LOCUS       NM_022196               3724 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus LIF, interleukin 6 family cytokine (Lif), mRNA.
ACCESSION   NM_022196
VERSION     NM_022196.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3724)
  AUTHORS   Davis,S.M., Collier,L.A., Messmer,S.J. and Pennypacker,K.R.
  TITLE     The Poststroke Peripheral Immune Response Is Differentially
            Regulated by Leukemia Inhibitory Factor in Aged Male and Female
            Rodents
  JOURNAL   Oxid Med Cell Longev 2020, 8880244 (2020)
   PUBMED   33376583
  REMARK    GeneRIF: The Poststroke Peripheral Immune Response Is
            Differentially Regulated by Leukemia Inhibitory Factor in Aged Male
            and Female Rodents.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3724)
  AUTHORS   Yu,H., Yin,S., Zhou,S., Shao,Y., Sun,J., Pang,X., Han,L., Zhang,Y.,
            Gao,X., Jin,C., Qiu,Y. and Wang,T.
  TITLE     Magnolin promotes autophagy and cell cycle arrest via blocking
            LIF/Stat3/Mcl-1 axis in human colorectal cancers
  JOURNAL   Cell Death Dis 9 (6), 702 (2018)
   PUBMED   29899555
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3724)
  AUTHORS   Keasey,M.P., Jia,C., Pimentel,L.F., Sante,R.R., Lovins,C. and
            Hagg,T.
  TITLE     Blood vitronectin is a major activator of LIF and IL-6 in the brain
            through integrin-FAK and uPAR signaling
  JOURNAL   J Cell Sci 131 (3) (2018)
   PUBMED   29222114
  REMARK    GeneRIF: blood-derived vitronectin (VTN) rapidly and potently
            activates leukemia inhibitory factor (LIF) and pro-inflammatory
            interleukin 6 (IL-6) in vitro and after vascular injury in the
            brain.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3724)
  AUTHORS   Felling,R.J., Covey,M.V., Wolujewicz,P., Batish,M. and Levison,S.W.
  TITLE     Astrocyte-produced leukemia inhibitory factor expands the neural
            stem/progenitor pool following perinatal hypoxia-ischemia
  JOURNAL   J Neurosci Res 94 (12), 1531-1545 (2016)
   PUBMED   27661001
  REMARK    GeneRIF: leukemia inhibitory factor is a key injury-induced
            cytokine that is stimulating the regenerative response of neural
            stem/progenitors
REFERENCE   5  (bases 1 to 3724)
  AUTHORS   Chung,T.W., Park,M.J., Kim,H.S., Choi,H.J. and Ha,K.T.
  TITLE     Integrin alphaVbeta3 and alphaVbeta5 are required for leukemia
            inhibitory factor-mediated the adhesion of trophoblast cells to the
            endometrial cells
  JOURNAL   Biochem Biophys Res Commun 469 (4), 936-940 (2016)
   PUBMED   26723254
REFERENCE   6  (bases 1 to 3724)
  AUTHORS   Yamaguchi,M., Miki,N., Ono,M., Ohtsuka,C., Demura,H., Kurachi,H.,
            Inoue,M., Endo,H., Taga,T., Kishimoto,T. et al.
  TITLE     Inhibition of growth hormone-releasing factor production in mouse
            placenta by cytokines using gp130 as a signal transducer
  JOURNAL   Endocrinology 136 (3), 1072-1078 (1995)
   PUBMED   7867561
REFERENCE   7  (bases 1 to 3724)
  AUTHORS   Hilton,D.J., Hilton,A.A., Raicevic,A., Rakar,S., Harrison-Smith,M.,
            Gough,N.M., Begley,C.G., Metcalf,D., Nicola,N.A. and Willson,T.A.
  TITLE     Cloning of a murine IL-11 receptor alpha-chain; requirement for
            gp130 for high affinity binding and signal transduction
  JOURNAL   EMBO J 13 (20), 4765-4775 (1994)
   PUBMED   7957045
REFERENCE   8  (bases 1 to 3724)
  AUTHORS   Yin,T. and Yang,Y.C.
  TITLE     Mitogen-activated protein kinases and ribosomal S6 protein kinases
            are involved in signaling pathways shared by interleukin-11,
            interleukin-6, leukemia inhibitory factor, and oncostatin M in
            mouse 3T3-L1 cells
  JOURNAL   J Biol Chem 269 (5), 3731-3738 (1994)
   PUBMED   7508917
REFERENCE   9  (bases 1 to 3724)
  AUTHORS   Stewart,C.L., Kaspar,P., Brunet,L.J., Bhatt,H., Gadi,I., Kontgen,F.
            and Abbondanzo,S.J.
