LOCUS       NM_031048               3407 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus LIF receptor subunit alpha (Lifr), mRNA.
ACCESSION   NM_031048
VERSION     NM_031048.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3407)
  AUTHORS   Huo,L., Fan,Y. and Wang,H.
  TITLE     Leukemia Inhibitory Factor Receptor Is Involved in Apoptosis in Rat
            Astrocytes Exposed to Oxygen-Glucose Deprivation
  JOURNAL   Biomed Res Int 2019, 1613820 (2019)
   PUBMED   30937308
  REMARK    GeneRIF: Lifr plays a pivotal role in the astrocyte apoptosis
            induced by hypoxic/low-glucose environments.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3407)
  AUTHORS   Chen,K.C., Hsieh,C.L., Peng,C.C. and Peng,R.Y.
  TITLE     Exercise rescued chronic kidney disease by attenuating cardiac
            hypertrophy through the cardiotrophin-1 -> LIFR/gp 130 -> JAK/STAT3
            pathway
  JOURNAL   Eur J Prev Cardiol 21 (4), 507-520 (2014)
   PUBMED   23064267
  REMARK    GeneRIF: In the chronic kidney disease-cardiac hypertrophy model
            exercise rescues cardiac disease via cardiotrophin-1/LIFR/gp
            130/JAK/STAT3 pathway.
REFERENCE   3  (bases 1 to 3407)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   4  (bases 1 to 3407)
  AUTHORS   Nogueira-Silva,C., Piairo,P., Carvalho-Dias,E., Peixoto,F.O.,
            Moura,R.S. and Correia-Pinto,J.
  TITLE     Leukemia inhibitory factor in rat fetal lung development:
            expression and functional studies
  JOURNAL   PLoS One 7 (1), e30517 (2012)
   PUBMED   22291973
  REMARK    GeneRIF: LIF and its subunit receptor LIFRalpha are constitutively
            expressed during fetal lung development and that they have an
            inhibitory physiological role on fetal lung branching.
REFERENCE   5  (bases 1 to 3407)
  AUTHORS   Liang,Y., Zhou,Y., Jiang,T., Zhang,Z., Wang,S. and Wang,Y.
  TITLE     Expression of LIF and LIFR in periodontal tissue during orthodontic
            tooth movement
  JOURNAL   Angle Orthod 81 (4), 600-608 (2011)
   PUBMED   21446866
  REMARK    GeneRIF: continuous orthodontic forces induce the upregulation of
            production, suggesting that LIFR may play important role in
            periodontium remodeling
REFERENCE   6  (bases 1 to 3407)
  AUTHORS   Schuster,B., Kovaleva,M., Sun,Y., Regenhard,P., Matthews,V.,
            Grotzinger,J., Rose-John,S. and Kallen,K.J.
  TITLE     Signaling of human ciliary neurotrophic factor (CNTF) revisited.
            The interleukin-6 receptor can serve as an alpha-receptor for CTNF
  JOURNAL   J Biol Chem 278 (11), 9528-9535 (2003)
   PUBMED   12643274
REFERENCE   7  (bases 1 to 3407)
  AUTHORS   Aikawa,J., Ikeda-Naiki,S., Ohgane,J., Min,K.S., Imamura,T.,
            Sasai,K., Shiota,K. and Ogawa,T.
  TITLE     Molecular cloning of rat leukemia inhibitory factor receptor
            alpha-chain gene and its expression during pregnancy
  JOURNAL   Biochim Biophys Acta 1353 (3), 266-276 (1997)
   PUBMED   9349722
REFERENCE   8  (bases 1 to 3407)
  AUTHORS   Mosley,B., De Imus,C., Friend,D., Boiani,N., Thoma,B., Park,L.S.
            and Cosman,D.
  TITLE     Dual oncostatin M (OSM) receptors. Cloning and characterization of
            an alternative signaling subunit conferring OSM-specific receptor
            activation
  JOURNAL   J Biol Chem 271 (51), 32635-32643 (1996)
   PUBMED   8999038
REFERENCE   9  (bases 1 to 3407)
  AUTHORS   Hilton,D.J., Hilton,A.A., Raicevic,A., Rakar,S., Harrison-Smith,M.,
            Gough,N.M., Begley,C.G., Metcalf,D., Nicola,N.A. and Willson,T.A.
