LOCUS       NM_053771                832 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus lens intrinsic membrane protein 2 (Lim2), mRNA.
ACCESSION   NM_053771
VERSION     NM_053771.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 832)
  AUTHORS   Pras,E., Levy-Nissenbaum,E., Bakhan,T., Lahat,H., Assia,E.,
            Geffen-Carmi,N., Frydman,M., Goldman,B. and Pras,E.
  TITLE     A missense mutation in the LIM2 gene is associated with autosomal
            recessive presenile cataract in an inbred Iraqi Jewish family
  JOURNAL   Am J Hum Genet 70 (5), 1363-1367 (2002)
   PUBMED   11917274
REFERENCE   2  (bases 1 to 832)
  AUTHORS   Gonen,T., Grey,A.C., Jacobs,M.D., Donaldson,P.J. and Kistler,J.
  TITLE     MP20, the second most abundant lens membrane protein and member of
            the tetraspanin superfamily, joins the list of ligands of
            galectin-3
  JOURNAL   BMC Cell Biol 2, 17 (2001)
   PUBMED   11532191
  REMARK    GeneRIF: MP20 ia a galectin-3 ligand
REFERENCE   3  (bases 1 to 832)
  AUTHORS   Steele,E.C. Jr., Kerscher,S., Lyon,M.F., Glenister,P.H., Favor,J.,
            Wang,J. and Church,R.L.
  TITLE     Identification of a mutation in the MP19 gene, Lim2, in the
            cataractous mouse mutant To3
  JOURNAL   Mol Vis 3, 5 (1997)
   PUBMED   9238094
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 832)
  AUTHORS   Kerscher,S., Glenister,P.H., Favor,J. and Lyon,M.F.
  TITLE     Two new cataract loci, Ccw and To3, and further mapping of the Npp
            and Opj cataracts in the mouse
  JOURNAL   Genomics 36 (1), 17-21 (1996)
   PUBMED   8812411
REFERENCE   5  (bases 1 to 832)
  AUTHORS   Church,R.L. and Wang,J.H.
  TITLE     The human lens fiber-cell intrinsic membrane protein MP19 gene:
            isolation and sequence analysis
  JOURNAL   Curr Eye Res 12 (12), 1057-1065 (1993)
   PUBMED   8137630
REFERENCE   6  (bases 1 to 832)
  AUTHORS   Kumar,N.M., Jarvis,L.J., Tenbroek,E. and Louis,C.F.
  TITLE     Cloning and expression of a major rat lens membrane protein, MP20
  JOURNAL   Exp Eye Res 56 (1), 35-43 (1993)
   PUBMED   7679355
REFERENCE   7  (bases 1 to 832)
  AUTHORS   Louis,C.F., Hur,K.C., Galvan,A.C., TenBroek,E.M., Jarvis,L.J.,
            Eccleston,E.D. and Howard,J.B.
  TITLE     Identification of an 18,000-dalton protein in mammalian lens fiber
            cell membranes
  JOURNAL   J Biol Chem 264 (33), 19967-19973 (1989)
   PUBMED   2584203
REFERENCE   8  (bases 1 to 832)
  AUTHORS   Favor,J.
  TITLE     Characterization of dominant cataract mutations in mice:
            penetrance, fertility and homozygous viability of mutations
            recovered after 250 mg/kg ethylnitrosourea paternal treatment
  JOURNAL   Genet Res 44 (2), 183-197 (1984)
   PUBMED   6510713
REFERENCE   9  (bases 1 to 832)
  AUTHORS   Favor,J.
  TITLE     A comparison of the dominant cataract and recessive specific-locus
            mutation rates induced by treatment of male mice with
            ethylnitrosourea
  JOURNAL   Mutat Res 110 (2), 367-382 (1983)
   PUBMED   6877261
REFERENCE   10 (bases 1 to 832)
  AUTHORS   Ehling,U.H., Favor,J., Kratochvilova,J. and Neuhauser-Klaus,A.
