LOCUS       NM_001415091            1989 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Rattus norvegicus LIM homeobox 8 (Lhx8), transcript variant 1,
            mRNA.
ACCESSION   NM_001415091 XM_006233528
VERSION     NM_001415091.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1989)
  AUTHORS   Crews,F.T., Fisher,R.P., Qin,L. and Vetreno,R.P.
  TITLE     HMGB1 neuroimmune signaling and REST-G9a gene repression contribute
            to ethanol-induced reversible suppression of the cholinergic neuron
            phenotype
  JOURNAL   Mol Psychiatry 28 (12), 5159-5172 (2023)
   PUBMED   37402853
REFERENCE   2  (bases 1 to 1989)
  AUTHORS   Li,H., Qin,J., Jin,G., Zou,L., Shi,J., Han,X., Cheng,X. and
            Zhang,X.
  TITLE     Overexpression of Lhx8 inhibits cell proliferation and induces cell
            cycle arrest in PC12 cell line
  JOURNAL   In Vitro Cell Dev Biol Anim 51 (4), 329-335 (2015)
   PUBMED   25475040
  REMARK    GeneRIF: Lhx8 plays role as a suppressor gene of cell
            proliferation.
REFERENCE   3  (bases 1 to 1989)
  AUTHORS   Tomioka,T., Shimazaki,T., Yamauchi,T., Oki,T., Ohgoh,M. and
            Okano,H.
  TITLE     LIM homeobox 8 (Lhx8) is a key regulator of the cholinergic
            neuronal function via a tropomyosin receptor kinase A
            (TrkA)-mediated positive feedback loop
  JOURNAL   J Biol Chem 289 (2), 1000-1010 (2014)
   PUBMED   24265310
  REMARK    GeneRIF: Data indicate that LIM homeobox 8 (Lhx8) regulates
            functions of cholinergic neurons by modulating tropomyosin receptor
            kinase A (TrkA) expression.
REFERENCE   4  (bases 1 to 1989)
  AUTHORS   Zhu,P., Li,H., Jin,G., Tian,M., Tan,X., Shi,J., Zou,L. and Qin,J.
  TITLE     LIM-homeobox gene Lhx8 promote the differentiation of hippocampal
            newborn neurons into cholinergic neurons in vitro
  JOURNAL   In Vitro Cell Dev Biol Anim 49 (2), 103-107 (2013)
   PUBMED   23385486
  REMARK    GeneRIF: Although the potential interaction of Lhx8 with other
            factors remains unknown, our results suggested that neuronal
            subtype specification can be directly manipulated in the stage of
            immature newborn neurons by a specific transcription factor in
            vitro.
REFERENCE   5  (bases 1 to 1989)
  AUTHORS   Shi,J., Li,H., Jin,G., Zhu,P., Tian,M., Qin,J., Tan,X., Zhao,S.,
            Wang,F., Hua,Y. and Xiao,Y.
  TITLE     Lhx8 promote differentiation of hippocampal neural stem/progenitor
            cells into cholinergic neurons in vitro
  JOURNAL   In Vitro Cell Dev Biol Anim 48 (10), 603-609 (2012)
   PUBMED   23150137
  REMARK    GeneRIF: Lhx8 was not associated with the MAP2-positive neurons
            differentiation on adherent conditions, but played a role in the
            specification of cholinergic neurons derived from hippocampal
            neural stem/progenitor cells in vitro
REFERENCE   6  (bases 1 to 1989)
  AUTHORS   Pangas,S.A., Choi,Y., Ballow,D.J., Zhao,Y., Westphal,H.,
            Matzuk,M.M. and Rajkovic,A.
  TITLE     Oogenesis requires germ cell-specific transcriptional regulators
            Sohlh1 and Lhx8
  JOURNAL   Proc Natl Acad Sci U S A 103 (21), 8090-8095 (2006)
   PUBMED   16690745
REFERENCE   7  (bases 1 to 1989)
  AUTHORS   Fragkouli,A., Hearn,C., Errington,M., Cooke,S., Grigoriou,M.,
            Bliss,T., Stylianopoulou,F. and Pachnis,V.
  TITLE     Loss of forebrain cholinergic neurons and impairment in spatial
            learning and memory in LHX7-deficient mice
  JOURNAL   Eur J Neurosci 21 (11), 2923-2938 (2005)
   PUBMED   15978004
REFERENCE   8  (bases 1 to 1989)
  AUTHORS   Mori,T., Yuxing,Z., Takaki,H., Takeuchi,M., Iseki,K., Hagino,S.,
            Kitanaka,J., Takemura,M., Misawa,H., Ikawa,M., Okabe,M. and
            Wanaka,A.
