             JAXUCZ010000007.1  132829353-132829398 c
            286-750             JAXUCZ010000007.1  132821343-132821807 c
            751-835             JAXUCZ010000007.1  132808218-132808302 c
            836-984             JAXUCZ010000007.1  132807350-132807498 c
            985-1086            JAXUCZ010000007.1  132803416-132803517 c
            1087-1144           JAXUCZ010000007.1  132797925-132797982 c
            1145-1254           JAXUCZ010000007.1  132796079-132796188 c
            1255-1388           JAXUCZ010000007.1  132786917-132787050 c
            1389-4324           JAXUCZ010000007.1  132780556-132783491 c
FEATURES             Location/Qualifiers
     source          1..4324
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q36"
     gene            1..4324
                     /gene="Lima1"
                     /gene_synonym="eplin"
                     /note="LIM domain and actin binding 1"
                     /db_xref="GeneID:300228"
                     /db_xref="RGD:1564050"
     exon            1..90
                     /gene="Lima1"
                     /gene_synonym="eplin"
                     /inference="alignment:Splign:2.1.0"
     exon            91..239
                     /gene="Lima1"
                     /gene_synonym="eplin"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..2388
                     /gene="Lima1"
                     /gene_synonym="eplin"
                     /note="epithelial protein lost in neoplasm"
                     /codon_start=1
                     /product="LIM domain and actin-binding protein 1"
                     /protein_id="NP_001178544.1"
                     /db_xref="GeneID:300228"
                     /db_xref="RGD:1564050"
                     /translation="MESTPFNRRQWTSLSLRVTAKELSLVNKNKSSTIVEIFSKYQKA
                     AEEANMERKKNNTESLPQHFRRGTLSVLKKKWENPVAGAESHTDSLPNSSSDGGHTAD
                     HPPAEVTAKAAPGARADREEHTQPRSRFGSRPEAVTQCRYPRSEDSHDFKAQATESQN
                     MENCLGDSRHEAEKPEMSENTETSGKIEKYNVPLNRLKMMFEKGEHSQNKSPWTQGRN
                     AGGRRLSENSCSLDDLEIGAGHLSSSAFNSEKNESKRNLELPRLSETSIKDRMAKYQA
                     AVSKQSSPASYASELKPSESKTHKWEQKENVPPGPEACSIHQEGSKVSATENSLVAHP
                     VPAEDDTCNSQGRSEAQQPIYTKPLSPDARTSSLPESSPSKTAKKFQAPARESCVECQ
                     KTVYPMERLLANQQVFHISCFRCSYCNNKLSLGTYASLHGRIYCKPHFNQLFKSKGNY
                     DEGFGHKQHKDLWASKGENEETLGRPAQPPSAGETPHSPGVEDAPIAKVGVLAASMEA
                     KASSQREREENKPAETKKLRIAWPPPAEQGSSGSAPEEGFKVSKPKWPPEDEVCKTEA
                     PEDVDLDLKKLRRSSSLKERSRPFTVAASFRTSSVKSPKPLSPSLRKGWSEPEPEQSE
                     EFGGGTVTQTESPRPSREKESVGKSRWQSEEAEAEAEEAPRGRDGRSFELESESFIGN
                     GASIAEDDVAPAQRSPLEPESPGWPGFGDTTTAKEFNQKSQDVGFWEGEVVRELSVEE
                     QIKRNRYYDEDEDEE"
     exon            240..285
                     /gene="Lima1"
                     /gene_synonym="eplin"
                     /inference="alignment:Splign:2.1.0"
     exon            286..750
                     /gene="Lima1"
                     /gene_synonym="eplin"
                     /inference="alignment:Splign:2.1.0"
     exon            751..835
                     /gene="Lima1"
