LOCUS       NM_001419406            1534 bp    mRNA    linear   ROD 23-APR-2024
DEFINITION  Rattus norvegicus leukocyte immunoglobulin like receptor B4
            (Lilrb4), transcript variant 1, mRNA.
ACCESSION   NM_001419406 XM_006228238
VERSION     NM_001419406.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1534)
  AUTHORS   Jin,H., Huan,Z., Wu,Y., Yao,H., Zhang,L. and Ge,X.
  TITLE     Lilrb4 ameliorates ileal injury in rats with hemorrhagic shock and
            suppresses the activation of NF-kappaB signaling pathway
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (4), 167082 (2024)
   PUBMED   38367899
  REMARK    GeneRIF: Lilrb4 ameliorates ileal injury in rats with hemorrhagic
            shock and suppresses the activation of NF-kappaB signaling pathway.
REFERENCE   2  (bases 1 to 1534)
  AUTHORS   Chang,C.C., Zhang,Q.Y., Liu,Z., Clynes,R.A., Suciu-Foca,N. and
            Vlad,G.
  TITLE     Downregulation of inflammatory microRNAs by Ig-like transcript 3 is
            essential for the differentiation of human CD8(+) T suppressor
            cells
  JOURNAL   J Immunol 188 (7), 3042-3052 (2012)
   PUBMED   22387553
REFERENCE   3  (bases 1 to 1534)
  AUTHORS   Mori,Y., Tsuji,S., Inui,M., Sakamoto,Y., Endo,S., Ito,Y.,
            Fujimura,S., Koga,T., Nakamura,A., Takayanagi,H., Itoi,E. and
            Takai,T.
  TITLE     Inhibitory immunoglobulin-like receptors LILRB and PIR-B negatively
            regulate osteoclast development
  JOURNAL   J Immunol 181 (7), 4742-4751 (2008)
   PUBMED   18802077
REFERENCE   4  (bases 1 to 1534)
  AUTHORS   Bryceson,Y.T., Torgersen,K.M., Inngjerdingen,M., Berg,S.F.,
            Hoelsbrekken,S.E., Fossum,S. and Dissen,E.
  TITLE     The rat orthologue to the inhibitory receptor gp49B is expressed by
            neutrophils and monocytes, but not by NK cells or mast cells
  JOURNAL   Eur J Immunol 35 (4), 1230-1239 (2005)
   PUBMED   15756648
  REMARK    GeneRIF: Compared to mouse, the cytoplasmic domain of rat gp49B
            contains a third ITIM-like sequence
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Mar 31, 2023 this sequence version replaced XM_006228238.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY359280.1, SRR26643429.899.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760393,
                                           SAMEA5760400 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-78                JAXUCZ010000001.1  78853175-78853252   c
            79-114              JAXUCZ010000001.1  78852997-78853032   c
            115-399             JAXUCZ010000001.1  78852507-78852791   c
            400-702             JAXUCZ010000001.1  78852065-78852367   c
            703-738             JAXUCZ010000001.1  78850989-78851024   c
            739-855             JAXUCZ010000001.1  78850165-78850281   c
            856-931             JAXUCZ010000001.1  78849878-78849953   c
            932-969             JAXUCZ010000001.1  78849764-78849801   c
            970-1022            JAXUCZ010000001.1  78849466-78849518   c
            1023-1088           JAXUCZ010000001.1  78848235-78848300   c
            1089-1534           JAXUCZ010000001.1  78847685-78848130   c
FEATURES             Location/Qualifiers
     source          1..1534
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q12"
     gene            1..1534
                     /gene="Lilrb4"
                     /gene_synonym="Gp49b; GP49B2"
                     /note="leukocyte immunoglobulin like receptor B4"
                     /db_xref="GeneID:292594"
                     /db_xref="RGD:1359090"
     exon            1..78
                     /gene="Lilrb4"
                     /gene_synonym="Gp49b; GP49B2"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..1175
                     /gene="Lilrb4"
                     /gene_synonym="Gp49b; GP49B2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; leukocyte surface receptor; glycoprotein 49b;
                     leukocyte immunoglobulin-like receptor, subfamily B,
                     member 4"
                     /codon_start=1
                     /product="leukocyte immunoglobulin like receptor B4
                     isoform 1 precursor"
