LOCUS       NM_001394036            5759 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus DNA ligase 3 (Lig3), transcript variant 2, mRNA.
ACCESSION   NM_001394036 XM_006246989
VERSION     NM_001394036.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5759)
  AUTHORS   Zhang,S., Wang,X., Chen,G., Tong,L., Dai,T., Wang,L., Zhu,L.,
            Zhang,H. and Du,D.
  TITLE     CircRNA Galntl6 sponges miR-335 to ameliorate stress-induced
            hypertension through upregulating Lig3 in rostral ventrolateral
            medulla
  JOURNAL   Redox Biol 64, 102782 (2023)
   PUBMED   37315345
  REMARK    GeneRIF: CircRNA Galntl6 sponges miR-335 to ameliorate
            stress-induced hypertension through upregulating Lig3 in rostral
            ventrolateral medulla.
REFERENCE   2  (bases 1 to 5759)
  AUTHORS   Oh,S., Harvey,A., Zimbric,J., Wang,Y., Nguyen,T., Jackson,P.J. and
            Hendrickson,E.A.
  TITLE     DNA ligase III and DNA ligase IV carry out genetically distinct
            forms of end joining in human somatic cells
  JOURNAL   DNA Repair (Amst) 21, 97-110 (2014)
   PUBMED   24837021
REFERENCE   3  (bases 1 to 5759)
  AUTHORS   Akbari,M., Keijzers,G., Maynard,S., Scheibye-Knudsen,M., Desler,C.,
            Hickson,I.D. and Bohr,V.A.
  TITLE     Overexpression of DNA ligase III in mitochondria protects cells
            against oxidative stress and improves mitochondrial DNA base
            excision repair
  JOURNAL   DNA Repair (Amst) 16, 44-53 (2014)
   PUBMED   24674627
REFERENCE   4  (bases 1 to 5759)
  AUTHORS   Ruhanen,H., Ushakov,K. and Yasukawa,T.
  TITLE     Involvement of DNA ligase III and ribonuclease H1 in mitochondrial
            DNA replication in cultured human cells
  JOURNAL   Biochim Biophys Acta 1813 (12), 2000-2007 (2011)
   PUBMED   21878356
REFERENCE   5  (bases 1 to 5759)
  AUTHORS   Simsek,D., Brunet,E., Wong,S.Y., Katyal,S., Gao,Y., McKinnon,P.J.,
            Lou,J., Zhang,L., Li,J., Rebar,E.J., Gregory,P.D., Holmes,M.C. and
            Jasin,M.
  TITLE     DNA ligase III promotes alternative nonhomologous end-joining
            during chromosomal translocation formation
  JOURNAL   PLoS Genet 7 (6), e1002080 (2011)
   PUBMED   21655080
REFERENCE   6  (bases 1 to 5759)
  AUTHORS   Lakshmipathy,U. and Campbell,C.
  TITLE     The human DNA ligase III gene encodes nuclear and mitochondrial
            proteins
  JOURNAL   Mol Cell Biol 19 (5), 3869-3876 (1999)
   PUBMED   10207110
REFERENCE   7  (bases 1 to 5759)
  AUTHORS   Grawunder,U., Zimmer,D., Fugmann,S., Schwarz,K. and Lieber,M.R.
  TITLE     DNA ligase IV is essential for V(D)J recombination and DNA
            double-strand break repair in human precursor lymphocytes
  JOURNAL   Mol Cell 2 (4), 477-484 (1998)
   PUBMED   9809069
REFERENCE   8  (bases 1 to 5759)
  AUTHORS   Mackey,Z.B., Ramos,W., Levin,D.S., Walter,C.A., McCarrey,J.R. and
            Tomkinson,A.E.
  TITLE     An alternative splicing event which occurs in mouse pachytene
            spermatocytes generates a form of DNA ligase III with distinct
            biochemical properties that may function in meiotic recombination
  JOURNAL   Mol Cell Biol 17 (2), 989-998 (1997)
   PUBMED   9001252
REFERENCE   9  (bases 1 to 5759)
  AUTHORS   Caldecott,K.W., Tucker,J.D., Stanker,L.H. and Thompson,L.H.
  TITLE     Characterization of the XRCC1-DNA ligase III complex in vitro and
            its absence from mutant hamster cells
  JOURNAL   Nucleic Acids Res 23 (23), 4836-4843 (1995)
   PUBMED   8532526
REFERENCE   10 (bases 1 to 5759)
  AUTHORS   Chen,J., Tomkinson,A.E., Ramos,W., Mackey,Z.B., Danehower,S.,
            Walter,C.A., Schultz,R.A., Besterman,J.M. and Husain,I.