                     /gene_synonym="eplin"
                     /inference="alignment:Splign:2.1.0"
     exon            836..984
                     /gene="Lima1"
                     /gene_synonym="eplin"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1086
                     /gene="Lima1"
                     /gene_synonym="eplin"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1144
                     /gene="Lima1"
                     /gene_synonym="eplin"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1254
                     /gene="Lima1"
                     /gene_synonym="eplin"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..1388
                     /gene="Lima1"
                     /gene_synonym="eplin"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..4324
                     /gene="Lima1"
                     /gene_synonym="eplin"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtaggtgctg cagcccagtt gcgacaggtg cgctgggcag agcgcaggac tgtggccgtg
       61 caacgcggag ccccgacggc ttgtaagcag cccacagttg tctccgagtc cgtagacaag
      121 atggaatcga ctccgtttaa tagacggcag tggacttccc tgtcactgag agtaacagcc
      181 aaagaacttt ctctcgtcaa caagaacaag tcgtccacaa ttgtggaaat attctccaag
      241 taccagaaag cagctgaaga agcaaacatg gaaaggaaga aaaataacac tgaaagtctc
      301 ccgcagcact ttagaagagg gaccctgtct gtgttaaaga agaagtggga gaaccccgtg
      361 gcgggagcgg aatcccacac agactcactg ccaaacagca gcagcgacgg tgggcacacg
      421 gcggaccacc ctcctgctga agtgacagcc aaggctgctc ctggagccag agctgaccgg
      481 gaagagcaca cccagcccag atctagattt ggatctcgtc cggaagctgt tactcagtgt
      541 cggtatcccc gctcagagga cagccacgat tttaaagccc aggccacgga aagccaaaat
      601 atggaaaact gtctgggaga ttccaggcat gaagcagaga agcccgaaat gagcgaaaac
      661 acggaaactt caggcaaaat agagaaatac aacgttccac tgaacagact aaagatgatg
      721 tttgagaaag gtgaacacag ccaaaacaag agtccctgga cccagggccg aaatgcaggc
      781 ggaaggaggc tctctgaaaa cagctgttcc ctggacgatt tggaaatagg tgcaggtcat
      841 ttgtcttcct ctgccttcaa ctcggagaaa aatgagagta agcggaatct ggagctgcca
      901 cgcctctctg agacctccat aaaggaccgc atggccaagt accaggctgc cgtgtccaag
      961 cagagcagcc cagccagcta cgcaagtgag ctgaaaccca gtgaaagcaa aactcacaaa
     1021 tgggagcaga aggagaacgt gccccccggc cccgaggcct gcagcatcca tcaggaaggg
     1081 agcaaggttt ctgcaactga gaatagcctg gtggcccacc ctgtccctgc agaagatgac
     1141 acctgtaact cccaggggag gagtgaggcc cagcagccca tatacactaa gccgctgagt
     1201 cccgacgcca ggacctccag tcttccggaa agttctcctt ccaaaacagc gaagaagttt
     1261 caggcacccg caagagagag ctgcgtggag tgtcagaaga cggtgtatcc catggaacgg
     1321 ctcctggcca accagcaggt gtttcacatc agctgtttcc gatgctccta ctgcaacaac
     1381 aaactcagtc taggaacata tgcatcctta cacggaagaa tctattgtaa gcctcacttc
     1441 aaccaactct tcaagtccaa aggcaactat gacgaaggct ttgggcacaa gcagcataag
     1501 gatctgtggg caagcaaagg tgaaaatgaa gagactttgg ggagaccagc ccagcctccc
     1561 agtgcagggg agacccccca tagcccgggt gtagaagatg cccccatcgc caaggtcggc
     1621 gtgctggctg cgagtatgga agccaaggcc tcctctcaga gggagaggga agagaataag
     1681 ccagcggaga ccaagaagct gaggatcgcc tggcctcccc cagccgagca gggcagttca
     1741 ggaagtgccc cggaggaagg gttcaaagtg tcaaagccca agtggcctcc cgaggatgaa