                     /protein_id="NP_001406335.1"
                     /db_xref="GeneID:292594"
                     /db_xref="RGD:1359090"
                     /translation="MISMLTMLLYLGLILEHRTKIQAGHLPRPIIWAEPGSMIAIYTS
                     VTIWCQGSWEAQKYHLYKEGNVNPWDTQLPLETRNKAKFNIQYMTTTYADTYKCYYES
                     AAGFSEHSDAMELVMTGAYTNPSLSVWPSSDVTSGVSIAFKCSSSMGFGRFILIQDGK
                     DSFRWTLDSQRHDNQPFHATFVLDTVTPNHNGTFRCYGSFRNEPHLWSKSSDPLVLMV
                     SETKNQSPTHTEDGLKTYQKILTGVLVSFLLLLLLLLLLILIRYRYSCKKKATQRDAN
                     LQLTSGVPETTYRDRLHQKSSSPDATINEKYLYASVKNTQSEDNGELDSWNPPDKDPH
                     GIVYAQVKPSRLRKDTTSWRPKETQVVTYAQLCSRTQEYDNR"
     exon            79..114
                     /gene="Lilrb4"
                     /gene_synonym="Gp49b; GP49B2"
                     /inference="alignment:Splign:2.1.0"
     exon            115..399
                     /gene="Lilrb4"
                     /gene_synonym="Gp49b; GP49B2"
                     /inference="alignment:Splign:2.1.0"
     exon            400..702
                     /gene="Lilrb4"
                     /gene_synonym="Gp49b; GP49B2"
                     /inference="alignment:Splign:2.1.0"
     exon            703..738
                     /gene="Lilrb4"
                     /gene_synonym="Gp49b; GP49B2"
                     /inference="alignment:Splign:2.1.0"
     exon            739..855
                     /gene="Lilrb4"
                     /gene_synonym="Gp49b; GP49B2"
                     /inference="alignment:Splign:2.1.0"
     exon            856..931
                     /gene="Lilrb4"
                     /gene_synonym="Gp49b; GP49B2"
                     /inference="alignment:Splign:2.1.0"
     exon            932..969
                     /gene="Lilrb4"
                     /gene_synonym="Gp49b; GP49B2"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1022
                     /gene="Lilrb4"
                     /gene_synonym="Gp49b; GP49B2"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1088
                     /gene="Lilrb4"
                     /gene_synonym="Gp49b; GP49B2"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1534
                     /gene="Lilrb4"
                     /gene_synonym="Gp49b; GP49B2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agactgtccc aagaacacag ctacaaacat tactaggagt catcatgatc tccatgctca
       61 ccatgctgct gtaccttggt ctcattttgg aacacaggac taaaatacag gcaggacacc
      121 ttccaaggcc catcatctgg gccgagccag gctctatgat tgccatttat acatctgtga
      181 ctatctggtg tcaggggtct tgggaggccc agaagtatca tctgtataaa gagggaaatg
      241 taaatccttg ggacactcaa ctccctctgg aaaccaggaa taaggctaag ttcaacattc
      301 aatacatgac aaccacttat gcagacacat ataagtgtta ctatgagagt gctgctggtt
      361 tttcagagca cagtgatgcc atggagctgg tgatgacagg agcctataca aatcccagcc
      421 tgtcagtctg gcccagttct gatgtgacct ctggagtttc catagccttt aagtgtagct
      481 catccatggg atttggcaga ttcattctga tccaggacgg aaaagacagc tttcgatgga
      541 ccctggactc acaacgacat gacaaccaac cattccatgc tacttttgtt ctggacactg
      601 ttactcccaa ccacaatgga acattcagat gctatggctc ttttagaaat gaaccacatt
      661 tgtggtcgaa atcaagtgat ccccttgtcc tcatggtatc agaaaccaag aaccagtctc
      721 ctacacacac tgaagatgga ctgaaaacat accagaagat tttgactgga gtcttggtgt
      781 cattcctcct acttttatta ctcctgcttc ttctcatcct cattcgatac cggtatagtt
      841 gcaaaaagaa ggctactcaa agagatgcca acttacaatt gacttcaggg gttccagaaa
      901 caacatacag agatagactc caccagaaga gctccagccc agatgctacc atcaatgaaa
      961 aatacctgta tgcttctgtg aaaaacacac aatctgagga caatggagag ctggacagtt
     1021 ggaacccacc tgataaagac ccccatggaa ttgtgtacgc ccaggtgaaa ccctccagac
     1081 ttcggaagga tactacatcc tggagaccca aagagaccca ggttgtaacc tacgcccagt
     1141 tgtgcagcag gactcaggaa tatgacaacc gctgagacca gcaagcagcc aaagcaagaa
     1201 gaagacccag acccaacatt ccatgaatga aaactagaaa ttttctaaga cagtatttgt
     1261 ttccagtgga ctctgtttaa ttaatggcag ccatcatgaa tcatgggtca tcagaaactt
     1321 cttagaattt tgggaataca ctttattctt tgttcagaga taacaaatat ccttatattt
     1381 tgtaaataaa gctaaatctt tctcaataaa caattcataa agtgagaaac aaatgaagtg
     1441 aaatgttgtg aattgaatga caatgtaacc agggcacact gatcaatgaa actagaattt
     1501 tcagatccat gaataaatgc acaagtgaac aaaa
//