  TITLE     Cloning of a murine IL-11 receptor alpha-chain; requirement for
            gp130 for high affinity binding and signal transduction
  JOURNAL   EMBO J 13 (20), 4765-4775 (1994)
   PUBMED   7957045
REFERENCE   10 (bases 1 to 3407)
  AUTHORS   Stahl,N., Davis,S., Wong,V., Taga,T., Kishimoto,T., Ip,N.Y. and
            Yancopoulos,G.D.
  TITLE     Cross-linking identifies leukemia inhibitory factor-binding protein
            as a ciliary neurotrophic factor receptor component
  JOURNAL   J Biol Chem 268 (11), 7628-7631 (1993)
   PUBMED   8385113
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from D86345.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D86345.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760396, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..3407
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="WI"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q16"
     gene            1..3407
                     /gene="Lifr"
                     /note="LIF receptor subunit alpha"
                     /db_xref="GeneID:81680"
                     /db_xref="RGD:621431"
     exon            1..69
                     /gene="Lifr"
                     /inference="alignment:Splign:2.1.0"
     exon            70..230
                     /gene="Lifr"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..3373
                     /gene="Lifr"
                     /note="LIF-R; leukemia inhibitor factor receptor
                     alpha-chain; leukemia inhibitory factor receptor alpha;
                     LIF receptor alpha"
                     /codon_start=1
                     /product="leukemia inhibitory factor receptor precursor"
                     /protein_id="NP_112310.1"
                     /db_xref="GeneID:81680"
                     /db_xref="RGD:621431"
                     /translation="MGAFSWWRQPSWMADNKRGRMTPSLPWLLSALTLLHLMMHVNGL
                     KRGVQQDLKCTTNNMRVWDCSWPAPLGVSPGTVKDICIKDRPHSCHRLETTNVKIPAL
                     SPGDHEVTINYQNGFQSKFTLNEKDVSLVPDTPEILSLSADFSTSTLQLKWNDKGSAL
                     PYPSNATWEVKVLQNPRTEPVALVSLNTVLSGKDKGHHWNWTSELPLQCATHSVSIRW
                     HIDYPRFSGYKEWSEWSPLKNISWTRNTETNVFPQDKVVLAGSNMTICCISTTKVLSG
                     QIGNTFRPLIHLYGETVAINILNIPVSENSGSNVIFSTVDDVYGTVVFAGYPPDVPQK
                     LSCETHDLKEIICSWNPGRITGLVGPRNTEYTLFESISGKSAVFHRFEELANETYWLT
                     LKMAPDQEIHNFTLTARNPLGQTESAIVINATERVALHVPISLKVKDVNSTVVTLSWY
                     LPGNFTKINLVCQIEICKANSKKEVRNVTMRGAEDSTYHVAVDKLNPYTIYTFRVRCS
                     SETFWKWSKWSNEKRYLTTEATPSKGPDTWREWSSDGKNLIIYWKPLPINEANGKILS
                     YNVSCSSSEETQSLSEILDPQHKAEIKVNKNDYIISVVARNSAGSSPPSKIASMEIPN
                     DDITVEQAVGIGNRIFLSWQHNPNMTCDYVIKWCNSSWSEPCLLDWIKVPSNSTGTVI
                     ESDQFQPGVRYNFYLYGCTNQGYQLLRSTIGYIEELAPIVAPNFTVEDTSADSILVKW
                     DDIPVEELRGFLRGYLFYFQKGERDTPKTRSLETSHSDIKLKNITDISQKTLRIADLQ
                     GKTSYHLVLRAYTHGGLGPEKSMFVVTKENSVGLIIAILIPVAVAVIVGVVTSILCYR
                     KREWIKETFYPDIPNPENCKALQFQKSVCEGSNALKTLEMNPCTPNHVEVLESRSIPP
                     KIEDTEITSPVSERPGESSETDPENQAAVSYCPPIIEEEITNPAADEAGGASQVVYID
                     VQSMYQPQAKAEDEQDTDPVMVAGYKPQMRLPINPTAEDTTAEDEADKTAGYRPQANV
