LOCUS       NM_001106571            1903 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus LIM homeobox 2 (Lhx2), mRNA.
ACCESSION   NM_001106571 XM_001054855 XM_216050
VERSION     NM_001106571.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1903)
  AUTHORS   Cao,M., Zhao,J., Du,L., Chen,Z., Zhang,L., Liu,X., Cheng,J.,
            Yan,Y., Zhang,C. and Li,H.
  TITLE     The combination of hair follicle-specific marker LHX2 and
            co-expressed marker can distinguish between sweat gland placodes
            and hair placodes in rat
  JOURNAL   J Mol Histol 52 (6), 1225-1232 (2021)
   PUBMED   34581932
  REMARK    GeneRIF: The combination of hair follicle-specific marker LHX2 and
            co-expressed marker can distinguish between sweat gland placodes
            and hair placodes in rat.
REFERENCE   2  (bases 1 to 1903)
  AUTHORS   Muralidharan,B., Khatri,Z., Maheshwari,U., Gupta,R., Roy,B.,
            Pradhan,S.J., Karmodiya,K., Padmanabhan,H., Shetty,A.S., Balaji,C.,
            Kolthur-Seetharam,U., Macklis,J.D., Galande,S. and Tole,S.
  TITLE     LHX2 Interacts with the NuRD Complex and Regulates Cortical Neuron
            Subtype Determinants Fezf2 and Sox11
  JOURNAL   J Neurosci 37 (1), 194-203 (2017)
   PUBMED   28053041
REFERENCE   3  (bases 1 to 1903)
  AUTHORS   Hsu,L.C., Nam,S., Cui,Y., Chang,C.P., Wang,C.F., Kuo,H.C.,
            Touboul,J.D. and Chou,S.J.
  TITLE     Lhx2 regulates the timing of beta-catenin-dependent cortical
            neurogenesis
  JOURNAL   Proc Natl Acad Sci U S A 112 (39), 12199-12204 (2015)
   PUBMED   26371318
REFERENCE   4  (bases 1 to 1903)
  AUTHORS   Folgueras,A.R., Guo,X., Pasolli,H.A., Stokes,N., Polak,L., Zheng,D.
            and Fuchs,E.
  TITLE     Architectural niche organization by LHX2 is linked to hair follicle
            stem cell function
  JOURNAL   Cell Stem Cell 13 (3), 314-327 (2013)
   PUBMED   24012369
REFERENCE   5  (bases 1 to 1903)
  AUTHORS   Honda,S., Kozako,T., Shimeno,H., Soeda,S. and Harada,N.
  TITLE     LIM-homeodomain transcription factor, Lhx2, is involved in
            transcriptional control of brain-specific promoter/exon 1f of the
            mouse aromatase gene
  JOURNAL   J Neuroendocrinol 24 (11), 1367-1374 (2012)
   PUBMED   22734700
REFERENCE   6  (bases 1 to 1903)
  AUTHORS   Bach,I., Rodriguez-Esteban,C., Carriere,C., Bhushan,A., Krones,A.,
            Rose,D.W., Glass,C.K., Andersen,B., Izpisua Belmonte,J.C. and
            Rosenfeld,M.G.
  TITLE     RLIM inhibits functional activity of LIM homeodomain transcription
            factors via recruitment of the histone deacetylase complex
  JOURNAL   Nat Genet 22 (4), 394-399 (1999)
   PUBMED   10431247
REFERENCE   7  (bases 1 to 1903)
  AUTHORS   Bendall,A.J., Rincon-Limas,D.E., Botas,J. and Abate-Shen,C.
  TITLE     Protein complex formation between Msx1 and Lhx2 homeoproteins is
            incompatible with DNA binding activity
  JOURNAL   Differentiation 63 (3), 151-157 (1998)
   PUBMED   9697309
REFERENCE   8  (bases 1 to 1903)
  AUTHORS   Porter,F.D., Drago,J., Xu,Y., Cheema,S.S., Wassif,C., Huang,S.P.,
            Lee,E., Grinberg,A., Massalas,J.S., Bodine,D., Alt,F. and
            Westphal,H.
  TITLE     Lhx2, a LIM homeobox gene, is required for eye, forebrain, and
            definitive erythrocyte development
  JOURNAL   Development 124 (15), 2935-2944 (1997)
   PUBMED   9247336
REFERENCE   9  (bases 1 to 1903)
  AUTHORS   Roberson,M.S., Schoderbek,W.E., Tremml,G. and Maurer,R.A.
  TITLE     Activation of the glycoprotein hormone alpha-subunit promoter by a
            LIM-homeodomain transcription factor
  JOURNAL   Mol Cell Biol 14 (5), 2985-2993 (1994)
   PUBMED   7513049
REFERENCE   10 (bases 1 to 1903)
  AUTHORS   Xu,Y., Baldassare,M., Fisher,P., Rathbun,G., Oltz,E.M.,
            Yancopoulos,G.D., Jessell,T.M. and Alt,F.W.
