LOCUS       NM_001024268            3052 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Rattus norvegicus DNA ligase 1 (Lig1), mRNA.
ACCESSION   NM_001024268 NM_030855 XM_346533
VERSION     NM_001024268.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3052)
  AUTHORS   Gao,F., Wei,M., Wang,M., Yang,Y., Duan,X., Yang,L. and Sun,L.
  TITLE     The Role and Mechanism of Spinal NF-kappaB-CXCL1/CXCR2 in Rats with
            Nucleus Pulposus-induced Radicular Pain
  JOURNAL   Spine (Phila Pa 1976) 49 (7), E87-E99 (2024)
   PUBMED   38098294
  REMARK    GeneRIF: The Role and Mechanism of Spinal NF-kappaB-CXCL1/CXCR2 in
            Rats with Nucleus Pulposus-induced Radicular Pain.
REFERENCE   2  (bases 1 to 3052)
  AUTHORS   Kinboshi,M., Shimizu,S., Mashimo,T., Serikawa,T., Ito,H., Ikeda,A.,
            Takahashi,R. and Ohno,Y.
  TITLE     Down-Regulation of Astrocytic Kir4.1 Channels during the Audiogenic
            Epileptogenesis in Leucine-Rich Glioma-Inactivated 1 (Lgi1) Mutant
            Rats
  JOURNAL   Int J Mol Sci 20 (5), 1013 (2019)
   PUBMED   30813600
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3052)
  AUTHORS   Lehmann,A.R.
  TITLE     DNA polymerases and repair synthesis in NER in human cells
  JOURNAL   DNA Repair (Amst) 10 (7), 730-733 (2011)
   PUBMED   21601536
  REMARK    Review article
REFERENCE   4  (bases 1 to 3052)
  AUTHORS   Simsek,D., Brunet,E., Wong,S.Y., Katyal,S., Gao,Y., McKinnon,P.J.,
            Lou,J., Zhang,L., Li,J., Rebar,E.J., Gregory,P.D., Holmes,M.C. and
            Jasin,M.
  TITLE     DNA ligase III promotes alternative nonhomologous end-joining
            during chromosomal translocation formation
  JOURNAL   PLoS Genet 7 (6), e1002080 (2011)
   PUBMED   21655080
REFERENCE   5  (bases 1 to 3052)
  AUTHORS   Gao,Y., Katyal,S., Lee,Y., Zhao,J., Rehg,J.E., Russell,H.R. and
            McKinnon,P.J.
  TITLE     DNA ligase III is critical for mtDNA integrity but not
            Xrcc1-mediated nuclear DNA repair
  JOURNAL   Nature 471 (7337), 240-244 (2011)
   PUBMED   21390131
REFERENCE   6  (bases 1 to 3052)
  AUTHORS   Bentley,D.J., Harrison,C., Ketchen,A.M., Redhead,N.J., Samuel,K.,
            Waterfall,M., Ansell,J.D. and Melton,D.W.
  TITLE     DNA ligase I null mouse cells show normal DNA repair activity but
            altered DNA replication and reduced genome stability
  JOURNAL   J Cell Sci 115 (Pt 7), 1551-1561 (2002)
   PUBMED   11896201
REFERENCE   7  (bases 1 to 3052)
  AUTHORS   Grawunder,U., Zimmer,D., Fugmann,S., Schwarz,K. and Lieber,M.R.
  TITLE     DNA ligase IV is essential for V(D)J recombination and DNA
            double-strand break repair in human precursor lymphocytes
  JOURNAL   Mol Cell 2 (4), 477-484 (1998)
   PUBMED   9809069
REFERENCE   8  (bases 1 to 3052)
  AUTHORS   Mackey,Z.B., Ramos,W., Levin,D.S., Walter,C.A., McCarrey,J.R. and
            Tomkinson,A.E.
  TITLE     An alternative splicing event which occurs in mouse pachytene
            spermatocytes generates a form of DNA ligase III with distinct
            biochemical properties that may function in meiotic recombination
  JOURNAL   Mol Cell Biol 17 (2), 989-998 (1997)
   PUBMED   9001252
REFERENCE   9  (bases 1 to 3052)
  AUTHORS   Webster,A.D., Barnes,D.E., Arlett,C.F., Lehmann,A.R. and Lindahl,T.
  TITLE     Growth retardation and immunodeficiency in a patient with mutations
            in the DNA ligase I gene
  JOURNAL   Lancet 339 (8808), 1508-1509 (1992)
   PUBMED   1351188
REFERENCE   10 (bases 1 to 3052)
  AUTHORS   Elder,R.H., Montecucco,A., Ciarrocchi,G. and Rossignol,J.M.
