LOCUS       NM_031713               2651 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Rattus norvegicus leukocyte immunoglobulin like receptor B2
            (Lilrb2), mRNA.
ACCESSION   NM_031713
VERSION     NM_031713.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2651)
  AUTHORS   Zhang,J., Chen,L. and Gu,Y.D.
  TITLE     Changes in Expressions of Major Histocompatibility Complex Class I,
            Paired-Immunoglobulin-Like Receptor B, and Cluster of
            Differentiation 3zeta in Motor Cortical Representations of the
            Brachial Plexus After Avulsion in Rats
  JOURNAL   World Neurosurg 106, 211-218 (2017)
   PUBMED   28669876
  REMARK    GeneRIF: In the original motor cortical representations of the
            brachial plexus, mRNA and protein expression levels of MHCI, PirB,
            and CD3zeta were down-regulated 7 days post brachial plexus injury
            compared with control. Interestingly, mRNA and protein expression
            levels of these factors were up-regulated at 3 months compared with
            7 days, excepting PirB protein, whose expression was not
            increasing.
REFERENCE   2  (bases 1 to 2651)
  AUTHORS   Deng,B., Bai,F., Zhou,H., Zhou,D., Ma,Z., Xiong,L. and Wang,Q.
  TITLE     Electroacupuncture enhances rehabilitation through miR-181b
            targeting PirB after ischemic stroke
  JOURNAL   Sci Rep 6, 38997 (2016)
   PUBMED   27966582
  REMARK    GeneRIF: Electroacupuncture (EA) enhances rehabilitation against
            stroke by regulating epigenetic changes to directly act on its
            targets, such as the miR-181b/PirB/RhoA/GAP43 axis, which is a
            novel mechanism of EA therapy.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2651)
  AUTHORS   Wang,H. and Wu,J.
  TITLE     17beta-estradiol suppresses hyperoxia-induced apoptosis of
            oligodendrocytes through paired-immunoglobulin-like receptor B
  JOURNAL   Mol Med Rep 13 (3), 2892-2898 (2016)
   PUBMED   26821234
  REMARK    GeneRIF: Estradiol protects oligodendrocyte precursor cells from
            hyperoxiainduced apoptosis, predominantly through the
            downregulation of PirB.
REFERENCE   4  (bases 1 to 2651)
  AUTHORS   Wang,H. and Mu,D.Z.
  TITLE     [Neuroregeneration of newborn rats with hypoxic-ischemic brain
            damage following antibody-mediated neutralization of
            paired-immunoglobulin-like receptor B]
  JOURNAL   Zhongguo Dang Dai Er Ke Za Zhi 16 (1), 67-72 (2014)
   PUBMED   24461182
  REMARK    GeneRIF: PirB might be involved in hypoxic-ischemic brain damage
            (HIBD) through a Rho-ROCK-dependent mechanism.
REFERENCE   5  (bases 1 to 2651)
  AUTHORS   Kim,T., Vidal,G.S., Djurisic,M., William,C.M., Birnbaum,M.E.,
            Garcia,K.C., Hyman,B.T. and Shatz,C.J.
  TITLE     Human LilrB2 is a beta-amyloid receptor and its murine homolog PirB
            regulates synaptic plasticity in an Alzheimer's model
  JOURNAL   Science 341 (6152), 1399-1404 (2013)
   PUBMED   24052308
REFERENCE   6  (bases 1 to 2651)
  AUTHORS   Shiroishi,M., Kuroki,K., Rasubala,L., Tsumoto,K., Kumagai,I.,
            Kurimoto,E., Kato,K., Kohda,D. and Maenaka,K.
  TITLE     Structural basis for recognition of the nonclassical MHC molecule
            HLA-G by the leukocyte Ig-like receptor B2 (LILRB2/LIR2/ILT4/CD85d)
  JOURNAL   Proc Natl Acad Sci U S A 103 (44), 16412-16417 (2006)
   PUBMED   17056715
REFERENCE   7  (bases 1 to 2651)
  AUTHORS   Beinhauer,B.G., McBride,J.M., Graf,P., Pursch,E., Bongers,M.,
            Rogy,M., Korthauer,U., de Vries,J.E., Aversa,G. and Jung,T.
  TITLE     Interleukin 10 regulates cell surface and soluble LIR-2 (CD85d)
            expression on dendritic cells resulting in T cell
            hyporesponsiveness in vitro
  JOURNAL   Eur J Immunol 34 (1), 74-80 (2004)
   PUBMED   14971032
REFERENCE   8  (bases 1 to 2651)
  AUTHORS   Lepin,E.J., Bastin,J.M., Allan,D.S., Roncador,G., Braud,V.M.,
            Mason,D.Y., van der Merwe,P.A., McMichael,A.J., Bell,J.I.,
            Powis,S.H. and O'Callaghan,C.A.
  TITLE     Functional characterization of HLA-F and binding of HLA-F tetramers
            to ILT2 and ILT4 receptors
  JOURNAL   Eur J Immunol 30 (12), 3552-3561 (2000)
   PUBMED   11169396
REFERENCE   9  (bases 1 to 2651)
  AUTHORS   Berg,S.F., Fossum,S. and Dissen,E.