  TITLE     LH-2: a LIM/homeodomain gene expressed in developing lymphocytes
            and neural cells
  JOURNAL   Proc Natl Acad Sci U S A 90 (1), 227-231 (1993)
   PUBMED   7678338
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473983.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001054855.1, XM_216050.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132262,
                              SAMD00132265 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1903
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q12"
     gene            1..1903
                     /gene="Lhx2"
                     /gene_synonym="Lh-2; LH2A"
                     /note="LIM homeobox 2"
                     /db_xref="GeneID:296706"
                     /db_xref="RGD:71076"
     exon            1..179
                     /gene="Lhx2"
                     /gene_synonym="Lh-2; LH2A"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..1280
                     /gene="Lhx2"
                     /gene_synonym="Lh-2; LH2A"
                     /note="LIM homeobox protein 2; homeobox protein LH-2"
                     /codon_start=1
                     /product="LIM/homeobox protein Lhx2"
                     /protein_id="NP_001100041.1"
                     /db_xref="GeneID:296706"
                     /db_xref="RGD:71076"
                     /translation="MLFHSLSGPEVHGVIDEMDRRAKSEAPAISSAIDRGDTETTMPS
                     ISSDRAALCAGCGGKISDRYYLLAVDKQWHMRCLKCCECKLNLESELTCFSKDGSIYC
                     KEDYYRRFSVQRCARCHLGISASEMVMRARDLVYHLNCFTCTTCNKMLTTGDHFGMKD
                     SLVYCRLHFEALLQGEYPAHFNHADVAAAAAAAAAAKSAGLGSAGANPLGLPYYNGVG
                     TVQKGRPRKRKSPGPGADLAAYNAALSCNENDAEHLDRDQPYPSSQKTKRMRTSFKHH
                     QLRTMKSYFAINHNPDAKDLKQLAQKTGLTKRVLQVWFQNARAKFRRNLLRQENTGVD
                     KTSDATLQTGTPSGPASELSNASLSPSSTPTTLTDLTSPTLPTVTSVLTSVPGNLEGH
                     EPHSPSQTTLTNLF"
     exon            180..382
                     /gene="Lhx2"
                     /gene_synonym="Lh-2; LH2A"
                     /inference="alignment:Splign:2.1.0"
     exon            383..786
                     /gene="Lhx2"
                     /gene_synonym="Lh-2; LH2A"
                     /inference="alignment:Splign:2.1.0"
     exon            787..992
                     /gene="Lhx2"
                     /gene_synonym="Lh-2; LH2A"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1903
                     /gene="Lhx2"
                     /gene_synonym="Lh-2; LH2A"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagctgagg cggggggcaa gcccttcctc cgggcagccg cgtcccgggt cccgccgcga
       61 tgctgttcca cagtctgtcg ggccccgagg tgcacggggt catcgacgag atggaccgca
      121 gggccaagag cgaggctccg gccatcagct ccgccatcga ccgcggcgac acggagacga
      181 ccatgccgtc catcagcagt gaccgggcag cgttgtgtgc gggctgtggg ggcaagatct
      241 ctgaccgcta ctatttgctg gcagtagaca aacaatggca catgcgttgc ctcaagtgct
      301 gtgaatgcaa gctcaacctg gagtcggaac tcacctgctt cagcaaggat ggcagcatct
      361 actgcaaaga agactactac aggcggttct ctgtgcagcg ctgcgcccgc tgccacctgg
      421 gcatctcggc ctcagagatg gtgatgcgtg ctcgggactt ggtttatcac ctcaactgct
      481 tcacatgcac cacgtgtaac aagatgctga cgaccggcga ccacttcggc atgaaggaca
      541 gcctggtcta ttgccgcttg cacttcgagg cactgctgca aggcgaatac ccggcacact
      601 ttaaccatgc cgacgtggca gcggcggcag cggcagccgc agcagctaag agtgcaggat
      661 tgggctcagc tggggctaac ccgctgggtc ttccctacta caacggcgtg ggcactgtgc
      721 agaaggggag gccgagaaag cgcaaaagtc caggacccgg ggcagatctg gcagcctaca
      781 acgccgcgct gagctgtaac gagaacgacg cggaacacct ggatcgcgac cagccctacc
      841 ctagcagcca aaagacaaag cgcatgcgca cctccttcaa gcaccaccag cttcggacaa
      901 tgaagtctta ctttgccatt aaccacaatc ccgatgccaa ggacttgaag cagctcgcgc
      961 aaaagaccgg cctcaccaag agagtcctcc aggtctggtt tcagaatgcc cgggccaagt
     1021 tcaggcgcaa ccttttacgg caggaaaaca ctggtgtgga caagacttcg gatgccacgc
     1081 tgcagacagg gacaccgtca gggcccgcct cggagctgtc caacgcctcg ctcagcccct
     1141 ccagcactcc tacaaccctc acagacttga ctagccccac cctgccgact gtgacgtcag
     1201 tcttaacttc tgtgcctggc aacctggagg gccatgagcc ccacagccct tcacaaacga
     1261 ctcttaccaa ccttttctaa tgactcgcca cccccttctc ccctgagccc ccatgatttc
     1321 tttaaaaaag aaattatctt tagttgaatt ccaagtgtat tttaaaaata gcggtttgag
     1381 caactaacta accacgtttt aggatctcgc ctggaaacag agggggaaaa aagaattgtg
     1441 cgtcgggcta acgcagcggt gtgtgctgag gaattacttg ggagatatat ctgcaacaca
     1501 acatttgtgt ccctgtacag ttttgtggac tgagcgagga aaacaacaaa taatttaagt
     1561 tggctgagag cttccgtatt ttcaaagact gccacgtgcc ttaggaatac tgttttatct
     1621 tcatactttg gatgaattgt tcgttttttt ttctctccct ctttttctct ctgtatattt
     1681 atgaccagag caaaatgtaa aaaaggaaaa aaaaacaaaa aaacaaaaaa agtttgttac
     1741 tttgaatagt cctaaagaag aaaaagaaaa aaaaaaaaaa acaaggaaaa aaatcaaatc
     1801 ccctccaaca gtcgctttct tgttttagaa ttttaaggtg gaagtctgtt cggatatcag
     1861 aatttgtaaa acctaaccag taataaaatc acttatcgaa aag
//