  TITLE     Rat liver DNA ligases. Catalytic properties of a novel form of DNA
            ligase
  JOURNAL   Eur J Biochem 203 (1-2), 53-58 (1992)
   PUBMED   1730240
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 27, 2020 this sequence version replaced NM_001024268.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF276774.1, BC093604.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-108               JAXUCZ010000001.1  83243170-83243277
            109-179             JAXUCZ010000001.1  83244788-83244858
            180-272             JAXUCZ010000001.1  83247040-83247132
            273-408             JAXUCZ010000001.1  83249687-83249822
            409-520             JAXUCZ010000001.1  83250971-83251082
            521-613             JAXUCZ010000001.1  83253141-83253233
            614-721             JAXUCZ010000001.1  83259395-83259502
            722-847             JAXUCZ010000001.1  83261231-83261356
            848-923             JAXUCZ010000001.1  83261500-83261575
            924-1004            JAXUCZ010000001.1  83262592-83262672
            1005-1061           JAXUCZ010000001.1  83262919-83262975
            1062-1234           JAXUCZ010000001.1  83266059-83266231
            1235-1401           JAXUCZ010000001.1  83266894-83267060
            1402-1478           JAXUCZ010000001.1  83267446-83267522
            1479-1570           JAXUCZ010000001.1  83268667-83268758
            1571-1670           JAXUCZ010000001.1  83268970-83269069
            1671-1756           JAXUCZ010000001.1  83270125-83270210
            1757-1872           JAXUCZ010000001.1  83270852-83270967
            1873-1968           JAXUCZ010000001.1  83271334-83271429
            1969-2079           JAXUCZ010000001.1  83273157-83273267
            2080-2151           JAXUCZ010000001.1  83273834-83273905
            2152-2296           JAXUCZ010000001.1  83276304-83276448
            2297-2379           JAXUCZ010000001.1  83276605-83276687
            2380-2532           JAXUCZ010000001.1  83277949-83278101
            2533-2586           JAXUCZ010000001.1  83278930-83278983
            2587-2730           JAXUCZ010000001.1  83279627-83279770
            2731-2823           JAXUCZ010000001.1  83281290-83281382
            2824-3052           JAXUCZ010000001.1  83281479-83281707
FEATURES             Location/Qualifiers
     source          1..3052
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..3052
                     /gene="Lig1"
                     /note="DNA ligase 1"
                     /db_xref="GeneID:81513"
                     /db_xref="RGD:621424"
     exon            1..108
                     /gene="Lig1"
                     /inference="alignment:Splign:2.1.0"
     exon            109..179
                     /gene="Lig1"
                     /inference="alignment:Splign:2.1.0"
     CDS             163..2904
                     /gene="Lig1"
                     /EC_number="6.5.1.1"
                     /note="DNA ligase (ATP) 1; polydeoxyribonucleotide
                     synthase [ATP] 1; DNA ligase I; ligase I, DNA,
                     ATP-dependent"
                     /codon_start=1
                     /product="DNA ligase 1"
                     /protein_id="NP_001019439.1"
                     /db_xref="GeneID:81513"
                     /db_xref="RGD:621424"
                     /translation="MQRSIMSFFQPTTTEGKAKKPEKEIPSSIREKEPPPKVALKERN
                     RAVPESDSPVKRPGRKVAQVLSSEGEDEDEAPGTPQVQKPVSDSKQSSPPSPDSCPEN
                     SSPSMDISPSGFPKRRTARKQLPKRTIQDTLEEHNEDKDKAAKKRKKEDTQTPTESLT
                     EAEEVKQKEEQVEDQPTVPPEPTESPESVTLTKTENIPMCKAGVKQKPQEEEQSKPPA
                     RGAKPLSSFFTPRKPAVKTEVKQEESDTPRKEETKGAPDPTNYNPSKSNYHPIEDACW
                     KHGQKVPFLAVARTFEKIEEVSARLKMVETLSNLLRSVVALSPTDLLPVLYLSLNRLG