  TITLE     Dominant cataract mutations and specific-locus mutations in mice
            induced by radiation or ethylnitrosourea
  JOURNAL   Mutat Res 92 (1-2), 181-192 (1982)
   PUBMED   7088001
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 25, 2020 this sequence version replaced NM_053771.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M87053.1, L04191.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06621351, SAMN11044071
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                JAXUCZ010000001.1  102974188-102974214
            28-208              JAXUCZ010000001.1  102974932-102975112
            209-358             JAXUCZ010000001.1  102977820-102977969
            359-493             JAXUCZ010000001.1  102979677-102979811
            494-832             JAXUCZ010000001.1  102980020-102980358
FEATURES             Location/Qualifiers
     source          1..832
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..832
                     /gene="Lim2"
                     /gene_synonym="MP17; MP18; Mp19; MP20"
                     /note="lens intrinsic membrane protein 2"
                     /db_xref="GeneID:114903"
                     /db_xref="RGD:621482"
     exon            1..27
                     /gene="Lim2"
                     /gene_synonym="MP17; MP18; Mp19; MP20"
                     /inference="alignment:Splign:2.1.0"
     exon            28..208
                     /gene="Lim2"
                     /gene_synonym="MP17; MP18; Mp19; MP20"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..555
                     /gene="Lim2"
                     /gene_synonym="MP17; MP18; Mp19; MP20"
                     /note="lens intrinsic membrane protein 2, 19kDa"
                     /codon_start=1
                     /product="lens fiber membrane intrinsic protein"
                     /protein_id="NP_446223.1"
                     /db_xref="GeneID:114903"
                     /db_xref="RGD:621482"
                     /translation="MYSFMGGGLFCAWVGTILLVVATATDHWMQYRLSGSFAHQGLWR
                     YCLGNKCFLQTESIAYWNATRAFMILSALCATSGIIMGVLAFAQQSTFTRLSRPFSAG
                     IMFFASTLFVLLALAIYTGVTVSFLGRRFGDWRFSWSYILGWVALLMTFFAGIFYMCA
                     YRMHECRRLSTPR"
     exon            209..358
                     /gene="Lim2"
                     /gene_synonym="MP17; MP18; Mp19; MP20"
                     /inference="alignment:Splign:2.1.0"
     exon            359..493
                     /gene="Lim2"
                     /gene_synonym="MP17; MP18; Mp19; MP20"
                     /inference="alignment:Splign:2.1.0"
     exon            494..832
                     /gene="Lim2"
                     /gene_synonym="MP17; MP18; Mp19; MP20"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggctcagaa cagactctgc cactcagatc accatgtaca gcttcatggg tggcggcctc
       61 ttctgtgcct gggtggggac catcctgttg gtggtagcca cagcgacgga ccattggatg
      121 caataccggc tgtcagggtc ctttgcacac cagggcctgt ggcgttactg cctgggcaac
      181 aagtgcttcc tgcagacaga gagcatcgca tactggaatg ccacgcgggc tttcatgatc
      241 ctgtctgccc tgtgtgccac ctcgggcatc atcatgggtg tcctggcctt tgcgcagcaa
      301 tccaccttca cccgcctctc caggcccttc tctgctggca tcatgttttt tgcctccacc
      361 cttttcgtcc tgttggcctt ggccatttac accggagtca ccgttagttt cctcggccgc
      421 cgctttgggg actggcgctt ttcatggtct tacatcctgg gctgggtggc cctgctcatg
      481 accttctttg caggaatttt ctacatgtgt gcctaccgga tgcatgagtg ccggcgccta
      541 tccaccccac gctgagccct ggggcgaaac ttgcagccgg aagttacaac gaggacattg
      601 aagaggaagg ggaggaccta gaggccggaa gtcctggttc ctgagggaat gagggggctc
      661 agtcctgtat tctagcccct gacccctctg tcctgtgtgg ggaggaaaag tagggtcaag
      721 tgggagggaa ctgagacgaa gacataagcc tccacctgca ctgaggggtg gtagaaaaca
      781 gaaactcctt tagagagtga tttgggaatc taataaaact gatgtgaaac ta
//