  TITLE     Mammalian DNA ligase III: molecular cloning, chromosomal
            localization, and expression in spermatocytes undergoing meiotic
            recombination
  JOURNAL   Mol Cell Biol 15 (10), 5412-5422 (1995)
   PUBMED   7565692
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Mar 26, 2021 this sequence version replaced XM_006246989.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360194.1565251.1,
                                           SRR26643284.13758.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-126               JAXUCZ010000010.1  68215371-68215496
            127-680             JAXUCZ010000010.1  68217506-68218059
            681-824             JAXUCZ010000010.1  68220297-68220440
            825-1025            JAXUCZ010000010.1  68222545-68222745
            1026-1177           JAXUCZ010000010.1  68223407-68223558
            1178-1344           JAXUCZ010000010.1  68224323-68224489
            1345-1422           JAXUCZ010000010.1  68224619-68224696
            1423-1591           JAXUCZ010000010.1  68225446-68225614
            1592-1747           JAXUCZ010000010.1  68227026-68227181
            1748-1879           JAXUCZ010000010.1  68228756-68228887
            1880-1959           JAXUCZ010000010.1  68229404-68229483
            1960-2047           JAXUCZ010000010.1  68230233-68230320
            2048-2125           JAXUCZ010000010.1  68230773-68230850
            2126-2249           JAXUCZ010000010.1  68231085-68231208
            2250-2392           JAXUCZ010000010.1  68232119-68232261
            2393-2467           JAXUCZ010000010.1  68232587-68232661
            2468-2614           JAXUCZ010000010.1  68233029-68233175
            2615-2822           JAXUCZ010000010.1  68233982-68234189
            2823-2905           JAXUCZ010000010.1  68234752-68234834
            2906-5759           JAXUCZ010000010.1  68235850-68238703
FEATURES             Location/Qualifiers
     source          1..5759
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q26"
     gene            1..5759
                     /gene="Lig3"
                     /note="DNA ligase 3"
                     /db_xref="GeneID:303369"
                     /db_xref="RGD:1309875"
     exon            1..126
                     /gene="Lig3"
                     /inference="alignment:Splign:2.1.0"
     exon            127..680
                     /gene="Lig3"
                     /inference="alignment:Splign:2.1.0"
     CDS             131..3139
                     /gene="Lig3"
                     /EC_number="6.5.1.1"
                     /note="isoform 1 is encoded by transcript variant 2; DNA
                     ligase (ATP) 3; ligase III, DNA, ATP-dependent"
                     /codon_start=1
                     /product="DNA ligase 3 isoform 1"
                     /protein_id="NP_001380965.1"
                     /db_xref="GeneID:303369"
                     /db_xref="RGD:1309875"
                     /translation="MTLAFKTLFPRNLCALGRKELCLFSEQHHWPAIRQFSQWSETNL
                     LCGCCLLQRRKPVLSFQRGHLRPRATHLISWSGSHVGLCTGPCEMAEQRFCVDYAKRG
                     TAGCKKCKEKIVKGVCRIGKVVPNPFSESGGDMKEWYHIKCMFEKLERARATTKKIED
                     LTELEGWEELEDNEKEQISQHIADLSSKTAATPKKKATVQAKLTTTGQVTSPVKGASF
                     ITSTNPRKFSGFSAAKPNNSEQDPSSPAPKTSLSASKCDPKHKDCLLREFRKLCAMVA
                     ENPSYNTKTQIIHDFLQKGSTGDGFRGDVYLTVKLLLPGVIKSVYNLNDKQIVKLFSR