                     PPQQGLELGVGDGVLLKAVAQATGRQLESIRAEVAEKGDVGLVAENSRSTQRLMLPPP
                     PLTVSGVFTKFCDIARLTGSASMAKKMDIIKGLFVACRYSEARFIARSLSGRLRLGLA
                     EQSVLAALAQAVSLTPPGQEFPTAVVDAGKGKTAEARKMWLEEQGMILKQTFCEVPDL
                     DRIIPVLLEHGLESLPEHCKLSPGVPLKPMLAHPTRGVREVLKRFEEVDFTCEYKYDG
                     QRAQIHVLEGGEVKIFSRNQEDNSGKYPDIISRIPKIKHPSVTSFILDTEAVAWDREK
                     KQIQPFQVLTTRKRKEVDASEIQVQVCLYAFDLIYLNGESLARQPLSRRRQLLRENFV
                     ETEGEFVFATSLDTKDIEQIAEFLEQSVKDSCEGLMVKTLDVDATYEIAKRSHNWLKL
                     KKDYLEGVGDTLDLVVIGAYLGRGKRAGRYGGFLLAAYDEESEELQAICKLGTGFSDE
                     ELEEHHQSMQALLLPTPRPYVRIDGAVAPDHWLDPSVVWEVKCADLSLSPIYPAARGL
                     VDKEKGISLRFPRFIRVREDKQPEQATTSDQVASLYRKQSQIQNQQSSDLDSDVEDY"
     exon            180..272
                     /gene="Lig1"
                     /inference="alignment:Splign:2.1.0"
     exon            273..408
                     /gene="Lig1"
                     /inference="alignment:Splign:2.1.0"
     exon            409..520
                     /gene="Lig1"
                     /inference="alignment:Splign:2.1.0"
     exon            521..613
                     /gene="Lig1"
                     /inference="alignment:Splign:2.1.0"
     exon            614..721
                     /gene="Lig1"
                     /inference="alignment:Splign:2.1.0"
     exon            722..847
                     /gene="Lig1"
                     /inference="alignment:Splign:2.1.0"
     exon            848..923
                     /gene="Lig1"
                     /inference="alignment:Splign:2.1.0"
     exon            924..1004
                     /gene="Lig1"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1061
                     /gene="Lig1"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1234
                     /gene="Lig1"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1401
                     /gene="Lig1"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..1478
                     /gene="Lig1"
                     /inference="alignment:Splign:2.1.0"
     exon            1479..1570
                     /gene="Lig1"
                     /inference="alignment:Splign:2.1.0"
     exon            1571..1670
                     /gene="Lig1"
                     /inference="alignment:Splign:2.1.0"
     exon            1671..1756
                     /gene="Lig1"
                     /inference="alignment:Splign:2.1.0"
     exon            1757..1872
                     /gene="Lig1"
                     /inference="alignment:Splign:2.1.0"
     exon            1873..1968
                     /gene="Lig1"
                     /inference="alignment:Splign:2.1.0"
     exon            1969..2079
                     /gene="Lig1"
                     /inference="alignment:Splign:2.1.0"
     exon            2080..2151
                     /gene="Lig1"
                     /inference="alignment:Splign:2.1.0"
     exon            2152..2296
                     /gene="Lig1"
                     /inference="alignment:Splign:2.1.0"
     exon            2297..2379
                     /gene="Lig1"
                     /inference="alignment:Splign:2.1.0"
     exon            2380..2532
                     /gene="Lig1"
                     /inference="alignment:Splign:2.1.0"
     exon            2533..2586
                     /gene="Lig1"
                     /inference="alignment:Splign:2.1.0"
     exon            2587..2730
                     /gene="Lig1"
                     /inference="alignment:Splign:2.1.0"
     exon            2731..2823
                     /gene="Lig1"
                     /inference="alignment:Splign:2.1.0"
     exon            2824..3052
                     /gene="Lig1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcatcccgcc aaggtctgcg cgcgaaatct gtgtggcgcg aatttggggc tttcgagttt