  TITLE     The LIM homeobox gene, L3/Lhx8, is necessary for proper development
            of basal forebrain cholinergic neurons
  JOURNAL   Eur J Neurosci 19 (12), 3129-3141 (2004)
   PUBMED   15217369
REFERENCE   9  (bases 1 to 1989)
  AUTHORS   Shibaguchi,T., Kato,J., Abe,M., Tamamura,Y., Tabata,M.J., Liu,J.G.,
            Iwamoto,M., Wakisaka,S., Wanaka,A. and Kurisu,K.
  TITLE     Expression and role of Lhx8 in murine tooth development
  JOURNAL   Arch Histol Cytol 66 (1), 95-108 (2003)
   PUBMED   12703558
REFERENCE   10 (bases 1 to 1989)
  AUTHORS   Asbreuk,C.H., van Schaick,H.S., Cox,J.J., Kromkamp,M., Smidt,M.P.
            and Burbach,J.P.
  TITLE     The homeobox genes Lhx7 and Gbx1 are expressed in the basal
            forebrain cholinergic system
  JOURNAL   Neuroscience 109 (2), 287-298 (2002)
   PUBMED   11801365
  REMARK    GeneRIF: Combined expression of Lhx7 and Gbx1 plays a role in the
            development of the cholinergic system of the basal forebrain.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Dec 21, 2022 this sequence version replaced XM_006233528.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR21887623.1631541.1,
                                           SRR21887621.1025671.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16093042, SAMN16093043
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-289               JAXUCZ010000002.1  245929088-245929376 c
            290-376             JAXUCZ010000002.1  245927185-245927271 c
            377-538             JAXUCZ010000002.1  245926826-245926987 c
            539-660             JAXUCZ010000002.1  245923291-245923412 c
            661-881             JAXUCZ010000002.1  245921024-245921244 c
            882-985             JAXUCZ010000002.1  245920441-245920544 c
            986-1081            JAXUCZ010000002.1  245915307-245915402 c
            1082-1265           JAXUCZ010000002.1  245911125-245911308 c
            1266-1989           JAXUCZ010000002.1  245904712-245905435 c
FEATURES             Location/Qualifiers
     source          1..1989
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q45"
     gene            1..1989
                     /gene="Lhx8"
                     /gene_synonym="Lhx7"
                     /note="LIM homeobox 8"
                     /db_xref="GeneID:365963"
                     /db_xref="RGD:1308749"
     exon            1..289
                     /gene="Lhx8"
                     /gene_synonym="Lhx7"
                     /inference="alignment:Splign:2.1.0"
     CDS             209..1312
                     /gene="Lhx8"
                     /gene_synonym="Lhx7"
                     /note="isoform 1 is encoded by transcript variant 1;
                     LIM/homeobox protein Lhx8; LIM homeobox protein 8"
                     /codon_start=1
                     /product="LIM/homeobox protein Lhx8 isoform 1"
                     /protein_id="NP_001402020.1"
                     /db_xref="GeneID:365963"
                     /db_xref="RGD:1308749"
                     /translation="MYWKSDQMFVCKLEGKDVPELAVPREKCPGLMSEECGRPAALAA
                     GRTRKGAGEEGLVNPEGAGDEDSCSSSAPLSPSSSPQSMASGSVCPPGKCVCSSCGLE
                     IVDKYLLKVNDLCWHVRCLSCSVCRTSLGRHTSCYIKDKDIFCKLDYFRRYGTRCSRC
                     GRHIHSTDWVRRAKGNVYHLACFACFSCKRQLSTGEEFALVEEKVLCRVHFDCMLDNL
                     KREVENGNGISVEGALLTEQDVNHPKPAKRARTSFTADQLQVMQAQFAQDNNPDAQTL
                     QKLAERTGLSRRVIQVWFQNCRARHKKHVSPNHSSSAPVTAVPSSRLSPPMLEEMAYS
                     AYVPQDGTMLTALHSYMDAHQQLLDSSPCYPIQ"
     exon            290..376
                     /gene="Lhx8"