  TITLE     Blastocyst implantation depends on maternal expression of leukaemia
            inhibitory factor
  JOURNAL   Nature 359 (6390), 76-79 (1992)
   PUBMED   1522892
REFERENCE   10 (bases 1 to 3724)
  AUTHORS   Yamamori,T., Fukada,K., Aebersold,R., Korsching,S., Fann,M.J. and
            Patterson,P.H.
  TITLE     The cholinergic neuronal differentiation factor from heart cells is
            identical to leukemia inhibitory factor
  JOURNAL   Science 246 (4936), 1412-1416 (1989)
   PUBMED   2512641
  REMARK    Erratum:[Science 1990 Jan 19;247(4940):271]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On Sep 29, 2022 this sequence version replaced NM_022196.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR21887623.512134.1,
                                           SRR21887622.1065775.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-83                JAXUCZ010000014.1  83358164-83358246
            84-262              JAXUCZ010000014.1  83359841-83360019
            263-3724            JAXUCZ010000014.1  83360592-83364053
FEATURES             Location/Qualifiers
     source          1..3724
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14q21"
     gene            1..3724
                     /gene="Lif"
                     /note="LIF, interleukin 6 family cytokine"
                     /db_xref="GeneID:60584"
                     /db_xref="RGD:620865"
     exon            1..83
                     /gene="Lif"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..673
                     /gene="Lif"
                     /function="cytokine"
                     /note="cholinergic neuronal differentiation factor;
                     leukemia inhibitory factor (cholinergic differentiation
                     factor)"
                     /codon_start=1
                     /product="leukemia inhibitory factor precursor"
                     /protein_id="NP_071532.2"
                     /db_xref="GeneID:60584"
                     /db_xref="RGD:620865"
                     /translation="MKVLATGIVPLLLILHWKHGAGSPLPITPVNATCAIRHPCHGNL
                     MNQIKSQLAQLNGSANALFISYYTAQGEPFPNNVDKLCAPNMTDFPPFHANGTEKTKL
                     VELYRMVAYLGASLTNITWDQKNLNPTAVSLQIKLNATTDVMRGLLSNVLCRLCNKYH
                     VGHVDVPCVPDNSSKEAFQRKKLGCQLLGTYKQVISAVVQAF"
     exon            84..262
                     /gene="Lif"
                     /inference="alignment:Splign:2.1.0"
     exon            263..3724
                     /gene="Lif"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgaacttct gaaaacggcc tgcatctaag gtctcctcca aggccctctg gagtccagcc
       61 cataatgaag gtcttggcca cagggattgt gcccctactg ctcattctgc actggaaaca
      121 cggggcaggg agcccccttc ccatcacccc tgtaaatgcc acctgcgcca tacgccaccc
      181 gtgtcacggc aacctcatga accagatcaa gagtcaactg gctcaactca acggcagtgc
      241 caatgccctc tttatttcct attacacagc tcaaggggaa ccatttccca acaacgtgga
      301 taagctatgt gcgcccaaca tgacggattt cccacctttc catgccaatg ggacagagaa
      361 gaccaagttg gtcgagctgt atcggatggt cgcgtacctg ggagcctccc tgaccaacat
      421 cacctgggat cagaaaaacc tcaaccccac tgccgtgagc ctccagatca aactcaatgc
      481 gactacagac gtcatgaggg ggctccttag caacgtgctt tgccgtctgt gcaacaagta
      541 ccatgtgggc catgtggatg tgccctgtgt ccccgacaac tctagcaaag aagccttcca
      601 aaggaagaag ttgggctgcc agctcctggg gacatacaag caagtcatta gtgcggtggt
      661 ccaggccttc tagacaggag gtcttgagta tactgtggac tgaggggtct caggggcagg
      721 atccagttgt ggggaggggg gctcaatgtg ctgggggttt acaatgcaaa ggggactgct
      781 ggcagacccc agggatttcc agctactcac tgcactctgg gctgggccgt gatggagtct