       61 gcgtctccga gcgagctagt gtggtgtccc gcaaagtgat ttggagaggt acaactgatg
      121 aaaaaaaaag agcaagagag gaagggagag aattctgcca acatgcagag aagtattatg
      181 tcatttttcc aacccacaac aacagaaggt aaagcgaaga agccagagaa ggagataccc
      241 agcagcatca gagagaagga accccctcca aaggtggcat tgaaggagag gaatcgagca
      301 gtgcctgaga gtgattctcc agtgaagagg ccaggaagga aggtggccca ggttctgagc
      361 agtgaagggg aggacgaaga tgaagcccct ggcacccccc aagtccaaaa gcctgtgtca
      421 gactccaaac agagctctcc tcccagccct gactcctgtc ctgagaacag cagcccctcc
      481 atggacatct ccccatcagg attcccaaag cgccgaactg cacggaagca gctcccaaaa
      541 cggacaattc aagacactct tgaggagcac aatgaagaca aagacaaagc agctaagaaa
      601 aggaaaaaag aagatacaca gaccccaaca gaaagcctca cagaggctga agaagtaaaa
      661 cagaaggaag aacaggtgga ggaccagccc acagtacccc ctgagcccac agagtcccct
      721 gagtcagtaa ccctcacaaa gacagagaac attccaatgt gtaaggcagg tgtgaaacag
      781 aagcctcagg aagaagaaca gagcaagcct cctgccaggg gtgccaagcc actgagcagt
      841 ttcttcacac cccgaaaacc agcagtgaaa actgaagtca aacaagaaga gtcagacact
      901 ccaaggaagg aagagaccaa gggagccccg gatccaacca attataatcc ttccaagagt
      961 aactaccatc ccattgaaga tgcctgctgg aaacatggcc aaaaggttcc ttttcttgct
     1021 gtggcccgga catttgagaa gattgaggag gtgtctgctc ggcttaagat ggtggagaca
     1081 ctgagcaacc tgctgcgctc cgtggtggcc ctgtccccaa cagacctgct ccctgttctc
     1141 tatctcagcc tcaaccgcct tgggccgcct cagcagggtc tagaactggg tgttggtgat
     1201 ggtgtcctcc tcaaggcagt tgcccaggcc acaggtcgtc agctggagtc catccgggct
     1261 gaggtagctg agaaggggga tgtggggcta gtggcggaga acagccgaag cactcagagg
     1321 ctcatgctgc ctccacctcc acttactgtt tctggagtct ttaccaaatt ctgtgacatt
     1381 gcccggctca ctggcagtgc ttccatggcc aagaaaatgg acattatcaa gggccttttt
     1441 gttgcctgcc gctactcaga agcccggttt attgccaggt ccctaagtgg gcggctgcgc
     1501 cttgggctgg ctgagcagtc agtactggct gctcttgccc aggctgtgag cctcacaccc
     1561 cctggccaag aatttcccac agccgtggtg gatgctggga agggcaagac agcagaggcc
     1621 agaaagatgt ggttggaaga acaaggcatg atcttgaagc aaaccttctg tgaggtgcct
     1681 gatctggatc gcatcatccc tgtgctgctg gaacatggct tggaaagtct cccagagcac
     1741 tgcaagctga gcccaggggt tcctcttaaa ccaatgctgg cccatcccac tcggggtgtc
     1801 cgtgaggtcc tgaaacgctt tgaggaggtc gacttcacct gcgagtataa atacgatggg
     1861 cagcgggcac agatacatgt tctggaaggt ggagaagtga agatcttcag caggaaccag
     1921 gaagacaact caggaaagta tcctgacatc atcagccgca tccccaagat taaacacccc
     1981 tcagtcacat ctttcattct ggacactgag gctgtggcct gggaccggga aaagaagcag
     2041 atccagccat tccaagtgct caccacacgc aagcgcaagg aggttgatgc atcggagata
     2101 caggtacaag tgtgtctgta tgcttttgac ctcatctacc tcaacggaga gtccctggct
     2161 cgccagcccc tgtctcgacg ccggcagcta ctccgtgaga actttgtgga gacagagggt
     2221 gagtttgtct ttgccacctc cttggacacc aaggacatcg agcagattgc cgagttctta
     2281 gagcagtcag tgaaggactc ctgtgagggc ctgatggtga agaccctgga tgttgatgct
     2341 acctatgaga tcgccaagag gtcacacaac tggctcaagc tgaagaagga ctaccttgaa
     2401 ggtgtgggcg acactctaga ccttgtggtg attggtgcct acctgggccg ggggaagcgg
     2461 gctggccggt atgggggctt cctgttggct gcctacgatg aggagagtga agagctgcag
     2521 gccatatgca agctgggaac cggattcagc gacgaggagc tggaagaaca tcatcagagc
     2581 atgcaggccc ttttattgcc taccccacgc ccctatgtga ggattgatgg ggcagtggcc
     2641 ccagaccact ggctagaccc gagtgttgtg tgggaggtga aatgtgctga tctctccctg
     2701 tctcccatct accctgctgc tcggggcctg gtggacaaag aaaaagggat ctcccttcgt
     2761 ttccctcggt tcattcgtgt ccgtgaggat aagcagccag agcaggccac taccagtgac
     2821 caggtggcct ctttgtaccg gaagcagagt cagattcaga accagcaaag ctcagacttg
     2881 gactctgatg ttgaagatta ctaacctcct gctctcctgg acctggggtg gagattgaga
     2941 gaacatgctt actattggac tggttgtgtt gactggcgtg caggtgctta caggatgaga
     3001 tcctggggct gggatgcttc attttattca ataaatgact atcatttgac ta
//
