LOCUS       NM_145880               3390 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus LIM homeobox 1 (Lhx1), mRNA.
ACCESSION   NM_145880
VERSION     NM_145880.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3390)
  AUTHORS   Costello,I., Nowotschin,S., Sun,X., Mould,A.W., Hadjantonakis,A.K.,
            Bikoff,E.K. and Robertson,E.J.
  TITLE     Lhx1 functions together with Otx2, Foxa2, and Ldb1 to govern
            anterior mesendoderm, node, and midline development
  JOURNAL   Genes Dev 29 (20), 2108-2122 (2015)
   PUBMED   26494787
REFERENCE   2  (bases 1 to 3390)
  AUTHORS   Boualia,S.K., Gaitan,Y., Murawski,I., Nadon,R., Gupta,I.R. and
            Bouchard,M.
  TITLE     Vesicoureteral reflux and other urinary tract malformations in mice
            compound heterozygous for Pax2 and Emx2
  JOURNAL   PLoS One 6 (6), e21529 (2011)
   PUBMED   21731775
REFERENCE   3  (bases 1 to 3390)
  AUTHORS   Palmesino,E., Rousso,D.L., Kao,T.J., Klar,A., Laufer,E., Uemura,O.,
            Okamoto,H., Novitch,B.G. and Kania,A.
  TITLE     Foxp1 and lhx1 coordinate motor neuron migration with axon
            trajectory choice by gating Reelin signalling
  JOURNAL   PLoS Biol 8 (8), e1000446 (2010)
   PUBMED   20711475
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3390)
  AUTHORS   Poche,R.A., Kwan,K.M., Raven,M.A., Furuta,Y., Reese,B.E. and
            Behringer,R.R.
  TITLE     Lim1 is essential for the correct laminar positioning of retinal
            horizontal cells
  JOURNAL   J Neurosci 27 (51), 14099-14107 (2007)
   PUBMED   18094249
REFERENCE   5  (bases 1 to 3390)
  AUTHORS   Kittappa,R., Chang,W.W., Awatramani,R.B. and McKay,R.D.
  TITLE     The foxa2 gene controls the birth and spontaneous degeneration of
            dopamine neurons in old age
  JOURNAL   PLoS Biol 5 (12), e325 (2007)
   PUBMED   18076286
REFERENCE   6  (bases 1 to 3390)
  AUTHORS   Shimono,A. and Behringer,R.R.
  TITLE     Isolation of novel cDNAs by subtractions between the anterior
            mesendoderm of single mouse gastrula stage embryos
  JOURNAL   Dev Biol 209 (2), 369-380 (1999)
   PUBMED   10328927
REFERENCE   7  (bases 1 to 3390)
  AUTHORS   Karavanov,A.A., Karavanova,I., Perantoni,A. and Dawid,I.B.
  TITLE     Expression pattern of the rat Lim-1 homeobox gene suggests a dual
            role during kidney development
  JOURNAL   Int J Dev Biol 42 (1), 61-66 (1998)
   PUBMED   9496787
REFERENCE   8  (bases 1 to 3390)
  AUTHORS   Karavanov,A.A., Saint-Jeannet,J.P., Karavanova,I., Taira,M. and
            Dawid,I.B.
  TITLE     The LIM homeodomain protein Lim-1 is widely expressed in neural,
            neural crest and mesoderm derivatives in vertebrate development
  JOURNAL   Int J Dev Biol 40 (2), 453-461 (1996)
   PUBMED   8793615
REFERENCE   9  (bases 1 to 3390)
  AUTHORS   Richman,D.D. and Bozzette,S.A.
  TITLE     The impact of the syncytium-inducing phenotype of human
            immunodeficiency virus on disease progression
  JOURNAL   J Infect Dis 169 (5), 968-974 (1994)
   PUBMED   7909549
REFERENCE   10 (bases 1 to 3390)
  AUTHORS   Furuyama,T., Inagaki,S., Iwahashi,Y. and Takagi,H.