  TITLE     NILR-1, a novel immunoglobulin-like receptor expressed by
            neutrophilic granulocytes, is encoded by a leukocyte receptor gene
            complex on rat chromosome 1
  JOURNAL   Eur J Immunol 29 (6), 2000-2006 (1999)
   PUBMED   10382763
REFERENCE   10 (bases 1 to 2651)
  AUTHORS   Fanger,N.A., Cosman,D., Peterson,L., Braddy,S.C., Maliszewski,C.R.
            and Borges,L.
  TITLE     The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc
            receptor-mediated signaling in monocytes
  JOURNAL   Eur J Immunol 28 (11), 3423-3434 (1998)
   PUBMED   9842885
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF082534.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF082534.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN13663620 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2651              AF082534.1         1-2651
FEATURES             Location/Qualifiers
     source          1..2651
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="PVG"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q12"
     gene            1..2651
                     /gene="Lilrb2"
                     /gene_synonym="Lilrb3; NILR-1; Nilr1; Pirb"
                     /note="leukocyte immunoglobulin like receptor B2"
                     /db_xref="GeneID:65146"
                     /db_xref="RGD:70895"
     exon            1..155
                     /gene="Lilrb2"
                     /gene_synonym="Lilrb3; NILR-1; Nilr1; Pirb"
                     /inference="alignment:Splign:2.1.0"
     CDS             17..1765
                     /gene="Lilrb2"
                     /gene_synonym="Lilrb3; NILR-1; Nilr1; Pirb"
                     /note="type 1 one-pass transmembrane Ig-like receptor;
                     leukocyte immunoglobulin-like receptor, subfamily B (with
                     TM and ITIM domains), member 3; paired Ig-like receptor B"
                     /codon_start=1
                     /product="neutrophil immunoglobulin-like receptor 1"
                     /protein_id="NP_113901.2"
                     /db_xref="GeneID:65146"
                     /db_xref="RGD:70895"
                     /translation="MGTALPPGPYPLPKPFRKALYLCSQAELQPLRRDAMTFTCKALL
                     CLGMTLGLWITVLTEFLPRPILRVQPDTVVSTQSKVIFFCERSQGAELYCLYKKGNPR
                     NPRCKEIRPKPGKKVEFFISKIEPYHAGHYHCYYQIHGQWSEDSDALELVVTGVYDYN
                     ELRLSVLPSPVVTVGRNMTLHCISHSHYDKFILTKEDHKFTSSLDTQCIPPSGQCQAL
                     FVMGPMTSNHTGTFRCYGYYKHTPQLWSIPSEPLEIHISGLSKKPSLLTHQGHILDPG
                     VNLTLQCCSDINYDRFALYKVGGVDIMQHTSQQTDTGFSMTNFTLGYVHHSTGGQYRC
                     YGAHNLSSEWSASSDPLDILITGPIQMSTLPPITSMPPDQLESYVNALIGVSVAFLVF
                     LFILIFIILQRRHQRKFRKDGEEAQKEKELQYPTGAVEPISRDRDQQKRSNAAAATQE
                     ESVYASVEDMETEDGVELDTWKPPEGDPQGETYAQVKPSRLRRVEAIIPSAMSREQLN
                     TKYEQAEEGQEVDGQATESEEPQDVTYAQLCSRTLRQGTAAPPLSQAGEAPEEPSVYA
                     ALATACPGAVPKDKEQ"
     exon            156..191
                     /gene="Lilrb2"
                     /gene_synonym="Lilrb3; NILR-1; Nilr1; Pirb"
                     /inference="alignment:Splign:2.1.0"
     exon            192..479
                     /gene="Lilrb2"
                     /gene_synonym="Lilrb3; NILR-1; Nilr1; Pirb"
                     /inference="alignment:Splign:2.1.0"
     exon            480..788
                     /gene="Lilrb2"
                     /gene_synonym="Lilrb3; NILR-1; Nilr1; Pirb"
                     /inference="alignment:Splign:2.1.0"
     exon            789..1085
                     /gene="Lilrb2"
                     /gene_synonym="Lilrb3; NILR-1; Nilr1; Pirb"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1136
                     /gene="Lilrb2"
                     /gene_synonym="Lilrb3; NILR-1; Nilr1; Pirb"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1262
                     /gene="Lilrb2"
                     /gene_synonym="Lilrb3; NILR-1; Nilr1; Pirb"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..1338
                     /gene="Lilrb2"
                     /gene_synonym="Lilrb3; NILR-1; Nilr1; Pirb"