                     IFNCNPDDMARDLEQGDVSETIRVFFEQSKSFPPAAKSLLTIQEVDAFLLHLSKLTKE
                     DEQQQALQDIASRCTANDLKCIIRLIKHDLKMNSGAKHVLDALDPNAYEAFKASRNLQ
                     DVVERVLHNEQEVEKDPGRRRALSVQASLMTPVQPMLAEACKSIEYAMKKCPNGMFSE
                     IKYDGERVQVHKKGDHFSYFSRSLKPVLPHKVAHFKDYIPKAFPGGQSMILDSEVLLI
                     DNNTGKPLPFGTLGVHKKAAFQDANVCLFVFDCIYFNDVSLMDRPLCERRKFLHDNMV
                     EIRNRIMFSEMKQVTKASDLADMINRVIREGLEGLVLKDVKGTYEPGKRHWLKVKKDY
                     LNEGAMADTADLVVLGAFYGQGSKGGMMSIFLMGCYDPDSQKWCTVTKCAGGHDDATL
                     ARLQKELDMVKISKDPSKIPSWLKINKIYYPDFIVPDPKKAAVWEITGAEFSRSEAHT
                     ADGISIRFPRCTRIRDDKDWKSATNLPQLKELYQLSKDKADFAVVAGDEGSSTTGGSN
                     GENEGTAGSTVPRKGPKGPPSKSSASAKKTEQKLNDPSSRGGEKLAVKSSPVKVGMKR
                     KAADETPGLTKALLDVFTGVRLYLPPSTPDFRRLKRYFVAFNGDLVQEFDMASATHVL
                     GNRDKNTDAQLVSSEWIWACIRKRRLVAPC"
     exon            681..824
                     /gene="Lig3"
                     /inference="alignment:Splign:2.1.0"
     exon            825..1025
                     /gene="Lig3"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1177
                     /gene="Lig3"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1344
                     /gene="Lig3"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1422
                     /gene="Lig3"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..1591
                     /gene="Lig3"
                     /inference="alignment:Splign:2.1.0"
     exon            1592..1747
                     /gene="Lig3"
                     /inference="alignment:Splign:2.1.0"
     exon            1748..1879
                     /gene="Lig3"
                     /inference="alignment:Splign:2.1.0"
     exon            1880..1959
                     /gene="Lig3"
                     /inference="alignment:Splign:2.1.0"
     exon            1960..2047
                     /gene="Lig3"
                     /inference="alignment:Splign:2.1.0"
     exon            2048..2125
                     /gene="Lig3"
                     /inference="alignment:Splign:2.1.0"
     exon            2126..2249
                     /gene="Lig3"
                     /inference="alignment:Splign:2.1.0"
     exon            2250..2392
                     /gene="Lig3"
                     /inference="alignment:Splign:2.1.0"
     exon            2393..2467
                     /gene="Lig3"
                     /inference="alignment:Splign:2.1.0"
     exon            2468..2614
                     /gene="Lig3"
                     /inference="alignment:Splign:2.1.0"
     exon            2615..2822
                     /gene="Lig3"
                     /inference="alignment:Splign:2.1.0"
     exon            2823..2905
                     /gene="Lig3"
                     /inference="alignment:Splign:2.1.0"
     exon            2906..5759
                     /gene="Lig3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctccggttca aggacccgta tttaaagaga caggaggtct agtcatcgtg caaggcccgt
       61 ggccttgtgg gctcctggtc cggtggccgg tgcggagcgt cagagccagg gcagccgaga
      121 aggcagctat atgactttgg cctttaagac cctcttcccg agaaacctct gtgcccttgg
      181 cagaaaagaa ctgtgcctgt tttcagaaca gcatcactgg cctgccataa gacagttcag
      241 ccagtggtcg gaaacaaatc tcctttgtgg gtgctgcctc ctccagagaa gaaagcctgt
      301 cctatctttc cagagaggtc atctaagacc acgtgccacc caccttattt cgtggtcagg