                     NTWNLVSPDSPRSTDSNSEVVSFGSPCSINSRQFLIPPKDEDSPKSNGGGWSFTNFFQ
                     NKPND"
     exon            231..345
                     /gene="Lifr"
                     /inference="alignment:Splign:2.1.0"
     exon            346..476
                     /gene="Lifr"
                     /inference="alignment:Splign:2.1.0"
     exon            477..640
                     /gene="Lifr"
                     /inference="alignment:Splign:2.1.0"
     exon            641..815
                     /gene="Lifr"
                     /inference="alignment:Splign:2.1.0"
     exon            816..1070
                     /gene="Lifr"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1200
                     /gene="Lifr"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1370
                     /gene="Lifr"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1516
                     /gene="Lifr"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1679
                     /gene="Lifr"
                     /inference="alignment:Splign:2.1.0"
     exon            1680..1750
                     /gene="Lifr"
                     /inference="alignment:Splign:2.1.0"
     exon            1751..1964
                     /gene="Lifr"
                     /inference="alignment:Splign:2.1.0"
     exon            1965..2144
                     /gene="Lifr"
                     /inference="alignment:Splign:2.1.0"
     exon            2145..2246
                     /gene="Lifr"
                     /inference="alignment:Splign:2.1.0"
     exon            2247..2414
                     /gene="Lifr"
                     /inference="alignment:Splign:2.1.0"
     exon            2415..2576
                     /gene="Lifr"
                     /inference="alignment:Splign:2.1.0"
     exon            2577..2670
                     /gene="Lifr"
                     /inference="alignment:Splign:2.1.0"
     exon            2671..2749
                     /gene="Lifr"
                     /inference="alignment:Splign:2.1.0"
     exon            2750..3407
                     /gene="Lifr"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tagcaagcca gcaagcagca ctcctccatg gcctctgcat cagctcctgc ttccaggatc
       61 gttccctggg actgactgaa tagcacggac aatgggagct ttctcatggt ggagacagcc
      121 atcttggatg gcggacaata aaagagggag gatgactcca agcctgccat ggctcctgtc
      181 ggctctgact cttctgcatc tgatgatgca cgtgaatggt cttaagagag gggtacaaca
      241 agatctgaaa tgcacaacca acaatatgcg agtgtgggac tgctcatggc cagcacccct
      301 cggggtcagc cctggaactg ttaaagacat ttgcattaaa gacaggcccc attcctgcca
      361 tcgactagag acaacaaacg ttaagatccc agctctttca cccggtgatc acgaagtaac
      421 aataaattac caaaacggct ttcagagtaa attcacactg aatgaaaaag atgtttcttt
      481 agttccggat acccctgaga tcttgagttt gtctgctgac ttctcgacct ccacattaca
      541 actgaagtgg aatgacaaag ggtctgctct cccttacccc tccaatgcca cctgggaggt
      601 taaggttctg cagaatccga ggacggagcc cgtagcacta gtgtcactca acacagtgct
      661 gagtggtaaa gataaaggtc accactggaa ctggacctca gaactgccct tgcagtgtgc
      721 cactcactct gtgagcatta gatggcacat tgactaccct cgtttctctg ggtacaaaga
      781 gtggagtgag tggagcccgc tgaagaacat ttcctggacg cgtaataccg agactaacgt