      841 ggcgaagttg aaacttcatt aggcagagcc tccatccagc ccagcaccag ctagcgatgg
      901 caatgagggt gtcggactga gagatttccg tcccactcac tcactcagcc ccttgttcac
      961 tggctgggtg aacaagctgc acaaggtgtc tacagcagac agcaaagggc tgggaggtcc
     1021 tttgctgtcc ctcagaaaga ctttggaagg tttggttgag atgtggtagg gccaagggga
     1081 ctgggatcca gaaggactcc tttaattttg aagttttgtg aatggaagat agagggtacc
     1141 ctgggatgga atgtgtcctc tcttgagttg gatgagagag ttcaggcttt aggggttgtc
     1201 agatggaaga ttctagaagg ccactagtgt tcaggctctt acggaagcat agaggccctc
     1261 ttggggtcac caaagcctga tagacccaat tatcttcttt gccgtttccc ccacagcctg
     1321 gcatgactgg ggtctgccag ctggacctag aggtggcgtg ggtggaggtg ggaagaggca
     1381 ggttgcaaag gcaggtcccc agagtcctcc cagggaagga tctcttaact gtctaggagc
     1441 cagagaggga gcaaggcggc cattgttggg gcagtagcag actgcagatt tcatctgctt
     1501 ctcaacccct gagaacaggt gatctcgagc agacagacag gtagcataaa gtggaatgtc
     1561 atgtctgaga ccctggaggt cacaaaggta cttgaagggg accagagggc tgtctagggt
     1621 ccctggagca tggagaagca gaacttgagg tcagggtctc agggaagatg agacccagag
     1681 cgctgtgtct gacccagcgc ggttttctat ttattactat gtcctattta tgttaactta
     1741 ttggtgcttt aaatggcaaa gttaattccc cgaaatagta agaggctcca cactccggag
     1801 ctggggccac gtctcaccac ctagtggggc ctggtctgga agcagatgat tgttacaggt
     1861 acagctcatg ggtcaaatca gagagctggc tagctcccct atctcccact gtgactcact
     1921 tttaggagtc agggtccccc agaaagagct gagccacttt gtctctgtct ctctttctcc
     1981 tctctctctc tctctctctc tctctctctc tctctctctc tctctctctc tctctctctc
     2041 tctctctccc ccccccctcc ctctggtctc caagggggcg gagcagtttc ttgttgtttt
     2101 gtcccactga gctctctggc accccctgga ttcctgctct gcggcgcgcc attcataatg
     2161 gagtgaatgg ctctggaacc ttgggcaaag ctgattcctt cttcctcaaa ttgcagctga
     2221 ggagtgctga gacatcctga cccggcaccc agcgtgcttc catccagcat gggagctcct
     2281 cgggtggcct gaacacccac agagggtgaa tacaggcggt tggagcagtg caggccctga
     2341 atggggctga acggctgccc agtgctccag agaaggggag atcaaggccc gagacgcctg
     2401 ggccgcggac caggaagctg tggtccttgc ttcatcgctg ccttcccact cccgcccatg
     2461 tctgggctcc caggcaggga atccgatctg atctctcctt tgtgctgggg ccaggcaagc
     2521 agaggaacgc cctcgatctg ggagcagggt agggaggaag gcagccaagc tggggcagtg
     2581 gctgtctaca gagcctctga atagggcggt ccttagcagt taggctgcgg gattctgctt
     2641 catgcaattt tgcacctttt tctgtcattc tctaagcact ttacctggac ggcaggtgga
     2701 caggccctgg agctctgggt taggaaaggc tcggaaccct agactatggt gaggggcaca
     2761 cgtgtcagcg acaaagttgc tccaccattc tccacctgat gctgctgcat caggctcagc
     2821 tcaggaccgg gctgcccttc tccaagctga gatgtaactt gtctagaagc caaaatgatg
     2881 ccacagcctg gggcctgctg ggttttgtcg tcacttcaca tccatatgaa catggactct
     2941 ctgggctccg cccacctggc agctttgaag gctcagggac cgatggactc tctctgtgca
     3001 cagccccccc ccccagcccc tcccaccctg gctacccggg gcaaccacct gcctgcatct
     3061 tactccaaca gttcagagcc acgttgcaca gcattccaga accattgagc cttttggggc
     3121 aggcagttgt tcaccttgac gtctttcacc tgttagcatt gactcccacc aagcatgatg
     3181 ggtagcgtgt ctggaccaga gaagaagggc tggggcattc tgcagtttaa acagagagaa
     3241 gaataggggc ctttatttat tattcaaaac tccgaacctg gaagcactgt tagtttgctg
     3301 gtctgtctcc tctgtgctct tgtctgtgtc tgtgtcctcg atcctgactc aagcaatccc
     3361 gctctgtttt gctgactcct gagcagacat agcttgtggg ccaggacctt gccagccttg
     3421 agtggcagtg gcttcagaag tgaaatgatc tggctgtctg cattcgaatg actccccagt
     3481 cccagcctag cctctctttt gcactgctgg ttcagcccac tgggcctccg tcctttcctc
     3541 tggaagggac ttggccttgg gtgacaaatt cctctttgat gaatgtaccc tgtgggaatg
     3601 tttcatactg acagattatt tttatttatt caatgtcgta tttaagatat ttatttttta
     3661 tactgaagga gcaccctttt tttaagagaa ataaatgaaa taataaagaa cccattcttg
     3721 tcga
//