                     /inference="alignment:Splign:2.1.0"
     exon            1339..1376
                     /gene="Lilrb2"
                     /gene_synonym="Lilrb3; NILR-1; Nilr1; Pirb"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..1429
                     /gene="Lilrb2"
                     /gene_synonym="Lilrb3; NILR-1; Nilr1; Pirb"
                     /inference="alignment:Splign:2.1.0"
     exon            1430..1585
                     /gene="Lilrb2"
                     /gene_synonym="Lilrb3; NILR-1; Nilr1; Pirb"
                     /inference="alignment:Splign:2.1.0"
     exon            1586..2634
                     /gene="Lilrb2"
                     /gene_synonym="Lilrb3; NILR-1; Nilr1; Pirb"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtaatatgac catgtcatgg ggactgccct gcctccaggg ccataccctc ttcccaaacc
       61 cttcagaaag gctctgtatc tctgttctca agcagagttg cagcctctca gaagagatgc
      121 catgaccttc acctgcaaag ccctgctctg tcttggaatg actctgggcc tctggatcac
      181 agtgctgaca gagttcctcc ctaggccaat cctcagagta cagccagaca ctgtggtctc
      241 tacacagagt aaggtgatct tcttctgtga gaggagtcaa ggagccgaac tttattgtct
      301 ctataaaaag ggaaatccac gaaatccacg gtgcaaagaa attcgaccta aacctggcaa
      361 gaaggttgaa ttcttcatct caaaaattga accgtaccat gcaggacatt accactgtta
      421 ttatcagatc catggtcaat ggtcagagga cagtgatgcg ctggagctgg tagtgacagg
      481 agtctatgac tacaatgaac tcaggctgtc agtactgccc agccctgtgg tgacagtggg
      541 aaggaacatg acactgcact gtatctcaca tagtcactat gataaattca ttctcaccaa
      601 ggaagatcac aagttcacca gctcactgga cacacagtgt atacctccta gtggacagtg
      661 ccaagctctg tttgttatgg gacccatgac atcaaaccac accgggacat tccgatgtta
      721 tggttactac aagcatactc cacagttgtg gtcaataccc agtgagcccc tggaaattca
      781 tatctcaggg ctgtccaaga agccctctct gctaactcac caaggacaca tcctggaccc
      841 tggagttaac ctcacactgc agtgttgctc tgacatcaac tatgacagat ttgctctgta
      901 caaagttggg ggtgttgaca ttatgcagca cactagccag cagactgaca ctggcttctc
      961 catgaccaac ttcacactgg gctatgtaca ccactctact ggaggccaat acagatgcta
     1021 tggagcacac aacctctcct ctgagtggtc agcatccagt gatcccctgg acatcttgat
     1081 cacaggaccc attcaaatgt ctaccttgcc acccataaca tccatgccac cagatcagct
     1141 ggaaagttat gtgaatgctc tgataggagt gtctgtggcc ttcctggtgt tcctcttcat
     1201 cctcatcttc atcattctcc aaagaagaca tcagagaaaa ttcagaaagg atggtgaaga
     1261 ggcccagaaa gagaaagaac tacaatatcc tacaggagct gtggagccca taagcaggga
     1321 tagagaccag cagaagaggt ccaatgcagc tgctgccacc caggaggaaa gcgtttatgc
     1381 ttcagtagag gacatggaaa ctgaggatgg tgtggagctg gacacttgga aaccacctga
     1441 gggagatcca cagggagaga catacgccca agtaaaaccc tccaggctca ggagggtaga
     1501 agctatcatt ccttctgcca tgtcaaggga gcagctgaac acaaaatatg aacaagcaga
     1561 agagggccaa gaggtggacg gtcaggctac tgaatccgaa gagccccagg atgtgaccta
     1621 tgcccagctg tgcagcagga cactcagaca ggggacagct gcacctcctc tctcccaggc
     1681 aggagaagcc ccagaggagc ccagtgtata tgctgctcta gcgactgctt gcccaggagc
     1741 tgttcccaag gacaaggagc agtgatcctc tgcctgccag gatgcctaac agagactgcc
     1801 aagagactct gggaactttt ggaaacctga ttgcacttta ggtaacaaca cactttggaa
     1861 actaagccag atgtttccca ataatcaagt gaagtgagaa atgaaataga agggacggtt
     1921 ttacattgag acctaatttt aatgacattt ttcatcaaat gagaaaattt acagcctcag
     1981 tttcacagcc ttataattct aacccatggg aggctgaggc aggagaattg cctttgcttt
     2041 gtggccatag tgggatatct agtgaatttc atgataccct ggggtacata gtgagacatg
     2101 tttcaaacaa tgttagccac caaaggccag ggtggaagta tgtacttgaa agcctagcac
     2161 tttggaggag tggaaaggat ggtcaagtgg tcaaggtcat cttcagatac ataggagcct
     2221 acgagtaaga ggcaatccag gaacacacta gacactgtaa aaatagataa ataagccagg
     2281 cttggtagtg catgccttca gtctcagcac taagaaagta gagacaggca gatttgagca
     2341 aatctttgtg agttcaagac cagataatct acatagtaag ctccaataca gccagggaca
     2401 tacacataaa tcttgtctca aaatacataa acaaaatagg gccagtagga tgactcagaa
     2461 gtaaaggcac ttgcaaccat gactaatatc ttaagttcaa tcagcaggaa aactagaatg
     2521 agaaaaggaa ctccaagaaa tgttatctca tttctaccta agtccttgat gtccttccca
     2581 caaccaataa gtacttaaaa caattaaaaa ataaacaaaa acaaataacc acaaaaaaaa
     2641 aaaaaaaaaa a
//