      841 ttttcctcaa gacaaagtgg tacttgcagg ctcaaacatg acaatttgtt gtataagtac
      901 aacgaaggtg ctttcaggac agattggaaa tacgttccgc cctcttatcc atctttatgg
      961 ggagactgtc gccatcaaca tcctgaacat acctgtttct gaaaacagcg gctcaaatgt
     1021 gattttcagc acagtcgacg atgtgtatgg aacggtcgtc ttcgcaggct atccacccga
     1081 tgttcctcag aaactgagct gtgagacaca tgacttgaaa gagattatat gtagctggaa
     1141 tccgggaagg ataacgggac tggtgggccc acgcaacaca gaatacacct tatttgaaag
     1201 catttcagga aaatcggcag tgttccacag gtttgaagaa cttgcaaatg aaacctattg
     1261 gttaaccttg aaaatggctc ctgaccaaga aattcataac ttcaccctga ctgctcgcaa
     1321 tccactgggc cagacagaat cagcgatagt catcaacgca actgaaagag ttgctcttca
     1381 tgttcctatt tcattgaaag tgaaggacgt caattcaaca gtcgttacac tttcttggta
     1441 cttgccagga aattttacaa agattaatct tgtatgtcag attgaaattt gtaaagctaa
     1501 ttccaagaaa gaagtgcgga atgtcacaat gagaggagct gaggattcaa cctaccatgt
     1561 tgctgtggac aaactaaacc catatactat ctatactttc cgggttcgtt gttcttccga
     1621 aactttctgg aaatggagca agtggagtaa tgaaaagcga tatttaacca ctgaagccac
     1681 tccttcaaag ggaccagata cttggcgaga gtggagttct gatgggaaaa acttaatcat
     1741 ctactggaag cctttaccca tcaatgaagc taatggaaaa atactttcct acaatgtgtc
     1801 ctgttcatca agcgaggaga cacagtccct ttccgagatc ctcgatccac aacacaaagc
     1861 agagataaag gttaataaaa atgactacat catcagtgtg gtggcaagaa attctgccgg
     1921 ttcatctcca ccttcaaaaa tagccagtat ggaaatccca aatgatgaca tcacggtaga
     1981 gcaagcggtt ggaataggaa acaggatctt cctcagctgg cagcacaacc ccaacatgac
     2041 ctgtgactac gtgattaaat ggtgcaactc gtcatggtct gagccctgcc tcctggactg
     2101 gataaaggtt ccctcaaaca gcacggggac tgtcatcgag tctgatcagt ttcagccagg
     2161 agtgaggtat aacttttacc tctatgggtg tactaaccag ggatatcaac tgttacgttc
     2221 tacaattgga tacatagaag aattagctcc aattgtcgca ccaaacttta ctgtggaaga
     2281 cacatctgca gattcgatat tagtgaagtg ggacgacatc cccgtggagg agctccgagg
     2341 cttccttcga gggtatttat tctacttcca gaaaggagag agagacacac ccaagacacg
     2401 gagcttagag acaagtcact ctgacatcaa gctaaagaat atcactgaca tatcccagaa
     2461 gacactgcgg attgccgacc ttcagggtaa aaccagttac cacctggtcc tgcgggctta
     2521 tacacatggt ggactaggcc cagagaagag catgtttgtg gtgaccaagg agaactccgt
     2581 gggattgatt attgccatcc tcatcccagt ggctgtggct gtcattgttg gcgtggtaac
     2641 aagcatcctc tgctatcgga agcgagaatg gattaaagaa acattctacc ctgatattcc
     2701 caatccagaa aactgtaagg cgttacagtt tcagaagagc gtctgtgagg gaagcaacgc
     2761 tcttaagaca ttggaaatga atccatgcac cccaaatcac gtcgaagtcc tggaatctcg
     2821 gtcaataccc cctaaaatag aagacacaga aataacgtcc ccagtttctg agcgtcctgg
     2881 cgaaagctct gagacagacc ccgagaacca ggcggccgtg tcttactgcc cacccatcat
     2941 tgaggaggaa ataacaaacc cagcagcaga tgaggcggga ggggcttccc aggtcgtgta
     3001 cattgatgtg cagtccatgt atcagccaca agccaaagca gaggacgagc aggacactga
     3061 ccccgtgatg gtggcaggct ataagccaca gatgcgcctc cccattaacc ccacagcgga
     3121 agacacaaca gcagaagatg aagcggacaa gaccgcaggt tacagacctc aggccaacgt
     3181 aaatacttgg aatttggtct ccccagattc cccaaggtcc acagacagca acagtgaagt
     3241 tgtctcattt ggaagtccgt gctccatcaa ttccaggcaa tttttgattc ctcctaagga
     3301 tgaagactct cctaaatcta atggaggagg gtggtccttt acaaacttct tccagaacaa
     3361 accaaatgac taaccaggtc accctttgtc acttcagtct gccatct
//
