LOCUS       NM_001013906            1389 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus LHFPL tetraspan subfamily member 5 (Lhfpl5),
            mRNA.
ACCESSION   NM_001013906 XM_228037
VERSION     NM_001013906.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1389)
  AUTHORS   Xiong,W., Grillet,N., Elledge,H.M., Wagner,T.F., Zhao,B.,
            Johnson,K.R., Kazmierczak,P. and Muller,U.
  TITLE     TMHS is an integral component of the mechanotransduction machinery
            of cochlear hair cells
  JOURNAL   Cell 151 (6), 1283-1295 (2012)
   PUBMED   23217710
REFERENCE   2  (bases 1 to 1389)
  AUTHORS   Longo-Guess,C.M., Gagnon,L.H., Fritzsch,B. and Johnson,K.R.
  TITLE     Targeted knockout and lacZ reporter expression of the mouse Tmhs
            deafness gene and characterization of the hscy-2J mutation
  JOURNAL   Mamm Genome 18 (9), 646-656 (2007)
   PUBMED   17876667
REFERENCE   3  (bases 1 to 1389)
  AUTHORS   Kalay,E., Li,Y., Uzumcu,A., Uyguner,O., Collin,R.W., Caylan,R.,
            Ulubil-Emiroglu,M., Kersten,F.F., Hafiz,G., van Wijk,E.,
            Kayserili,H., Rohmann,E., Wagenstaller,J., Hoefsloot,L.H.,
            Strom,T.M., Nurnberg,G., Baserer,N., den Hollander,A.I.,
            Cremers,F.P., Cremers,C.W., Becker,C., Brunner,H.G., Nurnberg,P.,
            Karaguzel,A., Basaran,S., Kubisch,C., Kremer,H. and Wollnik,B.
  TITLE     Mutations in the lipoma HMGIC fusion partner-like 5 (LHFPL5) gene
            cause autosomal recessive nonsyndromic hearing loss
  JOURNAL   Hum Mutat 27 (7), 633-639 (2006)
   PUBMED   16752389
  REMARK    GeneRIF: LHFPL5 is essential for normal function of the human
            cochlea.
REFERENCE   4  (bases 1 to 1389)
  AUTHORS   Longo-Guess,C.M., Gagnon,L.H., Cook,S.A., Wu,J., Zheng,Q.Y. and
            Johnson,K.R.
  TITLE     A missense mutation in the previously undescribed gene Tmhs
            underlies deafness in hurry-scurry (hscy) mice
  JOURNAL   Proc Natl Acad Sci U S A 102 (22), 7894-7899 (2005)
   PUBMED   15905332
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000020.1 and BC087673.1.
            
            On Mar 16, 2021 this sequence version replaced NM_001013906.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087673.1, SRR26360172.57006.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760433
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                JAXUCZ010000020.1  6634058-6634095
            39-1389             BC087673.1         1-1351
FEATURES             Location/Qualifiers
     source          1..1389
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..1389
                     /gene="Lhfpl5"
                     /gene_synonym="Tmhs"
                     /note="LHFPL tetraspan subfamily member 5"
                     /db_xref="GeneID:294303"
                     /db_xref="RGD:1359370"
     exon            1..696
                     /gene="Lhfpl5"
                     /gene_synonym="Tmhs"
                     /inference="alignment:Splign:2.1.0"
     CDS             285..944
                     /gene="Lhfpl5"
                     /gene_synonym="Tmhs"
                     /note="tetraspan membrane protein of hair cell
                     stereocilia; lipoma HMGIC fusion partner-like 5 protein;
                     tetraspan transmembrane protein, hair cell stereocilia"
                     /codon_start=1
                     /product="LHFPL tetraspan subfamily member 5 protein"
                     /protein_id="NP_001013928.1"
                     /db_xref="GeneID:294303"
                     /db_xref="RGD:1359370"
                     /translation="MVKLLPAQEAAKIYHTNYVRNSRAVGVMWGTLTICFSVLVMALF
                     IQPYWIGDSVSTPQAGYFGLFSYCVGNVLSSELICKGGPLDFSSIPSRAFKTAMFFVA
                     LAMFLIIGSIICFSLFFVCNTATVYKICAWMQLAAATGLMIGCLVYPDGWDSSEVRRM
                     CGEQTGKYTLGHCTIRWAFMLAILSIGDALILSFLAFVLGYRQDKLLPDDYKADGNEE
                     V"
     exon            697..933
                     /gene="Lhfpl5"
                     /gene_synonym="Tmhs"
                     /inference="alignment:Splign:2.1.0"
     exon            934..979
                     /gene="Lhfpl5"
                     /gene_synonym="Tmhs"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1389
                     /gene="Lhfpl5"
                     /gene_synonym="Tmhs"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggcggcgc aggcccagac ccaggccgac tttgaggagg aggcagactc gagcccatcc
       61 tggtctgggc ggatacaggc gtctgggaag catctcttgc ggagccaagg ttgaccttgg
      121 cctgcttcgc tcccagctaa ctgggagaat gctcgcattg cgtcatgacc tcaggctgct
      181 cctcacacca ggctgaggac tgacccacga cctggccttc tactccctag atctgtggtc
      241 ctgcacccag ccagcgcctc cgacctagcc cagccgcctt cgccatggtg aagttgctgc
      301 cagcccagga ggccgccaag atctaccaca ccaactatgt gcgaaactcg cgcgccgtgg
      361 gggtgatgtg gggcacactc accatctgtt tctcggtgct ggtcatggcc ctctttatcc
      421 agccctactg gataggcgac agtgtgagca cgccacaggc tggctatttt ggcttgttct
      481 cgtactgtgt gggcaatgtg ctgtcgtcgg aactcatctg caagggcgga cctctggact
      541 tctcctctat cccctccaga gccttcaaga ccgccatgtt cttcgtggcc ttggcaatgt
      601 tcctcatcat cggctccatt atctgcttca gcctgttctt cgtctgtaac acagccacgg
      661 tctacaagat ttgcgcctgg atgcagctgg ctgcggccac gggcctgatg atcggatgtc
      721 tggtctaccc agatggttgg gactccagcg aggtgcggcg catgtgcggc gagcagacgg
      781 ggaagtatac gctgggccac tgcaccatcc gctgggcctt catgctggcc atcctcagta
      841 ttggagatgc actcatcctc tccttcttgg ctttcgtgtt gggctaccgg caggacaagc
      901 tccttccaga tgactacaag gccgatggga acgaggaagt ctgaagccat gaggtgctgg
      961 cgagccactc tcctggcagc tcacagtccg gccgacgccg ggcctccctc actgtgtgtg
     1021 ccactcatgg tgggctcctt ggaggtcaga agtttccaga aaccacacta ccttcaagtt
     1081 ctgcgcagat aactgtggtg atccaaagaa gatccccggg tgtgtggcgc acctgcctgc
     1141 agcctacact gtgccttgaa gcaggaacgg tggatttcac caaaaccttc aggtttaaac
     1201 aaaggccggg ttaagagaga cctgcaagtc ggataatccc ggagagttgc ctttttgccc
     1261 tatcttagcg gggacagaat tccgtcccat cgctgacaat gattatggtt cttacagttt
     1321 ttaggcagct tctctttcaa actctcagtc atcctcaaaa ccatgcagaa taaaaatcag
     1381 tgaggctaa
//