      361 gtcgcatgtg ggactctgta ctggcccctg tgagatggcc gaacagcggt tctgtgtgga
      421 ctatgccaag cggggcacag ctggctgcaa gaaatgcaag gagaagattg taaagggcgt
      481 atgccgcatt ggcaaagtgg tacccaatcc cttctcagag tctgggggtg atatgaaaga
      541 gtggtaccac attaagtgca tgtttgagaa actggagcgg gcgcgggcca ccacaaaaaa
      601 aattgaagac ctcacagagc tggaaggctg ggaagagctg gaagataatg aaaaggaaca
      661 gataagccag cacattgcag acctgtcttc caagacagct gccacaccga agaagaaagc
      721 tactgtccag gctaagctga caaccactgg ccaagtgaca tcaccagtga aaggcgcttc
      781 gtttattacc agtaccaatc cccggaaatt ttctggcttt tcagcagcca aaccgaacaa
      841 ctctgagcaa gacccctcaa gccctgctcc taagaccagt ctgtccgcaa gtaaatgtga
      901 ccctaagcac aaagattgtc tactacgaga attccggaag ctgtgtgcca tggtagctga
      961 aaatcctagc tataacacca agacccagat catccacgac ttcttgcaga aaggctccac
     1021 aggagatggc ttccgaggcg atgtgtacct gacagtgaag ctgctgctgc ctggtgtcat
     1081 caagagtgtg tacaacttga atgataagca gatagtgaaa ctgttcagcc gaatttttaa
     1141 ctgcaaccca gatgatatgg cccgggacct agaacagggt gacgtgtccg agacgatcag
     1201 agtcttcttt gagcagagca agtcttttcc cccagctgcc aaaagcctcc tcaccatcca
     1261 ggaggtggat gcatttcttc tgcacctctc caagctcacc aaagaggatg agcagcagca
     1321 ggccctgcag gacattgctt ccaggtgtac agccaatgac cttaagtgca ttatccggct
     1381 gatcaaacac gatctgaaga tgaactcggg tgcaaaacac gtgttagatg cccttgaccc
     1441 caatgcttat gaagccttca aagcatcacg caacctgcag gatgtggtgg agcgggtcct
     1501 tcacaatgag caggaggtgg agaaggaccc aggccggcgt cgggctctga gtgtccaggc
     1561 ctcattgatg acacctgtgc aacccatgct ggctgaggcc tgcaagtcca ttgagtatgc
     1621 aatgaagaag tgtcccaatg gcatgttctc tgagatcaag tacgatggtg agcgagtcca
     1681 ggtgcataag aagggagacc atttcagcta cttcagccgc agtctcaagc ctgtcttgcc
     1741 tcacaaggtg gcccacttta aggactatat tcccaaagcg tttcctgggg gtcaaagcat
     1801 gatcttggac tctgaagtgc tcctgattga taacaacaca ggcaaaccac tgccctttgg
     1861 gaccctggga gtacacaaga aagctgcttt ccaggatgct aatgtctgcc tgtttgtttt
     1921 tgattgtatc tactttaatg atgtcagctt gatggacagg cctctctgtg agcgacggaa
     1981 gtttcttcat gataacatgg ttgaaatccg taaccggatc atgttctcag aaatgaagca
     2041 agtcacaaaa gcttcagacc tggctgacat gataaaccgg gtgatccgag agggcctgga
     2101 aggtttggtg ctaaaggatg tgaagggtac atatgagcct ggaaaacgac actggctgaa
     2161 agttaagaaa gactatttga acgagggggc catggctgat acagctgatc tggtggttct
     2221 tggggccttc tatgggcaag ggagcaaagg tggaatgatg tccatcttcc tcatgggctg
     2281 ctatgacccc gacagccaga agtggtgcac tgttacaaaa tgtgctggag gccatgacga
     2341 tgccacactt gcccgcctgc agaaagagct agatatggtg aagattagca aggatcctag
     2401 caagataccc agctggctga agatcaacaa gatctactat cctgacttta tcgtcccaga
     2461 cccaaagaaa gctgctgtgt gggagatcac aggagcagaa ttctctcgat ctgaggcgca
     2521 tactgctgat gggatctcca tccgatttcc tcgatgcacc cgaatccggg atgacaagga
     2581 ctggaaatct gccactaacc tcccccaact caaggaactg taccagctgt ccaaagacaa
     2641 ggcagacttc gctgtggtgg ctggagatga ggggagctcc actactggag gcagcaatgg
     2701 tgagaatgag ggcactgctg ggtctactgt gccccgcaag ggccccaagg gaccccccag
     2761 taagtcctct gccagtgcca agaagactga acagaagctg aatgatccca gtagcagagg
     2821 tggagagaag ctggctgtga agtcttctcc tgtcaaagtg gggatgaaga ggaaagctgc
     2881 tgatgagacc ccaggcctga caaaggcgct gttggatgtc ttcactgggg tgaggctcta
     2941 cttgccacct tctacaccag acttcagacg gctcaaacgt tactttgtgg cattcaacgg
     3001 ggacctggta caggaatttg acatggcctc agccacacat gtgctgggta acagggacaa