     1801 gtctgcaaga cagaggcgcc ggaggatgta gatctggacc tgaagaagct gaggcgctct
     1861 tcgtccctga aggagaggag ccgcccgttt actgtcgcgg cttcctttcg aacctcctcg
     1921 gtcaagagcc ccaagccctt gtcgccgtcc ctcaggaagg gttggagcga gccggagccc
     1981 gagcagagtg aggagttcgg aggagggaca gtgacacaaa cggaaagccc caggccctct
     2041 cgggagaagg agagtgtggg aaaatcacgc tggcagagcg aggaagcgga agcggaagcg
     2101 gaggaagcgc cgaggggcag ggacggtcgt tcttttgagc tggagagtga gagttttata
     2161 ggaaatggcg caagcatagc tgaagacgac gtcgccccag cacagcggtc tccattagaa
     2221 cccgagtctc cgggttggcc tggctttgga gacaccacga ctgctaaaga attcaatcaa
     2281 aaatcccaag atgtcgggtt ctgggagggg gaagtggtcc gagagctgtc cgtggaggag
     2341 cagataaaga gaaaccggta ctatgacgag gatgaggatg aggaatgacc ggcctccagc
     2401 cttagattcc tgttagcaac tcactgccct ttatcaagtg ctgcgcacaa acaggcagct
     2461 cggcgccacg ggtcttttac gtgggagcaa ctttggaaat gaattcctgc ttgcaaaaca
     2521 gaacaaaacc aacccaaaac aacaccccaa aaccaattct aagtgcattg tggaaacacc
     2581 atcttaaacc tggtgtggtg gcacacacct ttgaatccca gcactctggt ggcacaggta
     2641 ggggagtctc tctgagttgg aggccagcct ggtctacaga gcaagttccg ggacagccag
     2701 ggttacccag agaaaccttg cctcaaaagc aaaaccaaac aaaaacaaag aacccctaca
     2761 ttttagcagg gaagggctaa gcagggattt ctctcaatga tgcagcccat ggtctgccgc
     2821 attcccccaa aatcaatatt aaagtgacta gatatttaga ggcacatttt cacactacag
     2881 agaccattgt gatattagag acattcagaa cacattcagg agcccagctc tcaaccagaa
     2941 gcactttagc ataaagggca cagtgtagca attttaccaa tttcattttt ttttaatttt
     3001 ttttagtact caactgctga aatcaaatat ttagtctttt gagcttttta aatgcatttt
     3061 cttcctctgg tagatatggg aaacttactt tcatcctact ctctgcactt ttaattaccg
     3121 aggcacaaaa cagcaacctt tggccaagtg agatggcccg ctgccgccag gtaaaggtgc
     3181 tgatttcaaa agcctcagtg cctgagttca atccccagag cctacgccca ggtgagcgag
     3241 aagcctgcac acggtcaccc tctgacaaac gtcccctgtg gctcacattc ccgtcatcgg
     3301 taataataaa caagttgtta aaacagagcc aacattacaa acacctctga gagagagcca
     3361 gacatggtac ccaggtgatc agtgccctat gccagtgtgc gcctgcactc tgggtgtctg
     3421 ctgtctgtcc tggcttctca catcctaccg aaagccgcag tgtttgtata agacactgtg
     3481 gatcaccgtc caccacactc caagcgaaag agaaccgaag atctgacctc cgaagcctca
     3541 gggttgaggc agatctcgtc agtccttaag gctctagaat gtatcgattt tcacggcaga
     3601 tgatatttcc gtcttggtaa atcaatttta ggcctctctt ctcaggcggt gtcctacttt
     3661 gattcattgt tgtgataaaa cgctgggcag aagcaactta gcagaggaag gtttgtttcc
     3721 acccacaggc cacagtgaag ggaaaccagg ccagaacctg ggggcaagaa ccgaagccga
     3781 ctgttcagga acaatgctca ctggcttcat ctctctggct tactcagctg gcattcttac
     3841 gccacccagg gccacctgac caaggtgacc ctactcacaa cacagacaga caaggcccac
     3901 aggccattct gttagaggca gcgcctcagc gcagagtccc acgtccaggc gagcctgtca
     3961 ggccagcaga cactggggag cacaggtgga cttctctggt attaaggctt tagaacagta
     4021 tacgcgagtg catttcttat atgtaactga taatcccaaa ttatgtgtag gaaggggacg
     4081 gggtgtttta agatagaggc cggggttggg gatttagctc agtggtagag cgcttgccta
     4141 gcaagcgcaa gtccctgggt tcggtcccca gctccgaaaa agagaaaaaa aaaaaaaaga
     4201 tagaggcctt tttgcatttg tagagattta gctccgtttt agagatgtaa gataatctgt
     4261 ttcctcatga tcttgtttag cctaaaacat ttttattcaa taaagctttt aatttacatt
     4321 ctaa
//