  TITLE     Distribution of Rlim, an LIM homeodomain gene, in the rat brain
  JOURNAL   Neurosci Lett 170 (2), 266-268 (1994)
   PUBMED   7914684
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Nov 25, 2020 this sequence version replaced NM_145880.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.62734.1,
                                           SRR26643287.25162.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-770               JAXUCZ010000010.1  69900307-69901076   c
            771-997             JAXUCZ010000010.1  69898406-69898632   c
            998-1275            JAXUCZ010000010.1  69898037-69898314   c
            1276-1441           JAXUCZ010000010.1  69896583-69896748   c
            1442-3390           JAXUCZ010000010.1  69894288-69896236   c
FEATURES             Location/Qualifiers
     source          1..3390
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q26"
     gene            1..3390
                     /gene="Lhx1"
                     /note="LIM homeobox 1"
                     /db_xref="GeneID:257634"
                     /db_xref="RGD:71074"
     exon            1..770
                     /gene="Lhx1"
                     /inference="alignment:Splign:2.1.0"
     CDS             601..1821
                     /gene="Lhx1"
                     /note="LIM homeobox protein 1; rlim; homeobox protein
                     Lim-1"
                     /codon_start=1
                     /product="LIM/homeobox protein Lhx1"
                     /protein_id="NP_665887.3"
                     /db_xref="GeneID:257634"
                     /db_xref="RGD:71074"
                     /translation="MVHCAGCKRPILDRFLLNVLDRAWHVKCVQCCECKCNLTEKCFS
                     REGKLYCKNDFFRCFGTKCAGCAQGISPSDLVRRARSKVFHLNCFTCMMCNKQLSTGE
                     ELYIIDENKFVCKEDYLSNSSVAKENSLHSATTGSDPSLSPDSQDPSQDDAKDSESAN
                     VSDKEGGSNENDDQNLGAKRRGPRTTIKAKQLETLKAAFAATPKPTRHIREQLAQETG
                     LNMRVIQVWFQNRRSKERRMKQLSALGARRHAFFRSPRRMRPLVDRLEPGELIPNGPF
                     SFYGDYQSEYYGPGGNYDFFPQGPPSSQAQTPVDLPFVPSSGPSGTPLGGLDHPLPGH
                     HPSSEAQRFTDILAHPPGDSPSPEPSLPGPLHSMSAEVFGPSPPFSSLSVNGGASYGN
                     HLSHPPEMNEAAVW"
     exon            771..997
                     /gene="Lhx1"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1275
                     /gene="Lhx1"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1441
                     /gene="Lhx1"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..3390
                     /gene="Lhx1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccctcccagg cccagcgcgg gtgcccagag cgtcccgact cgcttcaaga agccggcaat
       61 gtaggatcca aagcttttct actcccgtgt tttctttccg tgtttttttt aagggggaaa
      121 ccgggtggtg ggcagtctga cacgcacaca acctgccttc atactctgac aaaagcagat
      181 gcactttgac ttctgacagc tctacctcaa gctggagaga acccagcttt cccgaatcct
      241 gagctctttg cgtcttcctt ttcgtctgtt tccattttat ttatttacgt cccgccgcct
      301 ctctgggtga ccttcactcc ttcgcgggct ttgggcagaa gagccgcttt cttgcccgat
      361 tgagactgat tttcctcgcc tggtgagcgg aggtggcgct gctccacccc gctgccccgg
      421 gactccgggg ctgccctcta ccagcctggt ctctccctct tttgatttga cagtacgggt
      481 ttttgctttc ccgagtacag cgggtttctt ctttttggag gagctggttg tcttcagaag
      541 tcattccctg gactctaatt gccctgtcgc tccgggcctc accggaccaa accaaagacc
      601 atggtgcact gtgcgggctg caaaaggccc attctggacc gtttcctctt gaacgtgctg