                     /gene_synonym="Lhx7"
                     /inference="alignment:Splign:2.1.0"
     exon            377..538
                     /gene="Lhx8"
                     /gene_synonym="Lhx7"
                     /inference="alignment:Splign:2.1.0"
     exon            539..660
                     /gene="Lhx8"
                     /gene_synonym="Lhx7"
                     /inference="alignment:Splign:2.1.0"
     exon            661..881
                     /gene="Lhx8"
                     /gene_synonym="Lhx7"
                     /inference="alignment:Splign:2.1.0"
     exon            882..985
                     /gene="Lhx8"
                     /gene_synonym="Lhx7"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1081
                     /gene="Lhx8"
                     /gene_synonym="Lhx7"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1265
                     /gene="Lhx8"
                     /gene_synonym="Lhx7"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1989
                     /gene="Lhx8"
                     /gene_synonym="Lhx7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtgtggctg agagaggaat cttaagaaca gtgcgtcaga cagtggctac gatcactgtg
       61 tcctctttgg acccgagacg cactggtggc atcgctgtcc tgcctgttgg ctttccttgg
      121 cgttttgggg cggaggaggg aacactgctg acacccacag cctctgaccc tctggagctg
      181 gtatgtgacg agcagcgcct gcggggcaat gtattggaag agcgatcaga tgtttgtgtg
      241 taaactggag ggaaaggacg tgccggagct ggcggttccc cgcgagaagt gccccgggct
      301 catgtcggag gagtgcgggc ggcctgcagc cctggcggcc gggaggaccc gcaaaggcgc
      361 tggggaagaa ggactggtga atcccgaggg agccggggac gaggactcct gctcctcctc
      421 ggccccgctt tccccgtcgt cctcgcccca gtccatggcc tcgggctccg tgtgcccacc
      481 aggcaagtgt gtgtgcagca gctgcggcct ggagattgtg gacaaatacc tcctcaaggt
      541 gaatgactta tgctggcatg tccgctgtct ctcctgcagt gtctgcagaa cgtccctggg
      601 aaggcacaca agctgttaca ttaaggataa agacattttc tgtaaactcg attacttcag
      661 acggtatggg acacgctgct cccgctgtgg aaggcacatc cattctactg actgggtccg
      721 cagggccaag ggcaacgtgt atcacttggc ttgctttgcc tgcttttctt gcaagaggca
      781 actgtccacg ggagaggagt ttgccttggt agaggagaag gtcctctgta gagtgcactt
      841 tgactgcatg ctggacaatc tgaagagaga agtggagaac ggtaatggga ttagtgtgga
      901 aggagccctt ctcacagaac aagacgtcaa tcatccaaag ccagccaaaa gagctcggac
      961 cagcttcaca gccgatcagc tccaggttat gcaagcacag tttgctcagg acaacaaccc
     1021 agacgcacag accctccaga aactggcaga aaggacaggc ttaagccggc gagtcataca
     1081 ggtgtggttt cagaactgca gggctcgtca taagaaacat gtcagtccca accactcctc
     1141 ctctgccccg gtcacagcag tcccctcatc caggctgtct ccacccatgt tggaagaaat
     1201 ggcttattcc gcctacgtgc cccaggacgg gacgatgctg acggcgctgc attcatacat
     1261 ggacgctcac caacaactcc tggactccag cccttgctac cccatacaat gacccaactg
     1321 ccaataagtc atacttaatt ccttctttca gggatagaaa tgattgagga tataaacctg
     1381 tcatttatta tgtataaaat accattgaaa agatattaat gttaattttt tatttaacac
     1441 tcaaaggcat ttcgaacatc ctttcgccgt ccacgtatgt acctagagtt ggcctgcaag
     1501 acacttttat taattcttca ttttggtttt tttttttttg ggtaaaactt atgtttacaa
     1561 gaagaaaaca agtcaaaaca attttttttg tattgtctgg aaatagttgg ctccagtgtg
     1621 tgtctattaa cttatttgtc atcaaaagag cactttgcct aaaaggcagg actgatagtg
     1681 tgcaaaaacg tttacaatcc tttgtgaaac cgtagtttat cattagtttg tacctgtaag
     1741 ttattgttat aaatattatc tgtatttttt gtcatataca actttatacc ttgaagcttg
     1801 tatctgtgaa tttgcaactg aaatttattt tgccagtgtt ttctggacga gcttgagtgc
     1861 acgtccgttg tagcatgccg cacacaccca cggcggtgtc tgcacttggg gagttctagc
     1921 tgtaaataac actctagttt acgaagccta ccatcctaag ttcattaaac atttcgcatc
     1981 cttgtgaaa
//