     3061 gaacactgat gcccagttgg tctcttcaga gtggatttgg gcatgcatcc ggaaacggag
     3121 gctggtagct ccctgctagg actttgcttt tcctgctaac tctaccgata cacgaggctc
     3181 agcctgacgg gtagaggcct gttcgccaag cagcgcacct tctcacatcc tccgcctctt
     3241 tatggtctct tctggatcgg gagttagctg ctgtggacac aagcagttta attggatctt
     3301 cccaggtgct agttttgtct gaggtgctga tgaccaactt aaaccctcaa tcacactagg
     3361 cacagcactc tgccactgaa ctacagcttt ataaataaga aatggggatc agaagttcaa
     3421 ggctagcctg gggtaagaat ttgaacaaga ataagcatac tttcccccac tggtcccatc
     3481 tagtgttcct cagtgacgaa ggagtgctga gcggaatcta cttcctgtgc tcctcgcttc
     3541 cacgtgcatc ttaaaggtgt atttaaactg ttctcaaaca cttcttatac ctggcaaaac
     3601 ctttattatg tctggtccaa acccccatgt gaaagaacaa agtggtctcc aaatttccag
     3661 gtcattgcct ggagggagag ctgacatcta cagaaaagtg tcctccttgg agacagaggc
     3721 tccttgaagg tgaatttgcc tcatcaaaat ctgactgctc tcagcagcac aggtccatag
     3781 ctgggaaaat ctacataccc tgcctaccaa ggttggcttc tatgccatgt gtggcagatg
     3841 tccttgaagg ggaaagaaaa tgatttctgt gtataactgc acacaagggg tattttgcca
     3901 cagtggaagt gtcctaaact agccttatct gattgtcaag ccttgaaatg ggattagtgt
     3961 gactggcgaa agccataaac atttcaagac atcttcaaat ggtctcaagt taccggtgac
     4021 atcacatcat ctgagtatca gttcctcaag aggaatgggc agtcactgtt gccaaatcac
     4081 tgggcagcgg ccagtaacct cagacacctt gttgaaggca tgcaacacgg agcctggtaa
     4141 agatattatc caggaggagg cctagcttac acctcacttg ttaaaagttc acatttgggt
     4201 ctaagcatgg aactgtagta gaccgccttc tttgtctatg ttgtgccacc tcttgaagag
     4261 cagctctgtt cttattaact cagcaggctt ttctatccac ctgtgagcta ggttaatatg
     4321 atgggacctc ttaaacactt atgtgagcct ctaagataca gacctaccac cccacgtaac
     4381 tcctaaagta acatcccact aggaggctgc ttactagtct ggctgtcttt ctcctatttt
     4441 atagatgctc tgactagggt agagtaagcg acattcagtc tggtaagtta aacttttttt
     4501 attctagcct caaggcggaa gctgctttgt gctttgaaca cttggcttcc ttgcccaagc
     4561 agcttggtag agcatcaaag atgacttccc catcacacag ggctggaagt ttgtcccttt
     4621 gtccctttaa tgccttacta tatagtcact tcagcttgct gtctgtacat ttccctttgc
     4681 agaggttagg ctgtatgtag acctttgtat ctttcctgtc tttccacaca agcctaagca
     4741 tgacctgaaa cccccatccc ccaaggctgg aaacatgctc tctgtggctt ttgtttacac
     4801 aatgccagtt gatggcaggc agtgctcatt atgggatgct caacagatcc ggccatcaat
     4861 aagagacagg gtagaatcct ttcatccagc tctcccatag gtgatacact ccactccact
     4921 ccccttaggc acctggtcag gtaggtgggt acaggcctgt gtctactctg cagtctgctc
     4981 tttaggctgg gccaaccttg gagccacact tgtctgtatc caaacgctac tgtcagtgtt
     5041 ttggggtaac ttgaaaactt aactgcctac ctagctgtct tgagattcct ttcacttagc
     5101 tcttgaaggc ccctctacag tgggactgta ataacttcac acggtgcttg ccgtttgctc
     5161 ttgaatcacc cttacactta gctccacgag taactgttcc acaatcccat gtactcttgt
     5221 ggatcttggc caggtcacaa cacagagcat gtggcctgat gtctgcccac gtttacaagt
     5281 gttttgggaa cctctggtat catcccccca caccagatgg aacaggcatc tgtatttaaa
     5341 ctttattaca aaattataaa gcagagctct gtaacaaaaa atacacattt gggtatgctt
     5401 accacccagg tgagagaatc aatgtaagcc acttggagct atacatttat atccaagaga
     5461 tctcaaatgt gtacaacata gactattaat tcctttacag cttgttagtt tagaaccggc
     5521 tattccaacc agtcagcatc tttgaaaact aagtctcaac taaaatcttg gcgcaatcgg
     5581 caaagtccac agaataattg gaaggattag gtgtttccac attaattaag accaaggatc
     5641 cgtgaagaac agaaaaaggg gctcaggtat ttaaaaaaaa aaatcagttt ttctacctga
     5701 gatattaact ggaatgagtt ccaacttcca tttggtttaa caataaaaag gttatttga
//