      661 gacagggcct ggcatgtcaa gtgcgtccag tgctgtgaat gtaaatgcaa cctgaccgag
      721 aagtgcttct cccgggaagg caagctctac tgtaaaaacg acttcttccg atgtttcggt
      781 accaaatgcg cgggttgtgc gcagggcatc tctccaagcg atctggttcg gagagcgcga
      841 agcaaagtgt ttcacctcaa ctgcttcacc tgcatgatgt gtaacaagca gctctccacg
      901 ggcgaggagc tctacatcat cgatgagaac aagttcgttt gtaaagagga ttacctgagt
      961 aacagcagtg tcgccaaaga gaacagcctc cactcggcca ccacaggcag tgaccctagt
     1021 ttatctccgg attcccaaga tccatcgcag gatgatgcca aggactctga aagtgccaac
     1081 gtatcggata aggaaggtgg tagcaatgag aacgatgacc agaacctagg tgccaagcgc
     1141 aggggaccgc ggaccacgat caaagccaag caactggaga cgttgaaggc agcctttgca
     1201 gctacgccta agcccacacg ccatatccgc gagcaattgg cccaggagac tggcctcaac
     1261 atgcgtgtta tccaggtctg gttccagaat cgacgctcca aggagcggag gatgaagcag
     1321 ctaagcgcgc tgggtgcgcg gcgccacgcc tttttccgca gtcctcgccg gatgcggcct
     1381 ctggtggacc gcttggagcc gggcgaactc atccctaacg gccccttctc cttttatgga
     1441 gattaccaga gtgagtacta cggtcctgga ggcaactacg acttcttccc gcaaggacca
     1501 ccgtcctcgc aggcccagac accagtggac ctaccctttg tgccatcatc tgggccttcg
     1561 gggacgcccc ttggaggtct ggaccacccg ctgcctggcc accatccttc cagcgaggcg
     1621 cagcgattca ctgacatcct ggcacatccc ccaggggact cgcctagtcc tgagcccagc
     1681 ttgcccgggc ctctccactc catgtctgcg gaggtctttg ggcccagtcc acctttctca
     1741 tctctgtcgg tcaatggtgg agccagctac gggaatcact tgtctcaccc tcctgaaatg
     1801 aatgaggcag ccgtgtggta gcggggtctc gcatgggcca cgggagctcg tggttgtaca
     1861 gagacgagct tttatttcag aaaataggag atttaaaaaa aaaaacatta aaaaaaaaaa
     1921 aaagcaagcc tcctgctcca cttccttcag cctcggggac cattcttttt ggggagactg
     1981 gatggcaaag gggtccaaaa caggatccaa atccgcctcg cagtagagct ggtatatcca
     2041 cacagcggct gacaaagcgc agaactgggg ctccggaagg ggaattccga ggcatcccca
     2101 ccttcgcgac ctggatctgg atccatggac agactccacc agcggctcct ctggctaacg
     2161 gaagacgtct tagacagcct cgctcagtcc tgggcaatgc caggagcctg gggagggaga
     2221 cctacctaga agcgctctgc cagatgagga aggaaaagat gtcaggggcg ctccagtcca
     2281 gagggctcta gttctagttc tgggagatcc cttcttagtg ttgtctcaga gttcagcgat
     2341 gacaacaaac tcttaatagc ttcagaaaca ccgacctgct gtgcatcagg tgggactata
     2401 tatatatata ttttttgtct atctgggttt ttgatttttg ttttcgccaa aattgcaaaa
     2461 ttctaaatgt aaagccctca gtatcaacta ttctaccttc acacctctct ctctctctct
     2521 ctctttctct ctctctctct ctctctctct ctccctctcc cctacacaca cacacacaca
     2581 cacacacaca cacacacaca cacacacaca catgctcact cacactcaac ttctttccac
     2641 agtagggtct ccagccagac ctcttagtaa aatgacttga acatcacctc tacaaaaaag
     2701 tattctacct ttacatgaaa gttaaaaaaa aaaaagacta ttgaactaaa aacagtcaac
     2761 tgtttacgta taatgttaaa ttcaggagtt cagtgtttta ataatatatc ctgttttgaa
     2821 acctcttgtt caaaaacaaa atgttttgag caatcaacca aaattgttcc ttttcttttc
     2881 ctgtagatgt tctgacaggt ttgcagggct tgcggctcac tgtgctagta tgtaaaaagg
     2941 tgttgtttac acgaggcaaa gggaaaacat gatattcaga cagttgccaa atagaataaa
     3001 ctatagcaca attactgtaa tggttgcctg gcaccagcaa cctgagaaag tgttttaaaa
     3061 aaaaagtgtt acaaggttta aaaaaaaaac atctttgcta acttttagtc ctgttaaaca
     3121 ttcatgaaat tgttaatatg acttatatag acccacacag gttttatttt tgtgtcttta
     3181 aaataaaagt ccaaaatatt taaattttat ggtcaaatat gcagtcaaca gctgctactt
     3241 tttcctttat atattaaatt tctcatatgt cttttattgt tctaataaac ctaagcttgt
     3301 gtgacctcca gtgcatatta gaccattcac tgtatgaaag aaaacatgtt gaataaattt
     3361 gtgagttttt aataaaaata gaaaacctga
//
